Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-04T18:25:13.339Z Has data issue: false hasContentIssue false

Chapter 6 - Resting-State Functional Connectivity in Unipolar Depression

from Section 3 - Functional and Neurochemical Brain Studies

Published online by Cambridge University Press:  12 January 2021

By
Ziqi Chen  and
Qiyong Gong
Edited by
Sudhakar Selvaraj ,
Paolo Brambilla  and
Jair C. Soares
Sudhakar Selvaraj
Affiliation:
UTHealth School of Medicine, USA
Paolo Brambilla
Affiliation:
Università degli Studi di Milano
Jair C. Soares
Affiliation:
UT Harris County Psychiatric Center, USA
Get access

Summary

Unipolar depression, also known as unipolar or major depressive disorder (MDD), is a globally prevalent psychiatric disorder characterized by persistent sadness and a loss of interest in normally enjoyable activities, accompanied by an inability to carry out daily activities, for at least two weeks. Furthermore, patients with unipolar depression usually exhibit some of the following symptoms: loss of energy, sleeping more or less, anxiety, change in appetite, reduced concentration, indecisiveness, feeling of worthlessness, guilt, hopelessness, and thoughts or acts of self-harm or suicide. The lifetime risk of depression is approximately 10–20%, with rates being almost doubled in women.

Type
Chapter
Information
Mood Disorders
Brain Imaging and Therapeutic Implications
 , pp. 49 - 58
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Smith, K. Mental health: A world of depression. Nature. 2014; 515: 181.CrossRefGoogle ScholarPubMed
Lui, S, Zhou, XJ, Sweeney, JA, et al. Psychoradiology: The frontier of neuroimaging in psychiatry. Radiology. 2016; 281: 357–372.Google Scholar
Cordes, D, Haughton, VM, Arfanakis, K, et al. Mapping functionally related regions of brain with functional connectivity MR imaging. AJNR Am J Neuroradiol. 2000; 21: 1636–1644.Google Scholar
Beckmann, CF, DeLuca, M, Devlin, JT, et al. Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc Lond B Biol Sci. 2005; 360: 1001–1013.Google Scholar
Bullmore, E, Sporns, O. Complex brain networks: Graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 2009; 10: 186–198.Google Scholar
Sheline, YI. Neuroimaging studies of mood disorder effects on the brain. Biol Psychiatry. 2003; 54: 338–352.Google Scholar
Hasler, G, Fromm, S, Carlson, PJ, et al. Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects. Arch Gen Psychiatry. 2008; 65: 521–531.CrossRefGoogle ScholarPubMed
Qiu, L, Lui, S, Kuang, W, et al. Regional increases of cortical thickness in untreated, first-episode major depressive disorder. Transl Psychiatry. 2014; 4: e378.Google Scholar
Lui, S, Wu, Q, Qiu, L, et al. Resting-state functional connectivity in treatment-resistant depression. Am J Psychiatry. 2011; 168: 642–648.CrossRefGoogle ScholarPubMed
Degl’Innocenti, A, Agren, H and Backman, L. Executive deficits in major depression. Acta Psychiatr Scand. 1998; 97: 182–188.CrossRefGoogle ScholarPubMed
Nock, MK, Borges, G, Bromet, EJ, et al. Cross-national prevalence and risk factors for suicidal ideation, plans and attempts. Br J Psychiatry. 2008; 192: 98–105.Google Scholar
Cao, J, Chen, X, Chen, J, et al. Resting-state functional MRI of abnormal baseline brain activity in young depressed patients with and without suicidal behavior. J Affect Disord 2016; 205: 252–263.CrossRefGoogle ScholarPubMed
Zhang, S, Chen, JM, Kuang, L, et al. Association between abnormal default mode network activity and suicidality in depressed adolescents. BMC Psychiatry. 2016; 16: 337.CrossRefGoogle ScholarPubMed
Wei, S, Chang, M, Zhang, R, et al. Amygdala functional connectivity in female patients with major depressive disorder with and without suicidal ideation. Ann Gen Psychiatry. 2018; 17: 37.Google Scholar
Du, L, Zeng, J, Liu, H, et al. Fronto-limbic disconnection in depressed patients with suicidal ideation: A resting-state functional connectivity study. J Affect Disord. 2017; 215: 213–217.Google Scholar
Kim, K, Kim, SW, Myung, W, et al. Reduced orbitofrontal-thalamic functional connectivity related to suicidal ideation in patients with major depressive disorder. Scientific Reports. 2017; 7: 15772.Google Scholar
Iwabuchi, SJ, Krishnadas, R, Li, C, et al. Localized connectivity in depression: a meta-analysis of resting state functional imaging studies. Neurosci Biobehav Rev. 2015; 51: 77–86.CrossRefGoogle ScholarPubMed
Raichle, ME, MacLeod, AM, Snyder, AZ, et al. A default mode of brain function. Proc Natl Acad Sci U S A. 2001; 98: 676–682.Google Scholar
