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2 - Determinants of intrauterine growth

Published online by Cambridge University Press:  10 December 2009

Patti J. Thureen
By
John W. Sparks  and
Irene Cetin
Edited by
William W. Hay
Patti J. Thureen
Affiliation:
University of Colorado at Denver and Health Sciences Center
John W. Sparks
Affiliation:
Department of Pediatrics, University of Texas Medical School, Houston, Texas
Irene Cetin
Affiliation:
Clinica Ostetrica e Ginecologica, Universita degli Studi di Milano, Ospedale San Paolo, Milano, Italy
William W. Hay
Affiliation:
University of Colorado at Denver and Health Sciences Center
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Summary

Size matters

When considering outcomes of pregnancy, size at birth is among the most important characteristics of a successful pregnancy. In addition to duration of pregnancy and the qualitative development of the fetus, the anthropometric size of a newborn baby is of considerable significance. Long before the relatively modern concept of gestational age was well understood, medical personnel recognized and recorded the size, particularly the weight, of newborn babies, and both mortality and morbidity were correlated to birth size. This persists even today, with terms such as “Low Birth Weight” infants, which do not incorporate the concept of duration of pregnancy, as an important descriptor in the public health arena. Similarly, among the first questions asked by parents, is “How much does my baby weigh?,” a reflection of the importance of size in the common understanding of pregnancy.

As a practical issue, clinicians pay most attention to weight, length and head circumference, in part because both scales and rulers are easily available and accurate. Weight is particularly emphasized, in part because the measurement of weight is particularly insensitive to inter-observer measurement error. Other measures, such as surface area, BMI and weights raised to various powers (e.g. wt0.75, wt2, wt/length2) are also in common use, but require more difficult calculation or measurement. The close attention paid to weight is more a reflection of convenience, than biological importance, as other measures may more closely relate to matters of biological importance.

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Neonatal Nutrition and Metabolism , pp. 23 - 31
Publisher: Cambridge University Press
Print publication year: 2006

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References

Barker, D. P. G., Gluckman, P. D., Godfrey, K. M., et al.Fetal nutrition and cardiovascular disease in adult life. Lancet 1993b;341:938–41.CrossRefGoogle Scholar
Allan, W. C., Riviello, J. J. Jr.Perinatal cerebrovascular disease in the neonate. Parenchimal ischemic lesions in term and preterm infants. Ped. Clin. N. Amer. 1992;39:621–50.CrossRefGoogle Scholar
Barker, D. J.The fetal and infant origins of adult disease. Br. Med. J. 1990;301:1111.CrossRefGoogle ScholarPubMed
Barker, D. J.The intrauterine origins of cardiovascular disease. Acta Pediatr. Suppl. 1993a;82:93–9.CrossRefGoogle Scholar
Lubchenco, L. O., Hansman, C., Dressler, M., Boyd, E.Intrauterine growth as estimated from liveborn birth-weight data at 24 to 42 weeks of gestation. Pediatrics 1963;32:793–800.Google ScholarPubMed
Thomson, A. M., Billewicz, W. Z., Hytten, F. E.The assessment of fetal growth. J. Obstet. Gynaecol. Br. Commonw. 1968;75:903–16.CrossRefGoogle ScholarPubMed
