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Introduction

Published online by Cambridge University Press:  05 March 2022

Edited by
Néstor Gálvez-Jiménez ,
Amos D. Korczyn  and
Ramón Lugo-Sanchez
Néstor Gálvez-Jiménez
Affiliation:
Florida International University
Amos D. Korczyn
Affiliation:
Tel-Aviv University
Ramón Lugo-Sanchez
Affiliation:
Cleveland Clinic
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Summary

The non-motor manifestations of Parkinson’s disease have been known since the description of the disease by James Parkinson in 1817. In his ‘Essay of the Shaking Palsy’, he clearly stated ‘sleep becomes much disturbed … .the bowels, which had been all along torpid, in most cases demand stimulating medicines of very considerable power … .sometimes the expulsion of feces requiring mechanical aid’ [1]. However, for years the emphasis has been on the motor features which define the disease, largely by the availability of dopaminergic and other agents which alleviate the bradykinesia and rigidity, and partly also the tremor. In fact, these drugs added new non-motor manifestations.

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Chapter
Information
Non-motor Parkinson's Disease , pp. 1 - 2
Publisher: Cambridge University Press
Print publication year: 2022

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References

Parkinson, J. An essay on the shaking palsy. J Neuropsychiatry Clin Neurosci 2002; 14(2): 223–236.CrossRefGoogle ScholarPubMed
Schapira, AH, Chaudhuri, KR, Jenner, P. Non-motor features of Parkinson disease. Nat Rev Neurosci 2017; 18(7): 435.CrossRefGoogle ScholarPubMed
Korczyn, AD, Gurevich, T. Parkinson’s disease: before the motor symptoms and beyond. J Neurolog Sci 2010; 289(1–2): 2–6.Google Scholar
Doty, RL. Olfaction in Parkinson’s disease and related disorders. Neurobiol Dis 2012; 46(3): 527–552.Google Scholar
Boeve, BF, Silber, MH, Ferman, TJ. REM sleep behavior disorder in Parkinson’s disease and dementia with Lewy bodies. J Geriatr Psychiatry Neurol 2004; 17(3): 146–157.CrossRefGoogle ScholarPubMed
Korczyn, AD, Hassin-Baer, S. Can the disease course in Parkinson’s disease be slowed? BMC Med 2015; 13(1): 1–6.Google Scholar
Roos, DS, Twisk, JW, Raijmakers, PG, Doty, RL, Berendse, HW. Hyposmia as a marker of (non-) motor disease severity in Parkinson’s disease. J Neural Transm 2019; 126(11): 1471–1478.Google Scholar
Jellinger, KA, Korczyn, AD. Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease? BMC Med 2018; 16(1): 1–6.CrossRefGoogle ScholarPubMed

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