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Chapter 27 - Non-Neoplastic Diseases of the Anal Canal

Published online by Cambridge University Press:  06 June 2020

By
Morgan Moorghen
Edited by
Roger M. Feakins
Roger M. Feakins
Affiliation:
Royal Free London NHS Foundation Trust, London, UK
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Summary

The most common non-neoplastic conditions in the anal canal include haemorrhoids, fissures, fibroepithelial polyps and associated abscesses, manifestations of Crohn’s disease, human papilloma virus infection, and other sexually transmitted infections (some of which are secondary to HIV). Several dermatoses that are not site-specific may also involve the anal canal and perianal areas. These include eczema, psoriasis, lichen planus, lichen sclerosus, acanthosis nigricans, and hidradenitis suppurativa. Non-neoplastic polypoid lesions may occur, and these include condylomata acuminata and inflammatory cloacogenic polyps. Congenital abnormalities include imperforate anus and anal duplication. The former rarely, if ever, comes to attention of the histopathologist whereas the latter is occasionally encountered.

Keywords

anal canalhemorrhoidspolypfistulahuman papilloma virusdermatosiscongenital abnormalities
Type
Chapter
Information
Non-Neoplastic Pathology of the Gastrointestinal Tract
A Practical Guide to Biopsy Diagnosis
 , pp. 434 - 445
Publisher: Cambridge University Press
Print publication year: 2020

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References

Ellis, H, Mahadevan, V. In Clinical anatomy, 13th ed. Oxford: Wiley Blackwell, 2013; 89–94.Google Scholar
Rakinic, J, Poola, VP. Hemorrhoids and fistulas: new solutions to old problems. Curr Probl Surg. 2014;51:98–137.CrossRefGoogle ScholarPubMed
Hui, Y, Quddus, MR, Murthy, JN, et al. Human papillomavirus genotyping of incidental malignant and premalignant lesions on hemorrhoidectomy specimens. Am J Surg Pathol. 2017;41(3):382–8.Google Scholar
Matthyssens, LE, Ziol, M, Barrat, C, Champault, GG Routine surgical pathology in general surgery. Br J Surg. 2006;93(3):362–8.CrossRefGoogle ScholarPubMed
He, XH, Huang, J, Yao, J, et al. Routine histopathologic examination of benign anal lesions: is it necessary? Surg Today. 2015;45:416–21.Google Scholar
AGA technical review on perianal Crohn’s disease. Gastroenterology. 2003;125:1508–30.Google Scholar
Malaty, HM, Sansgiry, S, Artinyan, A, Hou, JK. Time trends, clinical characteristics, and risk factors of chronic anal fissure among a national cohort of patients with inflammatory bowel disease. Dig Dis Sci. 2016;61:861–4.Google Scholar
Bonheur, JL1, Braunstein, J, Korelitz, BI, Panagopoulos, G. Anal skin tags in inflammatory bowel disease: new observations and a clinical review. Inflamm Bowel Dis. 2008; 14(9):1236–9.Google Scholar
Sugrue, J, Nordenstam, J, Abcarian, H, et al. Pathogenesis and persistence of cryptoglandular anal fistula: a systematic review. Tech Coloproctol. 2017;21:425–32.CrossRefGoogle ScholarPubMed
Tago, S, Hai, Y, Ainoda, Y, Fujita, T, Takamori, M, Kikuchi, K. Perianal tuberculosis: a case report and review of the literature. World J Clin Cases. 2015;3(9):848–85.Google Scholar
Ferreira Cardoso, M, Carneiro, C, Carvalho Lourenço, L, et al. Actinomycosis causing recurrent perianal fistulae. ACG Case Rep J. 2017;4:1–4.Google ScholarPubMed
Taylor, BA, Williams, GT, Hughes, LE, Rhodes, J. The histology of anal skin tags in Crohn’s disease: an aid to confirmation of the diagnosis. Int J Colorectal Dis. 1989;4:197–9.CrossRefGoogle ScholarPubMed
Hoffman, LK, Ghias, MH, Lowes, MA. Pathophysiology of hidradenitis suppurativa. Cutan Med Surg. 2017;36:47–54.Google Scholar
Nagot, N, Ouedraogo, A, Foulongne, V, et al. Reduction of HIV-1RNA levels with therapy to suppress herpes simplex virus. N Engl J Med. 2007;356:790–9.Google Scholar
Ranu, H, Lee, J, Chio, M, Sen, P. Tumour-like presentations of anogenital Herpes simplex in HIV-positive patients. Int J Std AIDS. 2011;4:181–6.Google Scholar
Cone, MM, Whitlow, CB. Sexually transmitted and anorectal infectious diseases. Gastroenterol Clin N Am. 2013;42;877–92.Google Scholar
Mbata, TI, Onile, BA, Agbonlahor, DE et al. Diagnosis and management of chancroid in Nigeria. Malawi Med J. 2004;16:19–21.Google Scholar
Azevedo, T, Catarino, A, Ferreira, L, Borges, F, Mansinho, K. Disseminated molluscum contagiosum lesions in an HIV patient. Cleve Clin J Med. 2017;84(3):186–7.CrossRefGoogle Scholar
Gopal, P, Rajal, B. Shah, MD. Primary anal canal syphilis in men the clinicopathologic spectrum of an easily overlooked diagnosis. Arch Pathol Lab. 2015;139:1156–60.Google Scholar
Day, T, Bohl, TG, Scurry, J. Perianal lichen dermatoses: a review of 60 cases. Australas J Dermatol. 2016;57(3):210–15.Google Scholar
Giuliani, M, Troiano, G, Cordaro, M, et al. Rate of malignant transformation of oral lichen planus: a systematic review. Oral Dis. 2018;10: 1111–16.Google Scholar
Pugliese, JM, . Morey, AF, Peterson, AC. Lichen sclerosus: review of the literature and current recommendations for management. J Urol. 2007;178:2268–76.Google Scholar
Parfitt, JR, Shepherd, NA. Polypoid mucosal prolapse complicating low rectal adenomas: beware the inflammatory cloacogenic polyp. Histopathology. 2008;53:91–6.Google Scholar
Assi, R, Hashim, PW, Reddy, VB, Einarsdottir, H, Longo, WE. Sexually transmitted infections of the anus and rectum. World J Gastroenterol. 2014;20:15262–8.Google Scholar
Mirzaei, R, Mahjubi, B, Alvandipoor, M, Karami, MY. Late presentation of anal canal duplication in adults: a series of four rare cases. Ann Coloproctol. 2015;31(1):34–6.Google Scholar
Boulanger, GE, Abeta, E, Brau-Webera, AG, et al. Is histological analysis of pilonidal sinus useful? Retrospective analysis of 731resections. https://doi.org/10.1016/j.jviscsurg.2017.10.013Google Scholar

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