Book contents
- Insular Epilepsies
- Insular Epilepsies
- Copyright page
- Contents
- Contributors
- Foreword
- Chapter 1 A Brief History of Insular Cortex Epilepsy
- Section 1 The Human Insula from an Epileptological Standpoint
- Section 2 The Spectrum of Epilepsies Involving the Insula
- Chapter 7 Clinical Presentation of Insulo-Opercular Epilepsy in Adults
- Chapter 8 Clinical Presentation of Insulo-Opercular Epilepsy in Children
- Chapter 9 Are Painful Seizures Specific to Insular Epilepsy?
- Chapter 10 The Role of the Insula in Temporal Lobe Epilepsy and Temporal Lobe “Plus” Epilepsies
- Chapter 11 Insular-Origin Seizures with a Hypermotor Presentation
- Chapter 12 The Role of the Insula in Sudden Unexpected Death in Epilepsy (SUDEP)
- Section 3 Noninvasive Investigation of Insular Epilepsy
- Section 4 Invasive Investigation of Insular Epilepsy
- Section 5 Surgical Management of Insular Epilepsy
- Index
- References
Chapter 11 - Insular-Origin Seizures with a Hypermotor Presentation
from Section 2 - The Spectrum of Epilepsies Involving the Insula
Published online by Cambridge University Press: 09 June 2022
Book contents
- Insular Epilepsies
- Insular Epilepsies
- Copyright page
- Contents
- Contributors
- Foreword
- Chapter 1 A Brief History of Insular Cortex Epilepsy
- Section 1 The Human Insula from an Epileptological Standpoint
- Section 2 The Spectrum of Epilepsies Involving the Insula
- Chapter 7 Clinical Presentation of Insulo-Opercular Epilepsy in Adults
- Chapter 8 Clinical Presentation of Insulo-Opercular Epilepsy in Children
- Chapter 9 Are Painful Seizures Specific to Insular Epilepsy?
- Chapter 10 The Role of the Insula in Temporal Lobe Epilepsy and Temporal Lobe “Plus” Epilepsies
- Chapter 11 Insular-Origin Seizures with a Hypermotor Presentation
- Chapter 12 The Role of the Insula in Sudden Unexpected Death in Epilepsy (SUDEP)
- Section 3 Noninvasive Investigation of Insular Epilepsy
- Section 4 Invasive Investigation of Insular Epilepsy
- Section 5 Surgical Management of Insular Epilepsy
- Index
- References
Summary
Hypermotor seizures primarily arise from the frontal lobe; however, they have been shown to arise outside the frontal lobe in up to a third of patients. The insular cortex can be part of the hypermotor seizure network, acting either as a diffusion zone or as the seat of the seizure onset zone. Most patients experience predominantly nocturnal seizures with complex and stereotyped hypermotor behaviors with or without tonic or dystonic features. Although the hypermotor semiology of a seizure originating from the insulo-opercular region is often indistinguishable from that of a frontal onset, certain clinical features are paramount in recognizing an extra-frontal onset. In this chapter, we will review electro-clinical findings and semiology patterns of hypermotor seizures that suggest an insulo-opercular onset.
