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from Section 2 - Algorithms for Management of the Top Five ‘Direct Killers’
Published online by Cambridge University Press: 06 May 2021
Amniotic fluid embolus is the eighth most common cause of all maternal deaths, down one place from the previous edition of this book [2, 5]. At 0.35 per 100 000 maternities (95% CI 0.15–1.39) it has declined from the fourth to the fifth leading cause of direct maternal deaths in the United Kingdom. Maternal case fatality rates are between 11% and 32% in the United Kingdom, Australia and the United States [9, 4, ref surveillance]. There is a fall in case mortality rates which is probably due to high-level supportive care and diagnosis of milder cases [6].
Women who died or who had permanent neurological injury were more likely to present with cardiac arrest (83% vs. 33%, P < 0.001), be from ethnic-minority groups (adjusted odds ratio [AOR] 2.85; 95% CI 1.02–8.00), to have had a hysterectomy (OR 2.49; 95% CI 1.02–6.06) and were less likely to receive cryoprecipitate (OR 0.30; 95% CI 0.11–0.80) [1].
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