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Chapter 11 - The Effects of Aging on Male Fertility and the Health of Offspring

from Section 2 - The Biology of Male Reproduction and Infertility

Published online by Cambridge University Press:  06 December 2023

Douglas T. Carrell
Affiliation:
Utah Center for Reproductive Medicine
Alexander W. Pastuszak
Affiliation:
University of Utah
James M. Hotaling
Affiliation:
Utah Center for Reproductive Medicine
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Summary

Paternal age is increasing with time. Increasing evidence suggests that a man’s reproductive health changes with age. A man’s fertility may decline as he ages with evidence of an association with unassisted and assisted conception. In addition, there are risks to the pregnancy and child for older fathers. While the definition of advanced paternal age remains uncertain, the consequences of paternal age are becoming more quantifiable.

Type
Chapter
Information
Men's Reproductive and Sexual Health Throughout the Lifespan
An Integrated Approach to Fertility, Sexual Function, and Vitality
, pp. 87 - 96
Publisher: Cambridge University Press
Print publication year: 2023

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References

Khandwala, YS, Baker, VL, Shaw, GM, Stevenson, DK, Lu, Y, Eisenberg, ML. Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study. BMJ. 2018;363:18. doi:10.1136/bmj.k4372Google Scholar
Sauer, MV. Reproduction at an advanced maternal age and maternal health. Fertil Steril. 2015;103(5):11361143. doi:10.1016/j.fertnstert.2015.03.004CrossRefGoogle ScholarPubMed
Jenkins, TG, Aston, KI, Pflueger, C, Cairns, BR, Carrell, DT. Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility. PLoS Genet. 2014;10(7):113. doi:10.1371/journal.pgen.1004458Google Scholar
Jenkins, TG, Aston, KI, Cairns, BR, Carrell, DT. Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels. Fertil Steril. 2013;100(4):945951.e2. doi:10.1016/j.fertnstert.2013.05.039Google Scholar
Johnson, SL, Dunleavy, J, Gemmell, NJ, Nakagawa, S. Consistent age-dependent declines in human semen quality: a systematic review and meta-analysis. Ageing Res Rev. 2015;19:2233. doi:10.1016/j.arr.2014.10.007CrossRefGoogle ScholarPubMed
Santi, D, Spaggiari, G, Simoni, M. Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management – meta-analyses. Reprod Biomed Online. 2018;37(3):315326. doi:10.1016/j.rbmo.2018.06.023Google Scholar
Tan, J, Taskin, O, Albert, A, Bedaiwy, MA. Association between sperm DNA fragmentation and idiopathic recurrent pregnancy loss: a systematic review and meta-analysis. Reprod Biomed Online. 2019;38(6):951960. doi:10.1016/j.rbmo.2018.12.029CrossRefGoogle Scholar
Cocuzza, M, Athayde, KS, Agarwal, A, et al. Age-related increase of reactive oxygen species in neat semen in healthy fertile men. Urology. 2008;71(3):490494. doi:10.1016/j.urology.2007.11.041Google Scholar
Maher, GJ, Goriely, A, Wilkie, AOM. Cellular evidence for selfish spermatogonial selection in aged human testes. Andrology. 2013;2:304314. doi:10.1111/j.2047-2927.2013.00175.xGoogle Scholar
Selvin, E, Burnett, AL, Platz, EA. Prevalence and risk factors for erectile dysfunction in the US. Am J Med. 2007;120:151157. doi:10.1016/j.amjmed.2006.06.010Google Scholar
Agarwal, A, Gupta, S, Du, Plessis S, et al. Abstinence time and its impact on basic and advanced semen parameters. Urology. 2016;94:102110. doi:10.1016/j.urology.2016.03.059Google Scholar
Paduch, D, Polzer, P, Morgentaler, A, et al. Clinical and demographic correlates of ejaculatory dysfunctions other than premature ejaculation: a prospective, observational study. J Sex Med. 2015;12:22762286. doi:10.1111/jsm.13027Google Scholar
Kasman, AM, Bhambhvani, HP, Eisenberg, ML. Ejaculatory dysfunction in patients presenting to a men’s health clinic: a retrospective cohort study. Sex Med. 2020;8(3):454460. doi:10.1016/j.esxm.2020.05.002Google Scholar
Avellino, G, Theva, D, Oates, RD. Common urologic diseases in older men and their treatment: how they impact fertility. Fertil Steril. 2017;107(2):305311. doi:10.1016/j.fertnstert.2016.12.008Google Scholar
