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Chapter 17 - In vitro maturation of oocytes

from Section 5: - Alternatives to ovarian hyperstimulation

Published online by Cambridge University Press:  05 August 2011

By
Baris Ata ,
Dan Levin ,
Hananel Holzer  and
Seang Lin Tan
Edited by
Mohamed Aboulghar  and
Botros Rizk
Mohamed Aboulghar
Affiliation:
Cairo University and the IVF-ET Center
Botros Rizk
Affiliation:
University of South Alabama
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Summary

Controlled ovarian hyperstimulation (COS) proved to increase the success rate of in vitro fertilization (IVF), and the results achieved by most treatment centers exceed spontaneous conception rates in healthy, fertile couples. The in vitro maturation (IVM) technique aims to make use of the multiple immature oocytes that already exist in the ovaries of a reproductive-aged woman. A short course of gonadotropin administration has been suggested to improve the clinical outcome of IVM cycles through increasing developmental competence of immature oocytes and/or the number of in vivo-matured oocytes collected in an IVM cycle. Pregnancy rates seem to be significantly higher when an in vivo-matured oocyte has been collected. Young women with high antral-follicle counts seem to have the highest pregnancy rates with IVM. Once a successful IVM program has been implemented, all assisted reproduction treatment (ART) laboratory procedures can be performed with in vitro-matured oocytes if the need arises.

Keywords

aromatase inhibitorsclomiphene citratecontrolled ovarian hyperstimulationpoor-responder patientsMini-dose luteal phasegonadotropin-releasing hormone agonistfollicle-stimulating hormone
Type
Chapter
Information
Ovarian Stimulation , pp. 181 - 194
Publisher: Cambridge University Press
Print publication year: 2010

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