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Chapter 44 - Neurologic Complications in Pregnancy (Content last reviewed: 15th October 2018)

from Section 5 - Late Pregnancy – Maternal Problems

Published online by Cambridge University Press:  15 November 2017

By
J. Ricardo Carhuapoma ,
Michael W. Varner  and
Steven R. Levine
Edited by
David James ,
Philip Steer ,
Carl Weiner ,
Bernard Gonik  and
Stephen Robson
David James
Affiliation:
University of Nottingham
Philip Steer
Affiliation:
Imperial College London
Carl Weiner
Affiliation:
University of Kansas
Bernard Gonik
Affiliation:
Wayne State University, Detroit
Stephen Robson
Affiliation:
University of Newcastle
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Summary

Neurologic conditions are among the more common concurrent medical conditions encountered during pregnancy. Table 44.1 shows the prevalence of several such neurologic diseases. Despite their cumulative prevalence, the relative rarity of many of these conditions limits the actual clinical experience of both the managing obstetrician and the neurologist. In addition, the individual practitioner is further hampered by the limited amount of pregnancy-specific information available. The frequent overlap of symptoms associated with common pregnancy complaints, the sometimes disabling and lethal consequences of the disease, and the fetal effects of the maternal disease and/or treatment make the diagnosis and management of neurologic disease during pregnancy an often-daunting task.

Type
Chapter
Information
High-Risk Pregnancy
Management Options
 , pp. 1272 - 1320
Publisher: Cambridge University Press
First published in: 2017

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References

Further Reading

Briggs, GG, Freeman, R, Yaffe, SJ (eds). Drugs in Pregnancy and Lactation. Philadelphia, PA: Lippincott Williams & Williams, 2008.Google Scholar
Coutinho, JM, Majoie, CB, Coert, BA, Stam, J. Decompressive hemicraniectomy in cerebral sinus thrombosis: Consecutive case series and review of the literature. Stroke 2009; 40: 2233–5.CrossRefGoogle ScholarPubMed
Davis, SM, Donnan, GA. 4.5 hours: the new time window for tissue plasminogen activator in stroke. Stroke 2009; 40: 2266–7.CrossRefGoogle ScholarPubMed
Helms, AK, Drogan, O, Kittner, SJ. First trimester stroke prophylaxis in pregnant women with a history of stroke. Stroke 2009; 40: 1158–61.CrossRefGoogle ScholarPubMed
Murugappan, A, Coplin, WM, Al-Sadat, AN, et al. Thrombolytic therapy of acute ischemic stroke during pregnancy. Neurology 2006; 66: 768–70.CrossRefGoogle ScholarPubMed
Pennell, PB. Antiepileptic drug pharmacokinetics during pregnancy and lactation. Neurology 2003; 61: S35–42.Google Scholar
Piotin, M, de Souza Filho, CB, Kothimbakam, R, Moret, J. Endovascular treatment of acutely ruptured intracranial aneurysms in pregnancy. Am J Obstet Gynecol 2001; 185: 1261–2.CrossRefGoogle ScholarPubMed
Sances, G, Granella, F, Nappi, RE, et al. Course of migraine during pregnancy and postpartum: A prospective study. Cephalalgia 2003; 23: 197–205.Google Scholar
Sloan, MA, Stern, BJ. Cerebrovascular disease in pregnancy. Curr Treat Options Neurol 2003; 5: 391–407.Google Scholar
Wong, CA, Scavone, BM, Dugan, S, et al. Incidence of postpartum lumbosacral spine and lower extremity nerve injuries. Obstet Gynecol 2003; 101: 279–88.Google Scholar

References

Briggs, GG, Freeman, R, Yaffe, SJ (eds). Drugs in Pregnancy and Lactation. Philadelphia, PA: Lippincott Williams & Williams, 2008.Google Scholar
Barton, JR, Sibai, BM. Cerebral pathology in eclampsia. Clin Perinatol 1991; 18: 891–910.Google Scholar
Sheehan, HL, Lynch, JB (eds). Pathology of Toxemia of Pregnancy. Baltimore, MD: Williams & Wilkins, 1973.Google Scholar
Colosimo, C, Fineli, A, Moschini, M, Guerrini, P. CT findings in eclampsia. Neuroradiology 1985; 27: 313–17.Google Scholar
Crawford, S, Varner, MW, Digre, KB, Servais, G, Corbett, JJ. Cranial magnetic resonance imaging in eclampsia. Obstet Gynecol 1987; 70: 474–7.Google Scholar
Lewis, LK, Hinshaw, DB, Will, AD, et al. CT and angiographic correlation of severe neurological disease in toxemia of pregnancy. Neuroradiology 1988; 30: 59–64.Google Scholar
Raroque, JG, Orrison, WW, Rosenberg, GA. Neurologic involvement in toxemia of pregnancy: reversible MRI lesions. Neurology 1990; 40: 167–9.Google Scholar
Schwaighofer, BW, Jesselink, JR, Jealy, ME. MR demonstration of reversible brain abnormalities in eclampsia. J Comput Assist Tomogr 1989; 13: 310–12.CrossRefGoogle ScholarPubMed
Cunningham, FG, Fernandez, CO, Hernandez, C. Blindness associated with preeclampsia and eclampsia. Am J Obstet Gynecol 1995; 172: 1291–8.Google Scholar
Richards, A, Graham, D, Bullock, R. Clinicopathological study of neurological complications due to hypertensive disorders of pregnancy. J Neurol Neurosurg Psychiatry 1988; 51: 416–21.Google Scholar
Douglas, KA, Redman, CWG. Eclampsia in the United Kingdom. BMJ 1994; 309: 1395–400.Google Scholar
Hallum, AV. Eye changes in hypertensive toxemia of pregnancy. JAMA 1936; 106: 1649–51.Google Scholar
Carpenter, F, Kava, HL, Plotkin, D. The development of total blindness as a complication of pregnancy. Am J Obstet Gynecol 1953; 66: 641–7.Google Scholar
