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Chapter 27 - Focused Ultrasound in Parkinson’s Disease

from Section 2: - Hypokinetic Movement Disorders

Published online by Cambridge University Press:  07 January 2025

By
Ann-Kristin Helmers ,
Lennart H. Stieglitz  and
Beat Werner
Edited by
Erik Ch. Wolters  and
Christian R. Baumann
Erik Ch. Wolters
Affiliation:
Universität Zürich
Christian R. Baumann
Affiliation:
Universität Zürich
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Summary

Magnetic resonance-guided focused ultrasound (MRgHiFUS) can be used to create lesions in the depth of the brain without opening the skull, which opens up new treatment options. For patients who are not eligible for deep brain stimulation (DBS) for various reasons (for example, too much atrophy, vessels in the area of the trajectory, or advanced age) this can be a useful addition to the therapeutic armamentarium. To date, more than 3,500 patients have been treated with this method, with a focus on patients with essential tremor (ET) and tremor-dominant Parkinson’s disease (PD).

Keywords

PiezoelectricitythermographyMRgHiFUSclosed loop image guidancecavitationtargets
Type
Chapter
Information
International Compendium of Movement Disorders , pp. 328 - 338
Publisher: Cambridge University Press
Print publication year: 2025

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References

Harary, M, Segar, DJ, Huang, KT, et al. Focused ultrasound in neurosurgery: a historical perspective. Neurosurg Focus 2018;44(2):E2.CrossRefGoogle ScholarPubMed
Meyers, R, Fry, WJ, Fry, FJ, et al. Early experiences with ultrasonic irradiation of the pallidofugal and nigral complexes in hyperkinetic and hypertonic disorders. J Neurosurg 1959;16(1):32–54.CrossRefGoogle ScholarPubMed
Hynynen, K, Jolesz, FA. Demonstration of potential noninvasive ultrasound brain therapy through an intact skull. Ultrasound Med Biol 1998;24(2):275–283.CrossRefGoogle ScholarPubMed
Cline, HE, Schenck, JF, Watkins, RD, Hynynen, K, Jolesz, FA. Magnetic resonance-guided thermal surgery. Magn Reson Med 1993;30(1):98–106.CrossRefGoogle ScholarPubMed
Cline, HE, Hynynen, K, Hardy, CJ, et al. MR temperature mapping of focused ultrasound surgery. Magn Reson Med 1994;31(6):628–636.CrossRefGoogle ScholarPubMed
Martin, E, Jeanmonod, D, Morel, A, Zadicario, E, Werner, B. High-intensity focused ultrasound for noninvasive functional neurosurgery. Ann Neurol 2009;66(6):858–861.CrossRefGoogle ScholarPubMed
McDannold, N, Clement, GT, Black, P, Jolesz, F, Hynynen, K. Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery 2010;66(2):323–332; discussion 332.CrossRefGoogle ScholarPubMed
Elias, WJ, Lipsman, N, Ondo, WG, et al. A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl J Med 2016;375(8):730–739.CrossRefGoogle ScholarPubMed
Lynn, JG, Zwemer, RL, Chick, AJ. The biological application of focused untrasonic waves. Science 1942;96(2483):119–120.CrossRefGoogle Scholar
Schwartz, ML, Yeung, R, Huang, Y, et al. Skull bone marrow injury caused by MR-guided focused ultrasound for cerebral functional procedures. J Neurosurg 2018;130(3):758–762.CrossRefGoogle ScholarPubMed
Clement, GT, Hynynen, K. A non-invasive method for focusing ultrasound through the human skull. Phys Med Biol 2002;47(8):1219–1236.CrossRefGoogle ScholarPubMed
Jolesz, FA, Hynynen, K, McDannold, N, Tempany, C. MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery. Magn Reson Imaging Clin N Am 2005;13(3):545–560.CrossRefGoogle ScholarPubMed