Andrews-Hanna, JR, Reidler, JS, Sepulcre, J, et al. Functional-anatomic fractionation of the brain’s default network. Neuron. 2010; 65: 550–562.CrossRefGoogle ScholarPubMed
Buckner, RL, Andrews-Hanna, JR, Schacter, DL. The brain’s default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 2008; 1124: 1–38.CrossRefGoogle ScholarPubMed
Cavanna, AE, Trimble, MR. The precuneus: A review of its functional anatomy and behavioural correlates. Brain. 2006; 129: 564–583.CrossRefGoogle ScholarPubMed
Andrews-Hanna, JR, Smallwood, J, Spreng, RN. The default network and self-generated thought: Component processes, dynamic control, and clinical relevance. Ann N Y Acad Sci. 2014; 1316: 29–52.CrossRefGoogle ScholarPubMed
Leech, R, Sharp, DJ. The role of the posterior cingulate cortex in cognition and disease. Brain. 2014; 137: 12–32.Google Scholar
Greicius, MD, Krasnow, B, Reiss, AL, et al. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A. 2003; 100: 253–258.Google Scholar
van Tol, MJ, Li, M, Metzger, CD, et al. Local cortical thinning links to resting-state disconnectivity in major depressive disorder. Psychol Med. 2014; 44: 2053–2065.Google Scholar
Sheline, YI, Price, JL, Yan, Z, et al. Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proc Natl Acad Sci U S A. 2010; 107: 11020–11025.Google Scholar
Zhou, Y, Yu, C, Zheng, H, et al. Increased neural resources recruitment in the intrinsic organization in major depression. J Affect Disord. 2010; 121: 220–230.CrossRefGoogle ScholarPubMed
Alexopoulos, GS, Hoptman, MJ, Kanellopoulos, D, et al. Functional connectivity in the cognitive control network and the default mode network in late-life depression. J Affect Disord. 2012; 139: 56–65.Google Scholar
Andreescu, C, Tudorascu, DL, Butters, MA, et al. Resting state functional connectivity and treatment response in late-life depression. Psychiatry Res 2013; 214: 313–321.CrossRefGoogle ScholarPubMed
Greicius, MD, Flores, BH, Menon, V, et al. Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol Psychiatry. 2007; 62: 429–437.CrossRefGoogle ScholarPubMed
Zhu, X Wang, X, Xiao, J, et al. Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients. Biol Psychiatry. 2012; 71: 611–617.CrossRefGoogle ScholarPubMed
Li, B, Liu, L, Friston, KJ, et al. A treatment-resistant default mode subnetwork in major depression. Biol Psychiatry. 2013; 74: 48–54.CrossRefGoogle ScholarPubMed
Manoliu, A, Meng, C, Brandl, F, et al. Insular dysfunction within the salience network is associated with severity of symptoms and aberrant inter-network connectivity in major depressive disorder. Front Hum Neurosci. 2013; 7: 930.Google Scholar
Smith, SM, Fox, PT, Miller, KL, et al. Correspondence of the brain’s functional architecture during activation and rest. Proc Natl Acad Sci U S A. 2009; 106: 13040–13045.Google Scholar
Menon, V. Large-scale brain networks and psychopathology: A unifying triple network model. Trends Cogn Sci. 2011; 15: 483–506.CrossRefGoogle ScholarPubMed
Ye, T, Peng, J, Nie, B, et al. Altered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder. Eur J Radiol. 2012; 81: 4035–4040.Google Scholar
Wang, YL, Yang, SZ, Sun, WL, et al. Altered functional interaction hub between affective network and cognitive control network in patients with major depressive disorder. Behav Brain Res. 2016; 298: 301–309.Google Scholar
Liston, C, Chen, AC, Zebley, BD, et al. Default mode network mechanisms of transcranial magnetic stimulation in depression. Biol Psychiatry. 2014; 76: 517–526.Google Scholar
Stange, JP, Bessette, KL, Jenkins, LM, et al. Attenuated intrinsic connectivity within cognitive control network among individuals with remitted depression: Temporal stability and association with negative cognitive styles. Hum Brain Mapp. 2017; 38: 2939–2954.Google Scholar
Seeley, WW, Menon, V, Schatzberg, AF, et al. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci. 2007; 27: 2349–2356.Google Scholar
Sridharan, D, Levitin, DJ, Menon, V. A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. Proc Natl Acad Sci U S A. 2008; 105: 12569–12574.CrossRefGoogle ScholarPubMed
Goulden, N, Khusnulina, A, Davis, NJ, et al. The salience network is responsible for switching between the default mode network and the central executive network: replication from DCM. Neuroimage. 2014; 99: 180–190.CrossRefGoogle Scholar
