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8 - Grooming after cerebellar, basal ganglia, and neocortical lesions

Published online by Cambridge University Press:  04 August 2010

By
Robert Lalonde  and
C. Strazielle
Edited by
Allan V. Kalueff ,
Justin L. La Porte  and
Carisa L. Bergner
Allan V. Kalueff
Affiliation:
National Institute of Mental Health, Washington DC
Justin L. La Porte
Affiliation:
National Institute of Mental Health, Washington DC
Carisa L. Bergner
Affiliation:
National Institute of Mental Health, Washington DC
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Summary

Summary

Electrical stimulation of the midline cerebellum and striatum elicits grooming in rats. Lesioning methods with either surgery or genetic mutations indicate that these brain regions contribute to grooming behaviors. Grid2Lc mutant mice with selective cerebellar atrophy and Girk2Wv mutants with combined cerebellar and substantia nigra atrophy display different effects on grooming. While Grid2Lc mutants were affected in grooming completion but not serial ordering, the reverse was true in Girk2Wv mutants. Our results implicate cerebello–neocortical pathways in the completion of grooming chains, and a striato–pallido–neocortical pathway in the serial ordering of grooming chains.

Introduction and methodological considerations

The role of the cerebellum and basal ganglia on grooming is of some importance considering that grooming implies movement. It is therefore expected that part of the neural circuitry underlying grooming involves some aspect of motor function. In view of the importance of the cerebellum and basal ganglia in balance and posture (Lalonde and Strazielle 2007a), there is a special challenge in interpreting lesion effects of these brain regions on grooming. This is achievable by measuring serial ordering of grooming sequences. It is well established that rodents groom in a cephalocaudal order, anterior before posterior body parts (Richmond and Sachs 1980; Sachs 1988). Different types of grooming components may also be measured, such as face washing; licking of forelimbs, abdomen, back, and hindlimbs; as well as body shaking and scratching (Vanderwolf et al. 1978). Lesions may selectively affect some grooming components in a fashion inexplainable by motor deficits.

Type
Chapter
Information
Neurobiology of Grooming Behavior , pp. 145 - 155
Publisher: Cambridge University Press
Print publication year: 2010

