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Chapter 23 - Pediatric Sedation: Practical Considerations

Published online by Cambridge University Press:  12 December 2024

By
Eshel A. Nir  and
Jue Teresa Wang
Edited by
Richard D. Urman  and
Alan David Kaye
Richard D. Urman
Affiliation:
Ohio State University
Alan David Kaye
Affiliation:
Louisiana State University School of Medicine
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Summary

The delivery of sedation to children presents a significant challenge to many clinicians from a variety of specialties on a daily basis [1]. While tremendous evidence exists to guide the clinician through the pharmacology, physiology, and medical issues involved, the final sedative regimen is most likely based on the specific training of the provider and the experience that the individual brings to the procedure [1]. Collectively, all providers tasked with providing sedation to children must acknowledge the inherent limitations of their experiences and training; only then can clinicians bring sober and intelligent judgment to this critical arena.

Type
Chapter
Information
Moderate and Deep Sedation in Clinical Practice , pp. 285 - 324
Publisher: Cambridge University Press
Print publication year: 2024

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References

References

Kamat, PP, McCracken, CE, Simon, HK, et al. Trends in outpatient procedural sedation: 2007–2018. Pediatrics. 2020;145(5):e20193559; PMID:32332053CrossRefGoogle ScholarPubMed
Practice Guidelines for Moderate Procedural Sedation and Analgesia 2018: A report by the American Society of Anesthesiologists Task Force on Moderate Procedural Sedation and Analgesia, the American Association of Oral and Maxillofacial Surgeons, American College of Radiology, American Dental Association, American Society of Dentist Anesthesiologists, and Society of Interventional Radiology. Anesthesiology. 2018;128(3):437–79. PMID:29334501Google Scholar
Coté, CJ, Wilson, S, American Academy of Pediatrics. Guidelines for monitoring and management of pediatric patients before, during, and after sedation for diagnostic and therapeutic procedures. Pediatrics. 2019;143(6):e20191000. PMID: 31138666.CrossRefGoogle ScholarPubMed
Zielinska, M, Bartkowska-Sniatkowska, A, Becke, K, et al. Safe pediatric procedural sedation and analgesia by anesthesiologists for elective procedures: a clinical practice statement from the European Society for Paediatric Anaesthesiology. Paediatr Anaesth. 2019;29(6):583–90. PMID:30793427CrossRefGoogle ScholarPubMed
Green, SM, Roback, MG, Krauss, BS, et al. Unscheduled procedural sedation: a multidisciplinary consensus practice guideline. Ann Emerg Med. 2019;73(5):e51–65. PMID:31029297CrossRefGoogle ScholarPubMed
Blike, GT, Christoffersen, K, Cravero, JP, Andeweg, SK, Jensen, J. A method for measuring system safety and latent errors associated with pediatric procedural sedation. Anesth Analg. 2005;101(1):48-58. PMID: 15976205CrossRefGoogle ScholarPubMed
Society for Pediatric Sedation. Sedation provider course. https://pedsedation.org/offerings/sedation-provider-course (accessed May 2024)Google Scholar
Bhatt, M, Kennedy, RM, Osmond, MH, et al. Consensus Panel on Sedation Research of Pediatric Emergency Research Canada (PERC) and the Pediatric Emergency Care Applied Research Network (PECARN). Consensus-based recommendations for standardizing terminology and reporting adverse events for emergency department procedural sedation and analgesia in children. Ann Emerg Med. 2009;53(4):426–35.e4. doi:10.1016/j.annemergmed.2008.09.030; PMID: 19026467CrossRefGoogle ScholarPubMed
Mason, KP, Green, SM, Piacevoli, Q, International Sedation Task Force. Adverse event reporting tool to standardize the reporting and tracking of adverse events during procedural sedation: a consensus document from the World SIVA International Sedation Task Force. Br J Anaesth. 2012;108(1):13-20. doi:10.1093/bja/aer407; PMID:22157446CrossRefGoogle ScholarPubMed
Mason, KP, Roback, MG, Chrisp, D, et al. Results from the Adverse Event Sedation Reporting Tool: a global anthology of 7952 records derived from >160,000 procedural sedation encounters. J Clin Med. 2019;8(12):2087. doi:10.3390/jcm8122087; PMID:31805686CrossRefGoogle Scholar
Scherrer, PD, Mallory, MD, Cravero, JP, et al. The impact of obesity on pediatric procedural sedation-related outcomes: results from the Pediatric Sedation Research Consortium. Paediatr Anaesth. 2015;25(7):689–97. doi:10.1111/pan.12627; PMID:25817924CrossRefGoogle ScholarPubMed
Havidich, JE, Beach, M, Dierdorf, SF, et al. Preterm versus term children: analysis of sedation/anesthesia adverse events and longitudinal risk. Pediatrics. 2016;137(3):e20150463. doi:10.1542/peds.2015-0463; PMID:26917674CrossRefGoogle ScholarPubMed
Mallory, MD, Travers, C, McCracken, CE, Hertzog, J, Cravero, JP. Upper respiratory infections and airway adverse events in pediatric procedural sedation. Pediatrics. 2017;140(1):e20170009. doi:10.1542/peds.2017-0009; PMID:28759404CrossRefGoogle ScholarPubMed
Harless, J, Ramaiah, R, Bhananker, SM. Pediatric airway management. Int J Crit Illn Inj Sci. 2014;4(1):65–70. doi:10.4103/2229-5151.128015; PMID:24741500Google ScholarPubMed
Ferrari, LR. The pediatric airway: anatomy, challenges, and solutions. In Mason, KP, ed., Pediatric Sedation Outside of the Operating Room. Cham: Springer, 2021, 125–39. https://doi.org/10.1007/978-3-030-58406-1_8Google Scholar
Andropoulos, DB. Pediatric physiology: how does it differ from adults? Mason, KP, ed., Pediatric Sedation Outside of the Operating Room. Cham: Springer, 2021, 141–54. https://doi.org/10.1007/978-3-030-58406-1_9Google Scholar
Reddy, SK, Deutsch, N. Behavioral and emotional disorders in children and their anesthetic implications. Children (Basel). 2020;7(12):253. doi:10.3390/children7120253; PMID:33255535Google ScholarPubMed
