Book contents
- Interpersonal Emotion Dynamics in Close Relationships
- Studies in Emotion and Social Interaction
- Interpersonal Emotion Dynamics in Close Relationships
- Copyright page
- Contents
- Figures
- Tables
- Contributors
- Foreword
- Introduction
- Chapter 1 Conceptual approaches to studying interpersonal emotion dynamics
- Chapter 2 A general framework for capturing interpersonal emotion dynamics
- Chapter 3 Simplifying the complexity of interpersonal emotion dynamics with regression graphics
- Chapter 4 Methodological approaches to studying interpersonal emotion dynamics
- Chapter 5 Biochemical contributions to interpersonal emotion dynamics
- Chapter 6 Physiological correlates associated with interpersonal emotion dynamics
- Chapter 7 Interpersonal emotion dynamics in families
- Chapter 8 Interpersonal emotion dynamics within young adult romantic and peer relationships
- Chapter 9 Interpersonal emotion dynamics within intimate relationships
- Chapter 10 Next steps toward understanding interpersonal emotion dynamics
- Author Index
- Subject Index
- Studies in Emotion and Social Interaction
- References
Chapter 5 - Biochemical contributions to interpersonal emotion dynamics
Published online by Cambridge University Press: 14 September 2018
Book contents
- Interpersonal Emotion Dynamics in Close Relationships
- Studies in Emotion and Social Interaction
- Interpersonal Emotion Dynamics in Close Relationships
- Copyright page
- Contents
- Figures
- Tables
- Contributors
- Foreword
- Introduction
- Chapter 1 Conceptual approaches to studying interpersonal emotion dynamics
- Chapter 2 A general framework for capturing interpersonal emotion dynamics
- Chapter 3 Simplifying the complexity of interpersonal emotion dynamics with regression graphics
- Chapter 4 Methodological approaches to studying interpersonal emotion dynamics
- Chapter 5 Biochemical contributions to interpersonal emotion dynamics
- Chapter 6 Physiological correlates associated with interpersonal emotion dynamics
- Chapter 7 Interpersonal emotion dynamics in families
- Chapter 8 Interpersonal emotion dynamics within young adult romantic and peer relationships
- Chapter 9 Interpersonal emotion dynamics within intimate relationships
- Chapter 10 Next steps toward understanding interpersonal emotion dynamics
- Author Index
- Subject Index
- Studies in Emotion and Social Interaction
- References
Summary
Much like the early days of emotion research, study of the connections between biochemistry and emotion has largely examined these processes in intrapersonal contexts. This chapter highlights research on biochemistry and emotion with clear implications for interpersonal emotion dynamics and highlights the importance of considering the interpersonal context. To do so, we focus on two biochemical systems,: the serotonin system and the immune system, especially inflammation. A particular focus is on the effects of acetaminophen, which alters both central serotonin and inflammatory signaling. Based on work in the intrapersonal context, both systems affect reactivity to positive and negative events and both systems affect empathy, a core interpersonal emotional process. Underscoring the importance of moving biochemical emotions research into an interpersonal context, the direction of emotional effects of these systems appears to be context dependent. For example, much work indicates that inflammation decreases positive emotion, but recent work in an interpersonal context suggests that inflammation can increase positive reactivity when interacting with close others. Thus, we see the interpersonal context as a critical factor for understanding the relationship between biochemistry and emotion. Greater attention to the interpersonal context is likely to lead to advances in understanding of relationships, emotions, biochemistry, and health.
- Type
- Chapter
- Information
- Interpersonal Emotion Dynamics in Close Relationships , pp. 93 - 109Publisher: Cambridge University PressPrint publication year: 2018
References
Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001). The “Reading the Mind in the Eyes” test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry, 42(2), 241–51.CrossRefGoogle ScholarPubMed
Barrett, L. F. (2013). Psychological construction: the Darwinian approach to the science of emotion. Emotion Review, 5(4), 379–89.CrossRefGoogle Scholar
Belsky, J. (1997). Variation in susceptibility to environmental influence: an evolutionary argument. Psychological Inquiry, 8(3), 182–6.Google Scholar
Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: differential susceptibility to environmental influences. Psychological Bulletin, 135(6), 885–908.Google Scholar
Capuron, L., & Miller, A. H. (2004). Cytokines and psychopathology: lessons from interferon-alpha. Biological Psychiatry, 56(11), 819–24.Google Scholar