Yudkin, P. L., Aboualfa, M., Eyre, J. A., Redman, C. W. G., Wilkinson, A. R.New birthweight and head circumference centiles for gestational ages 24 to 42 weeks. Early Hum. Dev. 1987;15:45–52.CrossRefGoogle ScholarPubMed
Geirrson, R. T., Busby-Earle, R. M. C.Certain dates may not provide a reliable estimate of gestational age. Br. J. Obstet. Gynaecol. 1991;98:108–9.CrossRefGoogle Scholar
Wilcox, M. A., Gardosi, J., Mongelli, M., Ray, C., Johnson, I. R.Birthweight from pregnancies dated by ultrasonography in a multicultural British population. Br. Med. J. 1993;307:588–91.CrossRefGoogle Scholar
Hindmarsh, P. C., Geary, M. P. P., Rodeck, C. H., Kingdom, J. C., Cole, T. J.Intrauterine growth and its relationship to size and shape at birth. Pediatr. Res. 2002;52:263–8.CrossRefGoogle ScholarPubMed
Enzi, G., Zanardo, V., Caretta, F., Inelmen, E. M., Rubaltelli, F.Intrauterine growth and adipose tissue development. Am. J. Clin. Nutr. 1981;34:1785–90.CrossRefGoogle ScholarPubMed
Bernstein, I. M., Goran, M. I., Amini, S. B., Catalano, P. M.Differential growth of fetal tissues during the second half of pregnancy. Am. J. Obstet. Gynaecol. 1997;176:28–32.CrossRefGoogle ScholarPubMed
Nicolini, U., Ferrazzi, E., Molla, R., et al.Accuracy of an average ultrasonic laboratory in measurements of fetal biparietal diameter, head circumference and abdominal circumference. J. Perinat. Med. 1986;14:101–7.CrossRefGoogle ScholarPubMed
Ferrazzi, E., Todros, T., Groli, C., et al.Fitting growth curves to head and abdomen measurements of the fetus: a multicentric study. J. Clin. Ultrasound 1987;15:95–105.Google Scholar
Pardi, G., Cetin, I., Marconi, A. M.et al.Diagnostic value of blood sampling in fetuses with growth retardation. New Engl. J. Med. 1993;328:692–6.CrossRefGoogle ScholarPubMed
Cetin, I., Morpurgo, P. S., Radaelli, T.et al.Fetal plasma leptin concentration: relationship with different intrauterine growth patterns from 19 weeks to term. Pediatr. Res. 2000;48:646–51.CrossRefGoogle Scholar
Catalano, P. M., Tyzbir, E. D., Wolfe, R. R.et al.Carbohydrate metabolism during pregnancy in control subjects and women with gestational diabetes. Am. J. Physiol. 1993;264:E60–7.Google ScholarPubMed
Kalkhoff, R. K.Impact of maternal fuels and nutritional state on fetal growth. Diabetes 1991;40:61–5.CrossRefGoogle ScholarPubMed
Carrera, J. M., Devasa, R., Carrera, M. et al. Regulating factors. In Kurjak, A., ed. Textbook of Perinatal Medicine. London: Parthenon; 1998:1132–9.Google Scholar
Brooks, A. A., Johnson, M. R., Steer, P. J., Pawson, M. E., Abdalla, H. I.Birthweight: nature or nurture?Early Hum. Dev. 1995;42:29–35.CrossRefGoogle ScholarPubMed
Catalano, P. M., Drago, N. M., Amini, S. B.Factors affecting fetal growth and body composition. Am. J. Obstet. Gynaecol. 1995;172:1459–63.CrossRefGoogle ScholarPubMed
Catalano, P. M., Thomas, A. J., Huston, L. P., Fung, C. M.Effects of maternal metabolism on fetal growth and body composition. Diabetes Care 1998;21:B85–90.Google Scholar
Morison, I. M., Paton, C. J., Cleverley, S. D.The imprinted gene and parent-of-origin effect data-base. Nucleic Acids Res 2001;29:275–6.CrossRefGoogle Scholar
Falls, J. G., Pulford, D. J., Wylie, A. A., Jirtle, R. L.Genomic imprinting: implications for human disease. Am. J. Pathol. 1999;15:635–47.CrossRefGoogle Scholar
