Book contents
- The Neurology Riddle Book
- Series page
- The Neurology Riddle Book
- Copyright page
- Dedication
- Contents
- Foreword
- Preface
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
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- Index
88
Published online by Cambridge University Press: 21 November 2024
Book contents
- The Neurology Riddle Book
- Series page
- The Neurology Riddle Book
- Copyright page
- Dedication
- Contents
- Foreword
- Preface
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 16
- 17
- 18
- 19
- 20
- 21
- 22
- 23
- 24
- 25
- 26
- 27
- 28
- 29
- 30
- 31
- 32
- 33
- 34
- 35
- 36
- 37
- 38
- 39
- 40
- 41
- 42
- 43
- 44
- 45
- 46
- 47
- 48
- 49
- 50
- 51
- 52
- 53
- 54
- 55
- 56
- 57
- 58
- 59
- 60
- 61
- 62
- 63
- 64
- 65
- 66
- 67
- 68
- 69
- 70
- 71
- 72
- 73
- 74
- 75
- 76
- 77
- 78
- 79
- 80
- 81
- 82
- 83
- 84
- 85
- 86
- 87
- 88
- 89
- 90
- 91
- 92
- 93
- 94
- 95
- 96
- 97
- 98
- 99
- 100
- 101
- 102
- 103
- 104
- 105
- 106
- 107
- 108
- 109
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 117
- 118
- 119
- 120
- 121
- 122
- 123
- 124
- 125
- 126
- 127
- 128
- 129
- 130
- 131
- 132
- 133
- 134
- 135
- 136
- 137
- 138
- 139
- 140
- 141
- 142
- 143
- 144
- 145
- 146
- 147
- 148
- 149
- 150
- Index
Summary
The most common form of muscular dystrophy in adults, myotonic dystrophy (MD) is an autosomal dominant neuromuscular disease caused by the trinucleotide expansion of CTG repeats. The location of these CTG repeats differs between types of MD with the chromosome 19 gene DMPK (dystrophia-myotonica protein kinase) being the culprit gene in myotonic dystrophy type 1 (DM-1 aka Steinert’s disease), and the chromosome 3 gene ZnFP9 (zinc finger protein 9) being the culprit gene in myotonic dystrophy type 2 (DM-2). A greater number of CTG repeats predicts an earlier onset of disease.
- Type
- Chapter
- Information
- The Neurology Riddle Book150 Common and Rare Neurological Diseases in Riddle Form, pp. 277 - 280Publisher: Cambridge University PressPrint publication year: 2024