Caspi, A., Sugden, K., Moffitt, T. E., et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386–9.Google Scholar
Cloninger, C. R. (1987). A systematic method for clinical description and classification of personality variants: a proposal. Archives of General Psychiatry, 44(6), 573–88.Google Scholar
Crockett, M. J., Clark, L., Hauser, M. D., & Robbins, T. W. (2010). Serotonin selectively influences moral judgment and behavior through effects on harm aversion. Proceedings of the National Academy of Sciences, 107(40), 17433–8.Google Scholar
Culverhouse, R. C., Saccone, N. L., Horton, A. C., et al. (2018). Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry. 23, 133–42Google Scholar
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008). From inflammation to sickness and depression: when the immune system subjugates the brain. Nature Reviews Neuroscience, 9(1), 46–56.Google Scholar
Durso, G. R. O., Luttrell, A., & Way, B. M. (2015). Over-the-counter relief from pains and pleasures alike: acetaminophen blunts evaluation sensitivity to both negative and positive stimuli. Psychological Science, 26(6), 750–8.Google Scholar
Eisenberger, N. I., Inagaki, T. K., Rameson, L. T., Mashal, N. M., & Irwin, M. R. (2009). An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences. Neuroimage, 47(3), 881–90.Google Scholar
Eisenberger, N. I., Berkman, E. T., Inagaki, T. K., et al. (2010). Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biological Psychiatry, 68(8), 748–54.Google Scholar
Eisenberger, N. I., Inagaki, T. K., Mashal, N. M., & Irwin, M. R. (2010). Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain, Behavior, and Immunity, 24(4), 558–63.Google Scholar
Ekman, P. (1992). An argument for basic emotions. Cognition & Emotion, 6(3–4), 169–200.CrossRefGoogle Scholar
Feeney, B. C., & Collins, N. L. (2015). A new look at social support: a theoretical perspective on thriving through relationships. Personality and Social Psychology Review, 19, 113–47.Google Scholar
Graham, G. G., Davies, M. J., Day, R. O., Mohamudally, A., & Scott, K. F. (2013). The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology, 21(3), 201–32.Google Scholar
Grigoleit, J.-S., Kullmann, J. S., Wolf, O. T., et al. (2011). Dose-dependent effects of endotoxin on neurobehavioral functions in humans. PloS One, 6(12), e28330.CrossRefGoogle ScholarPubMed
Gyurak, A., Haase, C. M., Sze, J., et al. (2013). The effect of the serotonin transporter polymorphism (5-HTTLPR) on empathic and self-conscious emotional reactivity. Emotion, 13(1), 25–35.Google Scholar
Haase, C. M., Saslow, L. R., Bloch, L., et al. (2013). The 5-HTTLPR polymorphism in the serotonin transporter gene moderates the association between emotional behavior and changes in marital satisfaction over time. Emotion, 13(6), 1068–79.Google Scholar
Hatfield, E., Cacioppo, J. T., & Rapson, R. L. (1994). Emotional contagion. New York, NY: Cambridge University Press.Google Scholar
Holt-Lunstad, J., Smith, T. B., & Layton, J. B. (2010). Social relationships and mortality risk: a meta-analytic review. PLoS medicine, 7(7), e1000316.CrossRefGoogle Scholar
Howren, M. B., Lamkin, D. M., & Suls, J. (2009). Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosomatic Medicine, 71(2), 171–86.Google Scholar
Hysek, C. M., Schmid, Y., Simmler, L. D., et al. (2014). MDMA enhances emotional empathy and prosocial behavior. Social Cognitive and Affective Neuroscience, 9(11), 1645–52.Google Scholar
Inagaki, T. K., Muscatell, K. A., Irwin, M. R., Cole, S. W., & Eisenberger, N. I. (2012). Inflammation selectively enhances amygdala activity to socially threatening images. Neuroimage, 59(4), 3222–6.Google Scholar
Inagaki, T. K., Muscatell, K. A., Irwin, M. R., et al. (2015). The role of the ventral striatum in inflammatory-induced approach toward support figures. Brain, Behavior, and Immunity, 44, 247–52.CrossRefGoogle ScholarPubMed
Kemp, A. H., & Nathan, P. J. (2004). Acute augmentation of serotonin suppresses cardiovascular responses to emotional valence. The International Journal of Neuropsychopharmacology, 7(1), 65–70.Google Scholar
Kiecolt-Glaser, J. K., Loving, T. J., Stowell, J. R., et al. (2005). Hostile marital interactions, proinflammatory cytokine production, and wound healing. Archives of General Psychiatry, 62(12), 1377–84.Google Scholar
Kiecolt-Glaser, J. K., & Newton, T. L. (2001). Marriage and health: his and hers. Psychological Bulletin, 127(4), 472–503.Google Scholar
Lesch, K. P., Bengel, D., Heils, A., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274(5292), 1527–31.Google Scholar
Ma, Y. (2015). Neuropsychological mechanism underlying antidepressant effect: a systematic meta-analysis. Molecular Psychiatry, 20(3), 311–19.Google Scholar
McCabe, C., Mishor, Z., Cowen, P. J., & Harmer, C. J. (2010). Diminished neural processing of aversive and rewarding stimuli during selective serotonin reuptake inhibitor treatment. Biological Psychiatry, 67(5), 439–45.CrossRefGoogle ScholarPubMed
