Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-02T19:47:17.801Z Has data issue: false hasContentIssue false

Chapter 9 - Mood Disorders in Parkinson’s Disease

Published online by Cambridge University Press:  05 March 2022

By
Po-Heng Tsai  and
Ganesh Gopalakrishna
Edited by
Néstor Gálvez-Jiménez ,
Amos D. Korczyn  and
Ramón Lugo-Sanchez
Néstor Gálvez-Jiménez
Affiliation:
Florida International University
Amos D. Korczyn
Affiliation:
Tel-Aviv University
Ramón Lugo-Sanchez
Affiliation:
Cleveland Clinic
Get access

Summary

Parkinson’s disease (PD) is traditionally characterized by its motor symptoms of tremors, bradykinesia, rigidity, and postural instability [1]. However, it is now recognized that non-motor symptoms including neuropsychiatric manifestations are frequently present in PD, and their onset not only could precede motor symptoms but is also associated with increased dysfunction and reduced quality of life [2–4]. This chapter focuses on depression, the most commonly seen mood disorder in PD, and provides an overview of the epidemiology, clinical symptoms, proposed pathophysiology, diagnostic tools, and treatment options available for depression in PD.

Type
Chapter
Information
Non-motor Parkinson's Disease , pp. 91 - 98
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Jankovic, J. Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 2008; 79(4): 368–376.Google Scholar
Barone, P, et al. The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord 2009; 24(11): 1641–1649.CrossRefGoogle ScholarPubMed
Weintraub, D, et al. Effect of psychiatric and other nonmotor symptoms on disability in Parkinson’s disease. J Am Geriatr Soc 2004; 52(5): 784–788.CrossRefGoogle ScholarPubMed
Schrag, A, Jahanshahi M, , Quinn N, . What contributes to quality of life in patients with Parkinson’s disease? J Neurol Neurosurg Psychiatry 2000; 69(3): 308–312.Google Scholar
Ishihara, L, Brayne C, . A systematic review of depression and mental illness preceding Parkinson’s disease. Acta Neurol Scand 2006; 113(4): 211–220.CrossRefGoogle ScholarPubMed
Shiba, M, et al. Anxiety disorders and depressive disorders preceding Parkinson’s disease: a case-control study. Mov Disord 2000; 15(4): 669–677.3.0.CO;2-5>CrossRefGoogle ScholarPubMed
Ravina, B, et al. The impact of depressive symptoms in early Parkinson disease. Neurology 2007; 69(4): 342–347.Google Scholar
Starkstein, SE, et al. Depression in Parkinson’s disease. J Nerv Ment Dis 1990; 178(1): 27–31.Google Scholar
Reijnders, JS, et al. A systematic review of prevalence studies of depression in Parkinson’s disease. Mov Disord 2008; 23(2): 183–189; quiz 313.Google Scholar
Dissanayaka, NN, et al. Factors associated with depression in Parkinson’s disease. J Affect Disord 2011; 132(1–2): 82–88.Google Scholar
Schrag, A, Jahanshahi M, , Quinn NP, . What contributes to depression in Parkinson’s disease? Psychol Med 2001; 31(1): 65–73.Google Scholar
Kleiner-Fisman, G, et al. Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes. Mov Disord 2006; 21 (Suppl 14): S290–304.CrossRefGoogle ScholarPubMed
Aarsland, D, et al. Depression in Parkinson disease–epidemiology, mechanisms and management. Nat Rev Neurol 2011; 8(1): 35–47.Google Scholar
Ehgoetz Martens, KA, Lewis SJ, . Pathology of behavior in PD: what is known and what is not? J Neurol Sci 2017; 374: 9–16.Google Scholar
Ikemoto, S, Yang C, , Tan A, . Basal ganglia circuit loops, dopamine and motivation: a review and enquiry. Behav Brain Res 2015; 290: 17–31.Google Scholar
Schapira, AHV, Chaudhuri, KR, Jenner P., Non-motor features of Parkinson disease. Nat Rev Neurosci 2017; 18(7): 435–450.Google Scholar
Simpson, J, McMillan, H, Reeve D, . Reformulating psychological difficulties in people with Parkinson’s disease: the potential of a social relational approach to disablism. Parkinsons Dis 2013; 2013: 608562.Google Scholar
Gallagher, DA, Schrag A, . Psychosis, apathy, depression and anxiety in Parkinson’s disease. Neurobiol Dis 2012; 46(3): 581–589.Google Scholar
Marsh, L. Depression and Parkinson’s disease: current knowledge. Curr Neurol Neurosci Rep 2013; 13(12): 409.Google Scholar
Marsh, L, et al. Provisional diagnostic criteria for depression in Parkinson’s disease: report of an NINDS/NIMH Work Group. Mov Disord 2006; 21(2): 148–158.Google Scholar
