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Chapter 12 - Assessment of Gastric Biopsies

Published online by Cambridge University Press:  06 June 2020

By
Tim Andrews  and
Fiona Campbell
Edited by
Roger M. Feakins
Roger M. Feakins
Affiliation:
Royal Free London NHS Foundation Trust, London, UK
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Summary

The recognition of specific oesophageal infections and the distinction between gastro-oesophageal reflux disease and rarer forms of oesophagitis are key tasks for gastrointestinal pathologists reading mucosal biopsies. Infections can involve the oesophagus either primarily or as part of a wider process. This chapter highlights their features, discussing in detail the common infections including herpes simplex, cytomegalovirus, and Candida, and summarises the features of the rarer ones. A few additional types of oesophagitis have emerged recently, including eosinophilic oesophagitis and lymphocytic oesophagitis. This chapter reviews the recent literature and will discuss the controversies surrounding some of these new entities. There is an emphasis on the need for correlation between clinical/endoscopic information and microscopic appearances, and there is discussion of supplementary special studies including immunohistochemistry where relevant.

Keywords

immunosuppressionherpes simplexcytomegalovirusCandidaeosinophilic oesophagitislymphocytic oesophagitis
Type
Chapter
Information
Non-Neoplastic Pathology of the Gastrointestinal Tract
A Practical Guide to Biopsy Diagnosis
 , pp. 179 - 185
Publisher: Cambridge University Press
Print publication year: 2020

