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Section 4 - Invasive Investigation of Insular Epilepsy

Published online by Cambridge University Press:  09 June 2022

Edited by
Dang Nguyen ,
Jean Isnard  and
Philippe Kahane
Dang Nguyen
Affiliation:
Université de Montréal
Jean Isnard
Affiliation:
Claude Bernard University Lyon
Philippe Kahane
Affiliation:
Grenoble-Alpes University Hospital
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Insular Epilepsies , pp. 203 - 256
Publisher: Cambridge University Press
Print publication year: 2022

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References

References

Afif, A., Chabardes, S., Minotti, L., Kahane, P., and Hoffmann, D. (2008). “Safety and usefulness of insular depth electrodes implanted via an oblique approach in patients with epilepsy.” Operative Neurosurgery 62: ONS471–ONS480.CrossRefGoogle ScholarPubMed
Barba, C., Barbati, G., Minotti, L., Hoffmann, D., and Kahane, P. (2007). “Ictal clinical and scalp-EEG findings differentiating temporal lobe epilepsies from temporal ‘plus’ epilepsies.” Brain 130(pt 7): 1957–1967.Google Scholar
Barba, C., Rheims, S., Minotti, L., Guénot, M., Hoffmann, D., Chabardès, S., Isnard, J., Kahane, P., and Ryvlin, P. (2016). “Reply: Temporal plus epilepsy is a major determinant of temporal lobe surgery failures.” Brain 139(7): e36.Google Scholar
Cardinale, F., Cossu, M., Castana, L., Casaceli, G., Schiariti, M. P., Miserocchi, A., Fuschillo, D., Moscato, A., Caborni, C., Arnulfo, G., and Lo Russo, G. (2013). “Stereoelectroencephalography.” Neurosurgery 72(3): 353–366.Google Scholar
Catenoix, H., Mauguière, F., Montavont, A., Ryvlin, P., Guénot, M., and Isnard, J. (2015). “Seizures outcome after stereoelectroencephalography-guided thermocoagulations in malformations of cortical development poorly accessible to surgical resection.” Neurosurgery 77(1): 9–15.Google Scholar
Cossu, M., Cardinale, F., Castana, L., Citterio, A., Francione, S., Tassi, L., Benabid, A. L., and Lo Russo, G. (2005). “Stereoelectroencephalography in the presurgical evaluation of focal epilepsy: A retrospective analysis of 215 procedures.” Neurosurgery 57(4): 706–718.CrossRefGoogle ScholarPubMed
de Almeida, A. N., Olivier, A., Quesney, F., Dubeau, F., Savard, G., and Andermann, F. (2006). “Efficacy of and morbidity associated with stereoelectroencephalography using computerized tomography – or magnetic resonance imaging–guided electrode implantation.” Journal of Neurosurgery 104(4): 483–487.CrossRefGoogle ScholarPubMed
Dobesberger, J., Ortler, M., Unterberger, I., Walser, G., Falkenstetter, T., Bodner, T., Benke, T., Bale, R., Fiegele, T., Donnemiller, E., Gotwald, T., and Trinka, E. (2008). “Successful surgical treatment of insular epilepsy with nocturnal hypermotor seizures.” Epilepsia 49(1): 159–162.CrossRefGoogle ScholarPubMed
Duffau, H., Kujas, M., and Taillandier, L. (2006). “Episodic nocturnal wandering in a patient with epilepsy due to a right temporoinsular low-grade glioma: relief following resection. Case report.” J Neurosurg 104(3): 436–439.CrossRefGoogle Scholar
Dylgjeri, S., Taussig, D., Chipaux, M., Lebas, A., Fohlen, M., Bulteau, C., Ternier, J., Ferrand-Sorbets, S., Delalande, O., Isnard, J., and Dorfmuller, G. (2014). “Insular and insulo-opercular epilepsy in childhood: an SEEG study.” Seizure 23(4): 300–308.Google Scholar
Geevasinga, N., Archer, J. S., and Ng, K. (2014). “Choking, asphyxiation and the insular seizure.” J Clin Neurosci 21(4): 688–689.CrossRefGoogle ScholarPubMed
Gibbs, S. A., Figorilli, M., Casaceli, G., Proserpio, P., and Nobili, L. (2015). “Sleep related hypermotor seizures with a right parietal onset.” Journal of Clinical Sleep Medicine 11(8): 953–955.Google Scholar
Gonzalez-Martinez, J., Bulacio, J., Alexopoulos, A., Jehi, L., Bingaman, W., and Najm, I. (2012). “Stereoelectroencephalography in the ‘difficult to localize’ refractory focal epilepsy: Early experience from a North American epilepsy center.” Epilepsia 54(2): 323–330.Google Scholar
Guenot, M., Isnard, J., Ryvlin, P., Fischer, C., Ostrowsky, K., Mauguiere, F., and Sindou, M. (2001). “Neurophysiological monitoring for epilepsy surgery: The Talairach SEEG method.” Stereotactic and Functional Neurosurgery 77(1–4): 29–32.CrossRefGoogle ScholarPubMed
Isnard, J. (2009). “[Insular epilepsy: A model of cryptic epilepsy. The Lyon experience].” Rev Neurol (Paris) 165(10): 746–749.CrossRefGoogle Scholar
Isnard, J., Guenot, M., Ostrowsky, K., Sindou, M., and Mauguiere, F. (2000). “The role of the insular cortex in temporal lobe epilepsy.” Ann Neurol 48(4): 614–623.Google Scholar
Isnard, J., Guenot, M., Sindou, M., and Mauguiere, F. (2004). “Clinical manifestations of insular lobe seizures: a stereo-electroencephalographic study.” Epilepsia 45(9): 1079–1090.CrossRefGoogle ScholarPubMed
Kaido, T., Otsuki, T., Nakama, H., and Kaneko, Y. (2006). “Hypermotor seizure arising from insular cortex.” Epilepsia 47(9): 1587–1588.Google Scholar
Makrythanasis, P., Behr, C., Baulac, S., Hirsch, E., and Picard, F. (2016). “Choking fits during sleep related to epilepsy.” American Journal of Medicine 129(8): e137–e138.Google Scholar
Montavont, A., Kahane, P., Catenoix, H., Ostrowsky-Coste, K., Isnard, J., Guénot, M., Rheims, S., and Ryvlin, P. (2013). “Hypermotor seizures in lateral and mesial parietal epilepsy.” Epilepsy & Behavior 28(3): 408–412.Google Scholar
