Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-16T15:31:58.674Z Has data issue: false hasContentIssue false

Chapter 10 - Mood Disorders in Prader-Willi Syndrome

Published online by Cambridge University Press:  26 May 2022

Deepan Singh
Affiliation:
Maimonides Medical Center in Brooklyn
Get access

Summary

Mood disorders have a wide range of presentation – from major depressive episodes to mania. Both depression and mania can present with irritability; the notable differences between them are discussed in this chapter. Persistent sad mood and lack of enjoyment in usual activities is typically noted in depression, while a lack of need for sleep along with euphoric mood is typical for mania. Due to the spectrum of intervening mood disorders such as bipolar II illness and persistent depressive disorder, a thorough psychiatric evaluation is important. Since mood disorders may lead to dangerousness in the form of self-harm behavior, suicidality, and violence, a sudden and persistent change in mood should be considered a psychiatric emergency. Suicide is rare but unpredictable. Direct questions on whether a patient has thoughts about self-harm are important to differentiate habitual threatening statements from real intent. Treatment options for mood disorders including psychotherapy and medication management are discussed. Episodic mood disorders covered in this chapter are all treatable conditions when identified promptly and under the care of experienced mental health providers.

Type
Chapter
Information
Neuro-behavioral Manifestations of Prader-Willi Syndrome
A Guide for Clinicians and Caregivers
, pp. 90 - 102
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Kinnaird, E, Stewart, C, Tchanturia, K. Investigating alexithymia in autism: A systematic review and meta-analysis. Eur Psychiatry 2019;55:80–9.CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5).Google Scholar
Eyre, O, Hughes, RA, Thapar, AK, Leibenluft, E, Stringaris, A, Davey Smith, G, et al. Childhood neurodevelopmental difficulties and risk of adolescent depression: The role of irritability. J Child Psychol Psychiatry 2019;60(8):866–74.Google Scholar
Dykens, EM, Cassidy, SB. Correlates of maladaptive behavior in children and adults with Prader-Willi syndrome. Am J Med Genet 1995;60(6):546–9.CrossRefGoogle ScholarPubMed
Mao, R, Jalal, SM, Snow, K, Michels, VV, Szabo, SM, Babovic-Vuksanovic, D. Characteristics of two cases with dup(15)(q11.2-q12): One of maternal and one of paternal origin. Genet Med 2000;2(2):131–5.Google Scholar
Lerner, MD, Mazefsky, CA, Weber, RJ, Transue, E, Siegel, M, Gadow, KD, et al. Verbal ability and psychiatric symptoms in clinically referred inpatient and outpatient youth with ASD. J Autism Dev Disord 2018;48(11):3689701.Google Scholar
Cummings, EM, Cheung, RYM, Davies, PT. Prospective relations between parental depression, negative expressiveness, emotional insecurity, and children’s internalizing symptoms. Child Psychiatry Hum Dev 2013;44(6):698708.Google Scholar
Boettcher, J, Boettcher, M, Wiegand-Grefe, S, Zapf, H. Being the pillar for children with rare diseases: A systematic review on parental quality of life. Int J Environ Res Public Health 2021;18(9):4993. doi: 10.3390/ijerph18094993Google Scholar
Bigdeli, TB, Ripke, S, Peterson, RE, Trzaskowski, M, Bacanu, SA, Abdellaoui, A, et al. Genetic effects influencing risk for major depressive disorder in China and Europe. Transl Psychiatry 2017;7(3):e1074.Google Scholar
Wakschlag, LS, Estabrook, R, Petitclerc, A, Henry, D, Burns, JL, Perlman, SB, et al. Clinical implications of a dimensional approach: The normal–abnormal spectrum of early irritability. J Am Acad Child Adolesc Psychiatry 2015;54(8):626–34.CrossRefGoogle ScholarPubMed
