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Chapter 18 - Transplant Pathology

from Section 8 - Transplant Pathology of the Kidney

Published online by Cambridge University Press:  10 August 2023

By
Agnieszka Perkowska-Ptasinska
Edited by
Helen Liapis
Helen Liapis
Affiliation:
Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
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Summary

Given the superior outcomes compared to dialysis, most children with end-stage kidney disease (ESKD) are currently referred for kidney transplantation. Kidney transplants are exposed to various types of injuries that occur as a result of hemodynamic disturbances, transplant rejection, infections, drug toxicity, metabolic disorders, and the recurrence of diseases originating in the native kidneys. Kidney allograft biopsy is the primary tool in the diagnostics of graft pathologies, enabling identification of lesions that may potentially be stopped or slowed down with proper treatment. The majority of kidney transplant histopathological images are not fully specific and therefore must be interpreted in context. In recent years, serological testing for the detection and monitoring of antibodies directed against transplant and non-transplant antigens in the graft, as well as molecular approaches aiming to trace changes that develop in the transplant based on fluctuations in gene expression have added to the pathology repertoire. The widening spectrum of tests and methods available has deepened our understanding of transplant pathology and also improved the accuracy of diagnosis.

Keywords

Pediatric kidney transplantationrejectionpost-transplant complicationskidney transplant pathologyrecurrent diseaseprotocol biopsies
Type
Chapter
Information
Pediatric Nephropathology & Childhood Kidney Tumors , pp. 341 - 366
Publisher: Cambridge University Press
Print publication year: 2023

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References

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  • Transplant Pathology
  • Edited by Helen Liapis, Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
  • Book: Pediatric Nephropathology & Childhood Kidney Tumors
  • Online publication: 10 August 2023
  • Chapter DOI: https://doi.org/10.1017/9781108907224.019
Available formats
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  • Transplant Pathology
  • Edited by Helen Liapis, Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
  • Book: Pediatric Nephropathology & Childhood Kidney Tumors
  • Online publication: 10 August 2023
  • Chapter DOI: https://doi.org/10.1017/9781108907224.019
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Transplant Pathology
  • Edited by Helen Liapis, Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
  • Book: Pediatric Nephropathology & Childhood Kidney Tumors
  • Online publication: 10 August 2023
  • Chapter DOI: https://doi.org/10.1017/9781108907224.019
Available formats
×