Will, AD, Lewis, KL, Hinshaw, DB, et al. Cerebral vasoconstriction in toxemia. Neurology 1987; 37: 1555–7.Google Scholar
Schaefer, PW, Buonanno, FS, Gonzalez, RG, et al. Diffusion-weighted imaging discriminates between cytotoxic and vasogenic edema in a patient with eclampsia. Stroke 1997; 28: 1082–5.Google Scholar
Beck, DW, Menezes, AH. Intracerebral hemorrhage in a patient with eclampsia. JAMA 1981; 246: 1492.CrossRefGoogle Scholar
Lewis, G. Saving Mother’s Lives: Reviewing Maternal Deaths to Make Motherhood Safer: 2003–2005. The Seventh Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. London: CEMACH, 2007.Google Scholar
Mattar, F, Sibai, BM. Eclampsia. VIII. Risk factors for maternal morbidity. Am J Obstet Gynecol 2000; 182: 307–12.Google Scholar
Duley, L. Maternal mortality associated with hypertensive disorders of pregnancy in Africa, Asia, Latin America and the Caribbean. Br J Obstet Gynaecol 1992; 99: 547–53.CrossRefGoogle ScholarPubMed
Sibai, BM. Eclampsia. VI. Maternal-perinatal outcome in 254 consecutive cases. Am J Obstet Gynecol 1990; 163: 1049–55.Google Scholar
Berhan, Y, Berhan, A. Should magnesium sulfate be administered to women with mild pre-eclampsia? A systematic review of published reports. J Obstet Gynaecol Res 2015; 41: 831–42.Google Scholar
Miles, JF, Martin, JN, Blake, PG, et al. Postpartum eclampsia: A recurring perinatal dilemma. Obstet Gynecol 1990; 76: 328–31.Google ScholarPubMed
Lubarsky, SL, Barton, JR, Friedman, SA, et al. Late postpartum eclampsia revisited. Obstet Gynecol 1994; 83: 502–5.Google Scholar
Sibai, BM. Magnesium sulfate prophylaxis in preeclampsia. Am J Obstet Gynecol 2004/190: 1520–6.CrossRefGoogle ScholarPubMed
Coan, EJ, Collinridge, GL. Magnesium ions block an N-methyl-d-aspartate receptor–mediated component of synaptic transmission on rat hippocampus. Neurosci Lett 1985; 53: 21–6.Google Scholar
Stasheff, SF, Anderson, WW, Clark, S, et al. NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. Science 1989; 245: 648–51.Google Scholar
Standley, CA, Irtenkauf, SM, Stewart, L, et al. Magnesium sulfate versus phenytoin for seizure prevention in amygdala kindled rats. Am J Obstet Gynecol 1994; 171: 948–51.CrossRefGoogle ScholarPubMed
Mason, BA, Standley, CA, Irtenkauf, SM, et al. Magnesium is more efficacious than phenytoin in reducing N-methyl-d-aspartate seizures in rats. Am J Obstet Gynecol 1994; 171: 999–1002.Google Scholar
Duley, L, Gülmezoglu, AM, Henderson-Smart, DJ. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev 2003; (3): CD000025.Google Scholar
Lucas, MJ, Leveno, KJ, Cunningham, FG. A comparision of mangesium sulfate with phenytoin for the prevention of eclampsia. N Engl J Med 1995; 333: 201–5.Google Scholar
Henderson, JT, Whitlock, EP, O’Connor, E, et al. Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med 2014; 160: 695–703.Google Scholar
Magee, LA, Ornstein, MP, von Dadelszen, P. Management of hypertension in pregnancy. BMJ 1999; 318: 1332–6.Google Scholar
Harden, CL, Hopp, J, Ting, TY, et al. Practice parameter update: management issues for women with epilepsy: focus on pregnancy (an evidence-based review): obstetric complications and change in seizure frequency: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 2009; 73: 126–32.Google Scholar
Cook, SD, Troiano, R, Bansil, S, et al. Multiple sclerosis and pregnancy. In Devinski, O, Hainline, B (eds), Neurologic Complications of Pregnancy. New York, NY: Raven, 1993, pp. 83–95.Google Scholar
Yerby, MS, Devinsky, O. Epilepsy and pregnancy. Adv Neurol 1994; 64: 45–64.Google Scholar
Schmidt, D, Conyen, R, Avanzini, GM, et al. Change of seizure frequency in pregnancy epileptic women. J Neurol Neurosurg Psychiatry 1983; 46: 751–5.Google Scholar
Delgado-Escueta, AV, Jantz, D. Consensus guidelines: preconception counseling, management, and care of the pregnant women with epilepsy. Neurology 1992; 42: 149–60.Google Scholar
Yerby, M, Freil, PN, McCormick, KB, et al. Pharmacokinetics of anticonvulsants in pregnancy: alteration in plasma protein binding. Epilepsy Res 1990; 5: 223–8.Google Scholar
Perruca, E, Crema, A. Plasma protein binding of drugs in pregnancy. Clin Pharmacokinet 1982; 7: 336–52.Google Scholar
Nelson, KB, Ellenberg, JH. Maternal seizure disorder, outcome of pregnancy, and neurologic abnormalities in the children. Neurology 1982; 32: 1247–54.Google Scholar
Samren, EB, van Duijn, CM, Koch, S, et al. Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy. Epilepsia 1997; 38: 981–90.Google Scholar
Lindhout, D, Rene, JE, Hoppener, A, et al. Teratogenicity of antiephileptic drug combinations with special emphasis on epoxidation of carbamazepine. Epilepsia 1984; 25: 77–83.Google Scholar
Hanson, JW, Smith, DW. The fetal hydantoin syndrome. J Pediatr 1975; 87: 285–90.CrossRefGoogle ScholarPubMed
Rudd, NL, Freedom, RM. A possible primidone embryopathy. J Pediat 1979; 94: 835–7.Google Scholar
Jones, KL, Lacro, RV, Johnson, KA, et al. Pattern of malformations in the children of women treated with carbamazepine during pregnancy. N Engl J Med 1989; 320: 1661–6.Google Scholar
Buehler, BA, Delimont, D, van Waes, M, et al. Prenatal prediction of risk of the fetal hydantoin syndrome. N Engl J Med 1990; 322: 1567–72.Google Scholar