Han, SH, Park, JW, Choi, SI, et al. Effect of immersive virtual reality education before chest radiography on anxiety and distress among pediatric patients: a randomized clinical trial. JAMA Pediatr. 2019 1;173(11):1026–31. doi:10.1001/jamapediatrics.2019.3000; PMID:31498380CrossRefGoogle ScholarPubMed
Tyson, ME, Bohl, DD, Blickman, JG. A randomized controlled trial: child life services in pediatric imaging. Pediatr Radiol. 2014;44(11):1426–32. doi:10.1007/s00247-014-3005-1; PMID:24801818CrossRefGoogle ScholarPubMed
Bryant, BE, Adler, AC, Mann, DG, Malek, J. “You can’t make me!” Managing adolescent dissent to anesthesia. Paediatr Anaesth. 2021;31(4):397–403. doi:10.1111/pan.14119; PMID:33386692CrossRefGoogle ScholarPubMed
Bollinger, L.L., Yao, L.P. (2021). Pediatric sedatives and the Food and Drug Administration (FDA): challenges, limitations, and drugs in development. Mason, KP, ed., Pediatric Sedation Outside of the Operating Room. Cham: Springer, 2021, 647–56. https://doi.org/10.1007/978-3-030-58406-1_32Google Scholar
Krauss, B, Green, SM. Procedural sedation and analgesia in children. Lancet. 2006;367(9512):766–80. doi:10.1016/S0140-6736(06)68230-5; PMID: 16517277Google ScholarPubMed
Cravero, JP, Roback, MG. Pediatric procedural sedation: pharmacologic agents. Topic 82857 Version 28.0 In UpToDate, Stack AM, Randolph AG, eds. www.uptodate.com/contents/procedural-sedation-in-children-selection-of-medications (accessed April 27, 2022)Google Scholar
Kost, S, Roy, A. Procedural sedation and analgesia in the pediatric emergency department: a review of sedative pharmacology. Clin Pediatr Emerg Med. 2010;11(4):233–43.CrossRefGoogle Scholar
Meesters, N, Simons, S, van Rosmalen, J, et al. Waiting 2 minutes after sucrose administration-unnecessary? Arch Dis Child Fetal Neonatal Ed. 2017;102(2):F167–9. doi:10.1136/archdischild-2016-310841; PMID:28157669PMCIDCrossRefGoogle ScholarPubMed
Pansini, V, Curatola, A, Gatto, A, Intranasal drugs for analgesia and sedation in children admitted to pediatric emergency department: a narrative review. Ann Transl Med. 2021;9(2):189. doi:10.21037/atm-20-5177; PMID:33569491CrossRefGoogle ScholarPubMed
Kennedy, RM (2021). Sedation in the emergency department: a complex and multifactorial challenge. In Mason, KP, ed., Pediatric Sedation Outside of the Operating Room. Cham: Springer, 2021, 413–73 https://doi.org/10.1007/978-3-030-58406-1_22Google Scholar
Goyal, R, Singh, S, Shukla, RN, Patra, AK, Bhargava, DV. Ketodex, a combination of dexmedetomidine and ketamine for upper gastrointestinal endoscopy in children: a preliminary report. J Anesth. 2013;27(3):461–3. doi:10.1007/s00540-012-1538-8; PMID:23223916CrossRefGoogle ScholarPubMed
Yang, F, Liu, Y, Yu, Q, Analysis of 17 948 pediatric patients undergoing procedural sedation with a combination of intranasal dexmedetomidine and ketamine. Paediatr Anaesth. 2019;29(1):85–91. doi:10.1111/pan.13526; PMID:30484930CrossRefGoogle Scholar
Guthrie, DB, Boorin, MR, Sisti, AR, et al. Retrospective comparison of intramuscular admixtures of ketamine and dexmedetomidine versus ketamine and midazolam for preoperative sedation. Anesth Prog. 2021;68(1):3-9. doi:10.2344/anpr-67-04-02; PMID:33827122CrossRefGoogle ScholarPubMed
Hartshorn, S, Middleton, PM. Efficacy and safety of inhaled low-dose methoxyflurane for acute paediatric pain: a systematic review. Trauma. 2019;21(2):94–102. doi:10.1177/1460408618798391CrossRefGoogle Scholar
Jephcott, C, Grummet, J, Nguyen, N, Spruyt, O. A review of the safety and efficacy of inhaled methoxyflurane as an analgesic for outpatient procedures. Br J Anaesth. 2018;120(5):1040–8. doi:10.1016/j.bja.2018.01.011; PMID:29661381CrossRefGoogle Scholar
Prescribing information for BIFAVO. https://bynder.acaciapharma.com/m/403e8c343b2922de/original/Byfavo-PI.pdfGoogle Scholar
Kim, KM. Remimazolam: pharmacological characteristics and clinical applications in anesthesiology. Anesth Pain Med (Seoul). 2022;17(1):1–11. doi:10.17085/apm.21115; PMID:35139608CrossRefGoogle ScholarPubMed
Pesic, M, Schippers, F, Saunders, R, Webster, L, Donsbach, M, Stoehr, T. Pharmacokinetics and pharmacodynamics of intranasal remimazolam: a randomized controlled clinical trial. Eur J Clin Pharmacol. 2020;76(11):1505–16. doi: 10.1007/s00228-020-02984-z; PMID:32886178CrossRefGoogle ScholarPubMed
Shildt, N, Traube, C, Dealmeida, M, “Difficult to sedate”: successful implementation of a benzodiazepine-sparing analgosedation protocol in mechanically ventilated children. Children (Basel). 2021; 28;8(5):348. doi:10.3390/children8050348; PMID:33924822Google ScholarPubMed
Liu, XI, Schuette, P, Burckart, GJ, et al. A comparison of pediatric and adult safety studies for antipsychotic and antidepressant drugs submitted to the United States food and drug administration. J Pediatr. 2019;208:236–42.e3. doi:10.1016/j.jpeds.2018.12.033; PMID:30679050CrossRefGoogle ScholarPubMed
Alp, H, Elmacı, AM, Alp, EK, Say, B. Comparison of intranasal midazolam, intranasal ketamine, and oral chloral hydrate for conscious sedation during paediatric echocardiography: results of a prospective randomised study. Cardiol Young. 2019;29(9):1189–95. doi:10.1017/S1047951119001835; PMID:31451130CrossRefGoogle ScholarPubMed
Li, BL, Yuen, VM, Zhou, JL, et al. A randomized controlled trial of oral chloral hydrate vs intranasal dexmedetomidine plus buccal midazolam for auditory brainstem response testing in children. Paediatr Anaesth. 2018;28(11):1022–8. doi:10.1111/pan.13498; PMID: 30281180CrossRefGoogle ScholarPubMed
Fong, CY, Lim, WK, Li, L, Lai, NM. Chloral hydrate as a sedating agent for neurodiagnostic procedures in children. Cochrane Database Syst Rev. 2021;8(8):CD011786. doi:10.1002/14651858.CD011786.pub3; PMID:34397100Google ScholarPubMed