Horn, DI, Yu, C, Steiner, J, et al. Glutamatergic and resting-state functional connectivity correlates of severity in major depression – the role of pregenual anterior cingulate cortex and anterior insula. Front Syst Neurosci. 2010 July 15; 4: 33.Google ScholarPubMed
Avery, JA, Drevets, WC, Moseman, SE, et al. Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the insula. Biol Psychiatry. 2014; 76: 258–266.Google Scholar
Hamilton, JP, Chen, MC, Gotlib, IH. Neural systems approaches to understanding major depressive disorder: an intrinsic functional organization perspective. Neurobiol Dis. 2013; 52: 4–11.CrossRefGoogle ScholarPubMed
Yuen, GS, Gunning-Dixon, FM, Hoptman, MJ, et al. The salience network in the apathy of late-life depression. Int J Geriatr Psychiatry. 2014; 29: 1116–1124.Google Scholar
Cullen, KR, Westlund, MK, Klimes-Dougan, B, et al. Abnormal amygdala resting-state functional connectivity in adolescent depression. JAMA Psychiatry. 2014; 71: 1138–1147.Google Scholar
Yue, Y, Yuan, Y, Hou, Z, et al. Abnormal functional connectivity of amygdala in late-onset depression was associated with cognitive deficits. PLoS One. 2013; 8: e75058.Google Scholar
Ramasubbu, R, Konduru, N, Cortese, F, et al. Reduced intrinsic connectivity of amygdala in adults with major depressive disorder. Front Psychiatry. 2014; 5: 17.Google Scholar
Tahmasian, M, Knight, DC, Manoliu, A, et al. Aberrant intrinsic connectivity of hippocampus and amygdala overlap in the fronto-insular and dorsomedial-prefrontal cortex in major depressive disorder. Front Hum Neurosci. 2013; 7: 639.Google Scholar
Veer, IM, Beckmann, CF, van Tol, MJ, et al. Whole brain resting-state analysis reveals decreased functional connectivity in major depression. Front Syst Neurosci. 2010 September 20; 4: 41.Google Scholar
Jiang, Y, Duan, M, Chen, X, et al. Common and distinct dysfunctional patterns contribute to triple network model in schizophrenia and depression: A preliminary study. Prog Neuropsychopharmacol Biol Psychiatry. 2017; 79: 302–310.CrossRefGoogle ScholarPubMed
Abbott, CC, Lemke, NT, Gopal, S, et al. Electroconvulsive therapy response in major depressive disorder: A pilot functional network connectivity resting state fMRI investigation. Front Psychiatry. 2013; 4: 10.Google Scholar
Mulders, PC, van Eijndhoven, PF, Schene, AH, et al. Resting-state functional connectivity in major depressive disorder: A review. Neurosci Biobehav Rev. 2015; 56: 330–344.CrossRefGoogle ScholarPubMed
Palaniyappan, L, Liddle, PF. Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction. J Psychiatry Neurosci. 2012; 37: 17–27.Google Scholar
Gong, Q, He, Y. Depression, neuroimaging and connectomics: A selective overview. Biol Psychiatry. 2015; 77: 223–235.CrossRefGoogle ScholarPubMed
Zhang, J, Wang, J, Wu, Q, et al. Disrupted brain connectivity networks in drug-naive, first-episode major depressive disorder. Biol Psychiatry. 2011; 70: 334–342.CrossRefGoogle ScholarPubMed
Meng, C, Brandl, F, Tahmasian, M, et al. Aberrant topology of striatum’s connectivity is associated with the number of episodes in depression. Brain. 2014; 137: 598–609.Google Scholar
Lord, A, Horn, D, Breakspear, M, et al. Changes in community structure of resting state functional connectivity in unipolar depression. PLoS One. 2012; 7: e41282.CrossRefGoogle ScholarPubMed
Bohr, IJ, Kenny, E, Blamire, A, et al. Resting-state functional connectivity in late-life depression: Higher global connectivity and more long distance connections. Front Psychiatry. 2012; 3: 116.Google ScholarPubMed
Wang, J, Wang, L, Zang, Y, et al. Parcellation-dependent small-world brain functional networks: a resting-state fMRI study. Hum Brain Mapp. 2009; 30: 1511–1523.CrossRefGoogle ScholarPubMed
Zalesky, A, Fornito, A, Harding, IH, et al. Whole-brain anatomical networks: does the choice of nodes matter? Neuroimage. 2010; 50: 970–983.Google Scholar
Tao, H, Guo, S, Ge, T, et al. Depression uncouples brain hate circuit. Mol Psychiatry. 2013; 18: 101–111.Google Scholar
Jin, C, Gao, C, Chen, C, et al. A preliminary study of the dysregulation of the resting networks in first-episode medication-naive adolescent depression. Neurosci Lett. 2011; 503: 105–109.Google Scholar
Pine, DS, Cohen, E, Cohen, P, et al. Adolescent depressive symptoms as predictors of adult depression: Moodiness or mood disorder? Am J Psychiatry. 1999; 156: 133–135.Google Scholar
van den Heuvel, MP, Hulshoff Pol, HE. Exploring the brain network: A review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol. 2010; 20: 519–534.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×