Contents

pp v-vi

List of contributors

pp vii-viii

Preface by HIROSHI OKAMOTO

pp ix-x

Introductory overview by HIROSHI OKAMOTO

pp 1-6

I - The molecular biology of peptide hormones in the islets of Langerhans

pp 7-8

1 - The organization and structure of insulin genes

pp 9-26

2 - The regulation of insulin gene expression

pp 27-48

3 - The translational control of proinsulin synthesis by glucose

pp 49-66

4 - The structure and regulation of the glucagon gene

pp 67-86

5 - The structure and regulation of the somatostatin gene

pp 87-106

6 - The mosaic evolution of the pancreatic polypeptide gene

pp 107-124

7 - The structure and expression of genes of vasoactive intestinal peptide and related peptides

pp 125-144

8 - Pancreastatin: a novel pancreatic hormone

pp 145-152

9 - The processing of peptide precursors

pp 153-206

II - Molecular aspects of diabetes mellitus

pp 207-208

10 - The molecular basis of experimental diabetes

pp 209-232

11 - Class II histocompatibility genes and diabetes

pp 233-250

12 - The role of the insulin gene in diabetes: use of restriction fragment length polymorphisms in diagnosis

pp 251-262

13 - Abnormal products of the human insulin gene

pp 263-286

14 - A novel gene, rig, activated in insulinomas

pp 287-300

15 - A novel gene, reg, expressed in regenerating islets

pp 301-314

16 - Defects of signal transduction in a tumoral islet cell line

pp 315-339

Index

pp 340-352