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Chapter 24 - Epilepsy in Pregnancy

from Section 4 - Neurological Disorders in Pregnancy

Published online by Cambridge University Press:  23 February 2023

By
Raluca Pana  and
Amira El-Messidi
Edited by
Amira El-Messidi  and
Alan D. Cameron
Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

A 30-year-old nulligravida with epilepsy is referred by her primary care provider to your hospital center’s high-risk obstetrics unit for preconception counseling.

Keywords

Preconception counselingAntiepileptic drugsBreakthrough seizuresInvestigationsTeratogenicityMaternal-fetal risksStatus epilepticusAntepartum, intrapartum managementContraception
Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
 , pp. 337 - 348
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

Campbell, E, Kennedy, F, Russell, A, et al. Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. J Neurol Neurosurg Psychiatry. 2014;85(9):1029–1034.CrossRefGoogle ScholarPubMed
Committee on Practice Bulletins-Obstetrics. Practice Bulletin No. 187: Neural tube defects. Obstet Gynecol. 2017;130(6):e279–e290.Google Scholar
Douglas Wilson, R, Van Mieghem, T, Langlois, S, et al. Guideline No. 410: Prevention, screening, diagnosis, and pregnancy management for fetal neural tube defects. J Obstet Gynaecol Can. 2021;43(1):124–139.e8.CrossRefGoogle ScholarPubMed
Harden, CL, Hopp, J, Ting, TY, et al. Practice parameter update: management issues for women with epilepsy – focus on pregnancy (an evidence-based review): obstetrical complications and change in seizure frequency: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology. 2009;73(2):126–132. Reaffirmed 2013.Google Scholar
Harden, CL, Pennell, PB, Koppel, BS, et al. Practice parameter update: management issues for women with epilepsy – focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology. 2009;73(2):142–149.CrossRefGoogle Scholar
Patel, SI, Pennell, PB. Management of epilepsy during pregnancy: an update. Ther Adv Neurol Disord. 2016;9(2):118–129. Reaffirmed 2013.CrossRefGoogle ScholarPubMed
Rajiv, KR, Radhakrishnan, A. Status epilepticus in pregnancy – can we frame a uniform treatment protocol? Epilepsy Behav. 2019;101(Pt B):106376.CrossRefGoogle Scholar
Royal College of Obstetricians and Gynaecologists. Epilepsy in pregnancy. Green-Top Guideline No. 68. London: RCOG; 2016.Google Scholar
Tomson, T, Battino, D, Bromley, R, et al. Management of epilepsy in pregnancy: a report from the International League Against Epilepsy (ILAE) Task Force on Women and Pregnancy. Epileptic Disord. 2019;21(6):497–517.Google Scholar
Viale, L, Allotey, J, Cheong-See, F, et al. Epilepsy in pregnancy and reproductive outcomes: a systematic review and meta-analysis. Lancet. 2015;386(10006):1845–1852.CrossRefGoogle ScholarPubMed

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