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5 - Grooming syntax as a sensitive measure of the effects of subchronic PCP treatment in rats

Published online by Cambridge University Press:  04 August 2010

By
Marie-Claude Audet  and
Sonia Goulet
Edited by
Allan V. Kalueff ,
Justin L. La Porte  and
Carisa L. Bergner
Allan V. Kalueff
Affiliation:
National Institute of Mental Health, Washington DC
Justin L. La Porte
Affiliation:
National Institute of Mental Health, Washington DC
Carisa L. Bergner
Affiliation:
National Institute of Mental Health, Washington DC
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Summary

Summary

Grooming is increasingly recognized as a reliable marker of stress-related disturbances in animal models of neuropsychiatric disorders. We previously reported that subchronic exposure to 10 mg/kg of phencyclidine (PCP) for 15 days in rats increased grooming expression under both stressful and appetitive conditions, but impaired grooming syntax only when the behavior was elicited with stressful water sprays directed at the face. For the purpose of this chapter, new indexes from the same rats subjected to the water spray condition were analyzed. Results showed that the PCP group aborted less chains after face washing and spent a lower proportion of time in anterior grooming than control animals. Phencyclidine treatment also increased incorrect chain initiations and enhanced the duration of Phase IV within completed syntactic chains. Finally, PCP-injected rats were less engaged in nongrooming activities, and were more inactive. In a context where grooming was needed rostrally after facial contacts with water sprays, these results indicate that subchronic PCP treatment compromised hygiene efficiency and engendered an unfocused and perseverative grooming, most likely combined with an abnormal stress response. These observations suggest that the two leading approaches in the study of grooming patterning may provide pivotal sets of qualitative observations that help identify hygienic and stress-related irregularities in animal models.

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Chapter
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Neurobiology of Grooming Behavior , pp. 88 - 107
Publisher: Cambridge University Press
Print publication year: 2010

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