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Chapter 13 - Point-of-Care Hematology

Published online by Cambridge University Press:  28 April 2020

Andrew B. Leibowitz
Affiliation:
Icahn School of Medicine at Mount Sinai
Suzan Uysal
Affiliation:
Icahn School of Medicine at Mount Sinai
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Summary

Perioperative management of hemostasis and coagulopathy is a complex, time-sensitive task for the anesthesiologist. The combination of anticoagulant medications and possible inherent bleeding disorders makes the ability to diagnose potential causes and risks of bleeding and guide therapy critically important. Point-of-care testing is an essential tool that has been used in clinical practice for decades and provides rapid results at the bedside. This chapter details recent advances in the monitoring of coagulation and hemostasis to assist the practitioner in guiding therapy, reduce the administration of unnecessary blood products, and improve patient outcomes

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Publisher: Cambridge University Press
Print publication year: 2020

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References

Hattersley, PG. Activated coagulation time of whole blood. JAMA 1966;196:436–40.CrossRefGoogle ScholarPubMed
Garvin, S, FitzGerald, DC, Despotis, G, Shekar, P, Body, SC. Heparin concentration-based anticoagulation for cardiac surgery fails to reliably predict heparin bolus dose requirements. Anesth Analg 2010;111:849–55.Google Scholar
Gravlee, GP, Arora, S, Lavender, SW, et al. Predictive value of blood clotting tests in cardiac surgical patients. Ann Thorac Surg 1994;58:216–21.CrossRefGoogle ScholarPubMed
Hett, DA, Walker, D, Pilkington, SN, Smith, DC. Sonoclot analysis. Br J Anaesth 1995;75:771–6.CrossRefGoogle ScholarPubMed
Bischof, DB, Ganter, MT, Shore-Lesserson, L, et al. Viscoelastic blood coagulation measurement with Sonoclot predicts postoperative bleeding in cardiac surgery after heparin reversal. J Cardiothorac Vasc Anesth 2015;29:715–22.CrossRefGoogle ScholarPubMed
Dzemali, O, Ganter, MT, Zientara, A, et al. Evaluation of a new Sonoclot device for heparin management in cardiac surgery. Clin Appl Thromb Hemost 2017;23:20–6.Google Scholar
Luddington, RJ. Thromboelastography/thromboelastometry. Clin Lab Haematol 2005;27:8190.Google Scholar
Ak, K, Isbir, CS, Tetik, S, et al. Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: a prospective randomized study. J Card Surg 2009;24:404–10.CrossRefGoogle ScholarPubMed
Shore-Lesserson, L, Manspeizer, HE, DePerio, M, Francis, S, Vela-Cantos, F, Ergin, MA. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg 1999;88:312–9.Google Scholar
Shore-Lesserson, L, Baker, RA, Ferraris, VA, et al. The Society of Thoracic Surgeons, The Society of Cardiovascular Anesthesiologists, and The American Society of ExtraCorporeal Technology: Clinical Practice Guidelines-Anticoagulation During Cardiopulmonary Bypass. Ann Thorac Surg 2018;105:650–62.Google Scholar
Di Nisio, M, Middeldorp, S, Buller, HR. Direct thrombin inhibitors. N Engl J Med 2005;353:1028–40.CrossRefGoogle ScholarPubMed
Stangier, J, Rathgen, K, Stahle, H, Gansser, D, Roth, W. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 2007;64:292303.Google Scholar
Stangier, J, Stahle, H, Rathgen, K, Fuhr, R. Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects. Clin Pharmacokinet 2008;47:4759.Google Scholar
Nielsen, VG, Steenwyk, BL, Gurley, WQ, Pereira, SJ, Lell, WA, Kirklin, JK. Argatroban, bivalirudin, and lepirudin do not decrease clot propagation and strength as effectively as heparin-activated antithrombin in vitro. J Heart Lung Transplant 2006;25:653–63.Google Scholar
Samama, MM, Guinet, C. Laboratory assessment of new anticoagulants. Clin Chem Lab Med 2011;49:761–72.Google Scholar
