Case 66 - Pseudoappendicitis

Summary

Imaging description

CT is a highly accurate test for the diagnosis of acute appendicitis, with a sensitivity and specificity of 94% or greater [1–4]. Appendiceal enlargement and periappendiceal inflammation are the most sensitive signs of acute appendicitis.

The maximum diameter of the normal appendix varies widely among patients and ranges from 3 to 11 mm [5]. Various maximum diameter thresholds for the diagnosis of appendicitis with CT have been suggested, the most common being 6 mm. However, 24–45% of the population has an appendiceal diameter greater than 6 mm, making this threshold sensitive, but not specific [5, 6]. Hence, one should not diagnose acute appendicitis based on outer diameter alone. In particular, many normal appendices containing air will have an increased outer–outer wall diameter but non-thickened wall (Figure 66.1).

Airless fluid within an appendix of greater than 6mm outer wall diameter is rarely identified in normal patients, and although this does occur in 1–4% of normal appendices (Figure 66.2), it should raise the suspicion for appendicitis in the symptomatic patient [6, 7]. A “depth” of fluid within the appendix of greater than 2.6mm has been suggested as more sensitive and specific for acute appendicitis by one institution [8, 9].

As the outer diameter of the appendix includes a variable quantity of luminal contents, many have suggested evaluating the mural thickness of the appendix. The mural thickness can be assessed either by measuring it directly in patients with luminal contents or, in patients without appendiceal luminal contents, by measuring the outer wall diameter of the appendix and dividing by two. The average single-wall thickness of the normal appendix on CT is approximately 1.5mm (range, 0.25–3.1mm), and only 0.9–2% of normal patients will have an appendiceal wall thickness of 3mm or more [7, 10].