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Chapter 16 - What Science May Come for Embryo Selection?

Published online by Cambridge University Press:  26 April 2023

By
Paolo Rinaudo  and
Eleni Jaswa
Edited by
Catherine Racowsky ,
Jacques Cohen  and
Nicholas Macklon
Catherine Racowsky
Affiliation:
Hôpital Foch, France
Jacques Cohen
Affiliation:
IVF 2.0, New York
Nicholas Macklon
Affiliation:
London Women's Clinic
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Summary

The success of artificial reproductive technologies (ART) requires effective methods for selecting embryos with optimal potential for generating a live birth. A glimpse into the landscape of future of ART reveals a field replete with breakthrough opportunities. In the context of the current pace of scientific discovery and technological development, we can expect the development of different novel technologies for gametes and embryo selection. Among these new technologies we can envision embryo selection technologies based on metabolic markers; the use of artificial intelligence and deep learning; non-invasive, label-free microscopy; and cell-sorting techniques for sperm selection. It is also likely that embryos will be scored based on the relative activation of stress-pathways; embryos showing an intermediate, “Goldilocks” level of stress will be preferentially selected. Overall, it will be important to thoughtfully consider and discuss the ethical implications of new technologies that could be used in ART.

Keywords

Embryo selectiongamete selectionartificial intelligenceimaging techniquesembryo homeostasisassisted reproduction technologyfuture
Type
Chapter
Information
Manual of Embryo Selection in Human Assisted Reproduction , pp. 168 - 176
Publisher: Cambridge University Press
Print publication year: 2023

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