Nowak, G. The ecarin clotting time, a universal method to quantify direct thrombin inhibitors. Pathophysiol Haemost Thromb 2003;33:173–83.Google Scholar
Siegmund, R, Boer, K, Poeschel, K, Wolf, G, Deufel, T, Kiehntopf, M. Comparison of the ecarin chromogenic assay and different aPTT assays for the measurement of argatroban concentrations in plasma from healthy individuals and from coagulation factor deficient patients. Thromb Res 2008;123:159–65.CrossRefGoogle ScholarPubMed
Vaishnava, P, Eagle, KA. Coronary stents and risk for noncardiac surgery: much ado about something, nothing, or DAPT? J Am Coll Cardiol 2016;67:1050–2.Google Scholar
van Ryn, J, Stangier, J, Haertter, S, et al. Dabigatran etexilate–a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 2010;103:1116–27.Google ScholarPubMed
Lange, U, Nowak, G, Bucha, E. Ecarin chromogenic assay–a new method for quantitative determination of direct thrombin inhibitors like hirudin. Pathophysiol Haemost Thromb 2003;33:184–91.CrossRefGoogle ScholarPubMed
Avecilla, ST, Ferrell, C, Chandler, WL, Reyes, M. Plasma-diluted thrombin time to measure dabigatran concentrations during dabigatran etexilate therapy. Am J Clin Pathol 2012;137:572–4.Google Scholar
Love, JE, Ferrell, C, Chandler, WL. Monitoring direct thrombin inhibitors with a plasma diluted thrombin time. Thromb Haemost 2007;98:234–42.Google Scholar
Ufer, M. Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development. Thromb Haemost 2010;103:572–85.Google ScholarPubMed
Ruff, CT, Giugliano, RP, Braunwald, E, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet 2014;383:955–62.Google Scholar
Levy, JH, Spyropoulos, AC, Samama, CM, Douketis, J. Direct oral anticoagulants: new drugs and new concepts. JACC Cardiovasc Interv 2014;7:1333–51.Google Scholar
Favaloro, EJ, Lippi, G. Laboratory testing in the era of direct or non-vitamin K antagonist oral anticoagulants: a practical guide to measuring their activity and avoiding diagnostic errors. Semin Thromb Hemost 2015;41:208–27.Google Scholar
Douxfils, J, Mullier, F, Robert, S, et al. Impact of dabigatran on a large panel of routine or specific coagulation assays. Laboratory recommendations for monitoring of dabigatran etexilate. Thromb Haemost 2012;107:985–97.Google Scholar
Douxfils, J, Tamigniau, A, Chatelain, B, et al. Measurement of non-VKA oral anticoagulants versus classic ones: the appropriate use of hemostasis assays. Thromb J 2014;12:24.Google Scholar
Eller, T, Busse, J, Dittrich, M, et al. Dabigatran, rivaroxaban, apixaban, argatroban and fondaparinux and their effects on coagulation POC and platelet function tests. Clin Chem Lab Med 2014;52:835–44.Google Scholar
Dias, JD, Norem, K, Doorneweerd, DD, et al. Use of thromboelastography (TEG) for detection of new oral anticoagulants. Arch Pathol Lab Med 2015;139:665–73.Google Scholar
Solbeck, S, Meyer, MA, Johansson, PI, et al. Monitoring of dabigatran anticoagulation and its reversal in vitro by thromboelastography. Int J Cardiol 2014;176:794–9.Google Scholar
Solbeck, S, Ostrowski, SR, Stensballe, J, Johansson, PI. Thromboelastography detects dabigatran at therapeutic concentrations in vitro to the same extent as gold-standard tests. Int J Cardiol 2016;208:14–8.Google Scholar
Cotton, BA, McCarthy, JJ, Holcomb, JB. Acutely injured patients on dabigatran. N Engl J Med 2011;365:2039–40.Google Scholar
Davis, PK, Musunuru, H, Walsh, M, et al. The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine. Thromb Haemost 2012;108:586–8.Google Scholar
Herrmann, R, Thom, J, Wood, A, et al. Thrombin generation using the calibrated automated thrombinoscope to assess reversibility of dabigatran and rivaroxaban. Thromb Haemost 2014;111:989–95.Google Scholar
Stein, P, Bosshart, M, Brand, B, et al. Dabigatran anticoagulation and Stanford type A aortic dissection: lethal coincidence: case report with literature review. Acta Anaesthesiol Scand 2014;58:630–7.Google Scholar
