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Chapter 2 - History of Clinical Trial Research

from Part I - Introduction and History of Clinical Trial Research

Published online by Cambridge University Press:  20 March 2023

Jay J. H. Park ,
Edward J. Mills  and
J. Kyle Wathen
By
Jay J. H. Park ,
J. Kyle Wathen  and
Edward J. Mills
Jay J. H. Park
Affiliation:
McMaster University, Ontario
Edward J. Mills
Affiliation:
McMaster University, Ontario
J. Kyle Wathen
Affiliation:
Cytel, Cambridge, Massachusetts
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Summary

In this chapter, we review the history of clinical trials. We review the famous 1948 streptomycin trial for tuberculosis to highlight how the discipline of randomised clinical trials was born out of economic hardship. Other historical events of adaptive trial designs and master protocols are discussed in this chapter.

Keywords

History of clinical trialsECMO trialplay the winneradaptive trial designsmaster protocols1948 streptomycin trialFDAprecision medicine
Type
Chapter
Information
Introduction to Adaptive Trial Designs and Master Protocols , pp. 15 - 20
Publisher: Cambridge University Press
Print publication year: 2023

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