Men's Reproductive and Sexual Health Throughout the Lifespan An Integrated Approach to Fertility, Sexual Function, and Vitality
Book contents
- Men’s Reproductive and Sexual Health throughout the Lifespan
- Men’s Reproductive and Sexual Health throughout the Lifespan
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 An Introduction to Men’s Health Care
- Section 2 The Biology of Male Reproduction and Infertility
- Chapter 4 Current Understanding of the Physiology and Histology of Human Spermatogenesis
- Chapter 5 Male Reproductive Endocrinology
- Chapter 6 Sperm Chromatin Packaging and the Toroid Linker Model
- Chapter 7 Ejaculation and Sperm Transport
- Chapter 8 Genetic Aspects of Male Infertility
- Chapter 9 The Mechanistic and Predictive Utility of Sperm Epigenetics
- Chapter 10 Aging and Environmental Interactions with the Sperm Epigenome
- Chapter 11 The Effects of Aging on Male Fertility and the Health of Offspring
- Section 3 Clinical Evaluation and Treatment of Male Infertility
- Section 4 Laboratory Evaluation and Treatment of Male Infertility
- Section 5 Medical and Surgical Management of Issues of Male Health
- Index
- References
Chapter 9 - The Mechanistic and Predictive Utility of Sperm Epigenetics
from Section 2 - The Biology of Male Reproduction and Infertility
Published online by Cambridge University Press: 06 December 2023
Book contents
- Men’s Reproductive and Sexual Health throughout the Lifespan
- Men’s Reproductive and Sexual Health throughout the Lifespan
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 An Introduction to Men’s Health Care
- Section 2 The Biology of Male Reproduction and Infertility
- Chapter 4 Current Understanding of the Physiology and Histology of Human Spermatogenesis
- Chapter 5 Male Reproductive Endocrinology
- Chapter 6 Sperm Chromatin Packaging and the Toroid Linker Model
- Chapter 7 Ejaculation and Sperm Transport
- Chapter 8 Genetic Aspects of Male Infertility
- Chapter 9 The Mechanistic and Predictive Utility of Sperm Epigenetics
- Chapter 10 Aging and Environmental Interactions with the Sperm Epigenome
- Chapter 11 The Effects of Aging on Male Fertility and the Health of Offspring
- Section 3 Clinical Evaluation and Treatment of Male Infertility
- Section 4 Laboratory Evaluation and Treatment of Male Infertility
- Section 5 Medical and Surgical Management of Issues of Male Health
- Index
- References
Summary
For many years sperm epigenetics has been a focus of studies hoping to identify novel mechanisms that drive infertility and offspring health abnormalities. This effort has yielded many exciting prospects but to date no direct and firm mechanistic pathways have been fully elucidated. This is largely a result of the unique nature of the mature sperm that is reflected in the distinct epigenetic signatures that are found therein. This unique landscape makes traditional approaches for understanding mechanisms difficult. However, the utility of sperm epigenetic marks in the prediction of specific reproductive outcomes is becoming clearer. While the mechanisms that explain the biological underpinnings of some of the associations between sperm epigenetics and reproductive health have yet to be elucidated, the value that these marks offer in prediction of various reproductive outcomes is becoming clearer.
- Type
- Chapter
- Information
- Men's Reproductive and Sexual Health Throughout the LifespanAn Integrated Approach to Fertility, Sexual Function, and Vitality, pp. 76 - 80Publisher: Cambridge University PressPrint publication year: 2023
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