Kroonen, LT, Herman, M, Pizzutillo, PD, Macewen, GD. Prader-Willi syndrome: Clinical concerns for the orthopaedic surgeon. J Pediatr Orthop 2006;26(5):673–9.Google Scholar
Kurlansik, SL, Ibay, AD. Seasonal affective disorder. Am Fam Physician 2012;86(11):1037–41.Google Scholar
Tuunainen, A, Kripke, DF, Endo, T. Light therapy for non-seasonal depression. Cochrane Database Syst Rev 2004;(2):CD004050.Google ScholarPubMed
Mandell, DS. Psychiatric hospitalization among children with autism spectrum disorders. J Autism Dev Disord 2008;38(6):1059–65.Google Scholar
Paolucci, EM, Loukov, D, Bowdish, DME, Heisz, JJ. Exercise reduces depression and inflammation but intensity matters. Biol Psychol 2018;133:7984.Google Scholar
Zhou, X, Teng, T, Zhang, Y, Del Giovane, C, Furukawa, TA, Weisz, JR, et al. Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: A systematic review and network meta-analysis. Lancet Psychiatry 2020;7(7):581601.CrossRefGoogle ScholarPubMed
Beck, AT, Rush, AJ, Shaw, BF, Emery, G. Cognitive Therapy of Depression (The Guilford Clinical Psychology and Psychopathology Series). 1st ed. New York: Guilford Press, 1987.Google Scholar
Strauss, C, Cavanagh, K, Oliver, A, Pettman, D. Mindfulness-based interventions for people diagnosed with a current episode of an anxiety or depressive disorder: A meta-analysis of randomised controlled trials. PLoS ONE 2014;9(4):e96110.Google Scholar
Singh, NN, Lancioni, GE, Myers, RE, Karazsia, BT, Courtney, TM, Nugent, K. A mindfulness-based intervention for self-management of verbal and physical aggression by adolescents with Prader-Willi syndrome. Dev Neurorehabil 2017;20(5):253–60.Google Scholar
Kabat Zin, J. Clinical Handbook of Mindfulness. New York: Springer New York, 2009.Google Scholar
Griffiths, JJ, Zarate, CA, Rasimas, JJ. Existing and novel biological therapeutics in suicide prevention. Am J Prev Med 2014;47(3 Suppl 2):S195S203.Google Scholar
Baweja, R, Mayes, SD, Hameed, U, Waxmonsky, JG. Disruptive mood dysregulation disorder: Current insights. Neuropsychiatr Dis Treat 2016;12:2115–24.Google Scholar
Leibenluft, E, Cohen, P, Gorrindo, T, Brook, JS, Pine, DS. Chronic versus episodic irritability in youth: A community-based, longitudinal study of clinical and diagnostic associations. J Child Adolesc Psychopharmacol 2006;16(4):456–66.Google Scholar
Singh, D, Sasson, A, Rusciano, V, Wakimoto, Y, Pinkhasov, A, Angulo, M. Cycloid psychosis comorbid with Prader-Willi syndrome: A case series. Am J Med Genet A 2019;179(7):1241–5.Google Scholar
Leverich, GS, Altshuler, LL, Frye, MA, Suppes, T, McElroy, SL, Keck, PE, et al. Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers. Am J Psychiatry 2006;163(2):232–9.Google Scholar
Scott, J, Leboyer, M. Consequences of delayed diagnosis of bipolar disorders. Encephale 2011;37 Suppl 3:S173S175.CrossRefGoogle ScholarPubMed
Chatterton, ML, Stockings, E, Berk, M, Barendregt, JJ, Carter, R, Mihalopoulos, C. Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: Network meta-analysis. Br J Psychiatry 2017;210(5):333–41.CrossRefGoogle ScholarPubMed
Chu, C-S, Stubbs, B, Chen, T-Y, Tang, C-H, Li, D-J, Yang, W-C, et al. The effectiveness of adjunct mindfulness-based intervention in treatment of bipolar disorder: A systematic review and meta-analysis. J Affect Disord 2018;225:234–45.Google Scholar
Correll, CU, Sheridan, EM, DelBello, MP. Antipsychotic and mood stabilizer efficacy and tolerability in pediatric and adult patients with bipolar I mania: A comparative analysis of acute, randomized, placebo-controlled trials. Bipolar Disord 2010;12(2):116–41.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×