Book contents
- Marijuana and Madness
- Marijuana and Madness
- Copyright page
- Contents
- Contributors
- Preface
- 1 How cannabis works in the brain
- 2 Other cannabinoids
- 3 The function of the endocannabinoid system
- 4 Is cannabis becoming more potent?
- 5 What are the policy implications of the evidence on cannabis and psychosis?
- 6 Cannabis, endocannabinoids and neurodevelopment
- 7 The impact of pubertal exposure to cannabis on the brain: a focus on animal studies
- 8 Cannabis and cognition: short- and long-term effects
- 9 Does cannabis cause lasting brain damage?
- 10 The association between cannabis use and depression: a review of the evidence
- 11 Cannabis, cannabinoids and bipolar disorder
- 12 Which cannabis users develop psychosis?
- 13 Cannabinoids and the cerebellum: a potential role in the development of psychosis
- 14 The neural basis for the acute effects of cannabis on learning and psychosis
- 15 Does cannabis use cause schizophrenia? The epidemiological evidence
- 16 Postmortem studies of the brain cannabinoid system in schizophrenia
- 17 The endocannabinoid system in schizophrenia
- 18 The acute effects of cannabinoids in patients with psychotic illness
- 19 Cannabis abuse and the course of schizophrenia
- 20 Understanding cannabis use in schizophrenia
- 21 Addressing cannabis use in people with psychosis
- Index
12 - Which cannabis users develop psychosis?
Published online by Cambridge University Press: 05 November 2011
Book contents
- Marijuana and Madness
- Marijuana and Madness
- Copyright page
- Contents
- Contributors
- Preface
- 1 How cannabis works in the brain
- 2 Other cannabinoids
- 3 The function of the endocannabinoid system
- 4 Is cannabis becoming more potent?
- 5 What are the policy implications of the evidence on cannabis and psychosis?
- 6 Cannabis, endocannabinoids and neurodevelopment
- 7 The impact of pubertal exposure to cannabis on the brain: a focus on animal studies
- 8 Cannabis and cognition: short- and long-term effects
- 9 Does cannabis cause lasting brain damage?
- 10 The association between cannabis use and depression: a review of the evidence
- 11 Cannabis, cannabinoids and bipolar disorder
- 12 Which cannabis users develop psychosis?
- 13 Cannabinoids and the cerebellum: a potential role in the development of psychosis
- 14 The neural basis for the acute effects of cannabis on learning and psychosis
- 15 Does cannabis use cause schizophrenia? The epidemiological evidence
- 16 Postmortem studies of the brain cannabinoid system in schizophrenia
- 17 The endocannabinoid system in schizophrenia
- 18 The acute effects of cannabinoids in patients with psychotic illness
- 19 Cannabis abuse and the course of schizophrenia
- 20 Understanding cannabis use in schizophrenia
- 21 Addressing cannabis use in people with psychosis
- Index
Summary
There has been much debate as to whether the association between cannabis and subclinical expression of psychosis is causal, or whether psychotic experiences may prompt cannabis use in individuals at genetic risk for psychosis as a means of self-medication. The Genetic Risk and Outcome in Psychosis (GROUP) study investigated the association between familial liability for psychosis and sensitivity to cannabis, using patient sibling and sibling-control pairs analyses. This study focused on gene-environment interactions relevant to psychotic disorders, and included patients with psychotic disorder, their siblings and community controls. Caspi and colleagues highlighted the importance of individual genetic vulnerability when they reported an interaction between cannabis use and variation in the gene that encodes catecholamine-O-methyl transferase (COMT). Given that different types of cannabis clearly affect mental health differentially, more research is needed to understand how genetic liability may increase sensitivity to, or preference for, the specific constituents of cannabis.
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- Marijuana and Madness , pp. 137 - 143Publisher: Cambridge University PressPrint publication year: 2011
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