Iapichino, GE, Bianchi, P, Ranucci, M, Baryshnikova, E. Point-of-care coagulation tests monitoring of direct oral anticoagulants and their reversal therapy: state of the art. Semin Thromb Hemost 2017;43:423–32.Google ScholarPubMed
Escolar, G, Arellano-Rodrigo, E, Lopez-Vilchez, I, et al. Reversal of rivaroxaban-induced alterations on hemostasis by different coagulation factor concentrates – in vitro studies with steady and circulating human blood. Circ J 2015;79:331–8.Google Scholar
Korber, MK, Langer, E, Ziemer, S, et al. Measurement and reversal of prophylactic and therapeutic peak levels of rivaroxaban: an in vitro study. Clin Appl Thromb Hemost 2014;20:735–40.Google Scholar
Perzborn, E, Heitmeier, S, Laux, V, Buchmuller, A. Reversal of rivaroxaban-induced anticoagulation with prothrombin complex concentrate, activated prothrombin complex concentrate and recombinant activated factor VII in vitro. Thromb Res 2014;133:671–81.Google Scholar
Saraf, S, Christopoulos, C, Salha, IB, Stott, DJ, Gorog, DA. Impaired endogenous thrombolysis in acute coronary syndrome patients predicts cardiovascular death and nonfatal myocardial infarction. J Am Coll Cardiol 2010;55:2107–15.CrossRefGoogle ScholarPubMed
Saraf, S, Wellsted, D, Sharma, S, Gorog, DA. Shear-induced global thrombosis test of native blood: pivotal role of ADP allows monitoring of P2Y12 antagonist therapy. Thromb Res 2009;124:447–51.Google Scholar
Yamamoto, J, Inoue, N, Otsui, K, Ishii, H, Gorog, DA. Global Thrombosis Test (GTT) can detect major determinants of haemostasis including platelet reactivity, endogenous fibrinolytic and thrombin generating potential. Thromb Res 2014;133:919–26.Google Scholar
Yamamoto, J, Yamashita, T, Ikarugi, H, et al. Gorog thrombosis test: a global in-vitro test of platelet function and thrombolysis. Blood Coagul Fibrinolysis 2003;14:31–9.Google Scholar
Sharma, S, Farrington, K, Kozarski, R, et al. Impaired thrombolysis: a novel cardiovascular risk factor in end-stage renal disease. Eur Heart J 2013;34:354–63.CrossRefGoogle ScholarPubMed
Otsui, K, Gorog, DA, Yamamoto, J, et al. Global thrombosis test – a possible monitoring system for the effects and safety of dabigatran. Thromb J 2015;13:39.Google Scholar
Rosser, G, Tricoci, P, Morrow, D, et al. PAR-1 antagonist vorapaxar favorably improves global thrombotic status in patients with coronary disease. J Thromb Thrombolysis 2014;38:423–9.CrossRefGoogle ScholarPubMed
Kenet, G, Lubetsky, A, Shenkman, B, et al. Cone and platelet analyser (CPA): a new test for the prediction of bleeding among thrombocytopenic patients. Br J Haematol 1998;101:255–9.Google Scholar
Gerrah, R, Snir, E, Brill, A, Varon, D. Platelet function changes as monitored by cone and plate(let) analyzer during beating heart surgery. Heart Surg Forum 2004;7:E1915.Google Scholar
Spectre, G, Brill, A, Gural, A, et al. A new point-of-care method for monitoring anti-platelet therapy: application of the cone and plate(let) analyzer. Platelets 2005;16:293–9.Google Scholar
Varon, D, Lashevski, I, Brenner, B, et al. Cone and plate(let) analyzer: monitoring glycoprotein IIb/IIIa antagonists and von Willebrand disease replacement therapy by testing platelet deposition under flow conditions. Am Heart J 1998;135:S18793.Google Scholar
Gerrah, R, Brill, A, Tshori, S, et al. Using cone and plate(let) analyzer to predict bleeding in cardiac surgery. Asian Cardiovasc Thorac Ann 2006;14:310–5.Google Scholar
Shenkman, B, Schneiderman, J, Tamarin, I, et al. Testing the effect of GPIIb-IIIa antagonist in patients undergoing carotid stenting: correlation between standard aggregometry, flow cytometry and the cone and plate(let) analyzer (CPA) methods. Thromb Res 2001;102:311–7.Google Scholar
Shenkman, B, Matetzky, S, Fefer, P, et al. Variable responsiveness to clopidogrel and aspirin among patients with acute coronary syndrome as assessed by platelet function tests. Thromb Res 2008;122:336–45.CrossRefGoogle ScholarPubMed