Shepard, MD, et al. Suicide in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2019; 90(7): 822–829.CrossRefGoogle ScholarPubMed
Bouwmans, AE, Weber WE., Neurologists’ diagnostic accuracy of depression and cognitive problems in patients with parkinsonism. BMC Neurol 2012; 12: 37.Google Scholar
Reijnders, JS, Lousberg R, , Leentjens AF, . Assessment of depression in Parkinson’s disease: the contribution of somatic symptoms to the clinimetric performance of the Hamilton and Montgomery-Asberg rating scales. J Psychosom Res 2010; 68(6): 561–565.Google Scholar
Torbey, E, Pachana NA, , Dissanayaka NN., Depression rating scales in Parkinson’s disease: a critical review updating recent literature. J Affect Disord 2015; 184: 216–224.Google Scholar
Thobois, S, et al. Non-motor dopamine withdrawal syndrome after surgery for Parkinson’s disease: predictors and underlying mesolimbic denervation. Brain 2010; 133(Pt 4): 1111–1127.Google Scholar
Mills, KA, et al. Efficacy and tolerability of antidepressants in Parkinson’s disease: a systematic review and network meta-analysis. Int J Geriatr Psychiatry 2018; 33(4): 642–651.Google Scholar
Weintraub, D, et al. Antidepressant studies in Parkinson’s disease: a review and meta-analysis. Mov Disord 2005; 20(9): 1161–1169.CrossRefGoogle ScholarPubMed
Miyasaki, JM, et al. Practice parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2006; 66(7): 996–1002.Google Scholar
Skapinakis, P, et al. Efficacy and acceptability of selective serotonin reuptake inhibitors for the treatment of depression in Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials. BMC Neurol 2010; 10: 49.Google Scholar
Liu, J, et al. Comparative efficacy and acceptability of antidepressants in Parkinson’s disease: a network meta-analysis. PLoS One 2013; 8(10): e76651.Google Scholar
Troeung, L, Egan SJ, , Gasson N., A meta-analysis of randomised placebo-controlled treatment trials for depression and anxiety in Parkinson’s disease. PLoS One 2013; 8(11): e79510.Google Scholar
Bomasang-Layno, E, et al. Antidepressive treatments for Parkinson’s disease: a systematic review and meta-analysis. Parkinsonism Relat Disord 2015; 21(8): 833–842; discussion 833.Google Scholar
Connolly, B, Fox SH, . Treatment of cognitive, psychiatric, and affective disorders associated with Parkinson’s disease. Neurotherapeutics 2014; 11(1): 78–91.Google Scholar
Richard, IH, et al. A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease. Neurology 2012; 78(16): 1229–1236.Google Scholar
Arbouw, ME, et al. Influence of initial use of serotonergic antidepressants on antiparkinsonian drug use in levodopa-using patients. Eur J Clin Pharmacol 2007; 63(2): 181–187.Google Scholar
Barone, P, et al. Pramipexole for the treatment of depressive symptoms in patients with Parkinson’s disease: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 2010; 9(6): 573–580.Google Scholar
Rektorova, I, et al. Pramipexole and pergolide in the treatment of depression in Parkinson’s disease: a national multicentre prospective randomized study. Eur J Neurol 2003; 10(4): 399–406.Google Scholar
Barone, P, et al. Pramipexole versus sertraline in the treatment of depression in Parkinson’s disease: a national multicenter parallel-group randomized study. J Neurol 2006; 253(5): 601–607.Google Scholar
Leentjens, AF. The role of dopamine agonists in the treatment of depression in patients with Parkinson’s disease: a systematic review. Drugs 2011; 71(3): 273–286.Google Scholar
Storch, A, et al. Nonmotor fluctuations in Parkinson disease: severity and correlation with motor complications. Neurology 2013; 80(9): 800–809.Google Scholar
Jiang, DQ, et al. Comparison of selegiline and levodopa combination therapy versus levodopa monotherapy in the treatment of Parkinson’s disease: a meta-analysis. Aging Clin Exp Res 2019; 32: 769–779.Google Scholar
Jiang, DQ, et al. Rasagiline combined with levodopa therapy versus levodopa monotherapy for patients with Parkinson’s disease: a systematic review. Neurol Sci 2020; 41(1): 101–109.Google Scholar
Jonsson, U, et al. Psychological treatment of depression in people aged 65 years and over: a systematic review of efficacy, safety, and cost-effectiveness. PLoS One 2016; 11(8): e0160859.Google Scholar
