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Chapter 39 - Neuroimaging of Parkinson’s disease and multiple system atrophy in patients with sleep disturbance

from Section 5 - Neuroimaging of sleep disorders

Published online by Cambridge University Press:  05 March 2013

By
Jason Valerio  and
A. Jon Stoessl
Edited by
Eric Nofzinger ,
Pierre Maquet  and
Michael J. Thorpy
Eric Nofzinger
Affiliation:
University of Pittsburgh
Pierre Maquet
Affiliation:
Université de Liège, Belgium
Michael J. Thorpy
Affiliation:
Sleep-Wake Disorders Center, Montefiore Medical Center, New York
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Summary

This chapter focuses on primary sleep disorders in Parkinson's disease (PD) and multiple system atrophy (MSA) and insights provided by functional neuroimaging research. Specific disorders to be considered include excessive daytime sleepiness (EDS), sleep disordered breathing, restless legs syndrome/periodic limb movements in sleep (RLS/PLMS), and rapid eye movement (REM) sleep behavior disorder (RBD). The chapter reviews the relevant neurochemical pathways in PD and MSA, and discusses specific sleep disorders. It explains the neurotransmitter in more detail, as it relates to PD, MSA, and sleep circuits. The neurotransmitter dopamine may play a role in REM sleep control, but there is limited direct evidence for this. Dopamine may also play a role in regulation of the sleep/wake cycle with a wakefulness promoting effect that is similar to histamine and hypocretin. In the future, a greater focus should be placed on non-dopaminergic pathways to evaluate sleep disorders in PD and MSA.

Keywords

narcolepsyneurotransmission studiesreward processingfunctional neuroimagingbrain perfusionemotional processing
Type
Chapter
Information
Neuroimaging of Sleep and Sleep Disorders , pp. 305 - 315
Publisher: Cambridge University Press
Print publication year: 2013

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