Toulon, P, Ozier, Y, Ankri, A, et al. Point-of-care versus central laboratory coagulation testing during haemorrhagic surgery. A multicenter study. Thromb Haemost 2009;101:394401.Google Scholar
Haas, T, Fries, D, Tanaka, KA, et al. Usefulness of standard plasma coagulation tests in the management of perioperative coagulopathic bleeding: is there any evidence? Br J Anaesth 2015;114:217–24.Google Scholar
Society of Thoracic Surgeons Blood Conservation Guideline Task F, Ferraris VA, Brown JR, et al. 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg 2011;91:944–82.Google Scholar
Task Force on Patient Blood Management for Adult Cardiac Surgery of the European Association for Cardio-Thoracic S, the European Association of Cardiothoracic Anaesthesiology (EACTA), Boer C, Meesters MI, et al. 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery. J Cardiothorac Vasc Anesth 2018;32(1):88120.Google Scholar
Carson, JL, Guyatt, G, Heddle, NM, et al. Clinical practice guidelines from the AABB: red blood cell transfusion thresholds and storage. JAMA 2016;316:2025–35.Google Scholar
Rossaint, R, Bouillon, B, Cerny, V, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care 2016;20:100.Google Scholar
Shaylor, R, Weiniger, CF, Austin, N, et al. National and international guidelines for patient blood management in obstetrics: a qualitative review. Anesth Analg 2017;124:216–32.Google Scholar
Shore-Lesserson, L, Manspeizer, HE, DePerio, M, et al. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg 1999;88:312–9.Google Scholar
Rahe-Meyer, N, Solomon, C, Winterhalter, M, et al. Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm surgery. J Thorac Cardiovasc Surg 2009;138:694702.Google Scholar
Ranucci, M, Baryshnikova, E, Ranucci, M, Silvetti, S, Surgical and Clinical Outcome Research (SCORE) Group. Fibrinogen levels compensation of thrombocytopenia-induced bleeding following cardiac surgery. Int J Cardiol 2017;249:96100.Google Scholar
Weber, CF, Gorlinger, K, Meininger, D, et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology 2012;117:531–47.Google Scholar
Spahn, DR. TEG(R)- or ROTEM(R)-based individualized goal-directed coagulation algorithms: don’t wait–act now! Crit Care 2014;18:637.Google Scholar
Stein, P, Kaserer, A, Spahn, GH, Spahn, DR. Point-of-care coagulation monitoring in trauma patients. Semin Thromb Hemost 2017;43:367–74.Google Scholar
Schochl, H, Nienaber, U, Maegele, M, et al. Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Crit Care 2011;15:R83.CrossRefGoogle ScholarPubMed
Gonzalez, E, Moore, EE, Moore, HB, et al. Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays. Ann Surg 2016;263:1051–9.CrossRefGoogle ScholarPubMed
Snegovskikh, D, Souza, D, Walton, Z, et al. Point-of-care viscoelastic testing improves the outcome of pregnancies complicated by severe postpartum hemorrhage. J Clin Anesth 2018;44:50–6.CrossRefGoogle ScholarPubMed
Butwick, AJ, Goodnough, LT. Transfusion and coagulation management in major obstetric hemorrhage. Curr Opin Anaesthesiol 2015;28:275–84.Google Scholar
Karkouti, K, Callum, J, Wijeysundera, DN, et al. Point-of-care hemostatic testing in cardiac surgery: a stepped-wedge clustered randomized controlled trial. Circulation 2016;134:1152–62.Google Scholar
Ranucci, M, Baryshnikova, E, Crapelli, GB, et al. Randomized, double-blinded, placebo-controlled trial of fibrinogen concentrate supplementation after complex cardiac surgery. J Am Heart Assoc 2015;4:e002066.Google Scholar
Gorlinger, K, Dirkmann, D, Hanke, AA, et al. First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. Anesthesiology 2011;115:1179–91.Google Scholar
Tanaka, KA, Esper, S, Bolliger, D. Perioperative factor concentrate therapy. Br J Anaesth 2013;111 Suppl 1:i35-49.Google Scholar
Da Luz, LT, Nascimento, B, Shankarakutty, AK, Rizoli, S, Adhikari, NK. Effect of thromboelastography (TEG(R)) and rotational thromboelastometry (ROTEM(R)) on diagnosis of coagulopathy, transfusion guidance and mortality in trauma: descriptive systematic review. Crit Care 2014;18:518.Google Scholar
