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Chapter 16 - Musculoskeletal Disorders and Pain in Parkinson’s Disease

Published online by Cambridge University Press:  05 March 2022

By
Ovidiu-Alexandru Bajenaru
Edited by
Néstor Gálvez-Jiménez ,
Amos D. Korczyn  and
Ramón Lugo-Sanchez
Néstor Gálvez-Jiménez
Affiliation:
Florida International University
Amos D. Korczyn
Affiliation:
Tel-Aviv University
Ramón Lugo-Sanchez
Affiliation:
Cleveland Clinic
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Summary

Musculoskeletal disorders and pain in Parkinson’s disease (PD) are two complex clinically and pathophysiologically distinct problems, but a high degree of overlap exists between the pathogenesis and understanding of these two types of clinical manifestations. Although not commonly recognized as such these non-motor symptoms are quite frequent, impacting patients’ qualify of life. . Early clinical observations [1] have noticed that both musculoskeletal disorders and pain related to these appear even in the prodromal phase, but also during definite PD manifestation, mainly by different algic syndromes determined by so-called fibromyalgia (fibrositis, tendinitis, myalgia), shoulder pain, cervicobrachialgia, ischialgia, lower back pain, and arthralgia. These probably appear indirectly as a component of PD, and seem to be significantly improved by the administration of levodopa. In PD patients with motor fluctuations, musculoskeletal pain tends to occur more often when parkinsonian disability is maximal and less frequently when disability is minimal [2].

Type
Chapter
Information
Non-motor Parkinson's Disease , pp. 178 - 186
Publisher: Cambridge University Press
Print publication year: 2022

