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3.7.5 - Multiple Organ Dysfunction Syndrome

from Section 3.7 - Infection and Immunity

Published online by Cambridge University Press:  27 July 2023

By
Ravi Bhatia
Edited by
Ned Gilbert-Kawai ,
Debashish Dutta  and
Carl Waldmann
Ned Gilbert-Kawai
Affiliation:
The Royal Liverpool Hospital
Debashish Dutta
Affiliation:
Princess Alexandra Hospital NHS Trust, Harlow
Carl Waldmann
Affiliation:
Royal Berkshire Hospital, Reading
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Summary

Key Learning Points

  1. 1. Multiple organ dysfunction syndrome (MODS) is a complex biological process in which an acute injury leads to sequential organ dysfunction.

  2. 2. The pathogenesis of MODS is still poorly understood but thought to be due to a dysregulated pro- and anti-inflammatory response to illness.

  3. 3. The clinical features of MODS comprise systemic inflammatory response syndrome plus sequential organ failure over hours or days.

  4. 4. To date, no clinical treatments have been shown to be beneficial in specifically treating MODS.

  5. 5. Evidence-based supportive care, alongside management of the underlying illness, is the current mainstay of treatment.

Keywords

inflammatory responsesepsisorgan failureimmune dysregulation
Type
Chapter
Information
Intensive Care Medicine
The Essential Guide
 , pp. 257 - 258
Publisher: Cambridge University Press
Print publication year: 2021

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References

References and Further Reading

Marshall, JC. Measuring organ dysfunction. Med Klin Intensivmed Notfmed 2020;115(Suppl 1):15–20.CrossRefGoogle ScholarPubMed
Ramírez, M. Multiple organ dysfunction syndrome. Curr Probl Pediatr Adolesc Health Care 2013;43:273–7.Google Scholar
Singer, M. The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence 2014;5:66–72.CrossRefGoogle ScholarPubMed
Varela, ML, Mogildea, M, Moreno, I, et al. Acute inflammation and metabolism. Inflammation 2018;41:1115–27.Google Scholar

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