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References

Berntson, GG and Paulicci, TS (1979): Fastigial modulation of brainstem behavioral mechanisms. Brain Res Bull 4:549–52.CrossRefGoogle ScholarPubMed
Berntson, GG and Schumacher, KM (1980): Effects of cerebellar lesions on activity, social interactions, and other motivated behaviors in the rat. J Comp Physiol Psychol 94:706–17.CrossRefGoogle ScholarPubMed
Berntson, GG and Torello, MW (1982): The paleocerebellum and the integration of behavioral function. Physiol Psychol 10:2–12.CrossRefGoogle Scholar
Berntson, GG, Potolicchio, SJ Jr and Miller, NE (1973): Evidence for higher functions of the cerebellum: eating and grooming elicited by cerebellar stimulation in cats (fastigial nucleus/superior cerebellar peduncle). Proc Natl Acad Sci USA 70:2497–9.CrossRefGoogle Scholar
Berntson, GG, Jang, JF and Ronca, AE (1988): Brainstem systems and grooming behaviors. Ann N Y Acad Sci 525:350–62.CrossRefGoogle ScholarPubMed
Berridge, KC (1989): Substantia nigra 6-OHDA lesions mimic striatopallidal disruption of syntactic grooming chains: a neural systems analysis of sequence control. Psychobiology 17:377–85.Google Scholar
Berridge, KC and Fentress, JC (1987): Disruption of natural grooming chains after striatopallidal lesions. Psychobiology 15:336–42.Google Scholar
Berridge, KC and Whishaw, IQ (1992): Cortex, striatum and cerebellum: control of serial order in a grooming sequence. Exp Brain Res 90:275–90.CrossRefGoogle Scholar
Blatt, GJ and Eisenman, LM (1985): A qualitative and quantitative light microscopic study of the inferior olivary complex of normal, reeler, and weaver mutant mice. J Comp Neurol 232:117–28.CrossRefGoogle ScholarPubMed
Bolivar, VJ, Danilchuk, W and Fentress, JC (1996): Separation of activation and pattern in grooming development of weaver mutant mice. Behav Brain Res 75:49–58.CrossRefGoogle Scholar
Cannon, RL, Paul, DJ, Baisden, RH and Woodruff, ML (1992): Alterations in self-grooming sequences in the rat as a consequence of hippocampal damage. Psychobiology 20:205–18.Google Scholar
Coscia, EM and Fentress, JC (1993): Neurological dysfunction expressed in the grooming behavior of developing weaver mutant mice. Behav Genet 23:533–41.CrossRefGoogle ScholarPubMed
Fornaguera, J and Schwarting, RKW (1999): Early behavioral changes after nigro-striatal system damage can serve as predictors of striatal dopamine depletion. Prog Neuropsychopharmacol Biol Psychiatry 23:1353–68.CrossRefGoogle ScholarPubMed
Hartgraves, SL and Randall, PK (1986): Dopamine agonist-induced stereotypic grooming and self-mutilation following striatal dopamine depletion. Psychopharmacology 90:358–63.CrossRefGoogle ScholarPubMed
Heckroth, JA (1994): Quantitative morphological analysis of the cerebellar nuclei in normal and Lurcher mutant mice. I. Morphology and cell number. J Comp Neurol 343:173–82.CrossRefGoogle ScholarPubMed
Heckroth, JA and Eisenman, LM (1991): Olivary morphology and olivocerebellar atrophy in adult Lurcher mutant mice. J Comp Neurol 312:641–51.CrossRefGoogle ScholarPubMed
Herrup, K and Trenkner, E (1987): Regional differences in cytoarchitecture of the weaver cerebellum suggest a new model for weaver gene action. Neuroscience 23:871–85.CrossRefGoogle ScholarPubMed
Hirano, A and Dembitzer, HM (1973): Cerebellar alterations in the weaver mouse. J Cell Biol 56:478–86.CrossRefGoogle ScholarPubMed
Kalueff, AV and Tuohimaa, P (2004): Grooming analysis algorithm for neurobehavioral research. Brain Res Prot 13:151–8.CrossRefGoogle Scholar
Kolb, B and Whishaw, IQ (1981): Decortication of rats in infancy or adulthood produces comparable functional losses on learned and species-typical behaviors. J Comp Physiol Psychol 95:468–83.CrossRefGoogle ScholarPubMed
Kropf, W and Kuschinsky, K (1993): Effects of stimulation of dopamine D1 receptors on the cortical EEG in rats: different influences by a blockade of D2 receptors and by an activation of putative dopamine autoreceptors. Neuropharmacology 32:493–500.CrossRefGoogle ScholarPubMed