Gaily, E, Granstorm, ML, Hiilesmaa, V, et al. Minor anomalies in offspring of eplileptic mothers. J Pediat 1988; 112: 520–9.Google Scholar
Lindhout, D, Omzigt, JGC, Cornel, MC. Spectrum of neural tube defects in 34 infants prenatally exposed to antiepileptic drugs. Neurology 1992; 42 (Suppl 5): 111–18.Google ScholarPubMed
Meador, KJ, Baker, GA, Browning, N, et al. Congitive function at 3 years of age after fetal exposure to antiepileptic drugs. N Engl J Med 2009; 360: 1597–605.Google Scholar
Vert, P, Deblay, MF. Hemorrhagic disorders in infants of epileptic mothers. In Janz, D, Richens, A, et al. (eds), Epilepsy, Pregnancy and the Child. New York: Raven, 1982.Google Scholar
Chong, DJ, Bazil, CW. Update on anticonvulsant drugs. Curr Neurol Neurosci Rep 2010; 10: 308–18.Google Scholar
Longo, B, Forinash, AB, Murphy, JA. Levetiracetam use in pregnancy. Ann Pharmacother 2009; 43: 1692–5.Google Scholar
Chen, P, Lin, JJ, Lu, CS, et al. Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. N Engl J Med 2011; 364: 1126–33.Google Scholar
Leckband, SG, Kelsoe, JR, Dunnenberg, HM, et al. Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing. Clin Pharmacol Ther 2013; 94: 324–8.Google Scholar
Crawford, P, Appleton, R, Betts, T, et al. Best practice guidelines for the management of women with epilepsy. The Women with Epilepsy Guidelines Development Group. Seizure 2000; 8: 201–17.Google Scholar
Hixson, JD. Stopping antiepileptic drugs: when and why? Curr Treat Options Neurol 2010; 12: 434–42.Google Scholar
Borthen, I, Eide, MG, Velby, G, Daltveit, AK, Gilhus, NE. Complications during pregnancy in women with epilepsy: population-based cohort study. BJOG 2009; 116: 1736–42.Google Scholar
Pennell, PB. Antiepileptic drug pharmacokinetics during pregnancy and lactation. Neurology 2003; 61: S35–42.Google Scholar
Verrotti, A, D’Egidio, C, Agostinelli, S, Verrotti, C, Pavone, P. Diagnosis and management of catamenial seizures: a review. Int J Womens Health 2012; 4: 535–41.Google Scholar
Donaldson, JO. Neurologic emergencies in pregnancy. Obstet Gynecol Clin North Am 1991; 18: 199–211.Google Scholar
Grear, KE, Bushnell, CD. Stroke and pregnancy: clinical presentation, evaluation, treatment, and epidemiology. Clin Obstet Gynecol 2013; 56: 350–9.Google Scholar
James, AH, Bushnell, CD, Jamison, MG, Myers, ER. Incidence and risk factors for stroke in pregnancy and the puerperium. Obstet Gynecol 2005; 106: 509–16.Google Scholar
Ji, R, Schwamm, LH, Pervez, MA, Singhal, AB. Ischemic stroke and transient ischemic attack in young adults: risk factors, diagnostic yield, neuroimaging, and thrombolysis. JAMA Neurol 2013: 70: 51–7.Google Scholar
Wiebers, D, Mokri, B. Internal carotid artery dissection after childbirth. Stroke 1985; 16: 956–9.Google Scholar
Hauenstein, E, Frank, H, Bauer, JS, Schneider, KT, Fischer, T. Takayasu’s arteritis in pregnancy: review of literature and discussion. J Perinat Med 2010; 38: 55–62.CrossRefGoogle ScholarPubMed
Tate, J, Bushnell, C. Pregnancy and stroke risk in women. Womens Health (Lond Engl) 2011; 7: 363–74.Google Scholar
Del Zotto, E, Giossi, A, Volonghi, I, Costa, P, Padovani, A, Pezzini, A. Ischemic stroke during pregnancy and puerperium. Stroke Res Treat 2011; 2011: 606780. doi: 10.4061/2011/606780.Google Scholar
Ezra, Y, Kidron, D, Beyth, Y. Fibromuscular dysplasia of the carotid arteries complicating pregnancy. Obstet Gynecol 1989; 73: 840–3.Google Scholar
Fletcher, A, Alkjaersig, N, Burstein, R. The influence of pregnancy upon blood coagulation and plasma fibrinolytic enzyme function. Am J Obstet Gynecol 1979; 134: 743–51.Google Scholar
Donaldson, JO. Thrombophilic coagulapathies and pregnancy-associated cerebrovascular disease. Curr Obstet Gynaecol 1991; 1: 186–90.Google Scholar
Lockwood, CJ. Pregnancy-associated changes in the hemostatic system. Clin Obstet Gynecol 2006; 49: 836–43.Google Scholar
Boketwa, MI, Bremme, K, Blomback, M. Arg 506-gln mutation in factor V and risk of thrombosis during pregnancy. Br J Haematol 1996; 92: 473–8.Google Scholar
Suppiej, A, Franzoi, M, Gentilomo, C, et al. High prevalence of inherited thrombophilia in “presumed peri-neonatal” ischemic stroke. Eur J Haematol 2008; 80: 71–5.Google Scholar
Egerman, RS, Sibai, BM. Imitators of preeclampsia and eclampsia. Clin Obstet Gynecol 1999; 42: 551–62.Google Scholar
Levine, SR, Brust, JCM, Futrel, N, et al. Cerebrovascular complication of the use of the “crack” forms of alkaloidal cocaine. N Engl J Med 1990; 323: 699–704.Google Scholar
King, TA, Perlman, JM, Laptook, AR, et al. Neurologic manifestations of in utero cocaine exposure in near-term and term infants. Pediatrics 1995; 96: 259–64.Google Scholar
Galli, M, Barbui, T. Antiphospholipid antibodies and thrombosis: strength of association. Hematol J 2003; 4: 180–6.Google Scholar
Levine, SR, Welch, KM. Antiphospholipid antibodies. Ann Neurol 1989; 26: 386–9.Google Scholar
Branch, DW. Antiphospholipid antibodies and pregnancy: maternal implications. Semin Perinatol 1990; 14: 139–46.Google Scholar
Triplett, DA. Antiphospholipid protein antibodies: laboratory detection and clinical relevance. Thromb Res 1995; 78: 1–31.Google Scholar
Fischer-Betz, R, Specker, C, Brinks, R, Schneider, M. Pregnancy outcome in patients with antiphospholipid syndrome after cerebral ischaemic events: an observational study. Lupus 2012; 21: 1183–9.Google Scholar
