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Chapter 19 - Drug-Induced Non-Motor Symptoms in Parkinson’s Disease

Published online by Cambridge University Press:  05 March 2022

By
Camila Aquino
Edited by
Néstor Gálvez-Jiménez ,
Amos D. Korczyn  and
Ramón Lugo-Sanchez
Néstor Gálvez-Jiménez
Affiliation:
Florida International University
Amos D. Korczyn
Affiliation:
Tel-Aviv University
Ramón Lugo-Sanchez
Affiliation:
Cleveland Clinic
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Summary

People with Parkinson’s disease (PD) experience a variety of non-motor symptoms. Many of these non-motor symptoms can appear in the early phases, in still drug-naïve patients. Others tend to develop overtime, with prolonged disease duration and exposure to higher doses of dopaminergic therapy [1]. Often, non-motor symptoms fluctuate in response to levodopa similarly to the pattern observed in motor fluctuations [2]. Complex mechanisms underlie the development of PD non-motor symptoms, therefore, the term “drug-induced” used in this chapter does not mean to “blame” the therapy for such complications. Instead, as discussed along the chapter, in most cases, the antiparkinsonian therapy simply worsens or triggers specific non-motor symptoms because PD increases patients’ susceptibility [3].

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Chapter
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Non-motor Parkinson's Disease , pp. 212 - 223
Publisher: Cambridge University Press
Print publication year: 2022

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