Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-745bb68f8f-g4j75 Total loading time: 0 Render date: 2025-01-27T15:33:19.820Z Has data issue: false hasContentIssue false

Chapter 27 - Sedation for Assisted Reproductive Technologies

Published online by Cambridge University Press:  12 December 2024

By
Vesela Kovacheva  and
Patricia M. Sequeira
Edited by
Richard D. Urman  and
Alan David Kaye
Richard D. Urman
Affiliation:
Ohio State University
Alan David Kaye
Affiliation:
Louisiana State University School of Medicine
Get access

Summary

Assisted reproductive technologies (ART) refers to a set of techniques utilizing reproductive cells and/or embryos outside of the body to help patients conceive. These technologies have been made possible by advances in endocrine assays, controlled ovarian stimulation, cryopreservation, ultrasonography, and a range of procedures on oocytes, sperm, and embryos. An ART physician is a gynecologist specially trained in reproductive endocrinology. In vitro fertilization (IVF) is a term used to describe the process of obtaining an oocyte and uniting it with sperm outside of the body, and later transferring the developing embryo into the uterus. The most common method for obtaining oocytes is the transvaginal ultrasound-guided oocyte retrieval. This procedure is also the most painful part of an IVF cycle and therefore requires sedation and analgesia. This chapter focuses on sedation for oocyte retrieval and related ART procedures.

Type
Chapter
Information
Moderate and Deep Sedation in Clinical Practice , pp. 368 - 378
Publisher: Cambridge University Press
Print publication year: 2024

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

References

Zegers-Hochschild, F, Adamson, GD, de Mouzon, J, et al. International Committee for Monitoring Assisted Reproductive Technology (IMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril. 2009;92:1520–4.CrossRefGoogle Scholar
Oskowitz, SP, Berger, MJ, Mullen, L, et al. Safety of a freestanding surgical unit for the assisted reproductive technologies. Fertil Steril. 1995;63:874–9.CrossRefGoogle ScholarPubMed
Yasmin, E, Dresner, M, Balen, A. Sedation and anaesthesia for transvaginal oocyte collection: an evaluation of practice in the UK. Hum Reprod 2004;19:2942–5.CrossRefGoogle ScholarPubMed
Elkington, NM, Kehoe, J, Acharya, U. Intravenous sedation in assisted conception units: a UK survey. Hum Fertil (Camb). 2003;6:74–6.CrossRefGoogle ScholarPubMed
Ditkoff, EC, Plumb, J, Selick, A, Sauer, MV. Anesthesia practices in the United States common to in vitro fertilization (ART) centers. J Assist Reprod Genet. 1997;14:145–7.CrossRefGoogle Scholar
Guasch, E, Gómez, R, Brogly, N, Gilsanz, F. Anesthesia and analgesia for transvaginal oocyte retrieval. Should we recommend or avoid any anesthetic drug or technique? Curr Opin Anaesthesiol. 2019;32(3):285–90.CrossRefGoogle ScholarPubMed
Kwan, I, Wang, R, Pearce, E, Bhattacharya, S. Pain relief for women undergoing oocyte retrieval for assisted reproduction. Cochrane Database Syst Rev. 2018;5(5):CD004829.Google ScholarPubMed
Gejervall, AL, Lundin, K, Stener-Victorin, E, et al. Effect of alfentanil dosage during oocyte retrieval on fertilization and embryo quality. Eur J Obstet Gynecol Reprod Biol. 2010;150:66–71.CrossRefGoogle ScholarPubMed
Bruce, DL, Hinkley, R, Norman, PF. Fentanyl does not inhibit fertilization or early development of sea urchin eggs. Anesth Analg. 1985;64:498–500.CrossRefGoogle ScholarPubMed
Casati, A, Valentini, G, Zangrillo, A, et al. Anaesthesia for ultrasound guided oocyte retrieval: midazolam/remifentanil versus propofol/fentanyl regimens. Eur J Anaesthesiol. 1999;16:773–8.CrossRefGoogle ScholarPubMed
Swanson, RJ, Leavitt, MG: Fertilization and mouse embryo development in the presence of midazolam. Anesth Analg. 1992;75:549–54.CrossRefGoogle ScholarPubMed
Mesen, TB, Kacemi-Bourhim, L, Marshburn, PB, et al. The effect of ketorolac on pregnancy rates when used immediately after oocyte retrieval. Fertil Steril. 2013;100:725–8.CrossRefGoogle ScholarPubMed
Apfel, CC, Läärä, E, Koivuranta, M, Greim, CA, Roewer, N. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology. 1999;91:693–700.CrossRefGoogle ScholarPubMed
Kovac, AL, O’Connor, TA, Pearman, MH, et al. Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled multicenter trial. J Clin Anesth. 1999;11:453–9.CrossRefGoogle ScholarPubMed
Kauppila, A, Isotalo, H, Kirkinen, P, et al. Metoclopramide-induced hyperprolactinaemia: effects on corpus luteum function, endometrial steroid receptor concentrations and 17 beta-hydroxysteroid dehydrogenase activity. Clin Endocrinol (Oxf). 1987;26:145–54.CrossRefGoogle ScholarPubMed
Forman, R, Fishel, SB, Edwards, RG, et al. The influence of transient hyperprolactinemia on in vitro fertilization in humans. J Clin Endocrinol Metab. 1985;60:517–22.CrossRefGoogle ScholarPubMed

Additional Reading

Bokhari, A, Pollard, BJ. Anaesthesia for assisted conception. Eur J Anaesthesiol. 1998;15:391–6.CrossRefGoogle ScholarPubMed
Elkington, M, Kehoe, J, Acharya, U. Policy and Practice Committee of the British Fertility Society. Recommendations for good practice for sedation in assisted conception. Hum Fertil (Camb). 2003;6:77–80.CrossRefGoogle Scholar
Gan, TJ, Meyer, T, Apfel, CC, et al. Consensus guidelines for managing postoperative nausea and vomiting. Anesth Analg. 2003;97:62–71.CrossRefGoogle ScholarPubMed
Kwan, I, Bhattacharya, S, Knox, F, McNeil, A. Conscious sedation and analgesia for oocyte retrieval procedures: a Cochrane review. Hum Reprod 2006;21:1672–9.CrossRefGoogle ScholarPubMed
Kwan, I, Wang, R, Pearce, E, Bhattacharya, S. Pain relief for women undergoing oocyte retrieval for assisted reproduction. Cochrane Database Syst Rev. 2018;5:CD004829.Google ScholarPubMed
Schenker, JG, Ezra, Y. Complications of assisted reproductive techniques. Fertil Steril. 1994;61:411–22.CrossRefGoogle ScholarPubMed
Toledano, RD, Kodali, BS, Camann, WR. Anesthesia drugs in the obstetric and gynecologic practice. Rev Obstet Gynecol. 2009;2:93–100.Google ScholarPubMed
Trout, SW, Vallerand, AH, Kemmann, E. Conscious sedation for in vitro fertilization. Fertil Steril. 1998;69:799–808.CrossRefGoogle ScholarPubMed
Tsen, LC. From Darwin to desflurane? Anesthesia for assisted reproductive technologies. Anesth Analg. 2002;94 (Suppl):109–14.Google Scholar
Wallach, EE, Zacur, HA. Reproductive Medicine and Surgery. St Louis, MO: Mosby, 1995:849.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×