Book contents
- Immunohistochemistry
- Immunohistochemistry
- Copyright page
- Dedication
- Contents
- Contributors
- Preface
- Chapter 1 Immunohistochemistry Fundamentals
- Chapter 2 Immunohistochemistry Quality Assurance and Quality Control
- Chapter 3 Automation and Robotics with the Leica Bond III
- Chapter 4 Automation and Robotics with the Roche Ventana BenchMark ULTRA
- Chapter 5 Automation and Robotics with the Agilent Dako Omnis
- Chapter 6 Immunohistochemistry for Research Applications
- Chapter 7 Troubleshooting Immunohistochemistry
- Chapter 8 Current Status of Immunohistochemistry
- Chapter 9 Immunohistochemistry for Future Applications
- Index
- References
Chapter 1 - Immunohistochemistry Fundamentals
Published online by Cambridge University Press: 16 June 2022
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Book contents
- Immunohistochemistry
- Immunohistochemistry
- Copyright page
- Dedication
- Contents
- Contributors
- Preface
- Chapter 1 Immunohistochemistry Fundamentals
- Chapter 2 Immunohistochemistry Quality Assurance and Quality Control
- Chapter 3 Automation and Robotics with the Leica Bond III
- Chapter 4 Automation and Robotics with the Roche Ventana BenchMark ULTRA
- Chapter 5 Automation and Robotics with the Agilent Dako Omnis
- Chapter 6 Immunohistochemistry for Research Applications
- Chapter 7 Troubleshooting Immunohistochemistry
- Chapter 8 Current Status of Immunohistochemistry
- Chapter 9 Immunohistochemistry for Future Applications
- Index
- References
Summary
The immunohistochemistry assay has evolved over many years. Primarily based on an antibody binding to epitopes in tissue sections, the technology has come a long way from its earliest manifestation using direct fluorescence labels. Current polymer technology is the result of many variations and adaptations on technique throughout the years. Indeed, much of its continued development is owed to early pioneers who experimented and overcame technical boundaries. This chapter is a broad discussion about what immunohistochemistry is from the historical perspective, and the individuals who have contributed to its expansion. It includes a journey about protocol adaptations and explanations of their context and applications. This chapter provides a sound basis in which to explore the rest of the book.
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- ImmunohistochemistryA Technical Guide to Current Practices, pp. 1 - 23Publisher: Cambridge University PressPrint publication year: 2022
References
American Association of Immunologists. Albert H Coons MD brief bio (online). Available at: www.aai.org/About/History/Past-Presidents-and-Officers/AlbertHCoons (Accessed 1 June 2021).Google Scholar
Bancroft, JD, Floyd, AD 2008. Light microscopy. In Bancroft, JD, Gamble, M, eds. Theory and practice of histological techniques. Churchill Livingstone Elsevier; 33–52.Google Scholar
Childs, GV 2014. History of immunohistochemistry. In McManus, LM, Mitchell, RN, eds. Pathobiology of human disease. Elsevier; 3775–96.Google Scholar
Complete Dictionary of Scientific Biography. Marrack, John Richardson (online). Available at: www.encyclopedia.com/science/dictionaries-thesauruses-pictures-and-press-releases/marrack-john-richardson (Accessed 15 April 2021).Google Scholar
De Matos, LL, Trufelli, DC, de Matos, MG, da Silva Pinhal, MA 2010. Immunohistochemistry as an important tool in biomarkers detection and clinical practice. Biomark Insights 9(5):9–20.Google Scholar
Faulk, WP, Taylor, GM 1971. Communication to the editors: An immunocolloid method for the electron microscope. Immunochemistry 8(11):1081–3.Google Scholar
Fox, CH, Johnson, FB, Whiting, J, Roller, PP 1985. Formaldehyde fixation. J Histochem Cytochem 33(8):845–53.CrossRefGoogle ScholarPubMed
Horobin, RW 2002. Xanthenes. In Horobin, RW, Kiernan, JA, eds. Conn’s biological stains: A handbook of dyes, stains and fluorochromes for use in biology and medicine. Taylor and Francis; 219–52.Google Scholar
Male, D, Roitt, I 1998. Introduction to the immune system. In Roitt, I, Brostoff, J, Male, M, eds. Immunology. Mosby; 1–12.Google Scholar
Moriarty, GC, Moriarty, CM, Sternberger, LA 1973. Ultrastructural immunocytochemistry with unlabeled antibodies and the peroxidase-antiperoxidase complex. A technique more sensitive than radioimmunoassay. J Histochem Cytochem 21(9):825–33.CrossRefGoogle ScholarPubMed
Nakane, PK 1968. Simultaneous localization of multiple tissue antigens using the peroxidase-labeled antibody method: A study on pituitary glands of the rat. J Histochem Cytochem 16(9):557–60.Google Scholar
NobelPrize.org. Emil von Behring: The founder of serum therapy. Nobel Prize Outreach AB 2021 (online). Available at: www.nobelprize.org/prizes/medicine/1901/behring/article/ (Accessed 11 July 2021).Google Scholar
Roth, J, Bendayan, M, Orci, L 1978. Ultrastructural localization of intracellular antigens by the use of protein A-gold complex. J Histochem Cytochem 26(12):1074–81.Google Scholar
Roth, J, Ziak, M, Guhl, B 2000. Non heating antigen retrieval techniques for light and electron microscopic immunolabeling. In Shi, SR, Gu, J, Taylor, CR, eds. Antigen retrieval techniques: Immunohistochemistry and molecular morphology. Eaton; 275–85.Google Scholar
Shi, SR, Cote, RJ, Taylor, CR 1997. Antigen retrieval immunohistochemistry: Past, present, and future. J Histochem Cytochem 45(3):327–43.CrossRefGoogle ScholarPubMed
Shi, SR, Cote, RJ, Taylor, CR 2001. Antigen retrieval techniques: Current perspectives. J Histochem Cytochem 49(8):931–7.CrossRefGoogle ScholarPubMed
Stacey, M 1994. Michael Heidelberger, 29 April 1888–25 June 1991. Biographical Memoirs of Fellows of the Royal Society 39:177–97 (online). Available at: https://royalsocietypublishing.org/doi/10.1098/rsbm.1994.0011 (Accessed 1 June 2021).Google Scholar
Sternberger, LA, Hardy, PH Jr, Cuculis, JJ, Meyer, HG 1970. The unlabeled antibody enzyme method of immunohistochemistry: Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem 18(5):315–33.CrossRefGoogle ScholarPubMed
Taylor, CR, Shi, S-R, Barr, NJ 2010. Techniques of immunohistochemistry: Principles, pitfalls and standardisation. In Dabbs, DJ, ed. Diagnostic immunohistochemistry: Theranostic and genomic applications. Saunders Elsevier; 1–41.Google Scholar
Tsutsumi, Y, Serizawa, A, Kawai, K 1995. Enhanced polymer one-step staining (EPOS) for proliferating cell nuclear antigen (PCNA) and Ki-67 antigen: Application to intra-operative frozen diagnosis. Pathol Int 45(2):108–15.Google Scholar
Van Epps, HL 2006. Michael Heidelberger and the demystification of antibodies. J Exp Med 203(1):5.Google Scholar
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