Rahe-Meyer, N, Levy, JH, Mazer, CD, et al. Randomized evaluation of fibrinogen vs placebo in complex cardiovascular surgery (REPLACE): a double-blind phase III study of haemostatic therapy. Br J Anaesth 2016;117:4151.Google Scholar
Bilecen, S, de Groot, JA, Kalkman, CJ, et al. Effect of fibrinogen concentrate on intraoperative blood loss among patients with intraoperative bleeding during high-risk cardiac surgery: a randomized clinical trial. JAMA 2017;317:738–47.Google Scholar
Afshari, A, Wikkelso, A, Brok, J, Moller, AM, Wetterslev, J. Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database Syst Rev 2011:CD007871.Google Scholar
Deppe, AC, Weber, C, Zimmermann, J, et al. Point-of-care thromboelastography/thromboelastometry-based coagulation management in cardiac surgery: a meta-analysis of 8332 patients. J Surg Res 2016;203:424–33.Google Scholar
Laursen, TH, Meyer, MAS, Meyer, ASP, et al. Thromboelastography early amplitudes in bleeding and coagulopathic trauma patients: results from a multicenter study. J Trauma Acute Care Surg 2018;84:334–41.Google Scholar
Dirkmann, D, Gorlinger, K, Dusse, F, Kottenberg, E, Peters, J. Early thromboelastometric variables reliably predict maximum clot firmness in patients undergoing cardiac surgery: a step towards earlier decision making. Acta Anaesthesiol Scand 2013;57:594603.Google Scholar
Song, JG, Jeong, SM, Jun, IG, Lee, HM, Hwang, GS. Five-minute parameter of thromboelastometry is sufficient to detect thrombocytopenia and hypofibrinogenaemia in patients undergoing liver transplantation. Br J Anaesth 2014;112:290–7.Google Scholar
Rajkumar, V, Kumar, B, Dutta, V, Mishra, AK, Puri, GD. Utility of Sonoclot in prediction of postoperative bleeding in pediatric patients undergoing cardiac surgery for congenital cyanotic heart disease: a prospective observational study. J Cardiothorac Vasc Anesth 2017;31:901–8.Google Scholar
Wanaka, K, Asada, R, Miyashita, K, et al. Novel HIT antibody detection method using sonoclot(R) coagulation analyzer. Thromb Res 2015;135:127–9.Google Scholar
Corey, FS, Walker, WF. Sonic estimation of elasticity via resonance: a new method of assessing hemostasis. Ann Biomed Eng 2016;44:1405–24.Google Scholar
Ferrante, EA, Blasier, KR, Givens, TB, et al. A novel device for the evaluation of hemostatic function in critical care settings. Anesth Analg 2016;123:1372–9.CrossRefGoogle ScholarPubMed
Huffmyer, JL, Fernandez, LG, Haghighian, C, Terkawi, AS, Groves, DS. Comparison of SEER sonorheometry with rotational thromboelastometry and laboratory parameters in cardiac surgery. Anesth Analg 2016;123:1390–9.Google Scholar
Naik, BI, Durieux, ME, Knisely, A, et al. SEER sonorheometry versus rotational thromboelastometry in large volume blood loss spine surgery. Anesth Analg 2016;123:1380–9.Google Scholar
Reynolds, PS, Middleton, P, McCarthy, H, Spiess, BD. A comparison of a new ultrasound-based whole blood viscoelastic test (SEER Sonorheometry) versus thromboelastography in cardiac surgery. Anesth Analg 2016;123:1400–7.Google Scholar
Bhatt, DL. Role of antiplatelet therapy across the spectrum of patients with coronary artery disease. Am J Cardiol 2009;103:11A9A.Google Scholar
Jennings, LK. Role of platelets in atherothrombosis. Am J Cardiol 2009;103:4A10A.Google Scholar
Breet, NJ, van Werkum, JW, Bouman, HJ, et al. High on-aspirin platelet reactivity as measured with aggregation-based, cyclooxygenase-1 inhibition sensitive platelet function tests is associated with the occurrence of atherothrombotic events. J Thromb Haemost 2010;8:2140–8.Google Scholar
Breet, NJ, van Werkum, JW, Bouman, HJ, Ten Berg, JM, Hackeng, CM. Platelet function tests for the monitoring of P2Y12 inhibitors. Expert Opin Med Diagn 2010;4:251–65.Google Scholar