Montavont, A., Mauguiere, F., Mazzola, L., Garcia-Larrea, L., Catenoix, H., Ryvlin, P., and Isnard, J. (2015). “On the origin of painful somatosensory seizures.” Neurology 84(6): 594–601.CrossRefGoogle ScholarPubMed
Nesbitt, A. D., Kosky, C. A., and Leschziner, G. D. (2013). “Insular seizures causing sleep-related breathlessness.” Lancet 382(9906): 1756.CrossRefGoogle ScholarPubMed
Nishibayashi, H., Ogura, M., Taguchi, M., Miki, J., Uematsu, Y., and Itakura, T. (2009). “Nondominant parietotemporal cortical dysplasia manifesting as hypermotor seizures.” Epilepsy & Behavior 14(4): 691–695.CrossRefGoogle ScholarPubMed
Nobili, L., Cossu, M., Mai, R., Tassi, L., Cardinale, F., Castana, L., Citterio, A., Sartori, I., Lo Russo, G., and Francione, S. (2004). “Sleep-related hyperkinetic seizures of temporal lobe origin.” Neurology 62(3): 482–485.CrossRefGoogle ScholarPubMed
Penfield, W., and Faulk, M. E., Jr. (1955). “The insula; further observations on its function.” Brain 78(4): 445–470.Google Scholar
Proserpio, P., Cossu, M., Francione, S., Tassi, L., Mai, R., Didato, G., Castana, L., Cardinale, F., Sartori, I., Gozzo, F., Citterio, A., Schiariti, M., Lo Russo, G., and Nobili, L. (2011). “Insular-opercular seizures manifesting with sleep-related paroxysmal motor behaviors: a stereo-EEG study.” Epilepsia 52(10): 1781–1791.Google Scholar
Provini, F., Plazzi, G., Tinuper, P., Vandi, S., Lugaresi, E., and Montagna, P. (1999). “Nocturnal frontal lobe epilepsy: A clinical and polygraphic overview of 100 consecutive cases.” Brain 122(6): 1017–1031.Google Scholar
Rheims, S., Ryvlin, P., Scherer, C., Minotti, L., Hoffmann, D., Guenot, M., Mauguière, F., Benabid, A.-L., and Kahane, P. (2008). “Analysis of clinical patterns and underlying epileptogenic zones of hypermotor seizures.” Epilepsia 49(12): 2030–2040.Google Scholar
Robles, S. G., Gelisse, P., El Fertit, H., Tancu, C., Duffau, H., Crespel, A., and Coubes, P. (2009). “Parasagittal transinsular electrodes for stereo-EEG in temporal and insular lobe epilepsies.” Stereotact Funct Neurosurg 87(6): 368–378.Google Scholar
Roper, S. N., Levesque, M. F., Sutherling, W. W., and Engel, J. (1993). “Surgical treatment of partial epilepsy arising from the insular cortex.” Journal of Neurosurgery 79(2): 266–269.CrossRefGoogle ScholarPubMed
Ryvlin, P. (2006). “Avoid falling into the depths of the insular trap.” Epileptic Disord 8 (suppl 2): S37–S56.Google Scholar
Ryvlin, P., Cross, J. H., and Rheims, S. (2014). “Epilepsy surgery in children and adults.” Lancet Neurol 13(11): 1114–1126.Google Scholar
Ryvlin, P., and Kahane, P. (2005). “The hidden causes of surgery-resistant temporal lobe epilepsy: Extratemporal or temporal plus? Editorial review.” Current Opinion in Neurology 18(2): 125–127.Google Scholar
Ryvlin, P., Minotti, L., Demarquay, G., Hirsch, E., Arzimanoglou, A., Hoffman, D., Guenot, M., Picard, F., Rheims, S., and Kahane, P. (2006). “Nocturnal hypermotor seizures, suggesting frontal lobe epilepsy, can originate in the insula.” Epilepsia 47(4): 755–765.CrossRefGoogle ScholarPubMed
Seeck, M., Zaim, S., Chaves-Vischer, V., Blanke, O., Maeder-Ingvar, M., Weissert, M., and Roulet, E. (2003). “Ictal bradycardia in a young child with focal cortical dysplasia in the right insular cortex.” Eur J Paediatr Neurol 7(4): 177–181.Google Scholar
Silfvenius, H., Gloor, P., and Rasmussen, T. (1964). “Evaluation of insular ablation in surgical treatment of temporal lobe epilepsy.” Epilepsia 5: 307–320.CrossRefGoogle ScholarPubMed
Staack, A. M., Bilic, S., Wendling, A.-S., Scholly, J., Kraus, U., Strobl, K., Bodin, F., Zentner, J., and Steinhoff, B. J. (2011). “Hyperkinetic seizures in patients with temporal lobe epilepsy: Clinical features and outcome after temporal lobe resection.” Epilepsia 52(8): 1439–1446.CrossRefGoogle ScholarPubMed
Surbeck, W., Bouthillier, A., Weil, A. G., Crevier, L., Carmant, L., Lortie, A., Major, P., and Nguyen, D. K. (2011). “The combination of subdural and depth electrodes for intracranial EEG investigation of suspected insular (peri-Sylvian) epilepsy.” Epilepsia 52(3): 458–466.Google Scholar
Surges, R., Scott, C. A., and Walker, M. C. (2009). “Peri-ictal atrioventricular conduction block in a patient with a lesion in the left insula: case report and review of the literature.” Epilepsy Behav 16(2): 347–349.CrossRefGoogle Scholar
Tayah, T., Savard, M., Desbiens, R., and Nguyen, D. K. (2013). “Ictal bradycardia and asystole in an adult with a focal left insular lesion.” Clin Neurol Neurosurg 115(9): 1885–1887.Google Scholar
Wagner, K., Uherek, M., Horstmann, S., Kadish, N. E., Wisniewski, I., Mayer, H., Buschmann, F., Metternich, B., Zentner, J., and Schulze-Bonhage, A. (2013). “Memory outcome after hippocampus sparing resections in the temporal lobe.” Journal of Neurology, Neurosurgery & Psychiatry 84(6): 630–636.Google Scholar
Wang, L., Mathews, G. C., Whetsell, W. O., and Abou-Khalil, B. (2008). “Hypermotor seizures in patients with temporal pole lesions.” Epilepsy Research 82(1): 93–98.Google Scholar
Yu, T., Zhang, G., Wang, Y., Cai, L., Zhou, X., Du, W., and Li, Y. (2013). “Surgical treatment of hypermotor seizures originating from the temporal lobe.” Seizure 22(10): 862–866.CrossRefGoogle ScholarPubMed
Zhang, H., Yao, Q., Zhao, X., Jin, X., Wang, C., Guo, H., You, Y., Wang, H., and Gao, G. (2008). “A hypermotor seizure with a focal orbital frontal lesion originating in the insula: a case report.” Epilepsy Res 82(2–3): 211–214.CrossRefGoogle ScholarPubMed

