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Case 18 - Peripheral Nerve Hyperexcitability Syndromes: Morvan Syndrome

from Peripheral Neuropathies

Published online by Cambridge University Press:  29 November 2024

Jessica E. Hoogendijk
Affiliation:
University Medical Center Utrecht
Marianne de Visser
Affiliation:
Amsterdam University Medical Center
Pieter A. van Doorn
Affiliation:
Erasmus MC, University Medical Center, Rotterdam
Erik H. Niks
Affiliation:
Leiden University Medical Center
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Summary

A 58-year-old previously healthy man had complaints of fluctuating drooping eyelids and weakness of neck extensors, arms, and legs. He almost continuously experienced double vision. Following a diagnosis of myasthenia gravis and improvement with pyridostigmine, he noticed twitches and spasms of muscles virtually all over his body. This became severe, he did not sleep well, was restless, and almost continuously felt the urge to move and walk around. His wife mentioned that he also behaved differently. Initially, a pyridostigmine intoxication was considered, but lowering the dose did not help. Additionally, some autonomic features (constipation, erectile dysfunction) appeared.

Type
Chapter
Information
Neuromuscular Disease
A Case-Based Approach
, pp. 122 - 123
Publisher: Cambridge University Press
Print publication year: 2024

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References

Suggested Reading

De Wel, B, Claeys, KG. Neuromuscular hyperexcitability syndromes. Curr Opin Neurol 2021;34(5):714720. doi: 10.1097/WCO.0000000000000963. PMID: 34914668.CrossRefGoogle ScholarPubMed
Sawlani, K, Katirji, B. Peripheral nerve hyperexcitability syndromes. Continuum (Minneap Minn) 2017;23(5, Peripheral Nerve and Motor Neuron Disorders):14371450. doi: 10.1212/CON.0000000000000520. PMID: 28968370.Google ScholarPubMed

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