Orlov, D, McCluskey, SA, Selby, R, et al. Platelet dysfunction as measured by a point-of-care monitor is an independent predictor of high blood loss in cardiac surgery. Anesth Analg 2014;118:257–63.Google Scholar
Zaffar, N, Joseph, A, Mazer, CD, et al. The rationale for platelet transfusion during cardiopulmonary bypass: an observational study. Can J Anaesth 2013;60:345–54.Google Scholar
Wohlauer, MV, Moore, EE, Thomas, S, et al. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg 2012;214:739–46.Google Scholar
Nekludov, M, Bellander, BM, Blomback, M, Wallen, HN. Platelet dysfunction in patients with severe traumatic brain injury. J Neurotrauma 2007;24:1699–706.CrossRefGoogle ScholarPubMed
Bolliger, D, Tanaka, KA. Point-of-care coagulation testing in cardiac surgery. Semin Thromb Hemost 2017;43:386–96.Google Scholar
Tanaka, KA, Bolliger, D, Guzzetta, NA. Clinical and practical aspects of restoring thrombin generation in acute coagulopathic bleeding. Anesth Analg 2017;124:701.Google Scholar
Malm, CJ, Hansson, EC, Akesson, J, et al. Preoperative platelet function predicts perioperative bleeding complications in ticagrelor-treated cardiac surgery patients: a prospective observational study. Br J Anaesth 2016;117:309–15.Google Scholar
Mahla, E, Prueller, F, Farzi, S, et al. Does platelet reactivity predict bleeding in patients needing urgent coronary artery bypass grafting during dual antiplatelet therapy? Ann Thorac Surg 2016;102:2010–7.Google Scholar
Ranucci, M, Colella, D, Baryshnikova, E, Di Dedda, U, Surgical, Clinical Outcome Research Group. Effect of preoperative P2Y12 and thrombin platelet receptor inhibition on bleeding after cardiac surgery. Br J Anaesth 2014;113:970–6.CrossRefGoogle Scholar
Kane, LC, Woodward, CS, Husain, SA, Frei-Jones, MJ. Thromboelastography–does it impact blood component transfusion in pediatric heart surgery? J Surg Res 2016;200:21–7.Google Scholar
Karkouti, K, McCluskey, SA, Callum, J, et al. Evaluation of a novel transfusion algorithm employing point-of-care coagulation assays in cardiac surgery: a retrospective cohort study with interrupted time-series analysis. Anesthesiology 2015;122:560–70.Google Scholar
Ranucci, M, Baryshnikova, E, Pistuddi, V, et al. The effectiveness of 10 years of interventions to control postoperative bleeding in adult cardiac surgery. Interact Cardiovasc Thorac Surg 2017;24:196202.Google Scholar
Schochl, H, Nienaber, U, Hofer, G, et al. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care 2010;14:R55.CrossRefGoogle ScholarPubMed
Theusinger, OM, Stein, P, Levy, JH. Point of care and factor concentrate-based coagulation algorithms. Transfus Med Hemother 2015;42:115–21.Google Scholar
Born, GV, Cross, MJ. Effect of adenosine diphosphate on the concentration of platelets in circulating blood. Nature 1963;197:974–6.Google Scholar
Nishi, T, Ariyoshi, N, Nakayama, T, et al. Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in Japanese patients with stable coronary artery disease. Circ J 2015;79:2439–44.Google Scholar
Kakouros, N, Kickler, TS, Laws, KM, Rade, JJ. Hematocrit alters VerifyNow P2Y12 assay results independently of intrinsic platelet reactivity and clopidogrel responsiveness. J Thromb Haemost 2013;11:1814–22.Google Scholar
Rosengart, TK, Romeiser, JL, White, LJ, et al. Platelet activity measured by a rapid turnaround assay identifies coronary artery bypass grafting patients at increased risk for bleeding and transfusion complications after clopidogrel administration. J Thorac Cardiovasc Surg 2013;146:1259–66, 66 e1; discussion 66.Google Scholar
Berger, PB, Kirchner, HL, Wagner, ES, et al. Does preoperative platelet function predict bleeding in patients undergoing off pump coronary artery bypass surgery? J Interv Cardiol 2015;28:223–32.Google Scholar
Carcao, MD, Blanchette, VS, Stephens, D, et al. Assessment of thrombocytopenic disorders using the platelet function analyzer (PFA-100). Br J Haematol 2002;117:961–4.CrossRefGoogle ScholarPubMed