References

Guillaume, M. and Mazars, G., “Technique de résection de l’insula dans les épilepsies insulaires,” Rev Neurol, vol. 81, pp. 900–903, 1949.Google Scholar
Guillaume, M. and Mazars, G., “Cinq cas de foyers épileptogènes insulaires opérés,” Soc Française Neurol, pp. 766–769, 1949.Google Scholar
Penfield, W. and Faulk, M., “The insula: further observations on its function,” Brain, vol. 78, pp. 445–470, 1955.Google Scholar
Guillaume, M., Mazars, G., and Mazars, Y., “Indications chirurgicales dans les épilepsies dites ‘temporalis,’” Rev Neurol, vol. 88, pp. 461–501, 1953.Google Scholar
Silfvenius, H., Gloor, P., and Rasmussen, T., “Evaluation of insular ablation in surgical treatment of temporal lobe epilepsy,” Epilepsia, vol. 5, pp. 307–320, 1964.Google Scholar
Isnard, J., Guénot, M., Sindou, M., and Mauguière, F., “Clinical manifestations of insular lobe seizures: A stereo-electroencephalographic study,” Epilepsia, vol. 45, no. 9, pp. 1079–1090, 2004.CrossRefGoogle ScholarPubMed
Talairach, J. and Bancaud, J., “Methodology of anatomo-functional stereotaxic investigations,” Prog Neurol Surg, vol. 5, pp. 297–354, 1973.Google Scholar
Guenot, M. et al., “The Talairach SEEG method. Stereoelectroencephalography. Indications, results, complications and therapeutic applications in a series of 100 consecutive cases,” Stereotact Funct Neurosurg, vol. 77, pp. 29–32, 2001.Google Scholar
Cossu, M. et al., “Stereoelectroencephalography in the presurgical evaluation of focal epilepsy: A retrospective analysis of 215 procedures,” Neurosurgery, vol. 57, no. 4, pp. 706–718, 2005.CrossRefGoogle ScholarPubMed
Isnard, J., Guénot, M., Ostrowsky, K., Sindou, M., and Mauguière, F., “The role of the insular cortex in lobe epilepsy,” Ann Neurol, vol. 48, no. 4, pp. 614–623, 2000.3.0.CO;2-S>CrossRefGoogle ScholarPubMed
Tanriover, N., Rhoton, A. L., Kawashima, M., Ulm, A. J., and Yasuda, A., “Microsurgical anatomy of the insula and the Sylvian fissure,” J Neurosurg, vol. 100, no. 5, pp. 891–922, 2004.CrossRefGoogle ScholarPubMed
Zerouali, Y., Ghaziri, J., and Nguyen, D. K., Multimodal investigation of epileptic networks: The case of insular cortex epilepsy, 1st ed, vol. 226. Elsevier B.V., 2016.Google Scholar
Jobst, B. C. et al., “The Insula and Its Epilepsies,” Epilepsy Curr, vol. 19, no. 1, pp. 11–21, 2019.Google Scholar
Laoprasert, P., Ojemann, J. G., and Handler, M. H., “Insular epilepsy surgery,” Epilepsia, vol. 58, pp. 35–45, 2017.Google Scholar
Surbeck, W. et al., “The combination of subdural and depth electrodes for intracranial EEG investigation of suspected insular (peri-Sylvian) epilepsy,” Epilepsia, vol. 52, no. 3, pp. 458–466, 2011.Google Scholar
Park, Y. S. et al., “Insular epilepsy surgery under neuronavigation guidance using depth electrode,” Child’s Nerv Syst, vol. 25, no. 5, pp. 591–597, 2009.CrossRefGoogle ScholarPubMed
Weil, A. G., Fallah, A., Lewis, E. C., and Bhatia, S., “Medically resistant pediatric insular-opercular/peri-Sylvian epilepsy. Part 1: Invasive monitoring using the parasagittal transinsular apex depth electrode,” J Neurosurg Pediatr, vol. 18, no. 5, pp. 511–522, 2016.Google Scholar
Hale, A. T. et al., “Open resection versus laser interstitial thermal therapy for the treatment of pediatric insular epilepsy,” Clin Neurosurg, vol. 85, no. 4, pp. E730–E736, 2019.Google Scholar
Perry, M. S. et al., “Magnetic resonance imaging guided laser interstitial thermal therapy as treatment for intractable insular epilepsy in children,” J Neurosurg Pediatr, vol. 20, no. 6, pp. 575–582, 2017.Google Scholar
Catenoix, H., Mauguière, F., Montavont, A., Ryvlin, P., Guénot, M., and Isnard, J., “Seizures outcome after stereoelectroencephalography-guided thermocoagulations in malformations of cortical development poorly accessible to surgical resection,” Neurosurgery, vol. 77, no. 1, pp. 9–14, 2015.CrossRefGoogle ScholarPubMed
Mullatti, N. et al., “Stereotactic thermocoagulation for insular epilepsy: Lessons from successes and failures,” Epilepsia, vol. 60, no. 8, pp. 1565–1579, 2019.CrossRefGoogle ScholarPubMed
Ahmed, R. et al., “Diagnostic evaluation and surgical management of pediatric insular epilepsy utilizing magnetoencephalography and invasive EEG monitoring,” Epilepsy Res, vol. 140, December 2017, pp. 72–81, 2018.Google Scholar
Ryvlin, P. and Kahane, P., “The hidden causes of surgery-resistant temporal lobe epilepsy: Extratemporal or temporal plus?,” Curr Opin Neurol, vol. 18, no. 2, pp. 125–127, 2005.Google Scholar
Cardinale, F., “Letter to the editor: Stereoelectroencephalography for insular-opercular/peri-Sylvian epilepsy,” J Neurosurg Pediatr, vol. 19, no. 2, pp. 271–272, 2017.Google Scholar
Isnard, J. et al., “French guidelines on stereoelectroencephalography (SEEG),” Neurophysiol Clin, vol. 48, no. 1, pp. 5–13, 2018.CrossRefGoogle ScholarPubMed
Tandon, N. et al., “Analysis of morbidity and outcomes associated with use of subdural grids vs. stereoelectroencephalography in patients with intractable epilepsy,” JAMA Neurol, vol. 76, no. 6, pp. 672–681, 2019.Google Scholar
Yan, H. et al., “Method of invasive monitoring in epilepsy surgery and seizure freedom and morbidity: A systematic review,” Epilepsia, vol. 60, no. 9, pp. 1960–1972, 2019.Google Scholar