Harter, M, et al. Psychotherapy of depressive disorders: evidence in chronic depression and comorbidities. Nervenarzt 2018; 89(3): 252–262.Google Scholar
Meister, R, et al. Psychotherapy of depressive disorders: procedures, evidence and perspectives. Nervenarzt 2018; 89(3): 241–251.Google Scholar
Sankar, A, et al. A systematic review and meta-analysis of the neural correlates of psychological therapies in major depression. Psychiatry Res Neuroimaging 2018; 279: 31–39.Google Scholar
Farabaugh, A, et al. Cognitive-behavioral therapy for patients with Parkinson’s disease and comorbid major depressive disorder. Psychosomatics 2010; 51(2): 124–129.Google Scholar
Dobkin, RD, et al. Cognitive-behavioral therapy for depression in Parkinson’s disease: a randomized, controlled trial. Am J Psychiatry 2011; 168(10): 1066–1074.CrossRefGoogle ScholarPubMed
Dobkin, RD, et al. Cognitive behavioral therapy improves diverse profiles of depressive symptoms in Parkinson’s disease. Int J Geriatr Psychiatry 2019; 34(5): 722–729.Google Scholar
Xie, CL, et al. A systematic review and meta-analysis of cognitive behavioral and psychodynamic therapy for depression in Parkinson’s disease patients. Neurol Sci 2015; 36(6): 833–843.Google Scholar
van der Kolk, NM, King LA., Effects of exercise on mobility in people with Parkinson’s disease. Mov Disord 2013; 28(11): 1587–1596.Google Scholar
Sharma, NK, et al. A randomized controlled pilot study of the therapeutic effects of yoga in people with Parkinson’s disease. Int J Yoga 2015; 8(1): 74–79.Google Scholar
Boulgarides, LK, Barakatt E, , Coleman-Salgado B, . Measuring the effect of an eight-week adaptive yoga program on the physical and psychological status of individuals with Parkinson’s disease. A pilot study. Int J Yoga Therap 2014; 24: 31–41.Google Scholar
Kwok, JYY, et al. Effects of mindfulness yoga vs stretching and resistance training exercises on anxiety and depression for people with Parkinson disease: a randomized clinical trial. JAMA Neurol 2019; 76(7): 755–763.Google Scholar
Dissanayaka, NN, et al. Mindfulness for motor and nonmotor dysfunctions in Parkinson’s disease. Parkinsons Dis 2016; 2016: 7109052.Google Scholar
McLean, G, et al. Mindfulness-based stress reduction in Parkinson’s disease: a systematic review. BMC Neurol 2017; 17(1): 92.Google Scholar
Song, R, et al. The impact of Tai Chi and Qigong mind-body exercises on motor and non-motor function and quality of life in Parkinson’s disease: a systematic review and meta-analysis. Parkinsonism Relat Disord 2017; 41: 3–13.Google Scholar
Geduldig, ET, Kellner CH, . Electroconvulsive therapy in the elderly: new findings in geriatric depression. Curr Psychiatry Rep 2016; 18(4): 40.CrossRefGoogle ScholarPubMed
Figiel, GS, et al. ECT-induced delirium in depressed patients with Parkinson’s disease. J Neuropsychiatry Clin Neurosci 1991; 3(4): 405–411.Google Scholar
Williams, NR, et al. Unilateral ultra-brief pulse electroconvulsive therapy for depression in Parkinson’s disease. Acta Neurol Scand 2017; 135(4): 407–411.Google Scholar
Sackeim, HA, et al. Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. Brain Stimul 2008; 1(2): 71–83.Google Scholar
Rossi, S, et al. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol 2009; 120(12): 2008–2039.Google Scholar
D’Ostilio, K, Garraux G, . The network model of depression as a basis for new therapeutic strategies for treating major depressive disorder in Parkinson’s disease. Front Hum Neurosci 2016; 10: 161.CrossRefGoogle Scholar
Zhou, L, et al. Antidepressant effects of repetitive transcranial magnetic stimulation over prefrontal cortex of Parkinson’s disease patients with depression: a meta-analysis. Front Psychiatry 2018; 9: 769.Google Scholar
Xu, H, et al. Subthalamic nucleus and globus pallidus internus stimulation for the treatment of Parkinson’s disease: a systematic review. J Int Med Res 2017; 45(5): 1602–1612.Google Scholar
Wang, JW, et al. Cognitive and psychiatric effects of STN versus GPi deep brain stimulation in Parkinson’s disease: a meta-analysis of randomized controlled trials. PLoS One 2016; 11(6): e0156721.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×