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Chapter 51 - Drug-Induced Movement Disorders

from Section 4: - Dyscoordinative and Otherwise Inappropriate Motor Behaviors

Published online by Cambridge University Press:  07 January 2025

By
Umer Akbar  and
Joseph H. Friedman
Edited by
Erik Ch. Wolters  and
Christian R. Baumann
Erik Ch. Wolters
Affiliation:
Universität Zürich
Christian R. Baumann
Affiliation:
Universität Zürich
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Summary

This chapter provides an overview of legal drug-induced (neuroleptic and non-neuroleptic) movement disorders. Awareness of medications causing involuntary movements is critical to determine the appropriate treatment strategy. Certain movement disorders that are not typically associated with a central nervous system lesion (e.g., akathisia, tics, etc.) often do not require extensive testing beyond obtaining a thorough history and a neurologic exam, but other abnormal movements (e.g., ataxia, myoclonus, etc.) that are often caused by structural lesions may require neuroimaging for exclusion of an alternate etiology. In this chapter, we include all commonly used legal (marketed) drugs that have been implicated to induce movement disorders; nevertheless, due to the countless case reports, as well as the growing, endless list of such medications, our survey undoubtedly falls short on some compounds. The illegal parkinsonism-inducing drugs (street drugs) are discussed in Chapter 35.

Keywords

(Non)neuroleptic drug–induced dyskinesianeuroleptic malignant syndromedystonia/akathisia/ataxia/myoclonus/RLS/RBDtardive and tardive-like syndromes
Type
Chapter
Information
International Compendium of Movement Disorders , pp. 642 - 650
Publisher: Cambridge University Press
Print publication year: 2025

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