- Type
- Chapter
- Information
- Insular Epilepsies , pp. 118 - 133Publisher: Cambridge University PressPrint publication year: 2022
References
Lugaresi, E, Cirignotta, F. Hypnogenic paroxysmal dystonia: Epileptic seizure or a new syndrome? Sleep. 1981;4:129–138.Google Scholar
Tinuper, P, Cerullo, A, Cirignotta, F, Cortelli, P, Lugaresi, E, Montagna, P. Nocturnal paroxysmal dystonia with short-lasting attacks: Three cases with evidence for an epileptic frontal lobe origin of seizures. Epilepsia. 1990;31:549–556.Google Scholar
Meierkord, H, Fish, DR, Smith, SJ, Scott, CA, Shorvon, SD, Marsden, CD. Is nocturnal paroxysmal dystonia a form of frontal lobe epilepsy? Mov Disord. 1992;7:38–42.Google Scholar
Nobili, L, Francione, S, Mai, R, Tassi, L, Cardinale, F, Castana, L, Sartori, I, Lo Russo, G, Cossu, M. Nocturnal frontal lobe epilepsy: Intracerebral recordings of paroxysmal motor attacks with increasing complexity. Sleep. 2003;26:883–886.Google Scholar
Provini, F, Plazzi, G, Tinuper, P, Vandi, S, Lugaresi, E, Montagna, P. Nocturnal frontal lobe epilepsy. A clinical and polygraphic overview of 100 consecutive cases. Brain. 1999;122:1017–1031.Google Scholar
Terzaghi, M, Sartori, I, Mai, R, Tassi, L, Francione, S, Cardinale, F, Castana, L, Cossu, M, LoRusso, G, Manni, R, Nobili, L. Coupling of minor motor events and epileptiform discharges with arousal fluctuations in NFLE. Epilepsia. 2008;49:670–676.Google Scholar
Nobili, L, Francione, S, Mai, R, Cardinale, F, Castana, L, Tassi, L, Sartori, I, Didato, G, Citterio, A, Colombo, N, Galli, C, Lo Russo, G, Cossu, M. Surgical treatment of drug-resistant nocturnal frontal lobe epilepsy. Brain. 2007;130:561–573.CrossRefGoogle ScholarPubMed
Proserpio, P, Cossu, M, Francione, S, Tassi, L, Mai, R, Didato, G, Castana, L, Cardinale, F, Sartori, I, Gozzo, F, Citterio, A, Schiariti, M, Lo Russo, G, Nobili, L. Insular-opercular seizures manifesting with sleep-related paroxysmal motor behaviors: A stereo-EEG study. Epilepsia. 2011;52:1781–1791.Google Scholar
Gibbs, SA, Figorilli, M, Casaceli, G, Proserpio, P, Nobili, L. Sleep related hypermotor seizures with a right parietal onset. J Clin Sleep Med. 2015;11:953–955.CrossRefGoogle ScholarPubMed
Mai, R, Sartori, I, Francione, S, Tassi, L, Castana, L, Cardinale, F, Cossu, M, Citterio, A, Colombo, N, Lo Russo, G, Nobili, L. Sleep-related hyperkinetic seizures: Always a frontal onset? Neurol Sci. 2005;26:s220–s224.CrossRefGoogle ScholarPubMed
Ryvlin, P, Minotti, L, Demarquay, G, Hirsch, E, Arzimanoglou, A, Hoffman, D, Guénot, M, Picard, F, Rheims, S, Kahane, P. Nocturnal hypermotor seizures, suggesting frontal lobe epilepsy, can originate in the insula. Epilepsia. 2006;47:755–765.Google Scholar
Tinuper, P, Bisulli, F, Cross, JH, Hesdorffer, D, Kahane, P, Nobili, L, Provini, F, Scheffer, IE, Tassi, L, Vignatelli, L, Bassetti, C, Cirignotta, F, Derry, C, Gambardella, A, Guerrini, R, Halasz, P, Licchetta, L, Mahowald, M, Manni, R, Marini, C, Mostacci, B, Naldi, I, Parrino, L, Picard, F, Pugliatti, M, Ryvlin, P, Vigevano, F, Zucconi, M, Berkovic, S, Ottman, R. Definition and diagnostic criteria of sleep-related hypermotor epilepsy. Neurology. 2016;86:1834–1842.CrossRefGoogle ScholarPubMed
