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Chapter 7 - Cognitive Dysfunction in Parkinson’s Disease

Published online by Cambridge University Press:  05 March 2022

By
Damon Salzman  and
Shakeel Tabish
Edited by
Néstor Gálvez-Jiménez ,
Amos D. Korczyn  and
Ramón Lugo-Sanchez
Néstor Gálvez-Jiménez
Affiliation:
Florida International University
Amos D. Korczyn
Affiliation:
Tel-Aviv University
Ramón Lugo-Sanchez
Affiliation:
Cleveland Clinic
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Summary

In 1817, the English surgeon Dr James Parkinson penned his now classic work, “An Essay on the Shaking Palsy.” He describes the condition as, “an involuntary tremulous motion, with lessened muscular power, in parts not in action, and even when supported; with a propensity to bend the trunk forwards, and to pass from a walking to a running pace; the senses and intellects being uninjured” [1].

The description of this paralysis agitans (later renamed as Parkinson’s disease by Jean Marie Charcot) has largely remained unchanged today over 200 years later. However, we now realize that the latter part, that the senses and intellect being uninjured, is incorrect. This chapter will summarize the prevalence, incidence, pathophysiology, and the scope of the cognitive changes that are seen in this disease.

Type
Chapter
Information
Non-motor Parkinson's Disease , pp. 66 - 77
Publisher: Cambridge University Press
Print publication year: 2022

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