Green, SM, Roback, MG, Krauss, B, et al. Emergency Department Ketamine Meta-Analysis Study Group. Predictors of emesis and recovery agitation with emergency department ketamine sedation: an individual-patient data meta-analysis of 8,282 children. Ann Emerg Med. 2009;54(2):171–80.e1–4. doi:10.1016/j.annemergmed.2009.04.004; PMID:19501426Google Scholar
Grunwell, JR, Travers, C, McCracken, CE, Procedural sedation outside of the operating room using ketamine in 22,645 children: a report from the Pediatric Sedation Research Consortium. Pediatr Crit Care Med. 2016;17(12):1109-1116. doi:10.1097/PCC.0000000000000920; PMID:27505716CrossRefGoogle Scholar
Tsze, DS, Steele, DW, Machan, JT, Akhlaghi, F, Linakis, JG. Intranasal ketamine for procedural sedation in pediatric laceration repair: a preliminary report. Pediatr Emerg Care. 2012;28(8):767–70. doi:10.1097/PEC.0b013e3182624935; PMID:22858745CrossRefGoogle ScholarPubMed
Oliveira, J E Silva, L, Lee, JY, Bellolio, F, Homme, JL, Anderson, JL. Intranasal ketamine for acute pain management in children: A systematic review and meta-analysis. Am J Emerg Med. 2020;38(9):1860–6. doi:10.1016/j.ajem.2020.05.094; PMID:32739857Google Scholar
Poonai, N, Canton, K, Ali, S, et al. Intranasal ketamine for procedural sedation and analgesia in children: a systematic review. PLoS ONE. 2017;12(3):e0173253. doi:10.1371/journal.pone.0173253; PMID:28319161CrossRefGoogle ScholarPubMed
Pandey, RK, Bahetwar, SK, Saksena, AK, Chandra, G. A comparative evaluation of drops versus atomized administration of intranasal ketamine for the procedural sedation of young uncooperative pediatric dental patients: a prospective crossover trial. J Clin Pediatr Dent. 2011;36(1):79–84. doi:10.17796/jcpd.36.1.1774746504g28656; PMID:22900449CrossRefGoogle ScholarPubMed
Marçon, F, Guittet, C, Manso, MA, et al. Population pharmacokinetic evaluation of ADV6209, an innovative oral solution of midazolam containing cyclodextrin. Eur J Pharm Sci. 2018;114:46–54. doi:10.1016/j.ejps.2017.11.030. PMID: 29203151CrossRefGoogle ScholarPubMed
Klein, EJ, Brown, JC, Kobayashi, A, Osincup, D, Seidel, K. A randomized clinical trial comparing oral, aerosolized intranasal, and aerosolized buccal midazolam. Ann Emerg Med. 2011;58(4):323–9. doi:10.1016/j.annemergmed.2011.05.016; PMID:21689865CrossRefGoogle ScholarPubMed
Smith, D, Cheek, H, Denson, B, Pruitt, CM. Lidocaine pretreatment reduces the discomfort of intranasal midazolam administration: a randomized, double-blind, placebo-controlled trial. Acad Emerg Med. 2017;24(2):161–7. doi:10.1111/acem.13115; PMID:27739142CrossRefGoogle ScholarPubMed
O’Connell, NC, Woodward, HA, Flores-Sanchez, PL, et al. Comparison of preadministered and coadministered lidocaine for treating pain and distress associated with intranasal midazolam administration in children: a randomized clinical trial. J Am Coll Emerg Physicians Open. 2020 26;1(6):1562–70. doi:10.1002/emp2.12227; PMID:33392564Google ScholarPubMed
Tsze, DS, Mallory, MD, Cravero, JP. Practice patterns and adverse events of nitrous oxide sedation and analgesia: a report from the pediatric sedation research consortium. J Pediatr. 2016;169:260-5.e2. doi:10.1016/j.jpeds.2015.10.019; PMID: 26547401CrossRefGoogle ScholarPubMed
Veselis, R.A., Arslan-Carlon, V., (2021). Sedation: is it sleep, is it amnesia, what’s the difference? In Mason, KP, ed., Pediatric Sedation Outside of the Operating Room. Cham: Springer, 2021, 223–45. https://doi.org/10.1007/978-3-030-58406-1_14Google Scholar
Sulton, C, McCracken, C, Simon, HK, et al. Pediatric procedural sedation using dexmedetomidine: a report from the Pediatric Sedation Research Consortium. Hosp Pediatr. 2016;6(9):536–44. doi:10.1542/hpeds.2015-0280; PMID:27516413CrossRefGoogle ScholarPubMed
Green, SM, Andolfatto, G, Krauss, B. Ketofol for procedural sedation? Pro and con. Ann Emerg Med. 2011;57(5):444–8. doi:10.1016/j.annemergmed.2010.12.009; PMID:21237532CrossRefGoogle ScholarPubMed
Prescilla, RP (2021). Clinical pharmacology of sedatives, reversal agents, and adjuncts. In Mason, KP, ed., Pediatric Sedation Outside of the Operating Room. Cham: Springer, 2021, 171–97. https://doi.org/10.1007/978-3-030-58406-1_11Google Scholar
Green, SM, Andolfatto, G, Krauss, BS. Ketofol for procedural sedation revisited: pro and con. Ann Emerg Med. 2015;65(5):489–91. doi:10.1016/j.annemergmed.2014.12.002; PMID:25544732CrossRefGoogle ScholarPubMed
Weisz, K, Bajaj, L, Deakyne, SJ, et al. Adverse events during a randomized trial of ketamine versus co-administration of ketamine and propofol for procedural sedation in a pediatric emergency department. J Emerg Med. 2017;53(1):1–9. doi:10.1016/j.jemermed.2017.03.024; PMID:28433211CrossRefGoogle Scholar
Louer, R, McKinney, RC, Abu-Sultaneh, S, Lutfi, R, Abulebda, K. Safety and efficacy of a propofol and ketamine based procedural sedation protocol in children with cerebral palsy undergoing botulinum toxin injections. PM R. 2019;11(12):1320–1325. doi:10.1002/pmrj.12146; PMID:30761757CrossRefGoogle Scholar
Foo, TY, Mohd Noor, N, Yazid, MB, et al. Ketamine–propofol (ketofol) for procedural sedation and analgesia in children: a systematic review and meta-analysis. BMC Emerg Med. 2020;20(1):81. doi:10.1186/s12873-020-00373-4; PMID:33032544CrossRefGoogle ScholarPubMed
Tobias, JD. Dexmedetomidine and ketamine: an effective alternative for procedural sedation? Pediatr Crit Care Med. 2012;13(4):423–7. doi:10.1097/PCC.0b013e318238b81c; PMID:22067985CrossRefGoogle ScholarPubMed
Galinkin, JL, Janiszewski, D, Young, CJ, et al. Subjective, psychomotor, cognitive, and analgesic effects of subanesthetic concentrations of sevoflurane and nitrous oxide. Anesthesiology. 1997;87(5):1082–8. doi:10.1097/00000542-199711000-00012; PMID:9366460CrossRefGoogle ScholarPubMed
Janiszewski, DJ, Galinkin, JL, Klock, PA, et al. The effects of subanesthetic concentrations of sevoflurane and nitrous oxide, alone and in combination, on analgesia, mood, and psychomotor performance in healthy volunteers. Anesth Analg. 1999;88(5):1149–54. doi:10.1097/00000539-199905000-00034; PMID: 10320186Google ScholarPubMed