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References

Gonera, EG, van ’t Hof, M, Berger, HJC, van Weel, C, Horstink, MWIM. Symptoms and duration of the prodromal phase in Parkinson’ s disease. Mov Disord 1997; 12(6): 871–876.Google Scholar
Goetz, CG, Tanner, CM, Levy, M, Wilson, RS, Garron, DC. Pain in Parkinson’s disease. Mov Disord 1986; 1: 4549.Google ScholarPubMed
Leibson, CL, Maraganore, DM, Bower, JH, et al. Comorbid conditions associated with Parkinson’s disease: a population-based study. Mov Disord 2006; 21(4): 446–455.CrossRefGoogle ScholarPubMed
Ezzatian-Ahar, S, Schwarz, P, Pedersen, SW. Osteoporosis often occurs in Parkinson’s disease patients. Ugeskr Laeger 2014; 176(36): V03140145.Google ScholarPubMed
Park, SB, Chung, CK, Lee, JY, Lee, JY, Kim, J. Risk factors for vertebral, hip, and femoral fractures among patients with Parkinson’s disease: a 5-year follow-up in Korea. J Am Med Dir Assoc 2019; 20(5): 617–623.Google Scholar
Khlebtovsky, A, Djaldetti, R, Rodity, Y, et al. Progression of postural changes in Parkinson’s disease: quantitative assessment. J Neurol 2017; 264(4): 675–683.CrossRefGoogle ScholarPubMed
Galbusera, F, Bassani, T, Stucovitz, E, et al. Surgical treatment of spinal disorders in Parkinson’s disease. Eur Spine J 2018; 27(Suppl 1): 101–108.CrossRefGoogle ScholarPubMed
Lee, CK, Choi, SK, Shin, DA, et al. Parkinson’s disease and the risk of osteoporotic vertebral compression fracture: a nationwide population-based study. Osteoporos Int 2018; 29(5):1117–1124.CrossRefGoogle ScholarPubMed
Baker, JF, McClelland, S 3rd, Hart, RA, Bess, RS. Management of spinal conditions in patients with Parkinson disease. J Am Acad Orthop Surg 2017; 25(8): e157–e165.Google Scholar
Srivanitchapoom, P, Hallett, M. Camptocormia in Parkinson’s disease: definition, epidemiology, pathogenesis and treatment modalities. J Neurol Neurosurg Psychiatry 2016; 87(1): 75–85.Google ScholarPubMed
Lenoir, T, Guedj, N, Boulu, P, Guigui, P, Benoist, M. Camptocormia: the bent spine syndrome, an update. Eur Spine J 2010; 19: 1229–1237.CrossRefGoogle ScholarPubMed
Wrede, A, Margraf, NG, Goebel, HH, Deuschl, G, Schulz-Schaeffer, WJ. Myofibrillar disorganization characterizes myopathy of camptocormia in Parkinson’s disease. Acta Neuropathol 2012; 123: 419–432.Google Scholar
Bouchaud-Chabot, A, Sicre, J, Bardin, Th, Kahn, MF. Myosites focales. In: Kahn, MF et al. (eds.). L’actualite´ rhumatologique. Expansion scientifique Française; 1996, 55–64.Google Scholar
Charpentier, P, Dauphin, A, Stojkovic, T, et al. Maladie de Parkinson, camptocormie et myosite focale paraspinale. Revue Neurologique 2005; 161(4): 459–463.Google Scholar
Cumming, W, Weiser, R, Teoh, R, Hudgson, P, Walton, JN. Localized nodular myositis: a clinical and pathological variant of polymyositis. Q J Med 1977; 46(184): 531–546.Google ScholarPubMed
Heffner, R, Armbrustmacher, V, Eanle, K. Focal myositis. Cancer 1977; 40(1): 301–306.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
Schulz-Schaeffer, WJ. Camptocormia in Parkinson’s disease: a muscle disease due to dysregulated proprioceptive polysynaptic reflex arch. Front Aging Neurosci 2016; 8: 128.CrossRefGoogle ScholarPubMed
Schulz-Schaeffer, WJ, Margraf, NG, Munser, S, et al. Effect of neurostimulation on camptocormia in Parkinson’s disease depends on symptom duration. Mov Disord 2015; 30(3): 368–372.CrossRefGoogle ScholarPubMed
Margraf, NG, Wrede, A, Deuschl, G, Schulz-Schaeffer, WJ. Pathophysiological concepts and treatment of camptocormia. J Parkinsons Dis 2016; 6(3): 485–501.CrossRefGoogle ScholarPubMed
Tinazzi, M, Geroin, C, Gandolfi, M, et al. Pisa syndrome in Parkinson’s disease: an integrated approach from pathophysiology to management. The pathogenesis of Pisa syndrome in Parkinson’s disease. Mov Disord 2016; 31(12): 1785–1795.CrossRefGoogle Scholar
Castrioto, A, Piscicelli, C, Pérennou, D, Krack, P, Debu, B. The pathogenesis of Pisa syndrome in Parkinson’s disease. Mov Disord 2014; 29(9): 1100–1107.Google Scholar
Young, EH, Kunhyun, K, Won-Ho, C, et al. Pisa syndrome in Parkinson’s disease: pathogenic roles of verticality perception deficits. Sci Rep 2018; 8(1): 1804.Google Scholar
Albanese, A, Bhatia, K, Bressman, SB, et al. Phenomenology and classification of dystonia: a consensus update. Mov Disord 2013; 28(7): 863–873.CrossRefGoogle ScholarPubMed