Ishihara, Y, Calderon, A, Watanabe, H, et al. A precise and fast temperature mapping using water proton chemical shift. Magn Reson Med 1995;34(6):814–823.CrossRefGoogle ScholarPubMed
Sapareto, SA, Dewey, WC. Thermal dose determination in cancer therapy. Int J Radiat Oncol Biol Phys 1984;10(6):787–800.CrossRefGoogle ScholarPubMed
Chen, H, Brayman, AA, Bailey, MR, Matula, TJ. Blood vessel rupture by cavitation. Urol Res 2010;38(4):321–326.CrossRefGoogle ScholarPubMed
Fishman, PS, Elias, WJ, Ghanouni, P, et al. Neurological adverse event profile of magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor. Mov Disord 2018;33(5):843–847.CrossRefGoogle ScholarPubMed
Gallay, MN, Moser, D, Jeanmonod, D. Safety and accuracy of incisionless transcranial MR-guided focused ultrasound functional neurosurgery: single-center experience with 253 targets in 180 treatments. J Neurosurg 2018;130(4):1234–1248.CrossRefGoogle ScholarPubMed
Alshaikh, J, Fishman, PS. Revisiting bilateral thalamotomy for tremor. Clin Neurol Neurosurg 2017;158:103–107.CrossRefGoogle ScholarPubMed
Martínez-Fernández, R, Mahendran, S, Pineda-Pardo, JA, et al. Bilateral staged magnetic resonance-guided focused ultrasound thalamotomy for the treatment of essential tremor: a case series study. J Neurol Neurosurg Psychiatry 2021;92(9):927–937.CrossRefGoogle ScholarPubMed
Bond, AE, Shah, BB, Huss, DS, et al. Safety and efficacy of focused ultrasound thalamotomy for patients with medication-refractory, tremor-dominant Parkinson disease: a randomized clinical trial. JAMA Neurol 2017;74(12):1412–1418.CrossRefGoogle ScholarPubMed
Miller, TR, Guo, S, Melhem, ER, et al. Predicting final lesion characteristics during MR-guided focused ultrasound pallidotomy for treatment of Parkinson’s disease. J Neurosurg 2020;134(3):1083–1090.CrossRefGoogle ScholarPubMed
Eisenberg, HM, Krishna, V, Elias, WJ, et al. MR-guided focused ultrasound pallidotomy for Parkinson’s disease: safety and feasibility. J Neurosurg 2020;135(3):792–798.CrossRefGoogle ScholarPubMed
Máñez-Miró, JU, Rodríguez-Rojas, R, Del Álamo, M, Martínez-Fernández, R, Obeso, JA. Present and future of subthalamotomy in the management of Parkinson´s disease: a systematic review. Expert Rev Neurother 2021;21(5):533–545.CrossRefGoogle ScholarPubMed
Martínez-Fernández, R, Máñez-Miró, JU, Rodríguez-Rojas, R, et al. Randomized trial of focused ultrasound subthalamotomy for Parkinson’s disease. N Engl J Med 2020;383(26):2501–2513.CrossRefGoogle ScholarPubMed
McDannold, N, White, PJ, Cosgrove, R. Predicting bone marrow damage in the skull after clinical transcranial MRI-guided focused ultrasound with acoustic and thermal simulations. IEEE Trans Med Imaging 2020;39(10):3231–3239.CrossRefGoogle ScholarPubMed
Iorio-Morin, C, Yamamoto, K, Sarica, C, et al. Bilateral focused ultrasound thalamotomy for essential tremor (BEST-FUS Phase 2 Trial). Mov Disord 2021;36(11):2653–2662.CrossRefGoogle ScholarPubMed
Schlesinger, I, Eran, A, Sinai, A, et al. MRI guided focused ultrasound thalamotomy for moderate-to-severe tremor in Parkinson’s disease. Parkinsons Dis 2015;2015:219149.Google ScholarPubMed
Zaaroor, M, Sinai, A, Goldsher, D, et al. Magnetic resonance-guided focused ultrasound thalamotomy for tremor: a report of 30 Parkinson’s disease and essential tremor cases. J Neurosurg 2018;128(1):202–210.CrossRefGoogle ScholarPubMed