Tobias, JD. Therapeutic applications and uses of inhalational anesthesia in the pediatric intensive care unit. Pediatr Crit Care Med. 2008;9(2):169–79. doi:10.1097/PCC.0b013e31816688ef; PMID:18477930CrossRefGoogle ScholarPubMed
Sury, M, Bullock, I, Rabar, S, Demott, K, Guideline Development Group. Sedation for diagnostic and therapeutic procedures in children and young people: summary of NICE guidance. BMJ. 2010;341:c6819. doi:10.1136/bmj.c6819; PMID:21163835CrossRefGoogle Scholar
National Institute for Health and Care Excellence. Sedation in under 19s: using sedation for diagnostic and therapeutic procedures, 2010. www.nice.org.uk/guidance/cg112.Google Scholar
Cravero, JP, Roback, MG. Selection of medications for pediatric procedural sedation outside of the operating room. Topic 85542 Version 32.0. In UpToDate, Stack AM, Randolph AG, eds. www.uptodate.com/contents/selection-of-medications-for-pediatric-procedural-sedation-outside-of-the-operating-room (accessed June 2, 2022)Google Scholar
Cravero, JP, Roback, MG. Selection of medications for pediatric procedural sedation outside of the operating room. Society guideline links: procedural sedation in children. Topic 126190, Version 12.0. In UpToDate, Stack AM, Randolph AG, eds. www.uptodate.com/contents/selection-of-medications-for-pediatric-procedural-sedation-outside-of-the-operating-room (accessed June 2, 2022)Google Scholar
Andropoulos, DB. Sedation scales and discharge criteria: how do they differ? Which one to choose? Do they really apply to sedation? In Mason, KP, ed., Pediatric Sedation Outside of the Operating Room. Cham: Springer, 2021, 83–94. https://doi.org/10.1007/978-3-030-58406-1_5Google Scholar
Kamat, P, Tobias, JD. Sedation in the pediatric intensive care unit: challenges, outcomes, and future strategies in the United States. In Mason, KP, ed., Pediatric Sedation Outside of the Operating Room. Cham: Springer, 2021, 345–72. https://doi.org/10.1007/978-3-030-58406-1_19Google Scholar
Egbuta, C, Mason, KP. Current state of analgesia and sedation in the pediatric intensive care unit. J Clin Med. 2021;10(9):1847. doi:10.3390/jcm10091847; PMID:33922824CrossRefGoogle ScholarPubMed
Sury, MR, Bould, MD. Defining awakening from anesthesia in infants: a narrative review of published descriptions and scales of behavior. Paediatr Anaesth. 2011;21(4):364–72. doi: 10.1111/j.1460-9592.2011.03538.x; PMID:21324047CrossRefGoogle ScholarPubMed
Chernik, DA, Gillings, D, Laine, H. Validity and reliability of the Observer’s Assessment of Alertness/Sedation Scale: study with intravenous midazolam. J Clin Psychopharmacol. 1990;10(4):244–51. PMID:2286697Google ScholarPubMed
Shannon, M, Albers, G, Burkhart, K, et al. Safety and efficacy of flumazenil in the reversal of benzodiazepine-induced conscious sedation. The Flumazenil Pediatric Study Group. J Pediatr. 1997;131(4):582–6. doi:10.1016/s0022-3476(97)70066-0; PMID:9386663CrossRefGoogle ScholarPubMed
Madan, R, Kapoor, I, Balachander, S, Kathirvel, S, Kaul, HL. Propofol as a sole agent for paediatric day care diagnostic ophthalmic procedures: comparison with halothane anaesthesia. Paediatr Anaesth. 2001;11(6):671–7. doi:10.1046/j.1460-9592.2001.00741.x; PMID:11696142CrossRefGoogle ScholarPubMed
Malviya, S, Voepel-Lewis, T, Tait, AR, et al. Depth of sedation in children undergoing computed tomography: validity and reliability of the University of Michigan Sedation Scale (UMSS). Br J Anaesth. 2002;88(2):241–5. doi:10.1093/bja/88.2.241; PMID:11878656CrossRefGoogle ScholarPubMed
Sadhasivam, S, Ganesh, A, Robison, A, Kaye, R, Watcha, MF. Validation of the bispectral index monitor for measuring the depth of sedation in children. Anesth Analg. 2006;102(2):383–8. doi:10.1213/01.ANE.0000184115.57837.30. PMID:16428529CrossRefGoogle ScholarPubMed
Yuen, VM, Irwin, MG, Hui, TW, Yuen, MK, Lee, LH. A double-blind, crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine. Anesth Analg. 2007;105(2):374-80. doi:10.1213/01.ane.0000269488.06546.7c; PMID:17646493CrossRefGoogle ScholarPubMed
Liu, Y, Yu, Q, Sun, M, Median effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography examination in postcardiac surgery and normal children: an up-and-down sequential allocation trial. Eur J Anaesthesiol. 2018;35(1):43–8. doi:10.1097/EJA.0000000000000724; PMID:28937531CrossRefGoogle ScholarPubMed
Shields, CH, Styadi-Park, G, McCown, MY, Creamer, KM. Clinical utility of the bispectral index score when compared to the University of Michigan Sedation Scale in assessing the depth of outpatient pediatric sedation. Clin Pediatr (Phila). 2005;44(3):229–36. doi:10.1177/000992280504400306; PMID:15821847CrossRefGoogle Scholar
Su, F, Nicolson, SC, Zuppa, AF. A dose–response study of dexmedetomidine administered as the primary sedative in infants following open heart surgery. Pediatr Crit Care Med. 2013;14(5):499–507. doi:10.1097/PCC.0b013e31828a8800; PMID:23628837CrossRefGoogle Scholar
Kaplan, E, Shifeldrim, A, Kraus, D, et al. Intranasal dexmedetomidine vs oral triclofos sodium for sedation of children with autism undergoing electroencephalograms. Eur J Paediatr Neurol. 2022;37:19–24. doi:10.1016/j.ejpn.2022.01.005; PMID:35016051CrossRefGoogle ScholarPubMed
Hoeffe, J, Doyon Trottier, E, Bailey, B, et al. Intranasal fentanyl and inhaled nitrous oxide for fracture reduction: the FAN observational study. Am J Emerg Med. 2017;35(5):710–15. doi:10.1016/j.ajem.2017.01.004; PMID:28190665CrossRefGoogle ScholarPubMed
Tsze, DS, Ieni, M, Fenster, DB, et al. Optimal volume of administration of intranasal midazolam in children: a randomized clinical trial. Ann Emerg Med. 2017;69(5):600–9. doi:10.1016/j.annemergmed.2016.08.450. PMID:27823876CrossRefGoogle ScholarPubMed