Tinazzi, M, Juergenson, I, Squintani, G, et al. Pisa syndrome in Parkinson’s disease: an electrophysiological and imaging study. J Neurol 2013; 260(8): 2138–2148.CrossRefGoogle ScholarPubMed
Doherty, KM, van de Warrenburg, BP, Peralta, MC, et al. Postural deformities in Parkinson’s disease. Lancet Neurol 2011; 10(6): 538–549.CrossRefGoogle ScholarPubMed
Tinazzi, M, Fasano, A, Geroin, C, et al. Italian Pisa Syndrome Study Group. Pisa syndrome in Parkinson disease: an observational multicenter Italian study. Neurology 2015; 85(20): 1769–1779.CrossRefGoogle Scholar
Vrtovec, T, Pernus, F, Likar, B. A review of methods for quantitative evaluation of spinal curvature. Eur Spine J 2009; 18(5): 593–607.CrossRefGoogle ScholarPubMed
Vrtovec, T, Pernus, F, Likar, B. A review of methods for quantitative evaluation of axial vertebral rotation. Eur Spine J 2009; 18(8): 1079–1090.Google Scholar
de Azevedo, AKeC, Claudino, R, Conceição, JS, Swarowsky, A, Santos, MJd. Anticipatory and compensatory postural adjustments in response to external lateral shoulder perturbations in subjects with Parkinson’s disease. PLoS ONE 2016; 11(5): e0155012.CrossRefGoogle ScholarPubMed
Metta, V, Sanchez, TC, Padmakumar, C. Osteoporosis: a hidden nonmotor face of Parkinson’s disease. Int Rev Neurobiol 2017; 134: 877–890.CrossRefGoogle ScholarPubMed
Choi, SM, Kim, BC, Jung, HJ, . The association of musculoskeletal pain with bone mineral density in patients with Parkinson’s disease. Eur Neurol 2017; 77(3–4): 123–129.Google Scholar
Malochet-Guinamand, S, Durif, F, Thomas, T. Parkinson’s disease: a risk factor for osteoporosis. Joint Bone Spine 2015; 82(6):406–410.Google Scholar
van den Bos, F, Speelman, AD, Samson, M, et al. Parkinson’s disease and osteoporosis. Age Ageing 2013; 42(2):156–162.CrossRefGoogle ScholarPubMed
Invernizzi, M, Carda, S, Viscontini, GS, Cisari, C. Osteoporosis in Parkinson’s disease. Parkinsonism Relat Disord 2009; 15(5): 339–346.CrossRefGoogle ScholarPubMed
Lyell, V, Henderson, E, Devine, M, Gregson, C. Assessment and management of fracture risk in patients with Parkinson’s disease. Age Ageing 2015; 44(1): 34–41.Google Scholar
Seong‐Beom, K, Jee‐Hoon, R, Ji Hyun, K, et al. Ultrasonographic findings of shoulder disorders in patients with Parkinson’s disease. Mov Dis Volume 2008; 23(12): 1772–1776.Google Scholar
Papalia, R, Torre, G, Papalia, G, et al. Frozen shoulder or shoulder stiffness from Parkinson disease? Musculoskelet Surg 2019; 103(2): 115–119.CrossRefGoogle ScholarPubMed
Ya-Ting, C, Wen-Neng, C, Nai-Wen, T, et al. Clinical features associated with frozen shoulder syndrome in Parkinson’s disease. Parkinsons Dis 2015; 3: 1–7.Google Scholar
Endo, T, Hamasaki, T, Okuno, R, et al. Parkinsonian rigidity shows variable properties depending on the elbow joint angle. Parkinsons Dis 2013: 258374.CrossRefGoogle Scholar
Parkinson, J. An Essay on the Shaking Palsy. Sherwood, Neely, Jones; 1817.Google Scholar
Rodriguez-Violante, M, Alvarado-Bolanos, A, Cervantes-Arriaga, A, et al. Clinical determinants of Parkinson’s disease-associated pain using the King’s Parkinson’s Disease Pain Scale. Mov Disord Clin Pract 2017; 4(4): 545–551.CrossRefGoogle ScholarPubMed
Politis, M, Wu, K, Molloy, S, et al. Parkinson’s disease symptoms: the patient’s perspective. Mov Disord 2010; 25(11): 1646–1651.CrossRefGoogle ScholarPubMed
Hong-Bo, W, Zhen-Xin, Z, Han, W, et al. Epidemiology and clinical phenomenology for Parkinson’s disease with pain and fatigue. Parkinsonism Relat Disord 2012; 18S1: S222–S225.Google Scholar
Zesiewicz, TA, Sullivan, KL, Arnulf, I, et al. Practice parameter: treatment of nonmotor symptoms of Parkinson disease. Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2010; 74: 924–931.CrossRefGoogle Scholar
Antonini, A, Tinazzi, M, Abbruzzese, G, et al. Pain in Parkinson’s disease: facts and uncertainties. Eur J Neurol 2018; 25(7): 917–e69.CrossRefGoogle ScholarPubMed
Giuffrida, R, Vingerhoets, FJ, Bogousslavsky, J, Ghika, J. Pain in Parkinson’s disease. Rev Neurol 2005; 161(4): 407–418.Google Scholar
Ford, B. Pain in Parkinson’s disease. Mov Disord 2010; 25(Suppl 1): S98–S103.Google Scholar
Beiske, AG, Loge, JH, Rønningen, A, Svensson, E. Pain in Parkinson’s disease: prevalence and characteristics. Pain 2009; 141(1–2): 173–177.Google Scholar
Ha, AD, Jankovic, J. Pain in Parkinson’s disease. Mov Disord 2012; 27(4): 485–491.Google Scholar