Mechan, A. O., Esteban, B., O'Shea, E., et al. (2002). The pharmacology of the acute hyperthermic response that follows administration of 3, 4-methylenedioxymethamphetamine (MDMA,‘ecstasy’) to rats. British Journal of Pharmacology, 135(1), 170–80.Google Scholar
Miller, R., Wankerl, M., Stalder, T., Kirschbaum, C., & Alexander, N. (2013). The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cortisol stress reactivity: a meta-analysis. Molecular Psychiatry, 18(9), 1018–24.Google Scholar
Mischkowski, D., Crocker, J., & Way, B. M. (2016). From painkiller to empathy killer: acetaminophen (paracetamol) reduces empathy for pain. Social Cognitive and Affective Neuroscience, 11(9), 1345–53.Google Scholar
Moieni, M., Irwin, M. R., Jevtic, I., Breen, E. C., & Eisenberger, N. I. (2015). Inflammation impairs social cognitive processing: a randomized controlled trial of endotoxin. Brain, Behavior, and Immunity, 48, 132–8.Google Scholar
O'Connor, M.-F., Irwin, M. R., & Wellisch, D. K. (2009). When grief heats up: pro-inflammatory cytokines predict regional brain activation. NeuroImage, 47(3), 891–96.CrossRefGoogle ScholarPubMed
Owens, M. J., Knight, D. L., & Nemeroff, C. B. (2001). Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biological Psychiatry, 50(5), 345–50.Google Scholar
Pérez-Edgar, K., Bar-Haim, Y., McDermott, J. M., et al. (2010). Variations in the serotonin-transporter gene are associated with attention bias patterns to positive and negative emotion faces. Biological Psychology, 83(3), 269–71.Google Scholar
Pini, L. A., Sandrini, M., & Vitale, G. (1996). The antinociceptive action of paracetamol is associated with changes in the serotonergic system in the rat brain. European Journal of Pharmacology, 308(1), 31–40.Google Scholar
Price, J., Cole, V., & Goodwin, G. M. (2009). Emotional side-effects of selective serotonin reuptake inhibitors: qualitative study. The British Journal of Psychiatry, 195(3), 211–17.Google Scholar
Raison, C. L., Capuron, L., & Miller, A. H. (2006). Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends in Immunology, 27(1), 24–31.CrossRefGoogle ScholarPubMed
Randall, A. K., & Schoebi, D. (2015). Lean on me: susceptibility to partner affect attenuates psychological distress over a 12-month period. Emotion, 15(2), 201–10.CrossRefGoogle Scholar
Schmid, Y., Hysek, C. M., Simmler, L. D., et al. (2014). Differential effects of MDMA and methylphenidate on social cognition. Journal of Psychopharmacology, 28(9), 847–56.Google Scholar
Schoebi, D. (2008). The coregulation of daily affect in marital relationships. Journal of Family Psychology, 22(4), 595–604.Google Scholar
Schoebi, D., Way, B. M., Karney, B. R., & Bradbury, T. N. (2012). Genetic moderation of sensitivity to positive and negative affect in marriage. Emotion, 12(2), 208–12.Google Scholar
Sharpley, C. F., Palanisamy, S. K. A., Glyde, N. S., Dillingham, P. W., & Agnew, L. L. (2014). An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings. Behavioural Brain Research, 273, 89–105.Google Scholar
Smith, C. A., & Ellsworth, P. C. (1985). Patterns of cognitive appraisal in emotion. Journal of Personality and Social Psychology, 48(4), 813.Google Scholar
Uchino, B. N., & Way, B. M. (2017). Integrative pathways linking close family ties to health: a neurochemical perspective. The American Psychologist, 72(6), 590–600.Google Scholar
van Ijzendoorn, M. H., Belsky, J., & Bakermans-Kranenburg, M. J. (2012). Serotonin transporter genotype 5HTTLPR as a marker of differential susceptibility? A meta-analysis of child and adolescent gene-by-environment studies. Translational Psychiatry, 2, e147.Google Scholar
Vane, J. R. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature: New Biology, 231(25), 232–5.Google Scholar
Wardle, M. C., & de Wit, H. (2014). MDMA alters emotional processing and facilitates positive social interaction. Psychopharmacology, 231(21), 4219–29.CrossRefGoogle ScholarPubMed
Way, B. M., Brown, K. W., Quaglia, J., McCain, N., & Taylor, S. E. (2016). Nonsynonymous HTR2C polymorphism predicts cortisol response to psychosocial stress II: evidence from two samples. Psychoneuroendocrinology, 70, 142–51.Google Scholar
Way, B. M., & Gurbaxani, B. M. (2008). A genetics primer for social health research. Social and Personality Psychology Compass, 2(2), 785–816.Google Scholar
Way, B. M., & Taylor, S. E. (2010a). The serotonin transporter promoter polymorphism is associated with cortisol response to psychosocial stress. Biological Psychiatry, 67(5), 487–92.CrossRefGoogle ScholarPubMed
Way, B. M., & Taylor, S. E. (2010b). Social influences on health: is serotonin a critical mediator? Psychosomatic Medicine, 72(2), 107–12.Google Scholar
Wondra, J. D., & Ellsworth, P. C. (2015). An appraisal theory of empathy and other vicarious emotional experiences. Psychological Review, 122(3), 411–28.Google Scholar
- 1
- Cited by