Jang, YE, Ji, SH, Lee, JH, et al. The relationship between the effect-site concentration of propofol and sedation scale in children: a pharmacodynamic modeling study. BMC Anesthesiol. 2021;21(1):222. doi:10.1186/s12871-021-01446-y; PMID:34503455CrossRefGoogle ScholarPubMed
Lozano-Díaz, D, Valdivielso Serna, A, Garrido Palomo, R, et al. Validation of the Ramsay scale for invasive procedures under deep sedation in pediatrics. Paediatr Anaesth. 2021;31(10):1097–104. doi:10.1111/pan.14248; PMID:34173295CrossRefGoogle ScholarPubMed
Hoffman, GM, Nowakowski, R, Troshynski, TJ, Berens, RJ, Weisman, SJ. Risk reduction in pediatric procedural sedation by application of an American Academy of Pediatrics/American Society of Anesthesiologists process model. Pediatrics. 2002;109(2):236–43. doi:10.1542/peds.109.2.236; PMID:11826201CrossRefGoogle Scholar
Jeleazcov, C, Schmidt, J, Schmitz, B, Becke, K, Albrecht, S. EEG variables as measures of arousal during propofol anaesthesia for general surgery in children: rational selection and age dependence. Br J Anaesth. 2007;99(6):845–54. doi:10.1093/bja/aem275; PMID:17965418CrossRefGoogle ScholarPubMed
Herd, DW, Anderson, BJ, Keene, NA, Holford, NH. Investigating the pharmacodynamics of ketamine in children. Paediatr Anaesth. 2008;18(1):36–42. doi:10.1111/j.1460-9592.2007.02384.x; PMID:18095964CrossRefGoogle ScholarPubMed
Cravero, JP, Blike, GT, Surgenor, SD, Jensen, J. Development and validation of the Dartmouth Operative Conditions Scale. Anesth Analg. 2005;100(6):1614–21. doi:10.1213/01.ANE.0000150605.43251.84; PMID:15920183CrossRefGoogle ScholarPubMed
Trummel, JM, Surgenor, SD, Cravero, JP, Gordon, SR, Blike, GT. Comparison of differing sedation practice for upper endoscopic ultrasound using expert observational analysis of the procedural sedation. J Patient Saf. 2009;5(3):153–9. doi:10.1097/PTS.0b013e3181b53f80; PMID:19927048CrossRefGoogle ScholarPubMed
Chandran, V, Jagadisan, B, Ganth, B. Validation of Adapted Dartmouth Operative Conditions Scale for sedation during pediatric esophagogastroduodenoscopy. Paediatr Anaesth. 2017;27(6):621–8. doi:10.1111/pan.13127; PMID:28370856CrossRefGoogle ScholarPubMed
Cravero, JP, Askins, N, Sriswasdi, P, Validation of the Pediatric Sedation State Scale. Pediatrics. 2017;139(5):e20162897. doi:10.1542/peds.2016-2897; PMID:28557732CrossRefGoogle ScholarPubMed
Poonai, N, Coriolano, K, Klassen, T, et al. Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol. BMJ Open. 2020;10(12):e041319. doi:10.1136/bmjopen-2020-041319; PMID:33303457CrossRefGoogle ScholarPubMed
Vet, NJ, Kleiber, N, Ista, E, de Hoog, M, de Wildt, SN. Sedation in critically ill children with respiratory failure. Front Pediatr. 2016;4:89. doi:10.3389/fped.2016.00089; PMID:27606309CrossRefGoogle Scholar
Thompson, C, Shabanova, V, Giuliano, JS Jr. The SNAP index does not correlate with the State Behavioral Scale in intubated and sedated children. Paediatr Anaesth. 2013;23(12):1174–9. doi:10.1111/pan.12258; PMID:24103039CrossRefGoogle Scholar
Smith, HAB, Besunder, JB, Betters, KA, 2022 Society of Critical Care Medicine clinical practice guidelines on prevention and management of pain, agitation, neuromuscular blockade, and delirium in critically ill pediatric patients with consideration of the ICU environment and early mobility. Pediatr Crit Care Med. 2022;23(2):e74–110. doi:10.1097/PCC.0000000000002873; PMID:35119438CrossRefGoogle ScholarPubMed
Emrath, ET, Stockwell, JA, McCracken, CE, Simon, HK, Kamat, PP. Provision of deep procedural sedation by a pediatric sedation team at a freestanding imaging center. Pediatr Radiol. 2014;44(8):1020–5. doi:10.1007/s00247-014-2942-z; PMID:24859263CrossRefGoogle Scholar
Callahan, MJ, Cravero, JP. Should I irradiate with computed tomography or sedate for magnetic resonance imaging? Pediatr Radiol. 2022;52(2):340–4. doi:10.1007/s00247-021-04984-2; PMID:33710404CrossRefGoogle ScholarPubMed
Etzel-Hardman, D, Kapsin, K, Jones, S, Churilla, H. Sedation reduction in a pediatric radiology department. J Healthc Qual. 2009;31(4):34–9. doi:10.1111/j.1945-1474.2009.00035.x; PMID:19753806CrossRefGoogle Scholar
Wang, E, Thomas, JJ, Rodriguez, ST, Kennedy, KM, Caruso, TJ. Virtual reality for pediatric periprocedural care. Curr Opin Anaesthesiol. 2021;34(3):284–91. doi:10.1097/ACO.0000000000000983; PMID: 33935176CrossRefGoogle ScholarPubMed
Slovis, TL. Sedation and anesthesia issues in pediatric imaging. Pediatr Radiol. 2011;41(Suppl 2):514–6. doi:10.1007/s00247-011-2115-2; PMID:21847732CrossRefGoogle ScholarPubMed
Berkenbosch, JW. Options and considerations for procedural sedation in pediatric imaging. Paediatr Drugs. 2015;17(5):385–99. doi:10.1007/s40272-015-0140-6; PMID:26156106CrossRefGoogle ScholarPubMed
Ghai, B, Jain, K, Saxena, AK, Bhatia, N, Sodhi, KS. Comparison of oral midazolam with intranasal dexmedetomidine premedication for children undergoing CT imaging: a randomized, double-blind, and controlled study. Paediatr Anaesth. 2017;27(1):37–44. doi:10.1111/pan.13010; PMID: 27734549CrossRefGoogle ScholarPubMed
Mekitarian Filho, E, Robinson, F, de Carvalho, WB, Gilio, AE, Mason, KP. Intranasal dexmedetomidine for sedation for pediatric computed tomography imaging. J Pediatr. 2015;166(5):1313–15.e1. doi:10.1016/j.jpeds.2015.01.036; PMID:25748567CrossRefGoogle ScholarPubMed
Azizkhani, R, Heydari, F, Ghazavi, M, et al. Comparing sedative effect of dexmedetomidine versus midazolam for sedation of children while undergoing computerized tomography imaging. J Pediatr Neurosci. 2020;15(3):245–51. doi:10.4103/jpn.JPN_107_19; PMID:33531939Google ScholarPubMed
Burger, RK, Figueroa, J, McCracken, C, Mallory, MD, Kamat, PP. Sedatives used in children to obtain head CT in the emergency department. Am J Emerg Med. 2021;44:198–202. doi:10.1016/j.ajem.2020.02.035; PMID:32107128CrossRefGoogle ScholarPubMed
Gupta, A, Sen, I, Bhardwaj, N, et al. Prospective audit of sedation/anesthesia practices for children undergoing computerized tomography in a tertiary care institute. J Anaesthesiol Clin Pharmacol. 2020;36(2):156–61. doi:10.4103/joacp.JOACP_16_19; PMID:33013027Google ScholarPubMed
