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Chapter 5 - The Oocyte’s Role in Embryo Development

Published online by Cambridge University Press:  26 April 2023

By
David F. Albertini
Edited by
Catherine Racowsky ,
Jacques Cohen  and
Nicholas Macklon
Catherine Racowsky
Affiliation:
Hôpital Foch, France
Jacques Cohen
Affiliation:
IVF 2.0, New York
Nicholas Macklon
Affiliation:
London Women's Clinic
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Summary

For embryo development to proceed, the female gamete or oocyte must acquire and express nuclear and cytoplasmic determinants prior to, during, and following fertilization. The biological principles acquired during the process of oogenesis, involving hypertrophy, reorganization, and storage of maternal factors, must be coupled temporally with a phase of “maturation” occurring at the time of ovulation. In human ARTs, controlled ovarian stimulation (COS) is used to sustain the final stages of oogenesis with “maturation” being elicited by pharmacologically triggering ovulation. This chapter focuses on the maturation process in mammalian oocytes from a biological and clinical point of view emphasizing the role of maternal determinants in initiating and sustaining development of the embryo.

Type
Chapter
Information
Manual of Embryo Selection in Human Assisted Reproduction , pp. 43 - 52
Publisher: Cambridge University Press
Print publication year: 2023

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