Tilghman, S. M.The sins of the father and mother: genomic imprinting in mammalian development. Cell. 1999;96:185–93.CrossRefGoogle ScholarPubMed
Miozzo, M., Simoni, G.The role of imprinted genes in fetal growth. Biol. Neonate 2002;81:217–28.CrossRefGoogle ScholarPubMed
Moore, T., Haig, D.Genomic imprinting in mammalian development: a parental tug-of-war. Trends Genet. 1991;7:45–9.CrossRefGoogle ScholarPubMed
Gosden, R., Trasler, J., Lucifero, D., Faddy, M.Rare congenital disorders, imprinted genes and assisted reproductive technology. Lancet 2003;361:1975–7.CrossRefGoogle ScholarPubMed
Schieve, L. A., Meikle, S. F., Ferre, C.et al.Low and very low birth weight in infants conceived with use of assisted reproductive technology. New Engl. J. Med. 2002;346:731–7.CrossRefGoogle ScholarPubMed
Rycke, M., Liebaers, I., Steirteghem, A.Epigenetic risks related to assisted reproductive technologies. Risk analysis and epigenetic inheritance. Hum. Reprod. 2002;17:2487– 94.CrossRefGoogle ScholarPubMed
Thompson, J. G., Kind, K. L., Roberts, C. T., Robertson, S. A., Robinson, J. S.Epigenetic risks related to assisted reproductive technologies. Short and long-term consequences for health of children conceived through assisted reproduction technology: more reason for caution?Hum. Reprod. 2002;17:2783–6.CrossRefGoogle Scholar
Eastman, N. J., Jackson, E.Weight relationships in pregnancy. I. The bearing of maternal weight gain and pre-pregnancy weight on birth weight in full term pregnancies. Obstet. Gynecol. Surv. 1968;23:1003–25.CrossRefGoogle ScholarPubMed
Gluckman, P. D., Breier, B. H., Oliver, M., Harding, J., Bassett, N.Fetal growth in late gestation – a constrained pattern of growth. Acta Paediatr. Scand. Suppl. 1990;367:105–10.CrossRefGoogle Scholar
Pardi, G., Marconi, A. M., Cetin, I.Placental–fetal interrelationship in intrauterine growth restriction fetuses – a review. Placenta 2002;23:S136–41.CrossRefGoogle ScholarPubMed
Kalkhoff, R. K.Impact of maternal fuels and nutritional state on fetal growth. Diabetes 1991;40, Suppl. 2:61–5.CrossRefGoogle ScholarPubMed
Stein, Z., Susser, M.The Dutch famine, 1944/45 and reproductive process. Effects of six indices at birth. Pediatr. Res. 1975;9:70–6.Google Scholar
Lumey, L. H., Ravelli, A. C. J., Wiessing, L. G.et al.The Dutch famine birth cohort study: design, validation of exposure, and selected characteristics of subjects after 43 years follow up. Paediatr. Perinat. Epidemiol. 1993;7:354–67.CrossRefGoogle ScholarPubMed
Lumey, L. H., Stein, Z. A., Ravelli, A. C. J.Timing of prenatal starvation in women and birth weight in their first and second born offspring: the Dutch famine birth cohort study. Eur. J. Obstet. Gynecol. Reprod. Biol. 1995;61:23–30.CrossRefGoogle Scholar
Lumey, L. H.Compensatory placental growth after restricted maternal nutrition in early pregnancy. Placenta 1998;19:105–11.Google ScholarPubMed
Olsen, S. F., Secher, N. J.Low consumption of seafood in early pregnancy as a risk factor for preterm delivery: prospective cohort study. Br. Med. J. 2002;324:447–50.CrossRefGoogle Scholar
McArdle, H. J., Ashworth, C. J.Micronutrients in fetal growth and development. Br. Med. Bull. 1999;55:499–510.CrossRefGoogle ScholarPubMed
Barker, D. J.Fetal and Infant Origins of Adult Disease. London: BMJ Press; 1992.Google Scholar
, Cho S.-H., Choi, Y.Lipid peroxidation and antioxidant status is affected by different vitamin E levels when feeding fish oil. Lipids 1994;29:47–52.CrossRefGoogle Scholar