Lalonde, R and Strazielle, C (2007a): Brain regions and genes affecting postural control. Prog Neurobiol 81:45–60.CrossRefGoogle ScholarPubMed
Lalonde, R and Strazielle, C (2007b): Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistry. Brain Res 1140:51–74.CrossRefGoogle ScholarPubMed
Landsend, AS, Amiry-Moghaddam, M, Matsubara, Aet al. (1997): Differential localization of delta glutamate receptors in the rat cerebellum: coexpression with AMPA receptors in parallel fiber-spine synapses and absence from climbing fiber-spine synapses. J Neurosci 17:834–42.CrossRefGoogle ScholarPubMed
Lisander, B and Martner, J (1975): Integrated somatomotor and gastrointestinal adjustments induced from the cerebellar fastigial nucleus. Acta Physiol Scand 94:358–67.CrossRefGoogle ScholarPubMed
Maricich, SM, Soha, J, Trenkner, E and Herrup, K (1997): Failed cell migration and death of Purkinje cells and deep nuclear neurons in the weaver cerebellum. J Neurosci 17:3675–83.CrossRefGoogle ScholarPubMed
Micco, DJ Jr (1974): Complex behaviors elicited by stimulation of the dorsal pontine tegmentum in rats. Brain Res 75:172–6.CrossRefGoogle ScholarPubMed
Patil, N, Cox, DR, Bhat, Det al. (1995): A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Nat Genet 11:126–9.CrossRefGoogle ScholarPubMed
Richmond, G and Sachs, BD (1980): Grooming in Norway rats: the development and adult expression of a complex motor pattern. Behaviour 75:82–96.CrossRefGoogle Scholar
Roffler-Tarlov, S and Graybiel, AM (1986): Expression of the weaver gene in dopamine-containing neural systems is dose-dependent and affects both striatal and nonstriatal regions. J Neurosci 6:3319–30.CrossRefGoogle ScholarPubMed
Sachs, BD (1988): The development of grooming and its expression in adult animals. Ann N Y Acad Sci 525:1–17.CrossRefGoogle ScholarPubMed
Schein, JC, Hunter, DD and Roffler-Tarlov, S (1998): Girk2 expression in the ventral midbrain, cerebellum, and olfactory bulb and its relationship to the murine mutation weaver. Dev Biol 204:432–50.CrossRefGoogle ScholarPubMed
Shishliannikova, LV (1980): Behavioral activation developing after cessation of electrical stimulation of the caudate nucleus. Fiziol ZH SSR Im Sechenova 66:1165–70.Google ScholarPubMed
Snider, RS (1975): A cerebellar-ceruleus pathway. Brain Res 88:59–63.CrossRefGoogle ScholarPubMed
Strazielle, C and Lalonde, R (1998): Grooming in Lurcher mutant mice. Physiol Behav 64:57–61.CrossRefGoogle ScholarPubMed
Strazielle, C, Lalonde, R, Amdiss, Fet al. (1998): Distribution of dopamine transporters in basal ganglia of cerebellar ataxic mice by [125I]RTI-121 quantitative autoradiography. Neurochem Int 32:61–8.CrossRefGoogle Scholar
Takayama, C, Nakagawa, S, Watanabe, M, Mishina, M and Inoue, Y (1996): Developmental changes in expression and distribution of the glutamate receptor channel delta 2 subunit according to the Purkinje cell maturation. Dev Brain Res 92:147–55.CrossRefGoogle ScholarPubMed
Triarhou, LC, Norton, J and Ghetti, B (1988): Mesencephalic dopamine cell deficit involves areas A8, A9 and A10 in weaver mutant mice. Exp Brain Res 70:256–65.CrossRefGoogle ScholarPubMed
Vanderwolf, CH, Kolb, B and Cooley, RK (1978): Behavior of the rat after removal of the neocortex and hippocampal formation. J Comp Physiol Psychol 92:156–75.CrossRefGoogle ScholarPubMed
Vogel, MW, McInnes, M, Zanjani, HS and Herrup K, (1991): Cerebellar Purkinje cells provide target support over a limited spatial range: evidence from Lurcher chimeric mice. Dev Brain Res 64:87–94.CrossRefGoogle Scholar
Whishaw, IQ, Nonneman, AJ and Kolb, B (1981): Environmental constraints on motor abilities used in grooming, swimming, and eating by decorticate rats. J Comp Physiol Psychol 95:792–804.CrossRefGoogle ScholarPubMed
Winn, P (1998): Frontal syndrome as a consequence of lesions in the pedunculopontine tegmental nucleus: a short theoretical review. Brain Res Bull 47:551–63.CrossRefGoogle ScholarPubMed
Zuo, J, Jager, PI, Takahashi, KAet al. (1997): Neurodegeneration in Lurcher mutant mice caused by mutation in the delta 2 glutamate receptor gene. Nature 388:769–73.CrossRefGoogle Scholar

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