Practice advisory on anesthetic care for magnetic resonance imaging: an updated report by the American Society of Anesthesiologists Task Force on Anesthetic Care for magnetic resonance imaging. Anesthesiology. 2015;122(3):495–520. doi:10.1097/ALN.0000000000000458; PMID: 25383571CrossRefGoogle Scholar
Gorlin, A, Hoxworth, JM, Mueller, J. Occupational hazards of exposure to magnetic resonance imaging. Anesthesiology. 2015;123(4):976–7. doi:10.1097/ALN.0000000000000826; PMID:26372135CrossRefGoogle ScholarPubMed
Theys, C, Wouters, J, Ghesquière, P. Diffusion tensor imaging and resting-state functional MRI-scanning in 5- and 6-year-old children: training protocol and motion assessment. PLoS ONE. 2014;9(4):e94019. doi:10.1371/journal.pone.0094019; PMID:24718364CrossRefGoogle ScholarPubMed
Xu, HS, Cavaliere, RM, Min, RJ. Transforming the imaging experience while decreasing sedation rates. J Am Coll Radiol. 2020;17(1 Pt A):46–52. doi:10.1016/j.jacr.2019.08.005; PMID:31570312CrossRefGoogle ScholarPubMed
Jaimes, C, Gee, MS. Strategies to minimize sedation in pediatric body magnetic resonance imaging. Pediatr Radiol. 2016;46(6):916–27. doi:10.1007/s00247-016-3613-z; PMID:27229508CrossRefGoogle ScholarPubMed
Berkenbosch, JW, Wankum, PC, Tobias, JD. Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children. Pediatr Crit Care Med. 2005 ;6(4):435–9; quiz 440. doi:10.1097/01.PCC.0000163680.50087.93; PMID:15982430CrossRefGoogle ScholarPubMed
Mason, KP, Zurakowski, D, Zgleszewski, SE, et al. High dose dexmedetomidine as the sole sedative for pediatric MRI. Paediatr Anaesth. 2008;18(5):403–11. doi:10.1111/j.1460-9592.2008.02468.x; PMID:18363626CrossRefGoogle Scholar
Siddappa, R, Riggins, J, Kariyanna, S, Calkins, P, Rotta, AT. High-dose dexmedetomidine sedation for pediatric MRI. Paediatr Anaesth. 2011;21(2):153–8. doi:10.1111/j.1460-9592.2010.03502.x; PMID:21210884CrossRefGoogle ScholarPubMed
Mason, KP, Fontaine, PJ, Robinson, F, Zgleszewski, S. Pediatric sedation in a community hospital-based outpatient MRI center. AJR Am J Roentgenol. 2012;198(2):448–52. doi:10.2214/AJR.11.7346; PMID:22268192.CrossRefGoogle Scholar
Veselis, R, Kelhoffer, E, Mehta, M, et al. Propofol sedation in children: sleep trumps amnesia. Sleep Med. 2016;27–28:115–20. doi:10.1016/j.sleep.2016.10.002; PMID: 27938911Google ScholarPubMed
Schmitz, A, Weiss, M, Kellenberger, C, et al. Sedation for magnetic resonance imaging using propofol with or without ketamine at induction in pediatrics: a prospective randomized double-blinded study. Paediatr Anaesth. 2018;28(3):264–74. doi:10.1111/pan.13315; PMID:29377404CrossRefGoogle ScholarPubMed
Tug, A, Hanci, A, Turk, HS, et al. Comparison of two different intranasal doses of dexmedetomidine in children for magnetic resonance imaging sedation. Paediatr Drugs. 2015;17(6):479–85. doi:10.1007/s40272-015-0145-1; PMID:26323489CrossRefGoogle ScholarPubMed
Olgun, G, Ali, MH. Use of intranasal dexmedetomidine as a solo sedative for MRI of infants. Hosp Pediatr. 2018;hpeds.2017-0120. doi: 10.1542/hpeds.2017-0120; PMID: 29363517CrossRefGoogle Scholar
Sulton, C, Kamat, P, Mallory, M, Reynolds, J. The use of intranasal dexmedetomidine and midazolam for sedated magnetic resonance imaging in children: a report from the Pediatric Sedation Research Consortium. Pediatr Emerg Care. 2020;36(3):138–42. doi:10.1097/PEC.0000000000001199; PMID: 28609332CrossRefGoogle ScholarPubMed
Gyanesh, P, Haldar, R, Srivastava, D, et al. Comparison between intranasal dexmedetomidine and intranasal ketamine as premedication for procedural sedation in children undergoing MRI: a double-blind, randomized, placebo-controlled trial. J Anesth. 2014;28(1):12–18. doi:10.1007/s00540-013-1657-x; PMID:23800984CrossRefGoogle ScholarPubMed
Mason, KP, Lubisch, NB, Robinson, F, Roskos, R. Intramuscular dexmedetomidine sedation for pediatric MRI and CT. AJR Am J Roentgenol. 2011;197(3):720–5. doi:10.2214/AJR.10.6134; PMID:21862817CrossRefGoogle ScholarPubMed
Miller, J, Xue, B, Hossain, M, et al. Comparison of dexmedetomidine and chloral hydrate sedation for transthoracic echocardiography in infants and toddlers: a randomized clinical trial. Paediatr Anaesth. 2016;26(3):266–72. doi:10.1111/pan.12819; PMID:26616644CrossRefGoogle ScholarPubMed
Reynolds, J, Rogers, A, Medellin, E, Guzman, JA, Watcha, MF. A prospective, randomized, double-blind trial of intranasal dexmedetomidine and oral chloral hydrate for sedated auditory brainstem response (ABR) testing. Paediatr Anaesth. 2016;26(3):286–93. doi:10.1111/pan.12854; PMID:26814038CrossRefGoogle ScholarPubMed
Levit, Y, Mandel, D, Matot, I. Frequency-specific auditory brainstem response testing with age-appropriate sedation. Int J Pediatr Otorhinolaryngol. 2018;108:73–9. doi:10.1016/j.ijporl.2018.02.028; PMID:29605369CrossRefGoogle ScholarPubMed
Kandil, AI, Ok, MS, Baroch, KA et al. Why a propofol infusion should be the anesthetic of choice for auditory brainstem response testing in children. Anesth Analg. 2022;134(4):802–9. doi:10.1213/ANE.0000000000005693; PMID:35113042.Google Scholar
Ahmed, SS, Hicks, S, Slaven, JE, Nitu, M. Intermittent bolus versus continuous infusion of propofol for deep sedation during ABR/nuclear medicine studies. J Pediatr Intensive Care. 2017;6(3):176–81. doi:10.1055/s-0036-1597628; PMID:31073444CrossRefGoogle ScholarPubMed
Stephen, MC, Mathew, J, Varghese, AM, Kurien, M, Mathew, GA. A randomized controlled trial comparing intranasal midazolam and chloral hydrate for procedural sedation in children. Otolaryngol Head Neck Surg. 2015;153(6):1042–50. doi:10.1177/0194599815599381; PMID:26286872CrossRefGoogle ScholarPubMed
Merguerian, PA, Corbett, ST, Cravero, J. Voiding ability using propofol sedation in children undergoing voiding cystourethrograms: a retrospective analysis. J Urol. 2006;176(1):299–302. doi:10.1016/S0022-5347(06)00584-2; PMID:16753428CrossRefGoogle ScholarPubMed
