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Chapter 4 - The Sperm’s Role in Embryo Development

Published online by Cambridge University Press:  26 April 2023

By
Nahid Punjani ,
Russell P. Hayden  and
Peter N. Schlegel
Edited by
Catherine Racowsky ,
Jacques Cohen  and
Nicholas Macklon
Catherine Racowsky
Affiliation:
Hôpital Foch, France
Jacques Cohen
Affiliation:
IVF 2.0, New York
Nicholas Macklon
Affiliation:
London Women's Clinic
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Summary

The male’s contribution to early embryo development remains an underappreciated aspect of reproductive physiology that may become of increasing importance in the application of advanced reproductive technology (ART) in the coming years. Evidence is emerging regarding the importance of sperm chromatin organization, DNA integrity, and sperm-based epigenetic signals that are delivered to the oocyte. In this review we will discuss the current understanding of how the sperm influences early embryogenesis. The existing data connecting sperm factors to poor ART outcomes is critically presented. Finally, practical laboratory methods currently available to the clinical embryologist for sperm optimization will be outlined.

Type
Chapter
Information
Manual of Embryo Selection in Human Assisted Reproduction , pp. 31 - 42
Publisher: Cambridge University Press
Print publication year: 2023

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