Mahabadi, V, Amory, JK, Swerdloff, RS, et al. Combined transdermal testosterone gel and the gonadotropins in men. J Clin Endocrinol Metab. 2009;94(7):23132320. doi:10.1210/jc.2008-2604CrossRefGoogle ScholarPubMed
Kohn, TP, Louis, MR, Pickett, SM, et al. Age and duration of testosterone therapy predict time to return of sperm count after human chorionic gonadotropin therapy. Fertil Steril. 2017;107(2):351357.e1. doi:10.1016/j.fertnstert.2016.10.004CrossRefGoogle ScholarPubMed
Wang, C, Swerdloff, RS. Limitations of semen analysis as a test of male fertility and anticipated needs from newer tests. Fertil Steril. 2014;102(6):15021507. doi:10.1016/j.fertnstert.2014.10.021Google Scholar
Kidd, SA, Eskenazi, B, Wyrobek, AJ. Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril. 2001;75(2):237248. doi:10.1016/s0015-0282(00)01679-4Google Scholar
Li, WN, Jia, MM, Peng, YQ, Ding, R, Fan, LQ, Liu, G. Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017. Reprod Biol Endocrinol. 2019;17(107):18. doi:10.1186/s12958-019-0551-2CrossRefGoogle Scholar
Priskorn, L, Jensen, TK, Lindahl-Jacobsen, R, Skakkebæk, NE, Bostofte, E, Eisenberg, ML. Parental age at delivery and a man’s semen quality. Hum Reprod. 2014;29(5):10971102. doi:10.1093/humrep/deu039Google Scholar
Verón, GL, Tissera, AD, Bello, R, Beltramone, F, Estofan, G, Molina, RI, Vazquez-Levin, MH. Impact of age, clinical conditions, and lifestyle on routine semen parameters and sperm kinematics. Fertil Steril. 2018;110(1):6875e3. doi:10.1016/j.fertnstert.2018.03.016.Google Scholar
Seymour, F, Duffy, C, Koerner, A. A case of authenticated fertility in a man, aged 94. JAMA. 1935;105(18):14231424.Google Scholar
Johnson, S, Dunleavy, J, Gemmell, N, Nakagawa, S. Consistent age-dependent declines in human semen quality: a systematic review and meta-analysis. Ageing Res Rev. 2015;19:2233. doi:10.1016/j.arr.2014.10.007Google Scholar
Conti, SL, Eisenberg, ML. Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer. Asian J Androl. 2016;18(3):420424. doi:10.4103/1008-682X.175097Google Scholar
Hamilton, B, Hoyert, D, Martin, J, Strombino, D, Guyer, B. Annual summary of vital statistics: 2010–2011. Pediatrics. 2013;131(3):548558. doi:10.1542/peds.2012-3769Google Scholar
Khandwala, Y, Zhang, C, Lu, Y, Eisenberg, M. The age of fathers in the USA is rising: an analysis of 168,867,480 births from 1972 to 2015. Hum Reprod. 2017;32(10):21102116. doi:10.1093/humrep/dex267Google Scholar
Mazur, DJ, Lipshultz, LI. Infertility in the aging male. Curr Urol Rep. 2018;19(7):54. doi:10.1007/s11934-018-0802-3Google Scholar
Oldereid, NB, Wennerholm, U, Pinborg, A, et al. The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis. Hum Reprod Update. 2018;24(3):320389. doi:10.1093/humupd/dmy005Google Scholar
Ford, W, North, K, Taylor, H, Farrow, A, Hull, M, Golding, J. Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC Study Team (Avon Longitudinal Study of Pregnancy and Childhood). Hum Reprod. 2000;15(8):17031708. doi:10.1093/humrep/15.8.1703Google Scholar
Hassan, M, Killick, S. Effect of male age on fertility: evidence for the decline in male fertility with increasing age. Fertil Steril. 2003;79(Suppl. 3):15201527. doi:10.1016/s0015-0282(03)00366-2Google Scholar
de la Rochebrochard, E, Thonneau, P. Paternal age >or=40 years: an important risk factor for infertility. Am J Obs Gynecol. 2003;189(4):901905. doi:10.1067/s0002-9378(03)00753-1Google Scholar
Dain, L, Auslander, R, Dirnfeld, M. The effect of paternal age on assisted reproduction outcome. Fertil Steril. 2011;95(1):18. doi:10.1016/j.fertnstert.2010.08.029Google Scholar
Whitcomb, B, Levens, E, Turzanski-Fortner, R, et al. Contribution of male age to outcomes in assisted reproductive technologies. Fertil Steril. 2011;95(1):147151. doi:10.1016/j.fertnstert.2010.06.039Google Scholar
Mathieu, C, Ecochard, R, Bied, V, Lornage, J, Czyba, J. Cumulative conception rate following intrauterine artificial insemination with husband’s spermatozoa: influence of husband’s age. Hum Reprod. 1995;10(5):10901097. doi:10.1093/oxfordjournals.humrep.a136100CrossRefGoogle ScholarPubMed