Alizadeh, A, Naseri, M, Ravanshad, Y, et al. Use of sedative drugs at reducing the side effects of voiding cystourethrography in children. J Res Med Sci. 2017;22:42. doi:10.4103/1735-1995.202139; PMID:28465701CrossRefGoogle Scholar
Rao, J, Kennedy, SE, Cohen, S, Rosenberg, AR. A systematic review of interventions for reducing pain and distress in children undergoing voiding cystourethrography. Acta Paediatr. 2012;101(3):224–9. doi:10.1111/j.1651-2227.2011.02482.x; PMID:21981332CrossRefGoogle ScholarPubMed
Murat, I, Gall, O, Tourniaire, B. Procedural pain in children: evidence-based best practice and guidelines. Reg Anesth Pain Med. 2003;28(6):561–72. doi:10.1016/j.rapm.2003.08.023; PMID:14634949Google ScholarPubMed
Livingston, M, Lawell, M, McAllister, N. Successful use of nitrous oxide during lumbar punctures: a call for nitrous oxide in pediatric oncology clinics. Pediatr Blood Cancer. 2017;64(11). doi:10.1002/pbc.26610; PMID:28475231CrossRefGoogle Scholar
Goldman, RD. Analgesia for lumbar puncture in infants and children. Can Fam Physician. 2019;65(3):192–4. PMID:30867175Google ScholarPubMed
Harris, EA. Sedation and anesthesia options for pediatric patients in the radiation oncology suite. Int J Pediatr. 2010;2010:870921. doi:10.1155/2010/870921; PMID:20490268CrossRefGoogle ScholarPubMed
Frei-Welte, M, Weiss, M, Neuhaus, D, Ares, C, Mauch, J. Kinderanästhesie zur Protonenbestrahlung: Medizin fern ab der Klinik [Pediatric anesthesia for proton radiotherapy: medicine remote from the medical centre]. Anaesthesist. 2012;61(10):906–14 (in German). doi:10.1007/s00101-012-2085-2; PMID:23053305CrossRefGoogle Scholar
Mason, KP, Robinson, F, Fontaine, P, Prescilla, R. Dexmedetomidine offers an option for safe and effective sedation for nuclear medicine imaging in children. Radiology. 2013;267(3):911–7. doi: 10.1148/radiol.13121232; PMID: 23449958.CrossRefGoogle ScholarPubMed
Mandell, GA, Shalaby-Rana, E, Gordon, I. Society of Nuclear Medicine procedure guideline for pediatric sedation in nuclear medicine. January 5, 2003. http://s3.amazonaws.com/rdcms-snmmi/files/production/public/pg_ch31_0703.pdf.Google Scholar
Mason, KP, Padua, H, Fontaine, PJ, Zurakowski, D. Radiologist-supervised ketamine sedation for solid organ biopsies in children and adolescents. AJR Am J Roentgenol. 2009;192(5):1261–5. doi:10.2214/AJR.08.1743; PMID:19380549CrossRefGoogle ScholarPubMed
Lightdale, JR, Mahoney, LB, Schwarz, SM, Liacouras, CA. Methods of sedation in pediatric endoscopy: a survey of NASPGHAN members. J Pediatr Gastroenterol Nutr. 2007;45(4):500–2. doi:10.1097/MPG.0b013e3180691168; PMID:18030225CrossRefGoogle ScholarPubMed
Biber, JL, Allareddy, V, Allareddy, V, Prevalence and predictors of adverse events during procedural sedation anesthesia-outside the operating room for esophagogastroduodenoscopy and colonoscopy in children: age is an independent predictor of outcomes. Pediatr Crit Care Med. 2015;16(8):e251–9. doi:10.1097/PCC.0000000000000504; PMID:26218257CrossRefGoogle Scholar
van Beek, EJ, Leroy, PL. Safe and effective procedural sedation for gastrointestinal endoscopy in children. J Pediatr Gastroenterol Nutr. 2012;54(2):171–85. doi:10.1097/MPG.0b013e31823a2985; PMID: 21975965CrossRefGoogle ScholarPubMed
Cohen, S, Glatstein, MM, Scolnik, D, et al. Propofol for pediatric colonoscopy: the experience of a large, tertiary care pediatric hospital. Am J Ther. 2014;21(6):509–11. doi:10.1097/MJT.0b013e31826a94e9; PMID:23567786CrossRefGoogle ScholarPubMed
Amornyotin, S, Aanpreung, P, Prakarnrattana, U, et al. Experience of intravenous sedation for pediatric gastrointestinal endoscopy in a large tertiary referral center in a developing country. Paediatr Anaesth. 2009;19(8):784–91. doi:10.1111/j.1460-9592.2009.03063.x; PMID:19624366CrossRefGoogle Scholar
ASGE Standards of Practice Committee, Lightdale, JR, Acosta, R, et al. Modifications in endoscopic practice for pediatric patients. Gastrointest Endosc. 2014;79(5):699–710. doi:10.1016/j.gie.2013.08.014; PMID:24593951CrossRefGoogle ScholarPubMed
ASGE Standards of Practice Committee, Early, DS, Lightdale, JR, et al. Guidelines for sedation and anesthesia in GI endoscopy. Gastrointest Endosc. 2018;87(2):327–37. doi:10.1016/j.gie.2017.07.018; PMID:29306520CrossRefGoogle ScholarPubMed
Kresz, A, Mayer, B, Zernickel, M, Posovszky, C. Carbon dioxide versus room air for colonoscopy in deeply sedated pediatric patients: a randomized controlled trial. Endosc Int Open. 2019;7(2):E290–7. doi:10.1055/a-0806-7060; PMID:30705964Google ScholarPubMed
Hoffmann, CO, Samuels, PJ, Beckman, E, et al. Insufflation vs intubation during esophagogastroduodenoscopy in children. Paediatr Anaesth. 2010;20(9):821–30. doi:10.1111/j.1460-9592.2010.03357.x; PMID:20716074CrossRefGoogle ScholarPubMed
Patino, M, Glynn, S, Soberano, M, et al. Comparison of different anesthesia techniques during esophagogastroduedenoscopy in children: a randomized trial. Paediatr Anaesth. 2015;25(10):1013–9. doi:10.1111/pan.12717; PMID:26184697CrossRefGoogle ScholarPubMed
Rajasekaran, S, Hackbarth, RM, Davis, AT, et al. The safety of propofol sedation for elective nonintubated esophagogastroduodenoscopy in pediatric patients. Pediatr Crit Care Med. 2014;15(6):e261–9. doi:10.1097/PCC.0000000000000147; PMID:24849145CrossRefGoogle ScholarPubMed
Acquaviva, MA, Horn, ND, Gupta, SK. Endotracheal intubation versus laryngeal mask airway for esophagogastroduodenoscopy in children. J Pediatr Gastroenterol Nutr. 2014;59(1):54–6. doi:10.1097/MPG.0000000000000348; PMID:24637966CrossRefGoogle ScholarPubMed
Hartjes, KT, Dafonte, TM, Lee, AF, Lightdale, JR. Variation in pediatric anesthesiologist sedation practices for pediatric gastrointestinal endoscopy. Front Pediatr. 2021;9:709433. doi:10.3389/fped.2021.709433; PMID:34458212CrossRefGoogle Scholar