Cho, YU, Jang, S, Park, CJ, Chi, HS. Variables that affect platelet function analyzer-100 (PFA-100) closure times and establishment of reference intervals in Korean adults. Ann Clin Lab Sci 2008;38:247–53.Google Scholar
Fattorutto, M, Pradier, O, Schmartz, D, Ickx, B, Barvais, L. Does the platelet function analyser (PFA-100) predict blood loss after cardiopulmonary bypass? Br J Anaesth 2003;90:692–3.Google Scholar
Ng, KF, Lawmin, JC, Tsang, SF, Tang, WM, Chiu, KY. Value of a single preoperative PFA-100 measurement in assessing the risk of bleeding in patients taking cyclooxygenase inhibitors and undergoing total knee replacement. Br J Anaesth 2009;102:779–84.Google Scholar
Bolliger, D, Seeberger, MD, Tanaka, KA, et al. Pre-analytical effects of pneumatic tube transport on impedance platelet aggregometry. Platelets 2009;20:458–65.Google Scholar
Paniccia, R, Antonucci, E, Maggini, N, et al. Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy. Am J Clin Pathol 2009;131:834–42.Google Scholar
Mazzeffi, MA, Lee, K, Taylor, B, Tanaka, KA. Perioperative management and monitoring of antiplatelet agents: a focused review on aspirin and P2Y12 inhibitors. Korean J Anesthesiol 2017;70:379–89.Google Scholar
Bolliger, D, Filipovic, M, Matt, P, et al. Reduced aspirin responsiveness as assessed by impedance aggregometry is not associated with adverse outcome after cardiac surgery in a small low-risk cohort. Platelets 2016;27:254–61.Google Scholar
Kaiser, AF, Neubauer, H, Franken, CC, et al. Which is the best anticoagulant for whole blood aggregometry platelet function testing? Comparison of six anticoagulants and diverse storage conditions. Platelets 2012;23:359–67.Google Scholar
Rubak, P, Villadsen, K, Hvas, AM. Reference intervals for platelet aggregation assessed by multiple electrode platelet aggregometry. Thromb Res 2012;130:420–3.Google Scholar
Stissing, T, Dridi, NP, Ostrowski, SR, Bochsen, L, Johansson, PI. The influence of low platelet count on whole blood aggregometry assessed by multiplate. Clin Appl Thromb Hemost 2011;17:E2117.CrossRefGoogle ScholarPubMed
Rahe-Meyer, N, Winterhalter, M, Boden, A, et al. Platelet concentrates transfusion in cardiac surgery and platelet function assessment by multiple electrode aggregometry. Acta Anaesthesiol Scand 2009;53:168–75.Google Scholar
Carroll, RC, Chavez, JJ, Snider, CC, Meyer, DS, Muenchen, RA. Correlation of perioperative platelet function and coagulation tests with bleeding after cardiopulmonary bypass surgery. J Lab Clin Med 2006;147:197204.Google Scholar
Dalen, M, van der Linden, J, Lindvall, G, Ivert, T. Correlation between point-of-care platelet function testing and bleeding after coronary artery surgery. Scand Cardiovasc J 2012;46:32–8.Google Scholar
Sambu, N, Hobson, A, Curzen, N. “Short” thromboelastography as a test of platelet reactivity in response to antiplatelet therapy: validation and reproducibility. Platelets 2011;22:210–6.Google Scholar
Craft, RM, Chavez, JJ, Snider, CC, Muenchen, RA, Carroll, RC. Comparison of modified thrombelastograph and plateletworks whole blood assays to optical platelet aggregation for monitoring reversal of clopidogrel inhibition in elective surgery patients. J Lab Clin Med 2005;145:309–15.CrossRefGoogle ScholarPubMed
Tantry, US, Bliden, KP, Gurbel, PA. Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation. J Am Coll Cardiol 2005;46:1705–9.Google Scholar
Fabbro, M, 2nd, Winkler, AM, Levy, JH. Technology: is there sufficient evidence to change practice in point-of-care management of coagulopathy? J Cardiothorac Vasc Anesth 2017;31:1849–56.Google Scholar
Ranucci, M, Baryshnikova, E, Crapelli, GB, et al. Electric impedance platelet aggregometry in cardiac surgery patients: a comparative study of two technologies. Platelets 2016;27:185–90.Google Scholar

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