Fasano, A, Llinas, M, Munhoz, RP, et al. MRI-guided focused ultrasound thalamotomy in non-ET tremor syndromes. Neurology 2017;89(8):771–775.CrossRefGoogle ScholarPubMed
Ito, H, Fukutake, S, Yamamoto, K, et al. Magnetic resonance imaging-guided focused ultrasound thalamotomy for Parkinson’s disease. Intern Med 2018;57(7):1027–1031.CrossRefGoogle ScholarPubMed
Martínez-Fernández, R, Rodríguez-Rojas, R, Del Álamo, M, et al. Focused ultrasound subthalamotomy in patients with asymmetric Parkinson’s disease: a pilot study. Lancet Neurol 2018;17(1):54–63.CrossRefGoogle ScholarPubMed
Jung, NY, Park, CK, Kim, M, et al. The efficacy and limits of magnetic resonance-guided focused ultrasound pallidotomy for Parkinson’s disease: a Phase I clinical trial. J Neurosurg 2018 Aug 1;1–9.Google Scholar
Magara, A, Bühler, R, Moser, D, et al. First experience with MR-guided focused ultrasound in the treatment of Parkinson’s disease. J Ther Ultrasound 2014;2:11.CrossRefGoogle ScholarPubMed
Gallay, MN, Moser, D, Rossi, F, et al. MRgFUS pallidothalamic tractotomy for chronic therapy-resistant Parkinson’s disease in 51 consecutive patients: single center experience. Front Surg 2019;6:76.CrossRefGoogle ScholarPubMed
Gallay, MN, Moser, D, Magara, AE, Haufler, F, Jeanmonod, D. Bilateral MR-guided focused ultrasound pallidothalamic tractotomy for Parkinson’s disease with 1-year follow-up. Front Neurol 2021;12:601153.CrossRefGoogle ScholarPubMed
Iacopino, DG, Gagliardo, C, Giugno, A, et al. Preliminary experience with a transcranial magnetic resonance-guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson’s disease. Neurosurg Focus 2018;44(2):E7.CrossRefGoogle Scholar
Fasano, A, De Vloo, P, Llinas, M, et al. Magnetic resonance imaging-guided focused ultrasound thalamotomy in Parkinson tremor: reoperation after benefit decay. Mov Disord 2018;33(5):848–849.CrossRefGoogle ScholarPubMed
Chen, X, Wang, F, Chen, Q, Qin, XC, Li, Z. Analysis of neurotoxin 3-N-oxalyl-l-2,3-diaminopropionic acid and its alpha-isomer in Lathyrus sativus by high-performance liquid chromatography with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatization. J Agric Food Chem 2000;48(8):3383–3386.CrossRefGoogle ScholarPubMed
Foffani, G, Trigo-Damas, I, Pineda-Pardo, JA, et al. Focused ultrasound in Parkinson’s disease: a twofold path toward disease modification. Mov Disord 2019;34(9):1262–1273.CrossRefGoogle ScholarPubMed
Samiotaki, G, Acosta, C, Wang, S, Konofagou, EE. Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound-mediated blood–brain barrier opening in vivo. J Cereb Blood Flow Metab 2015;35(4):611–622.CrossRefGoogle ScholarPubMed
Rezai, AR, Ranjan, M, D’Haese, PF, et al. Noninvasive hippocampal blood–brain barrier opening in Alzheimer’s disease with focused ultrasound. Proc Natl Acad Sci U S A 2020;117(17):9180–9182.CrossRefGoogle ScholarPubMed
Gasca-Salas, C, Fernández-Rodríguez, B, Pineda-Pardo, JA, et al. Blood–brain barrier opening with focused ultrasound in Parkinson’s disease dementia. Nat Commun 2021;12(1):779.CrossRefGoogle ScholarPubMed
Zhan, W. Effects of focused-ultrasound-and-microbubble-induced blood–brain barrier disruption on drug transport under liposome-mediated delivery in brain tumour: a pilot numerical simulation study. Pharmaceutics 2020;12(1):E69.CrossRefGoogle ScholarPubMed
Quadri, SA, Waqas, M, Khan, I, et al. High-intensity focused ultrasound: past, present, and future in neurosurgery. Neurosurg Focus 2018;44(2):E16.CrossRefGoogle ScholarPubMed

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