Vriese, S. R., Dhont, M., Christophe, A. B.Oxidative stability of low density lipoproteins and vitamin E levels increase in maternal blood during normal pregnancy. Lipids 2001;36:361–6.CrossRefGoogle ScholarPubMed
Antipatis, C., Ashworth, C. J., Riley, S. C.et al.Vitamin A deficiency during rat pregnancy alters placental tumor necrosis factor-α signalling and apoptosis. Am. J. Reprod. Immunol. 2002;47:151– 8.CrossRefGoogle ScholarPubMed
Gambling, L., Charania, Z., Hannah, L.et al.Effect of iron deficiency on placental cytokine expression and fetal growth in the pregnant rat. Biol. Reprod. 2002;66:516–23.CrossRefGoogle ScholarPubMed
Bell, A. W., Kennaugh, J. M., Battaglia, F. C., Makowski, E. L., Meschia, G.Metabolic and circulatory studies of the fetal lamb at mid gestation. Am. J. Physiol. 1986;250:E538–44.Google Scholar
Sparks, J. W., Hay, W. W. Jr, Meschia, G., Battaglia, F. C.Partition of maternal nutrients to the placenta and fetus in the sheep. Eur. J. Obstet. Gynec. Reprod. Biol. 1983;14:331–40.CrossRefGoogle ScholarPubMed
Kaufmann, P., Scheffen, I. Placental development. In Polin, R. A., Fox, W. W., eds. Fetal and Neonatal Physiology. Philadelphia, PA: W. B. Saunders; 1998:59.Google Scholar
Illsley, N. P.Glucose transporters in the human placenta. Placenta 2000;21:14–22.CrossRefGoogle ScholarPubMed
Jansson, T.Amino acid transporters in the human placenta. Pediatr. Res. 2001;9:141–7.CrossRefGoogle Scholar
Marconi, A. M., Cetin, I., Buscaglia, M., Pardi, G.Midgestation cord sampling: what have we learned. Placenta 1992;13:115–22.CrossRefGoogle ScholarPubMed
Marconi, A. M., Paolini, C., Buscaglia, M.et al.The impact of gestational age and of fetal growth upon the maternal-fetal glucose concentration difference. Obstet. Gynecol. 1996;7:937–42.CrossRefGoogle Scholar
Cetin, I., Ronzoni, S., Marconi, A. M.et al.Maternal concentrations and fetal-maternal concentration differences of plasma amino acids in normal (appropriate-for-gestational-age) and intrauterine growth restricted pregnancies. Am. J. Obstet. Gynaecol. 1996;174:1575–83.CrossRefGoogle ScholarPubMed
Cetin, I.Amino acid interconversions in the fetal-placental unit: the animal model and human studies in vivo. Pediatr. Res. 2001;49:148–54.CrossRefGoogle ScholarPubMed
Battaglia, F. C., Regnault, T. R. H.Placental transport and metabolism of amino acids. Placenta 2001;22:145–61.CrossRefGoogle ScholarPubMed
Sparks, J. W., Ross, J. C., Cetin, I. Intrauterine growth and nutrition. In Polin, R. A., Fox, W. W., eds. Fetal and Neonatal Physiology. Philadelphia, PA: W. B. Saunders; 1998:267–89.Google Scholar
Crawford, M. A., Hassam, A. G., Williams, G.Essential fatty acids and fetal brain growth. Lancet 1976;1:452–3.CrossRefGoogle ScholarPubMed
Sinclair, A. J.Long chain polyunsaturated FAs in the mammalian brain. Proc. Nutr. Soc. 1975;34:287–91.CrossRefGoogle Scholar
Greiner, R. C., Winter, J., Nathanielsz, P. W., Brenna, J. T.Brain docosahexaenoate accretion in fetal baboons: bioequivalence of dietary alpha-linolenic and docosahexaenoic acids. Pediatr. Res. 1997;42:826–34.CrossRefGoogle ScholarPubMed
Dunlop, M., Court, J. M.Lipogenesis in developing human adipose tissue. Early Hum. Dev. 1978;2:123–30.CrossRefGoogle ScholarPubMed
Herrera, E.Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development. A Review. Placenta 2002;23:S9–19.CrossRefGoogle ScholarPubMed