Hader, W. J. et al., “Complications of epilepsy surgery – A systematic review of focal surgical resections and invasive EEG monitoring,” Epilepsia, vol. 54, no. 5, pp. 840–847, 2013.Google Scholar
Mullin, J. P. et al., “Is SEEG safe? A systematic review and meta-analysis of stereo-electroencephalography-related complications,” Epilepsia, vol. 57, no. 3, pp. 386–401, 2016.Google Scholar
Cardinale, F. et al., “Stereoelectroencephalography: Surgical methodology, safety, and stereotactic application accuracy in 500 procedures,” Neurosurgery, vol. 72, no. 3, pp. 353–366, 2013.CrossRefGoogle ScholarPubMed
Cardinale, F. et al., “Cerebral angiography for multimodal surgical planning in epilepsy surgery: Description of a new three-dimensional technique and literature review,” World Neurosurg, vol. 84, no. 2, pp. 358–367, 2015.Google Scholar
Cardinale, F. et al., “Stereoelectroencephalography: Retrospective analysis of 742 procedures in a single centre,” Brain, vol. 142, no. 9, pp. 2688–2704, 2019.Google Scholar
Cossu, M. et al., “Stereoelectroencephalography-guided radiofrequency thermocoagulation in the epileptogenic zone: A retrospective study on 89 cases,” J Neurosurg, vol. 123, no. 6, pp. 1358–1367, 2015.Google Scholar
Alomar, S., Mullin, J. P., Smithason, S., and Gonzalez-Martinez, J., “Indications, technique, and safety profile of insular stereoelectroencephalography electrode implantation in medically intractable epilepsy,” J Neurosurg, vol. 128, no. 4, pp. 1147–1157, 2018.Google Scholar
Bouthillier, A., Weil, A. G., Martineau, L., Letourneau-Guillon, L., and Nguyen, D., “Operculoinsular cortectomy for refractory epilepsy. Part 2: Is it safe?,” J Neurosurg, vol. 20, pp. 1–11, 2019.Google Scholar
Ikegaya, N. et al., “Surgical strategy to avoid ischemic complications of the pyramidal tract in resective epilepsy surgery of the insula: Technical case report,” J Neurosurg, vol. 128, no. 4, pp. 1173–1177, 2018.Google Scholar
Nguyen, D. K. et al., “Revisiting the role of the insula in refractory partial epilepsy,” Epilepsia, vol. 50, no. 3, pp. 510–520, 2009.Google Scholar
Tomycz, L. D., Hale, A. T., Haider, A. S., Clarke, D. F., and Lee, M. R., “Invasive insular sampling in pediatric epilepsy: A single-institution experience,” Oper Neurosurg, vol. 15, no. 3, pp. 310–317, 2018.Google Scholar
Robles, S., Gelisse, P., El Fertit, H., Tancu, C., H. Duffau, and A. Crespel, “Parasagittal transinsular electrodes for stereo- EEG in temporal and insular lobe epilepsies,” Stereotact Funct Neurosurg, vol. 87, pp. 368–378, 2009.Google Scholar
Afif, A., “Safety and usefulness of insular depth electrodes implanted via an oblique approach in patients with epilepsy,” Neurosurgery, vol. 62, no. 5, 2008.Google Scholar
Chassoux, F., Navarro, V., Catenoix, H., Valton, L., and Vignal, J., “Planning and management of SEEG,” Neurophysiol Clin Neurophysiol, vol. 45, pp. 25–37, 2018.CrossRefGoogle Scholar
Weil, A. G. et al., “Medically resistant pediatric insular-opercular/peri-Sylvian epilepsy. Part 2: Outcome following resective surgery,” J Neurosurg Pediatr, vol. 18, no. 5, pp. 523–535, 2016.Google Scholar
Bouthillier, A., Weil, A. G., Martineau, L., Létourneau-Guillon, L., and Nguyen, D. K., “Operculoinsular cortectomy for refractory epilepsy. Part 1: Is it effective?,” J Neurosurg, 2020;133:950–959Google Scholar
Cardinale, F., Casaceli, G., Raneri, F., Miller, J., and Lo Russo, G., “Implantation of stereoelectroencephalography electrodes: A systematic review,” J Clin Neurophysiol, vol. 33, no. 6, pp. 490–502, 2016.Google Scholar
Bourdillon, P. et al., “Stereotactic electroencephalography is a safe procedure, including for insular implantations,” World Neurosurg, vol. 99, pp. 353–361, 2017.Google Scholar
Cardinale, F., “Commentary: Incorporating new technology into a surgical technique: The learning curve of a single surgeon’s stereo-electroencephalography experience,” Neurosurgery, vol. 86, no. 3, pp. E290–E291, 2020.CrossRefGoogle ScholarPubMed
Bourdillon, P. et al., “Effective accuracy of stereoelectroencephalography: robotic 3D versus Talairach orthogonal approaches,” J Neurosurg, 2019;131:1938–1946.Google Scholar
Cardinale, F. et al., “A new tool for touch-free patient registration for robot-assisted intracranial surgery: Application accuracy from a phantom study and a retrospective surgical series,” Neurosurg Focus, vol. 42, no. 5, pp. 1–7, 2017.Google Scholar

References

Penfield, W, Faulk, ME, Jr. The insula; further observations on its function. Brain 1955;78(4):445–470.Google Scholar
Silfvenius, H, Gloor, P, Rasmussen, T. Evaluation of insular ablation in surgical treatment of temporal lobe epilepsy. Epilepsia 1964; 5: 307–320.Google Scholar
Isnard, J, Guénot, M, Ostrowsky, K, Sindou, M, Mauguière, F. The role of the insular cortex in temporal lobe epilepsy. Ann Neurol 2000; 48(4): 614–623.3.0.CO;2-S>CrossRefGoogle ScholarPubMed
Isnard, J, Guenot, M, Sindou, M, Mauguière, F. Clinical manifestations of insular lobe seizures: a stereo-electroencephalographic study. Epilepsia 2004; 45(9): 1079–1090.Google Scholar
Nguyen, DK, Nguyen, DB, Malak, R, Leroux, JM, Carmant, L, Saint-Hilaire, JM, Giard, N, Cossette, P, Bouthillier, A. Revisiting the role of the insula in refractory partial epilepsy. Epilepsia 2009; 50(3): 510–520.Google Scholar