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References

Loughrey, MB, Johnston, BT. Guidance on the effective use of upper gastrointestinal histopathology. Frontline Gastroenterol. 2014;5:88–95.CrossRefGoogle ScholarPubMed
Cadman, B, Dixon, MF, Wyatt, J. Value of routine, non-targeted biopsies in the diagnosis of gastric neoplasia. J Clin Pathol. 1997;50:832–4.CrossRefGoogle ScholarPubMed
Carpenter, HA, Talley, NJ. Gastroscopy is incomplete without biopsy: clinical relevance of distinguishing gastropathy from gastritis. Gastroenterology. 1995;108:917–24.CrossRefGoogle ScholarPubMed
Khakoo, SI, Lobo, AJ, Shepherd, NA, et al. Histological assessment of the Sydney classification of endoscopic gastritis. Gut. 1994;35:1172–6.CrossRefGoogle ScholarPubMed
Shepherd, NA, Valori, RM. The effective use of gastrointestinal histopathology: guidance for endoscopic biopsy in the gastrointestinal tract. Frontline Gastroenterol. 2014;5:84–7.Google Scholar
Koenig, M, Schofield, JB, Warren, BF, et al. The routine use of histochemical stains in gastrointestinal pathology: a UK-wide survey. Histopathology. 2009;55:214–7.Google Scholar
Wright, CL, Kelly, JK. The use of routine special stains for upper gastrointestinal biopsies. Am J Surg Pathol. 2006;30:357–61.Google Scholar
Dixon, MF, Genta, RM, Yardley, JH, et al. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol. 1996;20:1161–81.Google ScholarPubMed
Genta, RM, Lash, RH. Helicobacter pylori-negative gastritis: seek, yet ye shall not always find. Am J Surg Pathol. 2010;34:e25–34.CrossRefGoogle Scholar
Batts, KP, Ketover, S, Kakar, S, et al. Appropriate use of special stains for identifying Helicobacter pylori: Recommendations from the Rodger C. Haggitt Gastrointestinal Pathology Society. Am J Surg Pathol. 2013;37:e12–22.Google Scholar
Feakins, R, Allen, D, Campbell, F, et al. Tissue Pathways for Gastrointestinal and Pancreatobiliary Pathology. London: Royal College of Pathologists; 2016.Google Scholar
Arnason, T, Brown, IS, Goldsmith, JD, et al. Collagenous gastritis: a morphologic and immunohistochemical study of 40 patients. Mod Pathol. 2015;28:533–44.CrossRefGoogle ScholarPubMed
Chen, Z, Scudiere, JR, Montgomery, E. Medication-induced upper gastrointestinal tract injury. J Clin Pathol. 2009;62:113–9.CrossRefGoogle ScholarPubMed
http://apps.who.int/classifications/icd10/browse/2016/en#/K29 (accessed 30 March 2018).Google Scholar
Sugano, K, Tack, J, Kuipers, EJ, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015;64:1–15.Google Scholar
Price, AB. The Sydney system: histological division. J Gastroenterol Hepatol. 1991;6:209–22.Google Scholar
Sipponen, P, Price, AB. The Sydney System for classification of gastritis 20 years ago. J Gastroenterol Hepatol. 2011;26(Suppl 1):31–4.CrossRefGoogle ScholarPubMed
Bayerdörffer, E, Oertel, H, Lehn, N, et al. Topographic association between active gastritis and Campylobacter pylori colonisation. J Clin Pathol. 1989;42:834–9.Google Scholar
Genta, RM, Graham, DY. Comparison of biopsy sites for the histopathologic diagnosis of Helicobacter pylori: a topographic study of H. pylori density and distribution. Gastrointest Endosc. 1994;40:342–5.CrossRefGoogle ScholarPubMed
Correa, P, Yardley, JH. Grading and classification of chronic gastritis: one American response to the Sydney system. Gastroenterology. 1992;102:355–9.Google Scholar
Rubin, CE. Histological classification of chronic gastritis: an iconoclastic view. Gastroenterology. 1992;102:360–1.CrossRefGoogle ScholarPubMed
Rugge, M, Farinati, F, Baffa, R, et al. Gastric epithelial dysplasia in the natural history of gastric cancer: a multicentre prospective follow-up study. Gastroenterology. 1994;107:1288–96.Google Scholar
Rugge, M, de Boni, M, Pennelli, G, et al. Gastritis OLGA-staging and gastric cancer risk: a twelve year clinic-pathological follow-up study. Aliment Pharmacol Ther. 2010;31:1104–11.CrossRefGoogle Scholar
Capelle, LG, de Vries, AC, Haringsma, J, et al. The staging of gastritis with the OLGA system by using intestinal metaplasia as an accurate alternative for atrophic gastritis. Gastrointest Endosc. 2010;71:1150–8.Google Scholar
Andrew, A, Wyatt, JI, Dixon, MF. Observer variation in the assessment of chronic gastritis according to the Sydney System. Histopathology. 1994;25:317–22.Google Scholar
Genta, RM, Dixon, MF. The Sydney System revisited: the Houston International Gastritis Workshop. Am J Gastroenterol. 1995;90:1039–41.Google ScholarPubMed
Goldenring, JR, Nam, KT, Wang, TC, et al. Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for re-evaluation of metaplasias and the origins of gastric cancer. Gastroenterology. 2010;138:2207–10.Google Scholar
Hayat, M, Arora, DS, Wyatt, JI, et al. The pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence of duodenal pathology. J Clin Pathol. 1999;52:815–19.Google Scholar
Wu, TT, Hamilton, SR. Lymphocytic gastritis; association with aetiology and topology. Am J Surg Pathol. 1999;23:153–8.CrossRefGoogle ScholarPubMed
Rubio-Tapia, A, Herman, ML, Ludvigsson, JF, et al. Severe spruelike enteropathy associated with olmesartan. Mayo Clin Proc. 2012;87:732–8.CrossRefGoogle ScholarPubMed
Muir, A, Surrey, L, Kriegermeier, A, et al. Severe eosinophilic gastroenteritis in a Crohn’s disease patient treated with infliximab and adalimumab. Am J Gastroenterol. 2016;111:437–8.CrossRefGoogle Scholar
Bavi, P, Butler, M, Serra, S, et al. Immune modulator-induced changes in the gastrointestinal tract. Histopathology. 2017;71:495–7.CrossRefGoogle ScholarPubMed
Ma, C, Park, JY, Montgomery, EA, et al. A comparative clinicopathologic study of collagenous gastritis in children and adults: the same disorder with associated immune-mediated diseases. Am J Surg Pathol. 2015;39:802–12.Google Scholar
Kobayashi, M, Yamaguchi, O, Nagata, K, et al. Acute haemorrhagic gastritis after nivolumab treatment. Gastrointest Endosc. 2017;86:915–16.CrossRefGoogle ScholarPubMed

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