Gibbs, SA, Proserpio, P, Francione, S, Mai, R, Cardinale, F, Sartori, I, Castana, L, Plazzi, G, Tinuper, P, Cossu, M, Russo, GL, Tassi, L, Nobili, L. Clinical features of sleep-related hypermotor epilepsy in relation to the seizure-onset zone: A review of 135 surgically treated cases. Epilepsia. 2019;60:707–717.CrossRefGoogle Scholar
Zucconi, M, Oldani, A, Smirne, S, Ferini-Strambi, L. The macrostructure and microstructure of sleep in patients with autosomal dominant nocturnal frontal lobe epilepsy. J Clin Neurophysiol. 2000;17:77–86.Google Scholar
Vignatelli, L, Bisulli, F, Naldi, I, Ferioli, S, Pittau, F, Provini, F, Plazzi, G, Vetrugno, R, Montagna, P, Tinuper, P. Excessive daytime sleepiness and subjective sleep quality in patients with nocturnal frontal lobe epilepsy: A case-control study. Epilepsia. 2006;47:73–77.CrossRefGoogle ScholarPubMed
Gibbs, SA, Proserpio, P, Terzaghi, M, Pigorini, A, Sarasso, S, Lo Russo, G, Tassi, L, Nobili, L. Sleep-related epileptic behaviors and non-REM-related parasomnias: Insights from stereo-EEG. Sleep Med Rev. 2016;25:4–20.Google Scholar
Vignatelli, L, Bisulli, F, Giovannini, G, Licchetta, L, Naldi, I, Mostacci, B, Rubboli, G, Provini, F, Tinuper, P, Meletti, S. Prevalence of nocturnal frontal lobe epilepsy in the adult population of Bologna and Modena, Emilia-Romagna region, Italy. Sleep. 2015;38:479–485.Google Scholar
Nobili, L, Proserpio, P, Combi, R, Provini, F, Plazzi, G, Bisulli, F, Tassi, L, Tinuper, P. Nocturnal frontal lobe epilepsy. Curr Neurol Neurosci Rep. 2014;14:424.Google Scholar
Nobili, L, Cardinale, F, Magliola, U, Cicolin, A, Didato, G, Bramerio, M, Fuschillo, D, Spreafico, R, Mai, R, Sartori, I, Francione, S, Lo Russo, G, Castana, L, Tassi, L, Cossu, M. Taylor’s focal cortical dysplasia increases the risk of sleep-related epilepsy. Epilepsia. 2009;50:2599–2604.Google Scholar
Bonini, F, McGonigal, A, Trébuchon, A, Gavaret, M, Bartolomei, F, Giusiano, B, Chauvel, P. Frontal lobe seizures: from clinical semiology to localization. Epilepsia. 2014;55:264–277.Google Scholar
Lugaresi, E, Cirignotta, F, Montagna, P. Nocturnal paroxysmal dystonia. J Neurol Neurosurg Psychiatry. 1986;49:375–380.CrossRefGoogle ScholarPubMed
Terzaghi, M, Sartori, I, Mai, R, Tassi, L, Francione, S, Cardinale, F, Castana, L, Cossu, M, LoRusso, G, Manni, R, Nobili, L. Sleep-related minor motor events in nocturnal frontal lobe epilepsy. Epilepsia. 2007;48:335–441.CrossRefGoogle ScholarPubMed
Rheims, S, Ryvlin, P, Scherer, C, Minotti, L, Hoffmann, D, Guenot, M, Mauguière, F, Benabid, AL, Kahane, P. Analysis of clinical patterns and underlying epileptogenic zones of hypermotor seizures. Epilepsia. 2008;49:2030–2040.Google Scholar
Biraben, A, Taussig, D, Thomas, P, Even, C, Vignal, JP, Scarabin, JM, Chauvel, P. Fear as the main feature of epileptic seizures. J Neurol Neurosurg Psychiatry. 2001;70:186–191.CrossRefGoogle ScholarPubMed
Zhang, C, Zhao, BT, McGonigal, A, Hu, WH, Wang, X, Shao, XQ, Ma, YS, Zhang, JG, Zhang, K. Superior frontal sulcus focal cortical dysplasia. Type II: An MRI, PET, and quantified SEEG study. Front Neurol. 2019;10:1253.CrossRefGoogle ScholarPubMed