von Lehe, M, Wellmer, J, Urbach, H, Schramm, J, Elger CE, and Clusmann H. Insular lesionectomy for refractory epilepsy: Management and outcome. Brain 2009; 132(pt 4): 1048–1056.Google Scholar
Zerouali, Y, Ghaziri, J, Nguyen, DK. Multimodal investigation of epileptic networks: The case of insular cortex epilepsy. Progress in Brain Research 2016; 226: 1–33.Google Scholar
Hagiwara, K, Jung, J, Bouet, R, Abdallah, C, Guénot, M, Garcia-Larrea, L, Mauguière, F, Rheims, S, Isnard, J. How can we explain the frontal presentation of insular lobe epilepsy? The impact of non-linear analysis of insular seizures. Clin Neurophysiol 2017; 128(5): 780–791.Google Scholar
Afif, A, Chabardes, S, Minotti, L, Kahane, P, Hoffmann, D. Safety and usefulness of insular depth electrodes implanted via an oblique approach in patients with epilepsy. Neurosurgery 2008; 62(5 suppl 2):ONS471–479.Google ScholarPubMed
Alomar, S, Mullin, JP, Smithason, S, Gonzalez-Martinez, J. Indications, technique, and safety profile of insular stereoelectroencephalography electrode implantation in medically intractable epilepsy. J Neurosurg 2018; 128(4): 1147–1157.Google Scholar
Salado, AL, Koessler, L, De Mijolla, G, Schmitt, E, Vignal, JP, Civit, T, Tyvaert, L, Jonas, J, Maillard, LG, Colnat-Coulbois, S. sEEG is a safe procedure for a comprehensive anatomic exploration of the Insula: a retrospective study of 108 procedures representing 254 transopercular insular electrodes. Oper Neurosurg (Hagerstown) 2018; 14:1–8.Google Scholar
Cardinale, F, Rizzi, M, Vignati, E, Cossu, M, Castana, L, d’Orio, Piergiorgio, Revay, M, Della Constanza, M, Tassi, L, Mai, R, Sartori, I, Nobilo, L, Gozzo, F, Pelliccia, V, Mariani, V, Lo Russo, G, and Francione, S. Stereoelectroencephalography: Retrospective analysis of 742 procedures in a single centre. Brain 2019: 142; 2688–2704.Google Scholar
Weil, AG, Fallah, A, Lewis, EC, Bhatia, S. Medically resistant paediatric insular-opercular / perisylvian epilepsy. Part 1: Invasive monitoring using the parasagittal transinsular apex depth electrode. J Neurosurg Pediatr. 2016; 18(5): 511–522.CrossRefGoogle ScholarPubMed
Bouthillier, A, Surbeck, W, Weil, AG, Tayah, T, Nguyen, DK. The hybrid operculo-insular electrode: a new electrode for intracranial investigation of perisylvian/insular refractory epilepsy. Neurosurgery 2012; 70(6): 1574–1580.Google Scholar
Proserpio, P, Cossu, M, Francione, S, Tassi, L, Mai, R, Didato, G, Castana, L, Cardinale, F, Sartori, I, Gozzo, F, Citterio, A, Schiariti, M, Lo Russo, G, and Nobili, L. Insular-opercular seizures manifesting with sleep-related paroxysmal motor behaviors: A stereo-EEG study. Epilepsia 2011; 52(10): 1781–1791.Google Scholar
Dobersberger, J, Ortler, M, Unterberger, I, Walser, G, Falkenstetter, T, Bodner, T, Benke, T, Bale, R, Fiegele, T, Donnemiller, E, Gotwald, T, Trinka, E. Successful surgical treatment of insular epilepsy with nocturnal hypermotor siuzures. Epilepsia 2008; 49(1): 159–162.CrossRefGoogle Scholar
Dylgjeri, S, Taussig, D, Chipaux, M, Lebas, A, Fohlen, M, Bulteau, C, Ternier, J, Ferrand-Sorbets, S, Delalande, O, Isnard, J, Dorfmüller, G. Insular and insulo-opercular epilepsy in childhood: An SEEG study. Seizure 2014; 23: 300–308.Google Scholar
Levy, A, Yen Tran, TP, Boucher, O, Bouthillier A, and Nguyen DK.Operculo-insular epilepsy: Scalp and intracranial electroencephalographic findings. Journal of Clinical Neurophysiology 2017; 34(5): 438–447.Google Scholar
Ryvlin, P, Minotti, L, Demarquay, G, Hirsch, E, Arzimanoglou, A, Hoffman, D, Guénot, M, Picard, F, Rheims, S, Kahane, P. Nocturnal hypermotor seizures, suggesting frontal lobe epilepsy, can originate in the insula. Epilepsia 2006; 47(4): 755–765.Google Scholar
Gras-Combe, G, Minotti, L, Hoffmann, D, Krainik, A, Kahane, P, Chabardes, S. Surgery for nontumoral insular epilepsy explored by stereoelectroencephalography. Neurosurgery 2016; 79: 578–588.Google Scholar
Unnwongse, K, Jehi, L, Bulacio, J, Gonzalez-Martinez, J, Najm, I. Contralateral insular involvement producing false lateralizing signs in bitemporal epilepsy: A stereo-encephalography case report. Seizure 2012; 21(10): 816–819.Google Scholar
Lacuey, N, Zonjy, B, Kahriman, ES, Marashly, A, Miller, J, Lhatoo, SD, Lüders, HO. Homotopic reciprocal functional connectivity between anterior human insulae. Brain Struct Funct 2016; 221(5): 2695–2701.Google Scholar
Morel, A, Gallay, MN, Baechler, A, Wyss, M, Gallay, DS. The human insula: Architectonic organization and postmortem MRI registration. Neuroscience 2013; 236: 117–135.CrossRefGoogle ScholarPubMed
Almashaikhi, T, Rheims, S, Jung, J, Ostrowsky-Coste, K, Montavont, A, De Bellescize, J, Arzimanoglou, A, Keo Kosal, P, Guénot, M, Bertrand, O, Ryvlin, P. Functional connectivity of insular efferences. Hum Brain Mapp 2014; 35(10): 5279–5294.Google Scholar
Ghaziri, J, Tucholka, A, Girard, G, Houde, JC, Boucher, O, Gilbert, G, Descoteaux, M, Lippé, S, Rainville, P, Nguyen, DK. The corticocortical structural connectivity of the human insula. Cereb Cortex 2017; 27(2): 1216–1228.Google Scholar
Lagarde, S, Buzori, S, Trebuchon, A, Carron, R, Scavarda, D, Milh, M, McGonigal, A, Bartolomei, F. The repertoire of seizure onset patterns in human focal epilepsies: Determinants and prognostic values. Epilepsia 2019; 60: 85–95.Google Scholar
Mullatti, N, Landré, E, Mellerio, C, Oliveira, J, Laurent, A, Tural, B, Devaux, B, Chassoux, F. Stereotactic thermocoagulation for insular epilepsy: Lessons from successes and failures. Epilepsia 2019; 60: 1565–1579.Google Scholar
