Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-24T18:59:54.985Z Has data issue: false hasContentIssue false

Chapter 52 - Functional neuroimaging of alerting medication effects

from Section 5 - Neuroimaging of sleep disorders

Published online by Cambridge University Press:  05 March 2013

By
Robert Joseph Thomas
Edited by
Eric Nofzinger ,
Pierre Maquet  and
Michael J. Thorpy
Eric Nofzinger
Affiliation:
University of Pittsburgh
Pierre Maquet
Affiliation:
Université de Liège, Belgium
Michael J. Thorpy
Affiliation:
Sleep-Wake Disorders Center, Montefiore Medical Center, New York
Get access

Summary

This chapter provides a brief overview of some of the experimental challenges to obtain reliable pharmacological magnetic resonance imaging (phMRI) data, and summarizes the published literature. The chapter offers some plausible mechanistic insights into biological processes that mediate the effects of alerting medications, generically termed stimulants. The effect of sleep deprivation on functional connectivity within the default mode network and on brain regions typically activated during cognitive tasks was studied in 26 healthy participants. Nicotine or nicotinic stimulation decreases the activity in the default mode network. The alerting effects of cholinergic stimulation are well recognized, but clinical use in conditions of excessive daytime sleepiness has not been readily possible or even well studied. Repetitive consecutive testing using functional MRI (fMRI) has shown a progressive loss of functional activation, predominantly in the prefrontal cortex using a working memory 2-back task, which is prevented by modafinil and amphetamine treatment.

Keywords

structural neuroimaging studiesmultiple system atrophyneural mechanismsParkinson diseaseidiopathic REM sleep behavior disorderdementia with Lewy bodiesfunctional neuroimaging studies
Type
Chapter
Information
Neuroimaging of Sleep and Sleep Disorders , pp. 406 - 413
Publisher: Cambridge University Press
Print publication year: 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×