Cox, CB, Laborda, T, Kynes, JM, Hiremath, G. Evolution in the practice of pediatric endoscopy and sedation. Front Pediatr. 2021 14;9:687635. doi:10.3389/fped.2021.687635; PMID:34336742CrossRefGoogle Scholar
Ngamprasertwong, P, Mahmoud, M. Anesthesia for MRI enterography in children. J Clin Anesth. 2014;26(3):249. doi:10.1016/j.jclinane.2013.11.013; PMID:24806075CrossRefGoogle ScholarPubMed
Mollard, BJ, Smith, EA, Lai, ME, et al. MR enterography under the age of 10 years: a single institutional experience. Pediatr Radiol. 2016;46(1):43–9. doi:10.1007/s00247-015-3431-8; PMID:26224108CrossRefGoogle Scholar
Hartling, L, Milne, A, Foisy, M, et al. What works and what’s safe in pediatric emergency procedural sedation: an overview of reviews. Acad Emerg Med. 2016;23(5):519–30. doi:10.1111/acem.12938; PMID:26858095CrossRefGoogle ScholarPubMed
Bellolio, MF, Puls, HA, Anderson, JL, et al. Incidence of adverse events in paediatric procedural sedation in the emergency department: a systematic review and meta-analysis. BMJ Open. 2016;6(6):e011384. doi:10.1136/bmjopen-2016-011384; PMID:27311910CrossRefGoogle ScholarPubMed
Bhatt, M, Johnson, DW, Chan, J, et al. Risk factors for adverse events in emergency department procedural sedation for children. JAMA Pediatr. 2017;171(10):957–64. doi:10.1001/jamapediatrics.2017.2135; PMID:28828486CrossRefGoogle ScholarPubMed
Bhatt, M, Johnson, DW, Taljaard, M, et al. Association of preprocedural fasting with outcomes of emergency department sedation in children. JAMA Pediatr. 2018;172(7):678–85. doi:10.1001/jamapediatrics.2018.0830. Erratum in JAMA Pediatr. 2018;172(8):787; PMID:29800944CrossRefGoogle ScholarPubMed
Miller, AF, Monuteaux, MC, Bourgeois, FT, Fleegler, EW. Variation in pediatric procedural sedations across children’s hospital emergency departments. Hosp Pediatr. 2018;8(1):36–43. doi: 10.1542/hpeds.2017-0045; PMID:29233853CrossRefGoogle ScholarPubMed
Sahyoun, C, Cantais, A, Gervaix, A, et al. Pediatric Emergency Medicine Comfort and Analgesia Research in Europe (PemCARE) group of the Research in European Pediatric Emergency Medicine. Pediatric procedural sedation and analgesia in the emergency department: surveying the current European practice. Eur J Pediatr. 2021;180(6):1799–813. doi:10.1007/s00431-021-03930-6. Erratum in Eur J Pediatr. 2021 Feb 13; PMID:33511466Google ScholarPubMed
Poh, YN, Poh, PF, Buang, SN, Lee, JH. Sedation guidelines, protocols, and algorithms in PICUs: a systematic review. Pediatr Crit Care Med. 2014;15(9):885–92. doi: 10.1097/PCC.0000000000000255; PMID:25230314CrossRefGoogle ScholarPubMed
Sperotto, F, Mondardini, MC, Dell’Oste, C, et al. Pediatric Neurological Protection and Drugs (PeNPAD) Study Group of the Italian Society of Neonatal and Pediatric Anesthesia and Intensive Care (SARNePI). Efficacy and safety of dexmedetomidine for prolonged sedation in the PICU: a prospective multicenter study (PROSDEX). Pediatr Crit Care Med. 2020;21(7):625–36. doi:10.1097/PCC.0000000000002350; PMID:32224830CrossRefGoogle Scholar
Mondardini, MC, Daverio, M, Caramelli, F, et al. Dexmedetomidine for prevention of opioid/benzodiazepine withdrawal syndrome in pediatric intensive care unit: Interim analysis of a randomized controlled trial. Pharmacotherapy. 2022;42(2):145–53. doi:10.1002/phar.2654; PMID:34882826CrossRefGoogle ScholarPubMed
Sperotto, F, Giaretta, I, Mondardini, MC, et al. Ketamine prolonged infusions in the pediatric intensive care unit: a tertiary-care single-center analysis. J Pediatr Pharmacol Ther. 2021;26(1):73–80. doi:10.5863/1551-6776-26.1.73; PMID: 33424503Google ScholarPubMed
Mencía, S, Palacios, A, García, M, et al. An exploratory study of sevoflurane as an alternative for difficult sedation in critically ill children. Pediatr Crit Care Med. 2018;19(7):e335–41. doi:10.1097/PCC.0000000000001538; PMID: 29557840CrossRefGoogle Scholar
Eifinger, F, Hünseler, C, Roth, B, et al. Observations on the effects of inhaled isoflurane in long-term sedation of critically ill children using a modified AnaConDa© system. Klin Padiatr. 2013;225(4):206–11. doi:10.1055/s-0033-1345173; PMID:23797368Google ScholarPubMed
Committee on Fetus and Newborn and Section on Anesthesiology and Pain Medicine. Prevention and management of procedural pain in the neonate: an update. Pediatrics. 2016;137(2):e20154271. doi:10.1542/peds.2015-4271; PMID: 26810788CrossRefGoogle Scholar
Nasr, VG, DiNardo, JA. Sedation and analgesia in pediatric cardiac critical care. Pediatr Crit Care Med. 2016;17(8 Suppl 1):S225–31. doi:10.1097/PCC.0000000000000756; PMID:27490604CrossRefGoogle ScholarPubMed
Stark, A, Smith, PB, Hornik, CP, et al. Medication use in the neonatal intensive care unit and changes from 2010 to 2018. J Pediatr. 2022;240:66–71.e4. doi:10.1016/j.jpeds.2021.08.075; PMID:34481808CrossRefGoogle ScholarPubMed
Snyers, D, Tribolet, S, Rigo, V. Intranasal analgosedation for infants in the neonatal intensive care unit: a systematic review. Neonatology. 2022;119(3):273–84. doi:10.1159/000521949;PMID:35231912CrossRefGoogle ScholarPubMed
Allegaert, K, van den Anker, J. Sedation in the neonatal intensive care unit: international practice. In Mason, KP, ed., Pediatric Sedation Outside of the Operating Room. Cham: Springer, 2021, 305–43. https://doi.org/10.1007/978-3-030-58406-1_18Google Scholar

Additional Reading

Mason, KP (ed.). Pediatric Sedation Outside of the Operating Room: A Multispecialty International Collaboration. Springer Nature, Switzerland, 3rd Ed. 2021. ISBN-9783030584061. 910 pp. https://doi.org/10.1007/978-3-030-58406-1CrossRefGoogle Scholar
Tobias, JD, Cravero, JP, eds. Procedural Sedation for Infants, Children, and Adolescents. Elk Grove Village, IL: American Academy of Pediatrics, 2016.Google Scholar
Society for Pediatric Sedation (SPS) Podcast, accessible at: https://sps-podcast.captivate.fm/listenGoogle Scholar

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