Cloutman, L, Binney, R, Drakesmith, M, Parker, G, Ralph, M. The variation of function across the human insula mirrors its patterns of structural connectivity: Evidence from in vivo probabilistic tractography. NeuroImage 2012; 59: 3514–3521.CrossRefGoogle ScholarPubMed
Ghaziri, J, Tucholka, A, Girard, G, Boucher, O, Houde, JC, Descotaeux, M, Obaid, S, Gilbert, G, Rouleau, I, Nguyen, DK. Subcortical structural connectivity of insular subregions. SCIeNtIFIC RepoRTS (2018) 8: 8596.Google Scholar
Singh, R, Principe, A, Tadel, F, Hoffmann, D, Chabardes, S, Minotti, L, David, O, Kahane, P. Mapping the insula with stereo-electroencephalography: The emergence of semiology in insula lobe seizures. Submitted for publication.Google Scholar
Blauwblomme, T, Kahane, P, Minotti, L, Grouiller, F, Krainik, A, Vercueil, L, Chabardès, S, Hoffmann, D, David, O. Multimodal imaging reveals the role of gamma activity in eating reflex seizures. J Neurol Neurosurg Psychiatr 2011; 82: 1171–1173.CrossRefGoogle ScholarPubMed
Kurth, F, Zilles, K, Fox, PT, Laird, AR, Eickhoff, SB. A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis. Brain Struct Funct 2010; 214: 519–534.CrossRefGoogle ScholarPubMed
Nguyen, DK, Rouleau, I, Senechal, G, Ansaldo, AI, Gravel, M, Benfenati F, Cossette P.X-linked focal epilepsy with reflex bathing seizures: Characterization of a distinct epileptic syndrome. Epilepsia 2015; 56(7): 1098–1108.Google Scholar
Xiao, H, Yen Tran, TP, Petrin, M, Boucher, O, Mohamed, I, Boutillier, A, Nguyen, DK. Reflex operculoinsular seizures. Epileptic Disorders. 2016; 18(1): 19–25.Google Scholar
Peltola, ME, Trebucon, A, Lagarde, S, Scavarda, D, Carron, R, Metsähonkala, L, Lauronen, L, Lépine, A, Villeneuve, N, Bartolomei, F. Anatomoelectroclinical features of SEEG-confirmed pure insular-onset epilepsy. Epilepsy & Behavior 2020; 105: 106964.Google Scholar
Wang, H, McGonigal A, Zhang K, Guo Q, Zhang B, Wang X, Wang X, Lin J, Song X, Feng Q, Wang S, Wang M, Shao X, Liu X, Wang L, Zhou W. Semiologic subgroups of insulo-opercular seizures based on connectional architecture atlas. Epilepsia 2020; 61:984–9994.Google Scholar

References

Wendling, F, Benquet, P, Bartolomei, F. SEEG recordings: From signal processing to models of epileptogenic networks. In Latoo, S, Kahane, P, Luders, H (eds.), Invasive studies of the human epileptic brain, Oxford University Press: Oxford; 2019: 520–534.Google Scholar
Bartolomei, F, Nica, A, MP, Valenti-Hirsch, Adam, C, Denuelle, M. Interpretation of SEEG recordings. Neurophysiol Clin 2018;48(1):53–57.Google Scholar
Gotman, J. Automatic detection of seizures and spikes. J Clin Neurophysiol 1999;16:130–140.Google Scholar
Senhadji, L, Wendling, F. Epileptic transient detection: Wavelets and time-frequency approaches. Neurophysiol Clin 2002;32:175–192.Google Scholar
Brown, MW, III, Porter, BE, Dlugos, DJ, et al. Comparison of novel computer detectors and human performance for spike detection in intracranial EEG. Clin Neurophysiol 2007;118:1744–1752.Google Scholar
Jacobs, J, Zijlmans, M, Zelmann, R, et al. High-frequency electroencephalographic oscillations correlate with outcome of epilepsy surgery. Ann Neurol 2010;67:209–220.Google Scholar
Benar, CG, Chauviere, L, Bartolomei, F, et al. Pitfalls of high-pass filtering for detecting epileptic oscillations: a technical note on “false” ripples. Clin Neurophysiol 2010;121:301–310.Google Scholar
Staba, RJ, Wilson, CL, Bragin, A, et al. Quantitative analysis of high-frequency oscillations (80–500 Hz) recorded in human epileptic hippocampus and entorhinal cortex. J Neurophysiol 2002;88:1743–1752.Google Scholar
Gardner, AB, Worrell, GA, Marsh, E, et al. Human and automated detection of high-frequency oscillations in clinical intracranial EEG recordings. Clin Neurophysiol 2007;118:1134–1143.Google Scholar
Crepon, B, Navarro, V, Hasboun, D, et al. Mapping interictal oscillations greater than 200 Hz recorded with intracranial macroelectrodes in human epilepsy. Brain 2010;133:33–45.Google Scholar
Birot, G, Kachenoura, A, Albera, L, et al. Automatic detection of fast ripples. J Neurosci Methods 2013;213:236–249.Google Scholar
Roehri, N, Pizzo, F, Lagarde, S, et al. High-frequency oscillations are not better biomarkers of epileptogenic tissues than spikes. Ann Neurol 2018;83(1):84–97.Google Scholar
Roehri, N, Bartolomei, F. Are high-frequency oscillations better biomarkers of the epileptogenic zone than spikes? Curr Opin Neurol 2019;32:213–219.Google Scholar
Roehri, N, Pizzo, F, Lagarde, S, et al. High-frequency oscillations are not better biomarkers of epileptogenic tissues than spikes. Ann Neurol 2018;83:84–97.Google Scholar
Perucca, P, Dubeau, F, Gotman, J. Intracranial electroencephalographic seizure-onset patterns: Effect of underlying pathology. Brain 2014;137:183–196.Google Scholar
Lagarde, S, Buzori, S, Trebuchon, A, et al. The repertoire of seizure onset patterns in human focal epilepsies: Determinants and prognostic values. Epilepsia 2019;60:85–95.CrossRefGoogle ScholarPubMed
Alarcon, G, Binnie, CD, Elwes, RD, et al. Power spectrum and intracranial EEG patterns at seizure onset in partial epilepsy. Electroencephalogr Clin Neurophysiol 1995;94:326–337.Google Scholar
Bartolomei, F, Chauvel, P, Wendling, F. Epileptogenicity of brain structures in human temporal lobe epilepsy: a quantified study from intracerebral EEG. Brain 2008;131:1818–1830.CrossRefGoogle ScholarPubMed