Shapiro, SS. The lupus anticoagulant/antiphospholipid syndrome. Annu Rev Med 1995; 47: 533–53.Google Scholar
Levine, SR, Brey, RL, Sawaya, KL, et al. Recurrent stroke and thrombo-occlusive events in the antiphospholipid syndrome. Ann Neurol 1995; 38: 119–24.Google Scholar
Levine, SR, Salowich-Palm, L, Sawaya, KL, et al. IgG anticardiolipin antibody titer > 40 gpl and the risk of subsequent thrombo-occlusive events and death: a prospective cohort study. Stroke 1997; 28: 1660–4.Google Scholar
Grotta, J, Manner, C, Pettigrew, L, et al. Red blood cell disorders and stroke. Stroke 1986; 17: 811–17.Google Scholar
Hodgman, MT, Pessin, MS, Homans, DC, et al. Cerebral embolism as the initial manifestation of peripartum cardiomyopathy. Neurology 1982; 32: 668–71.Google Scholar
Connor, RCR, Adams, JH. Importance of cardiomyopathy and cerebral ischemia in the diagnosis of fatal coma in pregnancy. J Clin Pathol 1996; 19: 244–9.Google Scholar
Barnett, HJM, Boughner, DR, Taylor, DW. Further evidence relating mitral valve prolapse to cerebral ischemic events. N Engl J Med 1980; 302: 139–44.CrossRefGoogle ScholarPubMed
Levy, D, Savage, D. Prevalance and clinical features of mitral valve prolapse. Am Heart J 1987; 113: 1281–1290.Google Scholar
Bartz, PJ, Cetta, F, Cabalka, AK, et al. Paradoxical emboli in children and young adults: role of atrial septal defect and patent foramen ovale device closure. Mayo Clin Proc 2006; 81: 615–18.Google Scholar
Roberts, N, Ross, D, Flint, SK, Arya, R, Blott, M. Thromboembolism in pregnant women with mechanical prosthetic heart valves anticoagulated with low molecular weight heparin. BJOG 2001; 108: 327–9.Google Scholar
Vink, R, Van Den Brink, RB, Levi, M. Management of anticoagulant therapy for patients with prosthetic heart valves or atrial fibrillation. Hematology 2004; 9: 1–9.Google Scholar
Kebed, KY, Bishu, K, Al Adham, RI, et al. Pregnancy and postpartum infective endocarditis: a systematic review. Mayo Clin Proc 2014; 89: 1143–52.Google Scholar
Kang, AH, Graves, CR. Libman-Sacks endocarditis in a pregnant women with acute respiratory distress syndrome. Obstet Gynecol 1999; 93: 819–21.Google Scholar
Helms, AK, Drogan, O, Kittner, SJ. First trimester stroke prophylaxis in pregnant women with a history of stroke. Stroke 2009; 40: 1158–61.Google Scholar
Bates, SM, Greer, IA, Middeldorp, S, et al. VTE, thrombophilia, antithrombotic therapy, and pregnancy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141 (2 Suppl): e691S–736S. doi: 10.1378/chest.11-2300.Google Scholar
Fuller, KP, Turner, G, Polavarapu, S, Prabulos, AM. Guidelines for use of anticoagulation in pregnancy. Clin Lab Med 2013; 33: 343–56.Google Scholar
Stein, PD, Hull, RD, Matta, F, Yaekoub, AY, Liang, J. Incidence of thrombocytopenia in hospitalized patients with venous thromboembolism. Am J Med 2009; 122: 919–30.Google Scholar
Alban, S. Adverse effects of heparin. Handb Exp Pharmacol 2012; (207): 211–63.Google Scholar
Kher, A, Bauersachs, R, Nielsen, JD. The management of thrombosis in pregnancy: role of low-molecular-weight heparin. Thromb Haemost 2007; 97: 505–13.Google Scholar
Santoro, R, Iannaccaro, P, Prejano, S, Muleo, G. Efficacy and safety of the long-term administration of low-molecular-weight heparins in pregnancy. Blood Coagul Fibrinolysis 2009; 20: 240–3.Google Scholar
Witlin, AG, Mabie, WC, Sibai, BM. Peripartum cardiomyopathy: an ominous diagnosis. Am J Obstet Gynecol 1997; 176: 182–8.Google Scholar
Davis, SM, Donnan, GA. 4.5 hours: the new time window for tissue plasminogen activator in stroke. Stroke 2009; 40: 2266–7.Google Scholar
Li, Y, Margraf, J, Kluck, B, Jenny, D, Castaldo, J. Thrombolytic therapy for ischemic stroke secondary to paradoxical embolism in pregnancy: a case report and literature review. Neurologist 2012; 18: 44–8.Google Scholar
Murugappan, A, Coplin, WM, Al-Sadat, AN, et al. Thrombolytic therapy of acute ischemic stroke during pregnancy. Neurology 2006; 66: 768–70.Google Scholar
Jeng, JS, Tang, SC, Yip, PK. Incidence and etiologies of stroke during pregnancy and puerperium as evidenced in Taiwanese women. Cerebrovasc Dis 2004; 18: 290–5.Google Scholar
Srinivasan, K. Cerebral venous and arterial thrombosis in pregnancy and puerperium: a study of 135 patients. Angiology 1983; 34: 731–74.Google Scholar
Razmara, A, Bakhadirov, k, Batra, A, Feske, SK. Cerebrovascular complications of pregnancy and the postpartum period. Curr Cardiol Rep 2014; 16: 532. doi: 10.1007/211886-014-0532-1.Google Scholar
Khan, M, Wasay, M, Menon, B, et al. Pregnancy and puerperium-related strokes in Asian women. J Stroke Cerebrovasc Dis 2013; 22: 1292–8.Google Scholar
Ferro, JM, Canhao, P, Stam, J, Bousser, MG, Barinagarrementeria, F; ISCVT Investigators. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 2004; 34: 664–70.Google Scholar
Klai, S, Fekih-Mrissa, N, Mrissa, R, Rachdi, R, Gritli, N. Maternal cerebral venous thrombosis, uncommon but serious disorder, pathologic predictors and contribution of prothrombotic abnormalities. Blood Coagul Fibrinolysis 2013; 24: 269–72.Google Scholar
Deschiens, MA, Conard, J, Horellou, MH, et al. Coagulation studies, factor V Leiden, and anticardiolipin antibodies in 40 cases of cerebral venous thrombosis. Stroke 1996; 27: 1724–30.Google Scholar
