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Chapter 10 - Antiangiogenic agents for endometriosis

Published online by Cambridge University Press:  16 May 2011

By
Edurne Novella-Maestre ,
Carlos Simón ,
Juan A. García-Velasco  and
Antonio Pellicer
Edited by
David K. Gardner ,
Botros R. M. B. Rizk  and
Tommaso Falcone
David K. Gardner
Affiliation:
University of Melbourne
Botros R. M. B. Rizk
Affiliation:
University of South Alabama
Tommaso Falcone
Affiliation:
Cleveland Clinic Foundation
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Summary

Medical treatment of endometriosis is a necessary step in the management of the disease due to its high rate of recurrence and different clinical situations. Women with endometriosis present a peritoneal environment with increased angiogenic activity. Angiogenesis involves the formation of new blood vessels released by pre-existing vessels. Several antiangiogenic agents have been successfully tested in experimental models of endometriosis inhibiting new vessel formation. These compounds target specifically the endothelial cells without penetration in the tissues. Several anticancer drugs with antiangiogenic potential have been found to have a detrimental effect on reproductive function in both animal models and patients. The studies in experimental oncological models demonstrated that dopamine agonists (DA) have an antiangiogenic effect promoting the vascular endothelial growth factor receptors (VEGFR)-2 endocytosis in endothelial cells, preventing the VEGF-VEGFR-2 union and avoiding receptor phosphorylation and signal cascade.

Keywords

hydrosalpingeshysterosalpingographyin vitro fertilization cycle outcomeuterine leiomyomaultrasound evaluationinflammatory cytokines
Type
Chapter
Information
Human Assisted Reproductive Technology
Future Trends in Laboratory and Clinical Practice
 , pp. 101 - 109
Publisher: Cambridge University Press
Print publication year: 2011

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