Andrzejak, RG, David, O, Gnatkovsky, V, et al. Localization of epileptogenic zone on pre-surgical intracranial EEG recordings: Toward a validation of quantitative signal analysis approaches. Brain Topogr 2015;28:832–837.Google Scholar
Gnatkovsky, V, de Curtis, M, Pastori, C, et al. Biomarkers of epileptogenic zone defined by quantified stereo-EEG analysis. Epilepsia 2014;55:296–305.Google Scholar
David, O, Blauwblomme, T, Job, AS, et al. Imaging the seizure onset zone with stereo-electroencephalography. Brain 2011;134:2898–2911.Google Scholar
Grinenko, O, Li, J, Mosher, JC, Wang, IZ, Bulacio, JC, Gonzalez-Martinez, J, Chauvel PA. Fingerprint of the epileptogenic zone in human epilepsies. Brain 2018;141:117–131.Google Scholar
Marchi, A, Bonini, F, Lagarde, S, et al. Occipital and occipital “plus” epilepsies: A study of involved epileptogenic networks through SEEG quantification. Epilepsy Behav 2016;62:104–114.Google Scholar
Medina Villalon, S, Paz, R, Roehri, N, et al. EpiTools, a software suite for presurgical brain mapping in epilepsy: Intracerebral EEG. J Neurosci Methods 2018;303:7–15.Google Scholar
Bartolomei, F, Cosandier-Rimele, D, McGonigal, A, et al. From mesial temporal lobe to temporoperi-Sylvian seizures: A quantified study of temporal lobe seizure networks. Epilepsia 2010;51:2147–2158.Google Scholar
Bartolomei, F, Wendling, F, Bellanger, J, et al. Neural networks involved in temporal lobe seizures: A nonlinear regression analysis of SEEG signals interdependencies. Clin Neurophysiol 2001;112:1746–1760.Google Scholar
Hagiwara, K, Jung, J, Bouet, R, et al. How can we explain the frontal presentation of insular lobe epilepsy? The impact of non-linear analysis of insular seizures. Clin Neurophysiol 2017;128:780–791.Google Scholar
Blauwblomme, T, David, O, Minotti, L, et al. Prognostic value of insular lobe involvement in temporal lobe epilepsy: a stereoelectroencephalographic study. Epilepsia 2013;54:1658–1667.Google Scholar
Colombet, B, Woodman, M, Badier, JM, et al. AnyWave: A cross-platform and modular software for visualizing and processing electrophysiological signals. J Neurosci Methods 2015;242:118–126.Google Scholar
Roehri, N, Lina, JM, Mosher, JC, et al. Time-frequency strategies for increasing high-frequency oscillation detectability in intracerebral EEG. IEEE Trans Biomed Eng 2016;63:2595–2606.Google Scholar
Roehri, N, Pizzo, F, Bartolomei, F, et al. What are the assets and weaknesses of HFO detectors? A benchmark framework based on realistic simulations. PLoS One 2017;12:e0174702.Google Scholar
Kini, LG, Bernabei, JM, Mikhail, F, et al. Virtual resection predicts surgical outcome for drug-resistant epilepsy. Brain 2019 Dec;142(12):3892–3905.Google Scholar
Olmi, S, Petkoski, S, Guye, M, et al. Controlling seizure propagation in large-scale brain networks. PLoS Comput Biol 2019;15:e1006805.Google Scholar

References

Penfield, W, Faulk, Jr ME. The insula; further observations on its function. Brain. 1955;78:445–470.Google Scholar
Penfield, W, Jasper, H. Epilepsy and the functional anatomy of the human brain. Boston: Little Brown; 1954.Google Scholar
Mazzola, L, Isnard, J, Peyron, R, Mauguiere, F. Stimulation of the human cortex and the experience of pain: Wilder Penfield’s observations revisited. Brain. 2012;135:631–640.Google Scholar
Silfvenius, H, Gloor, P, Rasmussen, T. Evaluation of insular ablation in surgical treatment of temporal lobe epilepsy. Epilepsia. 1964;5:307–320Google Scholar
Bourdillon, P, Ryvlin, P, Isnard, J, Montavont, A, Catenoix, H, Mauguière, F, et al. Stereo-electroencephalography (SEEG) is a safe procedure including for insular implantations. World Neurosurgery. 2017;99:353–361.Google Scholar
Afif, A, Minotti, L, Kahane, P, Hoffmann, D. Anatomofunctional organization of the insular cortex: a study using intracerebral electrical stimulation in epileptic patients. Epilepsia. 2010;51:2305–2315.Google Scholar
Stephani, C, Fernandez-Baca Vaca, G, Maciunas, R, Koubeissi, M, Luders, HO. Functional neuroanatomy of the insular lobe. Brain Struct Funct. 2011;216:137–149.Google Scholar
Pugnaghi, M, Meletti, S, Castana, L, Francione, S, Nobili, L, Mai, R, et al. Features of somatosensory manifestations induced by intracranial electrical stimulations of the human insula. Clin Neurophysiol. 2011;122:2049–2058.Google Scholar
Mazzola, L, Mauguière, F, Isnard, J. Electrical stimulations of the human insula: their contribution to the ictal semiology of insular seizures. J Clin Neurophysiol. 2017;34(4):307–314.CrossRefGoogle Scholar
Yih, J, Beam, DE, Fox, KCR, Parvizi, J. Intensity of affective experience is modulated by magnitude of intracranial electrical stimulation in human orbitofrontal, cingulate and insular cortices. Soc Cogn Affect Neurosci. 2019;14(4):339–351.Google Scholar
Nathan, SS, Sinha, SR, Gordon, B, Lesser, RP, Thakor, NV. Determination of current density distributions generated by electrical stimulation of the human cerebral cortex. Electroencephalogr Clin Neurophysiol. 1993;86:183–192.Google Scholar
Oppenheimer, SM, Gelb, A, Girvin, JP, Hachinski, VC. Cardiovascular effects of human insular cortex stimulation. Neurology. 1992;42:1727–1732.Google Scholar
