Book contents
- Hormones and Pregnancy
- Hormones and Pregnancy
- Copyright page
- Contents
- Contributors
- Section I Hormones in the Physiology and Pharmacology of Pregnancy
- Section II Hormones and Gestational Disorders
- Chapter 8 Prolactin, Prolactinoma, and Pregnancy
- Chapter 9 Growth Hormone Disorders in Pregnancy
- Chapter 10 Gestational Diabetes
- Chapter 11 Obesity and Metabolic Syndrome in Pregnancy
- Chapter 12 Hormones and Pre-term Birth
- Chapter 13 Thyroid Dysfunction in Pregnancy and Postpartum
- Chapter 14 The Role of Hormones in Hypertensive Disorders of Pregnancy
- Chapter 15 Adrenal Disease in Pregnancy
- Chapter 16 Hormones and Multiple Pregnancy
- Chapter 17 Hormones in Pregnancy and the Developmental Origins of Health and Disease
- Index
- References
Chapter 9 - Growth Hormone Disorders in Pregnancy
from Section II - Hormones and Gestational Disorders
Published online by Cambridge University Press: 09 November 2022
Book contents
- Hormones and Pregnancy
- Hormones and Pregnancy
- Copyright page
- Contents
- Contributors
- Section I Hormones in the Physiology and Pharmacology of Pregnancy
- Section II Hormones and Gestational Disorders
- Chapter 8 Prolactin, Prolactinoma, and Pregnancy
- Chapter 9 Growth Hormone Disorders in Pregnancy
- Chapter 10 Gestational Diabetes
- Chapter 11 Obesity and Metabolic Syndrome in Pregnancy
- Chapter 12 Hormones and Pre-term Birth
- Chapter 13 Thyroid Dysfunction in Pregnancy and Postpartum
- Chapter 14 The Role of Hormones in Hypertensive Disorders of Pregnancy
- Chapter 15 Adrenal Disease in Pregnancy
- Chapter 16 Hormones and Multiple Pregnancy
- Chapter 17 Hormones in Pregnancy and the Developmental Origins of Health and Disease
- Index
- References
Summary
Growth hormone (GH) deficiency is associated with decreased fertility. Since the placenta starts to produce a biologically active GH variant in the first gestational weeks, GH replacement therapy is usually stopped upon confirmation of conception or in the first trimester. Also acromegaly is associated with decreased fertility caused either by size effects of the pituitary adenoma that might lead to gonadotroph insufficiency or co-secretion of prolactin. Women with acromegaly should be treated in centers with adequate experience. In women with macroadenomas, transsphenoidal removal or size reduction of the adenoma prior to conception should be considered. The size of GH producing adenomas or residual tumors usually does not increase during pregnancy and symptoms of acromegaly might even improve due to hepatic GH resistance caused by high estrogen concentrations. In case of symptomatic tumor growth during pregnancy pharmacologic therapy with the somatostatin analogs octreotide and lanreotide might be considered before surgery. Comorbidities of acromegaly such as impaired glucose tolerance, diabetes, and hypertension deserve special attention. Rebound disease activity after delivery is frequent.
- Type
- Chapter
- Information
- Hormones and PregnancyBasic Science and Clinical Implications, pp. 87 - 90Publisher: Cambridge University PressPrint publication year: 2022
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