Zuber, M, Toulon, P, Marnet, L, et al. Factor V Leiden mutation in cerebral venous thrombosis. Stroke 1996; 27: 1721–3.Google Scholar
Carhuapoma, JR, Mitsias, P, Levine, SR. Cerebral venous thrombosis and anticardiolipin antibodies. Stroke 1997; 28: 2363–9.Google Scholar
Provenzale, JM, Loganbill, HA. Dual sinus thrombosis and venous infarction associated with antiphospholipid antibodies: MR findings. J Comput Assist Tomogr 1994; 18: 719–23.Google Scholar
Coutinho, J, de Bruijn, SF, Deveber, G, Stam, J. Anticoagulation for cerebral venous sinus thrombosis. Cochrane Database Syst Rev 2011; (8): CD002005.Google Scholar
Khan, M, Kamal, AK, Wasay, M. Controversies of treatment modalities for cerebral venous thrombosis. Stroke Res Treat 2010; 2010: 956302.Google Scholar
Coutinho, JM, Majoie, CB, Coert, BA, Stam, J. Decompressive hemicraniectomy in cerebral sinus thrombosis: Consecutive case series and review of the literature. Stroke 2009; 40: 2233–5.Google Scholar
Dias, M, Sekhar, L. Intracranial hemorrhage from aneurysms and arteriovenous malformations during pregnancy and puerperium. Neurology 1990; 27: 855–66.Google Scholar
Enomoto, H, Goto, H. Moyamoya disease presenting as intracerebral hemorrhage during pregnancy: case report and review of the literature. Neurosurgery 1987; 20: 33–5.Google Scholar
Isla, A, Alvarez, F, Gonzalez, A, et al. Brain tumor and pregnancy. Obstet Gynecol 1997; 89: 19.Google Scholar
Henderson, CE, Torbey, M. Rupture of intracranial aneurysm associated with cocaine use during pregnancy. Am J Perinatol 1988; 5: 142.Google Scholar
Iriye, BK, Asrat, T, Adashek, JA, et al. Intraventricular haemorrhage and maternal brain death associated with antepartum cocaine abuse. Br J Obstet Gynaecol 1995; 102: 68–9.Google Scholar
Maher, LM, Peterson, PL, Dela-Cruz, C. Postpartum intracranical hemorrhage and phenylpropanolamine use. Neurology 1987; 37: 1686.Google Scholar
Barrow, DL, Reisner, A. Natural history of intracranial aneurysms and vascular malformations. Clin Neurosurg 1993; 40: 3.Google Scholar
Wilterdink, JL, Feldman, E. Cerebral hemorrhage. In Devinsky, O, Feldman, E, Hairlire, B (eds), Neurological Complications of Pregnancy. New York, NY: Raven, 1994, pp. 12–23.Google Scholar
Forster, DMC, Kunkler, IH, Hartland, P. Risk of cerebral bleeding from arteriovenous malformations in pregnancy: the Sheffield experience. Stereot Funct Neurosurg 1993; 61 (Suppl 1): 20–2.Google Scholar
Bateman, BT, Schumacher, HC, Bushnell, CD, et al. Intracerebral hemorrhage in pregnancy: frequency, risk factors, and outcome. Neurology 2006; 67: 424–9.Google Scholar
Horton, JC, Chambers, WA, Lynos, SL, et al. Pregnancy and the risk of hemorrhage from cerebral arteriovenous malformations. Neurosurgery 1990; 27: 867–71.Google Scholar
Piotin, M, de Souza Filho, CB, Kothimbakam, R, Moret, J. Endovascular treatment of acutely ruptured intracranial aneurysms in pregnancy. Am J Obstet Gynecol 2001; 185: 1261–2.Google Scholar
Willoughby, JS. Sodium nitroprusside, pregnancy and multiple intracranial aneurysms. Anaesth Intensive Care 1984; 12: 358–60.Google Scholar
Newman, B, Lam, AM. Induced hypotension for clipping of a cerebral aneurysm during pregnancy: a case report and brief review. Anesth Analg 1986; 65: 675–8.Google Scholar
Kassel, NF, Peerless, SJ, Durward, QJ, et al. Treatment of ischemic deficits from vasospasm with intravascular volume expansion and induced arterial hypertension. Neurosurgery 1982; 11: 337–43.Google Scholar
Kassel, NF, Sasaki, T, Colohan, AR, Nazar, G. Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke 1985; 16: 562–72.Google Scholar
Guida, M, Altieri, R, Palatucci, V, et al. Aneurysmal subarachnoid haemorrhage in pregnancy: a case series. Transl Med UniSa 2012; 2: 59–63.Google Scholar
Stånge, K, Halldin, M. Hypothermia in pregnancy. Anesthesiology 1983; 58: 460–1.Google Scholar
Belfort, MA, Saade, GR, Moise, KJ, et al. Nimodipine in the management of preeclampsia: maternal and fetal effects. Am J Obstet Gynecol 1994; 171: 417–24.Google Scholar
Duscay, CA, Thompson, JS, Wu, AT, Novy, MJ. The effects of calcium entry blocker (nicardipine) tocolysis in rhesus macaques: Fetal plasma concentrations and cardiorespiratory changes. Am J Obstet Gynecol 1987; 157: 1482–6.Google Scholar
Van Rossum, J, Wintzen, AR, Endtz, LJ, et al. Effect of tranexamic acid on rebleeding after subarachnoid hemorrhage: a double blind control trial. Ann Neurol 1977; 2: 238–42.Google Scholar
Robinson, JL, Hall, CS, Sedzimir, CB. AV malformations, aneurysms and pregnancy. J Neurosurg 1974; 41: 63–70.Google Scholar
Mosiewicz, A, Jakiel, G, Janusz, W, Markiewicz, P. Treatment of intracranial aneurysms during pregnancy. Ginekol Pol 2001; 72: 86–92.Google Scholar
Parkinson, D, Bachers, G. Arteriovenous malformations: summary of 100 consecutive supratentorial cases. J Neurosurg 1980; 53: 285–99.Google Scholar
Young, DC, Leveno, KJ, Whalley, PS. Induced delivery prior to surgery for ruptured cerebral aneurysm. Obstet Gynecol 1983; 61: 749–52.Google Scholar
Broderick, JP, Brott, T, Tomsick, T, Miller, R, Huster, G. Intracerebral hemorrhage more than twice as common as subarachnoid hemorrhage. J Neurosurg 1993; 78: 188–91.Google Scholar