Ghashghaei, HT, Hilgetag, CC, Barbas, H. Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala. Neuroimage. 2007;34:905–923.CrossRefGoogle ScholarPubMed
Nobili, L, Cossu, M, Mai, R, Tassi, L, Cardinale, F, Castana, L, Citterio, A, Sartori, I, Lo Russo, G, Francione, S. Sleep-related hyperkinetic seizures of temporal lobe origin. Neurology. 2004;62:482–485.Google Scholar
Dobesberger, J, Ortler, M, Unterberger, I, Walser, G, Falkenstetter, T, Bodner, T, Benke, T, Bale, R, Fiegele, T, Donnemiller, E, Gotwald, T, Trinka, E. Successful surgical treatment of insular epilepsy with nocturnal hypermotor seizures. Epilepsia. 2008;49:159–162.Google Scholar
Montavont, A, Kahane, P, Catenoix, H, Ostrowsky-Coste, K, Isnard, J, Guénot, M, Rheims, S, Ryvlin, P. Hypermotor seizures in lateral and mesial parietal epilepsy. Epilepsy Behav. 2013;28:408–412.CrossRefGoogle ScholarPubMed
Gibbs, SA, Proserpio, P, Francione, S, Mai, R, Cossu, M, Tassi, L, Nobili, L. Seizure duration and latency of hypermotor manifestations distinguish frontal from extrafrontal onset in sleep-related hypermotor epilepsy. Epilepsia. 2018;59:e130–134.CrossRefGoogle ScholarPubMed
Tassinari, CA, Rubboli, G, Gardella, E, Cantalupo, G, Calandra-Buonaura, G, Vedovello, M, Alessandria, M, Gandini, G, Cinotti, S, Zamponi, N, Meletti, S. Central pattern generators for a common semiology in fronto-limbic seizures and in parasomnias. A neuroethologic approach. Neurol Sci. 2005;26:s225–232.CrossRefGoogle ScholarPubMed
Wang, X, Hu, W, Zhang, K, Shao, X, Ma, Y, Sang, L, Zheng, Z, Zhang, C, Li, J, Zhang, JG. The anatomo-electrical network underlying hypermotor seizures. Front Neurol. 2018;9:243.CrossRefGoogle ScholarPubMed
Kaido, T, Otsuki, T, Nakama, H, Kaneko, Y, Kubota, Y, Sugai, K, Saito, O. Complex behavioral automatism arising from insular cortex. Epilepsy Behav. 2006;8:315–319.Google Scholar
Hagiwara, K, Jung, J, Bouet, R, Abdallah, C, Guénot, M, Garcia-Larrea, L, Mauguière, F, Rheims, S, Isnard, J. How can we explain the frontal presentation of insular lobe epilepsy? The impact of non-linear analysis of insular seizures. Clin Neurophysiol. 2017;128:780–791.CrossRefGoogle ScholarPubMed
Dylgjeri, S, Taussig, D, Chipaux, M, Lebas, A, Fohlen, M, Bulteau, C, Ternier, J, Ferrand-Sorbets, S, Delalande, O, Isnard, J, Dorfmüller, G. Insular and insulo-opercular epilepsy in childhood: An SEEG study. Seizure. 2014;23:300–308.CrossRefGoogle ScholarPubMed
Nguyen, DK, Nguyen, DB, Malak, R, Leroux, JM, Carmant, L, Saint-Hilaire, JM, Giard, N, Cossette, P, Bouthillier, A. Revisiting the role of the insula in refractory partial epilepsy. Epilepsia. 2009;50:510–520.Google Scholar
Isnard, J, Guénot, M, Sindou, M, Mauguière, F. Clinical manifestations of insular lobe seizures: A stereo-electroencephalographic study. Epilepsia. 2004;45:1079–1090.CrossRefGoogle ScholarPubMed
Fisher, RS, Cross, JH, French, JA, Higurashi, N, Hirsch, E, Jansen, FE, Lagae, L, Moshé, SL, Peltola, J, Roulet Perez, E, Scheffer, IE, Zuberi, SM. Operational classification of seizure types by the International League Against Epilepsy: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58:522–530.CrossRefGoogle ScholarPubMed