Chouchou, F, Mauguière, F, Vallayer, O, Catenoix, H, Isnard, J, Montavont, A, Jung, J, Pichot, V, Rheims, S, Mazzola, L. How the insula speaks to the heart: Cardiac responses to insular stimulation in humans.Hum Brain Mapp. 2019;40(9):2611–2622.Google Scholar
Nguyen, DK, Nguyen, DB, Malak, R, Leroux, JM, Carmant, L, Saint-Hilaire, JM, et al. Revisiting the role of the insula in refractory partial epilepsy. Epilepsia. 2009;50:510–520.CrossRefGoogle ScholarPubMed
Ostrowsky, K, Magnin, M, Ryvlin, P, Isnard, J, Guenot, M, Mauguière, F. Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation. Cereb Cortex. 2002;12(4):376–385.Google Scholar
Mazzola, L, Isnard, J, Peyron, R, Guenot, M, Mauguière, F. Somatotopic organization of pain responses to direct electrical stimulation of the human insular cortex. Pain. 2009;146:99–104.Google Scholar
Mazzola, L, Isnard, J, Mauguière, F. Somatosensory and pain responses to stimulation of the second somatosensory area (SII) in humans: A comparison with SI and insular responses.Cereb Cortex. 2006;16:960–968.Google Scholar
Frot, M, Magnin, M, Mauguière, F, Human, Garcia-Larrea L SII and posterior insula differently encode thermal laser stimuli. Cereb Cortex. 2007;17(3):610–620.Google Scholar
Catenoix, H, Isnard, J, Guénot, M, Petit, J, Rémy, C, Mauguière, F. The role of the anterior insular cortex in ictal vomiting: A stereotactic electroencephalography study. Epilepsy Behav. 2008;13:560–563.Google Scholar
Isnard, J, Guenot, M, Sindou, M, Mauguière, F. Clinical manifestations of insular lobe seizures: A stereo-electroencephalographic study. Epilepsia. 2004;45:1079–1090.Google Scholar
Ghaziri, J, Tucholka, A, Girard, G, Boucher, O, Houde, JC, Descoteaux, M, Obaid, S, Gilbert, G, Rouleau, I, Nguyen, DK. Subcortical structural connectivity of insular subregions. Sci Rep. 2018;8(1):8596.Google Scholar
Augustine, JR. Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Rev. 1996;22(3):229–244.Google Scholar
Mazzola, L, Royet, JP, Catenoix, H, Montavont, A, Isnard, J, Mauguière, F. Gustatory and olfactory responses to stimulation of the human insula. Ann Neurol. 2017;82(3):360–370.Google Scholar
Mazzola, L, Lopez, C, Faillenot, I, Chouchou, F, Mauguière, F, Isnard, J. Vestibular responses to direct stimulation of the human insular cortex. Ann Neurol. 2014;76:609–619.Google Scholar
Lopez, C, Blanke, O, Mast, FW. The vestibular cortex in the human brain revealed by coordinate-based activation likelihood estimation meta-analysis. Neuroscience. 2012;212:159–179.CrossRefGoogle ScholarPubMed
Kahane, P, Hoffmann, D, Minotti, L, Berthoz, A. Reappraisal of the human vestibular cortex by cortical electrical stimulation study. Ann Neurol. 2003;54:615–624.Google Scholar
Zhang, Y, Zhou, W, Wang, S, Zhou, Q, Wang, H, Zhang, B, Huang, J, Hong, B, Wang, X. The roles of subdivisions of human insula in emotion perception and auditory processing. Cereb Cortex. 2019;29(2):517–528.Google Scholar
Burton, H, Jones, EG. The posterior thalamic region and its cortical projection in New World and Old World monkeys. J Comp Neurol. 1976;168(2):249–301.Google Scholar
Picard, F, Scavarda, D, Bartolomei, F. Induction of a sense of bliss by electrical stimulation of the anterior insula. Cortex. 2013;49(10):2935–2937.Google Scholar
Bartolomei, F, Lagarde, S, Scavarda, D, Carron, R, Bénar, CG, Picard, F. The role of the dorsal anterior insula in ecstatic sensation revealed by direct electrical brain stimulation. Brain Stimul. 2019 Jun 5. PII: S1935-861X(19)30230-X. DOI: 10.1016/j.brs.2019.06.005. Epub ahead of print.Google Scholar
Yan, H, Liu, C, Yu, T, Yu, K, Xu, C, Wang, X, Ni, D, Li, Y. Mirth and laughter induced by electrical stimulation of the posterior insula. J Clin Neurosci. 2019;61:269–271.Google Scholar
Kurth, F, Zilles, K, Fox, PT, Laird, AR, Eickhoff, SB. A link between the systems: Functional differentiation and integration within the human insula revealed by meta-analysis. Brain Struct Funct. 2010;214:519–534.Google Scholar
Craig, AD. How do you feel now? The anterior insula and human awareness. Nat Rev Neurosci. 2009;10(1):59–70.Google Scholar
Legrain, V, Iannetti, GD, Plaghki, L, Mouraux, A. The pain matrix reloaded: A salience detection system for the body.Prog Neurobiol. 2011;93:111–124.Google Scholar
Liberati, G, Klöcker, A, Safranova, M, Ferrao Santos, S, Ribeiro Vaz, G, Raftopoulos, C, Mouraux, A. Nociceptive local fields potentials recorded from the human insula are not specific for nociception. PLoS Biol. 2016;6:14(1):e1002345. DOI: 10.1371/journal.pbio.1002345.Google Scholar
Liang, M, Su, Q, Mouraux, A, Iannetti, GD. Spatial patterns of brain activity preferentially reflecting transient pain and stimulus intensity. Cereb Cortex. 2019;29(5):2211–2227.Google Scholar
Montavont, A, Mauguière, F, Mazzola, L, Garcia-Larrea, L, Catenoix, H, Ryvlin, P, Isnard, J. On the origin of painful somatosensory seizures. Neurology. 2015;84:594–601.Google Scholar
Garcia-Larrea, L, Peyron, R. Pain matrices and neuropathic pain matrices: A review. Pain. 2013;154 (suppl 1):S29–S43.Google Scholar
Blawblomme, T, Kahane, P, Minotti, L, Grouiller, F, Krainik, A, Vercueil, L, Chabardès, S, Hoffmann, D, David, O. Multimodal imaging reveals the role of gamma activity in eating reflex seizures. J Neurol Neurosurg Psychiatry. 2011;82:1171–1173.Google Scholar
Small, DM. Taste representation in the human insula. Brain Struct Funct. 2010;214:551–61.Google Scholar

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