Hendrickse, W., Stammers, J. P., Hull, D.The transfer of free fatty acids across the human placenta. Br. J. Obstet. Gynaecol. 1985;92:945–52.CrossRefGoogle ScholarPubMed
Koletzko, B., Muller, J.Cis- and trans-isomeric fatty acids in plasma lipids of newborn infants and their mothers. Biol. Neonate 1990;57:172–8.CrossRefGoogle ScholarPubMed
Haggarty, P.Placental regulation of fatty acid delivery and its effect on fetal growth – a review. Placenta 2002;23:S28–38.CrossRefGoogle ScholarPubMed
Chambaz, J., Ravel, D., Manier, M. C.et al.Essential fatty acids interconversion in the human fetal liver. Biol. Neonate 1985;47:136–40.CrossRefGoogle ScholarPubMed
Uauy, R., Mena, P., Wegher, B., Nieto, S., Salemn, Jr.Long chain polyunsaturated fatty acid formation in neonates: effect of gestational age and intrauterine growth. Pediatr. Res. 2000;47:127–35.CrossRefGoogle ScholarPubMed
Demmelmair, H. R. U., Behrendt, E., Sauerwald, T., Koletzko, B.Estimation of arachidonic acid synthesis in full term neonates using natural variation of 13C-abundance. J. Pediatr. Gastroent. Nutr. 1995;21:31–6.CrossRefGoogle Scholar
Szitanyi, P., Koletzko, B., Mydlilova, A., Demmelmair, H.Metabolism of 13C-labeled linoleic acid in newborn infants during the first week of life. Pediatr. Res. 1999;45:669–73.CrossRefGoogle ScholarPubMed
Linnemann, K., Malek, A., Sager, R.et al.Leptin production and release in the dually in vitro perfused human placenta. J. Clin. Endocrinol. Metab. 2000:85:4298–301.Google ScholarPubMed
Giudice, L. C., Zegher, F., Gargosky, S. E.et al.Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth. J. Clin. Endocrinol. Metab. 1995;80:1548–55.Google ScholarPubMed
McIntyre, H. D., Serek, R., Crane, D. I.et al.Placental growth hormone (growth hormone), growth hormone-binding protein, and insulin-like growth factor axis in normal, growth-retarded, and diabetic pregnancies: correlations with fetal growth. J. Clin. Endocrinol. Metab. 2000;85:1143–50.Google ScholarPubMed
Wang, H. S., Chard, T.The role of insulin-like growth factor-I and insulin-like growth factor-binding protein-I in the control of human fetal growth. J. Endocrinol. 1992;133:149–59.CrossRefGoogle Scholar
Ashton, I. K., Zapf, J., Einschenk, I., MacKenzie, I. Z.Insulin-like growth factor (IGF) I and II in human fetal plasma and relationship to gestational age and foetal size during midpregnancy. Acta Endocrinol. 1985;110:558–63.Google ScholarPubMed
Sara, V. T., Hall, K., Misaki, M.et al.Ontogenesis of somatomedin and insulin receptors in the human fetus. J. Clin. Invest. 1983;71:1084–94.CrossRefGoogle ScholarPubMed
Han, V. K., Bassett, N., Walton, J., Challis, J. R.The expression of insulin-like growth factor (IGF) and IGF-binding protein (insulin-like growth factor binding protein) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface. J. Clin. Endocrinol. Metab. 1996;8:2680–93.Google Scholar
Han, V. K., Carter, A. M.Spatial and temporal patterns of expression of messenger RNA for insulin-like growth factors and their binding proteins in the placenta of man and laboratory animals. Placenta 2000;21:289–305.CrossRefGoogle ScholarPubMed
Nayak, N. R., Giudice, L. C.Comparative biology of the IGF system in endometrium, decidua, and placenta, and clinical implications for foetal growth and implantation disorders. Placenta 2003;24:281–96.CrossRefGoogle ScholarPubMed
Crossey, P. A., Pillai, C. C., Miell, J. P.Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mouse. J. Clin. Invest. 2002;110:411–8.CrossRefGoogle Scholar