Qureshi, AI, Tuhrim, S, Broderick, JP, et al. Spontaneous intracerebral hemorrhage. N Engl J Med 2001; 344: 1450–60.Google Scholar
Hemphill, JC, Greenberg, SM, Anderson, CS, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2015; 46: 2032–60.Google Scholar
Zhu, XL, Chan, MS, Poon, WS. Spontaneous intracranial hemorrhage: which patients need diagnostic cerebral angiography? A prospective study of 206 cases and review of the literature. Stroke 1997; 28: 1406–9.Google Scholar
Flibotte, JJ, Hagan, N, O’Donnell, J, Greenberg, SM, Rosand, J. Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology 2004; 63: 1059–64.Google Scholar
Lee, SB, Manno, EM, Layton, KF, Wijdicks, EF. Progression of warfarin-associated intracerebral hemorrhage after INR normalization with FFP. Neurology 2006; 67: 1272–4.Google Scholar
Diringer, MN. Intracerebral hemorrhage: pathophysiology and management. Crit Care Med 1993; 21: 1591–603.Google Scholar
Bhardwaj, A, Ulatowski, JA. Hypertonic saline solutions in brain injury. Curr Opin Crit Care 2004; 10: 126–31.Google Scholar
Misra, UK, Kalita, J, Ranjan, P, Mandal, SK. Mannitol in intracerebral hemorrhage: a randomized controlled study. J Neurol Sci 2005; 234: 41–5.Google Scholar
Dereeper, E, Berre, J, Vandesteene, A, Lefranc, F, Vincent, JL. Barbiturate coma for intracranial hypertension: clinical observations. J Crit Care 2002; 17: 58–62.Google Scholar
Kang, TM. Propofol infusion syndrome in critically ill patients. Ann Pharmacother 2002; 36: 1453–6.Google Scholar
Steiner, T, Ringleb, P, Hacke, W. Treatment options for large hemispheric stroke. Neurology 2001; 57 (5, Suppl 2): S61–8.Google Scholar
Poungvarin, N, Bhoopat, W, Viriyavejakul, A, et al. Effects of dexamethasone in primary supratentorial intracerebral hemorrhage. N Engl J Med 1987; 316: 1229–33.Google Scholar
Aegidius, K, Zwart, JA, Hagen, K, Stovner, L. The effect of pregnancy and parity on headache prevalence: the Head-HUNT study. Headache 2009; 49: 851–9.Google Scholar
Fox, MW, Harms, RW, Davis, DH. Selected neurologic complications of pregnancy. Mayo Clin Proc 1990; 65: 1595–618.Google Scholar
Sances, G, Granella, F, Nappi, RE, et al. Course of migraine during pregnancy and postpartum: a prospective study. Cephalalgia 2003; 23: 197–205.Google Scholar
Kvisvik, EV, Stovner, LJ, Helde, G, Bovim, G, Linde, M. Headache and migraine during pregnancy and puerperium: the MIGRA-study. J Headache Pain 2011; 12: 443–51.Google Scholar
Digre, KB. Headaches during pregnancy. Clin Obstet Gynecol 2013; 56: 317–29.Google Scholar
Contag, SA, Bushnell, C. Contemporary management of migrainous disorders in pregnancy. Curr Opin Obstet Gynecol 2010; 22: 437–45.Google Scholar
Macgregor, EA. Headache in pregnancy. Continuum (Minneap Minn) 2014; 20 (1 Neurology of Pregnancy): 128–47.Google Scholar
Bellissima, V, Ververs, TF, Visser, GH, Gazzolo, D. Selective serotonin reuptake inhibitors in pregnancy. Curr Med Chem 2012; 19: 4554–61.Google Scholar
Seebacher, J, Ribeiro, V, LeGillou, JL, et al. Epidural blood patch in the treatment of post dural puncture headache: a double blind study. Headache 1989; 29: 630–2.Google Scholar
Biousse, V, Bruce, BB, Newman, NJ. Update on the pathophysiology and management of idiopathic intracranial hypertension. J Neurol Neurosurg Psychiatry 2012; 83: 488–94.Google Scholar
Kesler, A, Kupferminc, M. Idiopathic intracranial hypertension and pregnancy. Clin Obstet Gynecol 2013; 56: 389–96.Google Scholar
Bradley, NK, Liakos, AM, McAllister, JP, et al. Maternal shunt dependency: implications for obstetric care, neurosurgical management, and pregnancy outcomes and a review of selected literature. Neurosurgery 1998; 43: 448–60.Google Scholar
Wisoff, JH, Kartzert, KJ, Handwerker, SM. Pregnancy in patients with cerebrospinal fluid shunts: report of a series and review of the literature. Neurosurgery 1991; 29: 827–31.Google Scholar
Cusimano, MD, Meffe, FM, Gentili, F, Semer, M. Ventriculoperitoneal shunt malfunction during pregnancy. Neurosurgery 1990; 27: 969–71.Google Scholar
Houston, CS, Clein, LJ. Ventriculoperitoneal shunt malfunction in a pregnant patient with meningomyelocele. Can Med Assoc J 1989; 141: 701–2.Google Scholar
Li, G, Dutta, S. Perioperative management of ventriculoperitoneal shunts during abdominal surgery. Surg Neurol 2008; 70: 492–5.Google Scholar
Baker, ER, Cardenas, DD, Benedetti, TJ. Risks associated with pregnancy in spinal cord injured women. Obstet Gynecol 1992; 80: 425–8.Google Scholar
American College of Obstetricians and Gynecologists. Obstetric Management of Patients with Spinal Cord Injuries. ACOG Committee Opinion 275. Washington, DC: ACOG, 2002.Google Scholar
Vrabec, JT, Isaacson, B, Van Hook, JW. Bell’s palsy and pregnancy. Otolaryngol Head Neck Surg 2007; 137: 858–61.Google Scholar
Voitk, AJ, Mueller, JC, Farlinger, DE, Johnston, RU. Carpal tunnel syndrome in pregnancy. Can Med Assoc J 1983; 128: 277–81.Google Scholar
Wand, JS. Carpal tunnel syndrome in pregnancy and lactation. J Hand Surg Br 1990; 15: 93–4.Google Scholar
Snell, NJ, Coysh, HL, Snell, BJ. Carpal tunnel syndrome presenting in the puerperium. Practitioner 1980; 224: 191–3.Google Scholar
Van Diver, T, Camann, W. Meralgia paresthetica in the parturient. Int J Obstet Anesth 1995; 4: 109–12.Google Scholar
