Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-13T09:28:26.219Z Has data issue: false hasContentIssue false

Chapter 4 - The Sperm’s Role in Embryo Development

Published online by Cambridge University Press:  26 April 2023

By
Nahid Punjani ,
Russell P. Hayden  and
Peter N. Schlegel
Edited by
Catherine Racowsky ,
Jacques Cohen  and
Nicholas Macklon
Catherine Racowsky
Affiliation:
Hôpital Foch, France
Jacques Cohen
Affiliation:
IVF 2.0, New York
Nicholas Macklon
Affiliation:
London Women's Clinic
Get access

Summary

The male’s contribution to early embryo development remains an underappreciated aspect of reproductive physiology that may become of increasing importance in the application of advanced reproductive technology (ART) in the coming years. Evidence is emerging regarding the importance of sperm chromatin organization, DNA integrity, and sperm-based epigenetic signals that are delivered to the oocyte. In this review we will discuss the current understanding of how the sperm influences early embryogenesis. The existing data connecting sperm factors to poor ART outcomes is critically presented. Finally, practical laboratory methods currently available to the clinical embryologist for sperm optimization will be outlined.

Type
Chapter
Information
Manual of Embryo Selection in Human Assisted Reproduction , pp. 31 - 42
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aitken, RJ, Baker, MA, Nixon, B. Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress? Asian J Androl, 2015;17(4):633–9.CrossRefGoogle ScholarPubMed
Bach, PV, Schlegel, PN. Sperm DNA damage and its role in IVF and ICSI. Basic Clin Androl. 2016;26:15.Google Scholar
Steger, K, Cavalcanti, MC, Schuppe, HC. Prognostic markers for competent human spermatozoa: fertilizing capacity and contribution to the embryo. Int J Androl. 2011;34(6 Pt 1):513–27.Google Scholar
Ward, WS. Function of sperm chromatin structural elements in fertilization and development. Mol Hum Reprod. 2010;16(1):30–6.Google Scholar
Aitken, RJ, De Iuliis, GN. On the possible origins of DNA damage in human spermatozoa. Mol Hum Reprod. 2010;16(1):3–13.Google Scholar
Colaco, S, Sakkas, D. Paternal factors contributing to embryo quality. J Assist Reprod Genet. 2018;35(11):1953–68.CrossRefGoogle ScholarPubMed
Van Voorhis, BJ, Barnett, M, Sparks, AE, Syrop, CH, Rosenthal, G, Dawson, J. Effect of the total motile sperm count on the efficacy and cost-effectiveness of intrauterine insemination and in vitro fertilization. Fertil Steril. 2001;75(4):661–8.Google Scholar
Depa-Martynow, M, Kempisty, B, Jagodziński, PP, Pawelczyk, L, Jedrzejczak, P. Impact of protamine transcripts and their proteins on the quality and fertilization ability of sperm and the development of preimplantation embryos. Reprod Biol. 2012;12(1):57–72.CrossRefGoogle ScholarPubMed
Sharma, U. Paternal contributions to offspring health: role of sperm small RNAs in intergenerational transmission of epigenetic information. Front Cell Dev Biol. 2019;7:215.Google Scholar
Giacone, F, Cannarella, R, Mongioì, LM, Alamo, A, Condorelli, RA, Calogero, AE, La Vignera, S. Epigenetics of male fertility: effects on assisted reproductive techniques. World J Mens Health. 2019;37(2):148–56.Google Scholar
Xie, P, Keating, D, Parrella, A, Cheung, S, Rosenwaks, Z, Goldstein, M, Palermo, GD. Sperm genomic integrity by TUNEL varies throughout the male genital tract. J Urol. 2020;203(4):802–8.CrossRefGoogle ScholarPubMed
Aitken, RJ, Smith, TB, Jobling, MS, Baker, MA, De Iuliis, GN. Oxidative stress and male reproductive health. Asian J Androl. 2014;16(1):31–8.CrossRefGoogle ScholarPubMed
Ni, K, Spiess, A-N, Schuppe, H-C, Steger, K. The impact of sperm protamine deficiency and sperm DNA damage on human male fertility: a systematic review and meta-analysis. Andrology. 2016;4(5):789–99.Google Scholar
Simon, L, Murphy, K, Shamsi, MB, Liu, L, Emery, B, Aston, KI, et al. Paternal influence of sperm DNA integrity on early embryonic development. Hum Reprod. 2014;29(11):2402–12.Google Scholar
Simon, L, Emery, BR, Carrell, DT. Review: diagnosis and impact of sperm DNA alterations in assisted reproduction. Best Pract Res Clin Obstet Gynaecol. 2017;44:38–56.Google Scholar
Zhao, J, Zhang, Q, Wang, Y, Li, Y. Whether sperm deoxyribonucleic acid fragmentation has an effect on pregnancy and miscarriage after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis. Fertil Steril. 2014;102(4):998–1005.e8.Google Scholar
Zini, A, Boman, JM, Belzile, E, Ciampi, A. Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis. Hum Reprod. 2008;23(12):2663–8.CrossRefGoogle ScholarPubMed
Henkel, RR, Schill, WB. Sperm preparation for ART. Reprod Biol Endocrinol. 2003;1:108.Google Scholar
Hinting, A, Lunardhi, H. Better sperm selection for intracytoplasmic sperm injection with the side migration technique. Andrologia. 2001;33(6):343–6.Google Scholar
Paulson, JD, Polakoski, KL, Leto, S. Further characterization of glass wool column filtration of human semen. Fertil Steril. 1979;32(1):125–6.Google Scholar
Parrella, A, Keating, D, Cheung, S, Xie, P, Stewart, JD, Rosenwaks, Z, Palermo, GD. A treatment approach for couples with disrupted sperm DNA integrity and recurrent ART failure. J Assist Reprod Genet. 2019;36(10):2057–66.CrossRefGoogle ScholarPubMed
Samuel, R, Feng, H, Jafek, A, Despain, D, Jenkins, T, Gale, B. Microfluidic-based sperm sorting & analysis for treatment of male infertility. Transl Androl Urol. 2018;7(Suppl 3):S336–47.CrossRefGoogle ScholarPubMed
Quinn, MM, Jalalian, L, Ribeiro, S, Ona, K, Demirci, U, Cedars, MI, Rosen, MP. Microfluidic sorting selects sperm for clinical use with reduced DNA damage compared to density gradient centrifugation with swim-up in split semen samples. Hum Reprod. 2018;33(8):1388–93.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×