Alsat, E., Guibourdenche, J., Couturier, A., Evain-Brion, D.Physiological role of human placental growth hormone. Mol. Cell Endocrinol. 1998;140:121–7.CrossRefGoogle ScholarPubMed
Zhang, Y., Proneca, R., Maffei, M.Positional cloning of the mouse obese gene and its human homologue. Nature 1995;372:425–32.CrossRefGoogle Scholar
Kennedy, A., Gettys, T. W., Wason, P.et al.The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity and energy expenditure. J. Clin. Endocrinol. Metab. 1997;82:1293–300.Google ScholarPubMed
Saad, M. F., Damani, S., Gingerich, R. L.et al.Sexual dimorphism in plasma leptin concentration. J. Clin. Endocrinol. Metab. 1997;82:579–84.Google ScholarPubMed
Schubring, C., Kiess, W., Englaro, P.et al.Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. J. Clin. Endocrinol. Metab. 1997;82:1480–83.CrossRefGoogle ScholarPubMed
Koistinen, H. A., Koivisto, V. A., Andersson, S.et al.Leptin concentration in cord blood correlates with intrauterine growth. J. Clin. Endocrinol. Metab. 1997;82:3328–30.Google ScholarPubMed
Shekawat, P. S., Garland, J. S., Shivpuri, C.et al.Neonatal cord blood leptin: its relationship to birth weight, body mass index, maternal diabetes, and steroids. Pediatr. Res. 1998;43:338– 43.CrossRefGoogle Scholar
Masuzaki, H., Ogawa, Y., Sagawa, N.et al.Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat. Med. 1997;241:1029–33.CrossRefGoogle Scholar

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  • Determinants of intrauterine growth
    • By John W. Sparks, Department of Pediatrics, University of Texas Medical School, Houston, Texas, Irene Cetin, Clinica Ostetrica e Ginecologica, Universita degli Studi di Milano, Ospedale San Paolo, Milano, Italy
  • Patti J. Thureen, University of Colorado at Denver and Health Sciences Center
  • Edited by William W. Hay, University of Colorado at Denver and Health Sciences Center
  • Book: Neonatal Nutrition and Metabolism
  • Online publication: 10 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544712.003
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Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Determinants of intrauterine growth
    • By John W. Sparks, Department of Pediatrics, University of Texas Medical School, Houston, Texas, Irene Cetin, Clinica Ostetrica e Ginecologica, Universita degli Studi di Milano, Ospedale San Paolo, Milano, Italy
  • Patti J. Thureen, University of Colorado at Denver and Health Sciences Center
  • Edited by William W. Hay, University of Colorado at Denver and Health Sciences Center
  • Book: Neonatal Nutrition and Metabolism
  • Online publication: 10 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544712.003
Available formats
×

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To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Determinants of intrauterine growth
    • By John W. Sparks, Department of Pediatrics, University of Texas Medical School, Houston, Texas, Irene Cetin, Clinica Ostetrica e Ginecologica, Universita degli Studi di Milano, Ospedale San Paolo, Milano, Italy
  • Patti J. Thureen, University of Colorado at Denver and Health Sciences Center
  • Edited by William W. Hay, University of Colorado at Denver and Health Sciences Center
  • Book: Neonatal Nutrition and Metabolism
  • Online publication: 10 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544712.003
Available formats
×