Fast, A, Shapiro, D, Ducommun, EJ, et al. Low-back pain in pregnancy. Spine 1987; 12: 368–71.Google Scholar
LaBan, MM, Perrin, JCS, Latimer, FR. Pregnancy and the herniated lumbar disc. Arch Phys Med Rehabil 1983; 64: 319–21.Google Scholar
Wong, CA, Scavone, BM, Dugan, S, et al. Incidence of postpartum lumbosacral spine and lower extremity nerve injuries. Obstet Gynecol 2003; 101: 279–88.Google Scholar
Weinreb, JC, Wolbarsht, LB, Cohen, JM, Brown, CE, Maravilla, KR. Prevalence of lumbosacral intervertebral disc abnormalities on MR images in pregnant and asymptomatic women. Radiology 1989; 170: 125–8.Google Scholar
Roy, S, Levine, AB, Herbison, GJ, Jacobs, SR. Intraoperative positioning during cesarean as a cause of sciatic neuropathy. Obstet Gynecol 2002; 99: 652–3.Google Scholar
Rodin, A, Ferner, R, Russell, R. Guillain–Barré syndrome in pregnancy and puerperium. J Obstet Gynecol 1988; 9: 39–42.Google Scholar
Chan, LY, Tsui, MH, Leung, TN. Guillain–Barré syndrome in pregnancy. Acta Obstet Gynecol Scand 2004; 83: 319–25.Google Scholar
Yamada, H, Noro, N, Kato, EH, et al. Massive intravenous immunoglobulin treatment in pregnancy complicated by Guillain–Barré syndrome. Eur J Obstet Gynecol Reprod Biol 2001; 97: 101–104.Google Scholar
Watson, WJ, Katz, VL, Bowes, WA. Plasmapheresis during pregnancy. Obstet Gynecol 1990; 76: 451–7.Google Scholar
van der Merché, FGA, Schmitz, PI. A randomized trial comparing intravenous immune globulin and plasma exchange in Guillain–Barré syndrome. Dutch Guillain–Barré Study Group. N Engl J Med 1992; 326: 1123–9.Google Scholar
Dyck, PJ, Prneas, J, Pollard, J. Chronic inflammatory demyelinating polyradiculaneuropathy. In Dyck, PJ, Griffin, JW, et al. (eds), Peripheral Neuropathy. Philadelphia, PA: Saunders, 1993, pp. 1498–517.Google Scholar
Gold, R, Stangel, M, Dalakas, MC. Drug insight: the use of intravenous immunoglobulin in neurology – therapeutic considerations and practical issues. Nat Clin Pract Neurol 2007; 3: 36–44.Google Scholar
Rudnik-Schoneborn, S, Zerres, K. Outcome in pregnancies complicated by myotonic dystrophy: a study of 31 patients and review of the literature. Eur J Obstet Gynecol Reprod Biol 2004; 114: 44–53.Google Scholar
Jaffe, R, Mock, M, Abramowitz, J, et al. Myotonic dystrophy and pregnancy: a review. Obstet Gynecol Surv 1986; 41: 272–8.Google Scholar
Hughes, RG, Lyall, EGH, Liston, WA. Obstetric and neonatal complications of myotonic dystrophy. J Obstet Gynaecol 1991; 11: 191–3.Google Scholar
Fall, LH, Young, WW, Power, JA, et al. Severe congestive heart failure and cardiomyopathy as a complication of myotonic dystrophy in pregnancy. Obstet Gynecol 1990; 76: 481–5.Google Scholar
Moorman, J, Coleman, R, Packer, D, et al. Cardiac involvement in myotonic dystrophy. Medicine (Baltimore) 1985; 64: 371–87.Google Scholar
Jaffe, R, Mock, M, Abramowitz, J, et al. Myotonic dystrophy and pregnancy: a review. Obstet Gynecol Surv 1986; 41: 272–8.Google Scholar
Grrella, P, Santarossa, C, Pennazzato, S, et al. Pregnancy, labour and delivery in myotonic dystrophy. Basic Appl Myol 1997; 7: 351–5.Google Scholar
Rutherford, MA, Heckmatt, JZ, Dubowitz, V. Congenital myotonic dystrophy: respiratory function at birth determines survival. Arch Dis Child 1989; 64: 191–5.Google Scholar
Reardon, W, Newcombe, R, Fenton, I, Sibert, J, Harper, PS. The natural history of congenital myotonic dystrophy: mortality and long term clinical aspects. Arch Dis Child 1993; 68: 177–81.Google Scholar
Harper, PS. Congenital myotonic dystrophy in Britain: genetic basis. Arch Dis Child 1975; 50: 514–21.Google Scholar
Bowater, RP, Wells, RD. The intrinsically unstable life of DNA triplet repeats associated with human hereditary disorders. Prog Nucleic Acid Res Mol Biol 2001; 66: 159–202.Google Scholar
Blumgart, CH, Hughes, DG, Redfern, N. Obstetric anaesthesia in dystrophia myotonica. Anaesthesia 1990; 45: 26–9.Google Scholar
Polman, CH, Reingold, SC, Banwell, B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald Criteria. Ann Neurol 2011; 69: 292–302.Google Scholar
Finkelsztejn, A, Brooks, JB, Paschoal, FM, Fragoso, YD. What can we really tell women with multiple sclerosis regarding pregnancy? A systematic review and meta-analysis of the literature. BJOG 2011; 118: 790–7.Google Scholar
Runmarker, B, Anderson, O. Pregnancy is associated with a lower risk of onset and a better prognosis in multiple sclerosis. Brain 1995; 118: 253–61.Google Scholar
Vukusic, S, Hutchinson, M, Hours, M, et al. Pregnancy and multiple sclerosis (the PRIMS study): clinical predictors of post-partum relapse. Brain 2004; 127: 1353–60.Google Scholar
Langer-Gould, A, Beaber, BE. Effects of pregnancy and breast feeding on the multiple sclerosis disease course. Clin Immunol 2013; 149: 244–50.Google Scholar
Worthington, J, Jones, R, Crawford, M, et al. Pregnancy and multiple sclerosis: a 3 year prospective study. J Neurol 1994; 241: 228–33.Google Scholar
Houtchens, MK. Pregnancy and multiple sclerosis. Semin Neurol 2007; 27: 434–41.Google Scholar
Hellwig, K, Correale, J. Artificial reproductive techniques in multiple sclerosis. Clin Immunol 2013; 149; 219–24.Google Scholar
Sadovnick, AD. Empiric recurrence risks for use in the genetic counselling of multiple sclerosis patients. Am J Med Genet 1984; 17: 713–14.Google Scholar