Sauerbier, A, Jenner, P, Todorova, A, Chaudhuri, KR. Non motor subtypes and Parkinson’s disease. Parkinsonism Relat Disord 2015; 22(Suppl 1): S41–S46.Google Scholar
Chaudhuri, KR, Rizos, A, Trenkwalder, C, et al. EUROPAR and the IPMDS Non Motor PD Study Group. King’s Parkinson’s disease pain scale, the first scale for pain in PD: an international validation. Mov Disord 2015; 30: 1623–1631.Google Scholar
Rana, AQ, Qureshi, AR, Rahman, L, et al. Association of restless legs syndrome, pain, and mood disorders in Parkinson’s disease. Int J Neurosci 2016; 126(2):116–120.Google Scholar
Sophie, M, Ford, B. Management of pain in Parkinson’s disease. CNS Drugs 2012; 26(11): 937–948.Google Scholar
Schreder, EJA, Swaab, DF. Pain in dementia. In Aminoff, MJ, Boller, F, Swaab, DF, Cervero, F, Jensen T (eds, . ). Handbook of Clinical Neurology, vol. 81. Elsevier; 2006, 817–829.Google Scholar
Haber, SN, Calzavara, R. The cortico-basal ganglia integrative network: the role of the thalamus. Brain Res Bull 2009; 16(78(2–3): 69–74.Google Scholar
Dellapina, E, Gerdelat-Mas, A, Ory-Magne, F, et al. Apomorphine effect on pain threshold in Parkinson’s disease: a clinical and positron emission tomography study. Mov Disord 2011; 26(1): 153–157.Google Scholar
Fava, M. The role of the serotonergic and noradrenergic neurotransmitter systems in the treatment of psychological and physical symptoms of depression. J Clin Psychiatry 2003; 64(Suppl 13): 26–29.Google Scholar
Ehrt, U, Larsen, JP, Aarsland, D. Pain and its relationship to depression in Parkinson disease. Am J Geriatr Psychiatry 2009; 17(4): 269–275.Google Scholar
Djaldetti, R, Yust-Katz, S, Kolianov, V, Melamed, E, Dabby, R. The effect of duloxetine on primary pain symptoms in Parkinson disease. Clin Neuropharmacol 2007; 30(4): 201–205.CrossRefGoogle ScholarPubMed
Polli, A, Weis, L, Biundo, R, et al. Anatomical and functional correlates of persistent pain in Parkinson’s disease. Mov Disord 2016; 31(12): 1854–1864.CrossRefGoogle ScholarPubMed
Lavreysen, H, Dautzenberg, FM. Therapeutic potential of group III metabotropic glutamate receptors. Curr Med Chem 2008; 15(7): 671–684.Google Scholar
Goudet, C, Chapuy, E, Alloui, A, et al. Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain. Pain 2008; 137(1): 112–124.CrossRefGoogle Scholar
Pertovaara, A, Wei, H. Dual influence of the striatum on neuropathic hypersensitivity. Pain 2008; 137(1): 50–59.Google Scholar
Chudler, EH, Dong, WK. The role of the basal ganglia in nociception and pain. Pain 1995; 60(1): 3–38.Google Scholar
Reichling, DB, Levine, JD. Pain and death: neurodegenerative disease mechanisms in the nociceptor. Ann Neurol 2011; 69(1): 13–21.Google Scholar
Nolano, M, Provitera, V, Estraneo, A, et al. Sensory deficit in Parkinson’s disease: evidence of a cutaneous denervation. Brain 2008; 131(Pt 7): 1903–1911.Google Scholar
Kanda, T, Tsukagoshi, H, Oda, M, Miyamoto, K, Tanabe, H. Changes of unmyelinated nerve fibers in sural nerve in amyotrophic lateral sclerosis, Parkinson’s disease and multiple system atrophy. Acta Neuropathol 1996; 91(2): 145–154.Google Scholar
Martinez-Martin, P, Rizos, AM, Wetmore, KB, et al., on behalf of EUROPAR & MDS Non-Motor PD Study Group. Relationship of nocturnal sleep dysfunction and pain subtypes in Parkinson’s disease. Mov Disord Clin Prac 2019; 6(1): 57–64.CrossRefGoogle Scholar
Trenkwalder, C, Chaudhuri, KR, Martinez-Martin, P, et al., PANDA study group. Prolonged-release oxycodone-naloxone for treatment of severe pain in patients with Parkinson’s disease (PANDA): a double-blind, randomised, placebo-controlled trial. Lancet Neurol 2015; 14(12): 1161–1170.Google Scholar
Martinez-Martin, P, Rojo-Abuin, JM, Rizos, A, et al. on behalf of KPPS, EUROPAR and the IPMDS Non Motor PD Study Group. Distribution and impact on quality of life of the pain modalities assessed by the King’s Parkinson’s disease pain scale. Parkinsons Dis 2017; 3: 8.Google Scholar
Oshima, H, Katayama, Y, Morishita, T, et al. Subthalamic nucleus stimulation for attenuation of pain related to Parkinson disease. J Neurosurg 2012; 116(1): 99–106.CrossRefGoogle ScholarPubMed
Mylius, V, Ciampi de Andrade, D, Cury, RG, et al. Pain in Parkinson’s disease: current concepts and a new diagnostic algorithm. Mov Dis Clin Prac 2015; 2(4): 357–364.Google Scholar

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