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Chapter 10 - Neuroimaging Brain Inflammation in Mood Disorders

from Section 3 - Functional and Neurochemical Brain Studies

Published online by Cambridge University Press:  12 January 2021

By
Jeffrey H. Meyer
Edited by
Sudhakar Selvaraj ,
Paolo Brambilla  and
Jair C. Soares
Sudhakar Selvaraj
Affiliation:
UTHealth School of Medicine, USA
Paolo Brambilla
Affiliation:
Università degli Studi di Milano
Jair C. Soares
Affiliation:
UT Harris County Psychiatric Center, USA
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Summary

Neuroimaging with positron emission tomography is increasingly developing radioligands that emulate targets traditionally within the domain of postmortem studies. Consequently, markers indicative of neuroinflammatory processes are advancing and enabling rapid assessment of the neuroinflammatory theory of major depressive disorder (MDD). One marker, translocator protein (TSPO), has now had a significant number of investigations in MDD and it is anticipated that investigations of other neuroinflammatory markers will be extended into mood disorders. Of these measures, neuroimaging of monoamine oxidase B demonstrates promising differences between MDD and health.

Type
Chapter
Information
Mood Disorders
Brain Imaging and Therapeutic Implications
 , pp. 121 - 134
Publisher: Cambridge University Press
Print publication year: 2021

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