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Chapter 12 - Autoimmune Causes of Medication-Resistant Epilepsy

Published online by Cambridge University Press:  20 August 2020

By
Anteneh M. Feyissa  and
Jeffrey W. Britton
Edited by
John M. Stern ,
Raman Sankar  and
Michael Sperling
John M. Stern
Affiliation:
Geffen School of Medicine at UCLA, Los Angeles, CA
Raman Sankar
Affiliation:
Geffen School of Medicine at UCLA, Los Angeles, CA
Michael Sperling
Affiliation:
Jefferson Hospital for Neurosciences, Philadelphia, PA
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Summary

Epilepsy affects approximately 65 million people worldwide. Despite expanding treatment options, up to one-third of patients remain medically intractable[1]. With the exception of surgery in a subset of these patients, epilepsy treatment is usually limited to suppression of seizures with anti-seizure medications (ASMs). Accumulating data support an autoimmune aetiology in some patients [2,3]. Identification of neural antibodies allows a direct means of establishing an autoimmune cause in many of these cases[3–6]. Table 12.1 shows the best-known currently identified autoimmune epilepsy syndromes.

Type
Chapter
Information
Medication-Resistant Epilepsy
Diagnosis and Treatment
 , pp. 100 - 117
Publisher: Cambridge University Press
Print publication year: 2020

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