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Published online by Cambridge University Press: 21 November 2024
Lambert Eaton myasthenic syndrome (LEMS) is an autoimmune disease caused by antibodies directed at presynaptic voltage-gated calcium channels (P/Q-type) that results in an overall reduced amount of acetylcholine released into the synaptic cleft at neuromuscular junctions and terminals of autonomic nerves. This syndrome is caused by a paraneoplastic process in 60% of patients, and of these patients, the most commonly associated cancer is small cell lung cancer. Compared to myasthenia gravis (MG), LEMS typically occurs in middle-aged adults.
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