Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-30T19:33:42.594Z Has data issue: false hasContentIssue false

2.01 - Chlorpromazine

from First-Generation (Typical) Antipsychotics

Published online by Cambridge University Press:  19 October 2021

Edited by
Michael Cummings  and
Stephen Stahl
Michael Cummings
Affiliation:
University of California, Los Angeles
Stephen Stahl
Affiliation:
University of California, San Diego
Get access

Summary

Agitation/aggression (severe, acute) associated with psychiatric disorders (e.g. bipolar disorder, schizophrenia), delirium, substance intoxication

Type
Chapter
Information
Management of Complex Treatment-resistant Psychotic Disorders , pp. 105 - 108
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Meyer, J. M. (2018). Pharmacotherapy of psychosis and mania. In Brunton, L. L., Hilal-Dandan, R. and Knollmann, B. C. (eds.). Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 13th ed. Chicago, IL: McGraw-Hill, pp. 279–302.Google Scholar
Dahl, S. G. (1986). Plasma level monitoring of antipsychotic drugs. Clinical utility. Clin Pharmacokinet, 11, 36–61.CrossRefGoogle ScholarPubMed
Van Putten, T., Marder, S. R., Wirshing, W. C., et al. (1991). Neuroleptic plasma levels. Schizophr Bull, 17, 197–216.CrossRefGoogle ScholarPubMed
Yeung, P. K., Hubbard, J. W., Korchinski, E. D., et al. (1993). Pharmacokinetics of chlorpromazine and key metabolites. Eur J Clin Pharmacol, 45, 563–569.CrossRefGoogle ScholarPubMed
Otagiri, M., Maruyama, T., Imai, T., et al. (1987). A comparative study of the interaction of warfarin with human alpha 1-acid glycoprotein and human albumin. J Pharm Pharmacol, 39, 416–420.Google Scholar
Castaneda-Hernandez, G., Bravo, G., Godfraind, T. (1991). Chlorpromazine treatment increases circulating digoxin like immunoreactivity in the rat. Proc West Pharmacol Soc, 34, 501–503.Google ScholarPubMed
Chetty, M., Miller, R., Moodley, S. V. (1994). Smoking and body weight influence the clearance of chlorpromazine. Eur J Clin Pharmacol, 46, 523–526.Google Scholar
Yoshii, K., Kobayashi, K., Tsumuji, M., et al. (2000). Identification of human cytochrome P450 isoforms involved in the 7-hydroxylation of chlorpromazine by human liver microsomes. Life Sci, 67, 175–184.CrossRefGoogle ScholarPubMed
Sunwoo, Y., Ryu, J., Jung, C., et al. (2004). Disposition of chlorpromazine in Korean healthy subjects with CYP2D6*10B mutation. Clin Pharmacol Ther, 75, P90.Google Scholar
Gardiner, S. J., Begg, E. J. (2006). Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacol Rev, 58, 521–590.CrossRefGoogle ScholarPubMed
Wojcikowski, J., Boksa, J., Daniel, W. A. (2010). Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver – a comparison with other phenothiazines. Biochem Pharmacol, 80, 1252–1259.CrossRefGoogle ScholarPubMed
Raitasuo, V., Lehtovaara, R., Huttunen, M. O. (1994). Effect of switching carbamazepine to oxcarbazepine on the plasma levels of neuroleptics. A case report. Psychopharmacology (Berl), 116, 115–116.CrossRefGoogle ScholarPubMed
Curry, S. H., Davis, J. M., Janowsky, D. S., et al. (1970). Factors affecting chlorpromazine plasma levels in psychiatric patients. Arch Gen Psychiatry, 22, 209–215.CrossRefGoogle ScholarPubMed
Loga, S., Curry, S., Lader, M. (1975). Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man. Br J Clin Pharmacol, 2, 197–208.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

  • Chlorpromazine
  • Edited by Michael Cummings, University of California, Los Angeles, Stephen Stahl, University of California, San Diego
  • Book: Management of Complex Treatment-resistant Psychotic Disorders
  • Online publication: 19 October 2021
Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Chlorpromazine
  • Edited by Michael Cummings, University of California, Los Angeles, Stephen Stahl, University of California, San Diego
  • Book: Management of Complex Treatment-resistant Psychotic Disorders
  • Online publication: 19 October 2021
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Chlorpromazine
  • Edited by Michael Cummings, University of California, Los Angeles, Stephen Stahl, University of California, San Diego
  • Book: Management of Complex Treatment-resistant Psychotic Disorders
  • Online publication: 19 October 2021
Available formats
×