Isnard, J, Hagiwara, K, Montavont, A, Catenoix, H, Rheims, S. Semiology of insular seizure. Rev Neurol (Paris). 2019;175:144–149.Google Scholar
Obaid, S, Zerouali, Y, Nguyen, DK. Insular epilepsy: Semiology and noninvasive investigations. J Clin Neurophysiol. 2017;34:315–323.Google Scholar
Saygi, S, Katz, A, Marks, DA, Spencer, SS. Frontal lobe partial seizures and psychogenic seizures: Comparison of clinical and ictal characteristics. Neurology. 1992;42:1274–1277.Google Scholar
Sinclair, DB, Wheatley, M, Snyder, T. Frontal lobe epilepsy in childhood. Pediatr Neurol. 2004;30:169–176.Google Scholar
Isnard, J, Magnin, M, Jung, J, Mauguière, F, Garcia-Larrea, L. Does the insula tell our brain that we are in pain? Pain. 2011;152:946–951.Google Scholar
Montavont, A, Mauguière, F, Mazzola, L, Garcia-Larrea, L, Catenoix, H, Ryvlin, P, Isnard, J. On the origin of painful somatosensory seizures. Neurology. 2015;84:594–601.Google Scholar
Mazzola, L, Mauguière, F, Isnard, J. Electrical stimulations of the human insula: Their contribution to the ictal semiology of insular seizures. J Clin Neurophysiol. 2017;34:307–314.CrossRefGoogle Scholar
Hagiwara, K, Garcia-Larrea, L, Tremblay, L, Montavont, A, Catenoix, H, Rheims, S, Guénot, M, Isnard, J. Pain behavior without pain sensation: an epileptic syndrome of “symbolism for pain”? Pain. 2020;161:502–508.CrossRefGoogle Scholar
Tassinari, CA, Cantalupo, G, Högl, B, Cortelli, P, Tassi, L, Francione, S, Nobili, L, Meletti, S, Rubboli, G, Gardella, E. Neuroethological approach to frontolimbic epileptic seizures and parasomnias: The same central pattern generators for the same behaviours. Rev Neurol (Paris). 2009;165:762–768.CrossRefGoogle ScholarPubMed
Augustine, JR. Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Brain Res Rev. 1996;22:229–244.Google Scholar
Taylor, KS, Seminowicz, DA, Davis, KD. Two systems of resting state connectivity between the insula and cingulate cortex. Hum Brain Mapp. 2009;30:2731–2745.Google Scholar
Cauda, F, D’Agata, F, Sacco, K, Duca, S, Geminiani, G, Vercelli, A. Functional connectivity of the insula in the resting brain. Neuroimage. 2011;55:8–23.Google Scholar
Deen, B, Pitskel, NB, Pelphrey, KA. Three systems of insular functional connectivity identified with cluster analysis. Cereb Cortex. 2011;21:1498–1506.Google Scholar
Ghaziri, J, Tucholka, A, Girard, G, Houde, JC, Boucher, O, Gilbert, G, Descoteaux, M, Lippé, S, Rainville, P, Nguyen, DK. The corticocortical structural connectivity of the human insula. Cereb Cortex. 2017;27:1216–1228.Google Scholar
Aupy, J, Wendling, F, Taylor, K, Bulacio, J, Gonzalez-Martinez, J, Chauvel, P. Cortico-striatal synchronization in human focal seizures. Brain. 2019;142:1282–1295.CrossRefGoogle ScholarPubMed
Chikama, M, McFarland, NR, Amaral, DG, Haber, SN. Insular cortical projections to functional regions of the striatum correlate with cortical cytoarchitectonic organization in the primate. J Neurosci. 1997;17:9686–9705.CrossRefGoogle ScholarPubMed
Ghaziri, J, Tucholka, A, Girard, G, Boucher, O, Houde, JC, Descoteaux, M, Obaid, S, Gilbert, G, Rouleau, I, Nguyen, DK. Subcortical structural connectivity of insular subregions. Sci Rep. 2018;8:8596.Google Scholar
- 2
- Cited by