Lu, E, Wang, BW, Guimond, C, et al. Disease-modifying drugs for multiple sclerosis in pregnancy: a systematic review. Neurology 2012; 79: 1130–5.Google Scholar
Lu, E, Wang, BW, Alwan, S, et al. A review of safety-related pregnancy data surrounding the oral disease-modifying drugs for multiple sclerosis. CNS Drugs 2014; 28: 89–94.Google Scholar
Ferrero, S, Pretta, S, Ragni, N. Multiple sclerosis: management issues during pregnancy. Eur J Obstet Gynecol Reprod Biol 2004; 15: 3-9.Google Scholar
Carroll, RS, Zhang, J, Black, PM. Expression of estrogen receptors alpha and beta in human meningiomas. J Neurooncol 1999; 42: 109–16.Google Scholar
Kasper, EM, Hess, PE, Silasi, M, et al. A pregnant female with a large intracranial mass: reviewing the evidence to obtain management guidelines for intracranial meningiomas during pregnancy. Surg Neurol Int 2010; 1: 95 doi: 10.4103/2152-7806.74242.Google Scholar
Verheecke, M, Halaska, MJ, Lok, CA, et al. Primary brain tumours, meningiomas and grain metastases in pregnancy: report on 27 cases and review of literature. Eur J Cancer 2014; 50: 1462–71.Google Scholar
Dildy, GA, Moise, KJ, Carpenter, RJ, Klima, T. Maternal malignancy metastatic to the products of conception: a review. Obstet Gynecol Surv 1989; 44: 535–40.Google Scholar
Weed, JC, Hunter, VJ. Diagnosis and management of brain metastasis from gestational trophoblastic disease. Oncology 1991; 5: 48–50.Google Scholar
Weed, JC, Wood, KT, Hammond, CB. Choriocarcinoma metastatic to the brain: therapy and prognosis. Semin Oncol 1982; 9: 208–12.Google Scholar
Nakagawa, Y, Tashiro, K, Isu, T, Tsuru, M. Occlusion of cerebral artery due to metastasis of chorioepithelioma. J Neurosurg 1979; 51: 247–50.Google Scholar
Huang, CY, Chen, CA, Hsieh, CY, Cheng, WF. Intracerebral hemorrhage as initial presentation of gestational choriocarcinoma: a case report and literature review. Int J Gynecol Cancer 2007; 17: 1166–71.Google Scholar
Gonzalez, JG, Elizonda, G, Saldivar, D, et al. Pituitary gland growth during normal pregnancy: an in vivo study using magnetic resonance imaging. Am J Med 1988; 85: 217–20.Google Scholar
Molitch, ME. Prolactinoma in pregnancy. Best Pract Res Clin Endocrinol Metab 2011; 25: 885–96.Google Scholar
Kulkarni, MV, Lee, KF, McArdle, CB, Yeakley, JW, Haar, FL. 1.5-T NR imaging of pituitary microadenomas: technical consideration and CT correlation. AJNR Am J Neuroradiol 1988; 9: 5–11.Google Scholar
Klibanski, A. Prolactinomas. N Engl J Med 2010; 362: 1219–26.Google Scholar
Auriemma, RS, Perone, Y, Di Sarno, A, et al. Results of a single-center observational 10-year survey study on recurrence of hyperprolactinemia after pregnancy and lactation. J Clin Endocrinol Metab 2013; 98: 372–9.Google Scholar
Kranick, SM, Mowry, EM, Colcher, A, Horn, S, Golbe, LI. Movement disorders and pregnancy: a review of the literature. Mov Disord 2010; 25: 665–71.Google Scholar
Bordelon, YM, Smith, M. Movement disorders in pregnancy. Semin Neurol 2007; 27: 467–75.Google Scholar
Golbe, LI. Pregnancy and movement disorders. Neurol Clin 1994; 12: 497–508.Google Scholar
Cardoso, F. Chorea gravidarum. Arch Neurol 2002; 59: 868–70.Google Scholar
Caviness, JN, Muenter, M. An unusual cause of recurrent chorea. Mov Disord 1991; 6: 355–7.Google Scholar
Lorincz, MT. Neurologic Wilson’s disease. Ann NY Acad Sci 2010; 1184: 173–87.Google Scholar
Dreifuss, FE, McKinney, WM. Wilson’s disease (hepatolenticular degeneration) and pregnancy. JAMA 1966; 195: 960–2.Google Scholar
Scheinberg, IH, Sternlieb, I. Pregnancy in penicillamine treated patients with Wilson’s disease. N Engl J Med 1975; 293: 1300–2.Google Scholar
Mjolneod, OK, Dommerud, SA, Rasmussen, K, Gjeruldsen, ST. Congeinital connective-tissue defect probably due to D-penicillamine treatment in pregnancy. Lancet 1971; 1: 673–5.Google Scholar
Malik, A, Khawaja, A, Sheikh, L. Wilson’s disease in pregnancy: case series and review of literature. BMC Res Notes 2013; 6: 421. doi: 10.1186/1756-0500-6-421.Google Scholar
Brewer, GJ, Johnson, VD, Dick, RD, Fink, JK, Kluin, KJ. Treatment of Wilson’s disease with zinc, SVII: treatment during pregnancy. Hepatology 2000; 31: 364–70.Google Scholar
Yeh, P, Walters, AS, Tsuang, JW. Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment. Sleep Breath 2012: 16: 987–1007.Google Scholar
Picchietti, DL, Hensley, JG, Bainbridge, JL, et al.; International Restless Legs Syndrome Study Group (IRLSSG). Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation. Sleep Med Rev 2015; 22: 64–77. http://dx.doi.org/10.1016/j.smrrv.2014.10.009 (accessed March 2017).Google Scholar
Srivanitchapoom, P, Pandey, S, Hallett, M. Restless legs syndrome and pregnancy: a review. Parkinsonism Relat Disord 2014; 20: 716–22.Google Scholar
Caine, SM, Kumar, A. Young onset Parkinson’s disease: practical management of medical issues. Parkinsonism Relat Disord 2008; 14: 132–42.Google Scholar
Shulman, LM, Minagar, A, Weiner, WJ. The effect of pregnancy in Parkinson’s disease. Mov Disord 2000; 15: 132–5.Google Scholar
Was, JR, Pinette, MG, Blackstone, J, Cartin, A. Brain abscess complicating pregnancy. Obstet Gynecol Surv 2004; 59: 207–13.Google Scholar

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