McPherson, N, Zander-Fox, D, Vincent, A, Lane, M. Combined advanced parental age has an additive negative effect on live birth rates – data from 4057 first IVF/ICSI cycles. J Assist Reprod Genet. 2018;35(2):279287. doi:10.1007/s10815-017-1054-8Google Scholar
Wu, Y, Kang, X, Zheng, H, Liu, H, Liu, J. Effect of paternal age on reproductive outcomes of in vitro fertilization. PLoS ONE. 2015;10(9):19. doi:10.1371/journal.pone.0135734Google Scholar
Kaarouch, I, Bouamoud, N, Madkour, A, et al. Paternal age: negative impact on sperm genome decays and IVF outcomes after 40 years. Mol Reprod Dev. 2018;85(3):271280. doi:10.1002/mrd.22963Google Scholar
Hajj, N, Zechner, U, Schneider, E, et al. Methylation status of imprinted genes and repetitive elements in sperm DNA from infertile males. Sex Dev. 2011;5:6069. doi:10.1159/000323806Google Scholar
Montjean, D, Ravel, C, Benkhalifa, M, et al. Methylation changes in mature sperm deoxyribonucleic acid from oligozoospermic men: assessment of genetic variants and assisted reproductive technology outcome. Fertil Steril. 2013;100(5):12411247.Google Scholar
de la Rochebrochard, E, de Mouzon, J, Thepot, F, Thonneau, P, French National IVF Registry (FIVNAT) Association. Fathers over 40 and increased failure to conceive: the lessons of in vitro fertilization in France. Fertil Steril. 2006;85(5):14201424. doi:10.1016/j.fertnstert.2005.11.040Google Scholar
Robertshaw, I, Khoury, J, Abdallah, ME, Warikoo, P, Hofmann, GE. The effect of paternal age on outcome in assisted reproductive technology using the ovum donation model. Reprod Sci. 2014;21(5):590593. doi:10.1177/1933719113506497Google Scholar
Begeria, R, Garcia, D, Obradors, A, Poisot, F, Vassena, R, Vernaeve, V. Paternal age and assisted reproductive outcomes in ICSI donor oocytes: is there an effect of older fathers? Hum Reprod. 2014;29(10):21142122. doi:10.1093/humrep/deu189Google Scholar
Frattarelli, JL, Miller, KA, Miller, BT, et al. Male age negatively impacts embryo development and reproductive outcome in donor oocyte assisted reproductive technology cycles. Fertil Steril. 2008;90(1):97103. doi:10.1016/j.fertnstert.2007.06.009Google Scholar
Sagi-dain, L, Sagi, S, Dirnfeld, M. Effect of paternal age on reproductive outcomes in oocyte donation model: a systematic review. Fertil Steril. 2015;104(4):857865.e1. doi:10.1016/j.fertnstert.2015.06.036Google Scholar
Bergh, C, Pinborg, A, Wennerholm, U. Parental age and child outcomes. Fertil Steril. 2019;111(6):10361046. doi:10.1016/j.fertnstert.2019.04.026CrossRefGoogle ScholarPubMed
Mayo, JA, Lu, Y, Stevenson, DK, Shaw, GM, Eisenberg, ML. Parental age and stillbirth: a population-based cohort of nearly 10 million California deliveries from 1991 to 2011. Ann Epidemiol. 2019;31:3237.e2. doi:10.1016/j.annepidem.2018.12.001Google Scholar
Taylor, JL, Debost, JPG, Morton, SU, et al. Paternal-age-related de novo mutations and risk for five disorders. Nat Commun. 2019;10(3043):19. doi:10.1038/s41467-019-11039-6Google Scholar
Contreras, ZA, Hansen, J, Ritz, B, Olsen, J, Yu, F, Heck, JE. Parental age and childhood cancer risk: a Danish population-based registry study. Cancer Epidemiol. 2017;49:202215. doi:10.1016/j.canep.2017.06.010Google Scholar
Wang, R, Metayer, C, Morimoto, L, et al. Parental age and risk of pediatric cancer in the offspring: a population-based record-linkage study in California. Am J Epidemiol. 2017;186(7):843856. doi:10.1093/aje/kwx160Google Scholar
Kasman, AM, Giudice, D, Eisenberg, ML. New insights to guide patient care: the bidirectional relationship between male infertility and male health. Fertil Steril. 2020;113(3):469477. doi:10.1016/j.fertnstert.2020.01.002Google Scholar
Del Giudice, F, Kasman, A, De Berardinis, E, Busseto, G, Belladelli, F, Eisenberg, ML. Association between male infertility and male specific malignancies: systematic review and metanalysis of the population-based retrospective cohort studies. Fertil Steril. 2020;114(5):984996. doi: 10.1016/j.fertnstert.2020.04.042Google Scholar
Del Giudice, F, Kasman, A, Ferro, M, et al. Clinical correlation among male infertility and overall male health: a systematic review of the literature. Investig Clin Urol. 2020;61(4):355371. doi:10.4111/icu.2020.61.4.355Google Scholar

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