from Section 2 - Common Neurologic Presentations: A Symptom-Based Approach
Published online by Cambridge University Press: 10 January 2024
Weakness is often a very complicated ED presenting complaint. A detailed history and physical examination, and diligent search for etiology, are required. First, the clinician must elucidate true weakness versus fatigue. Fatigue is best defined as a decrease in the ability to perform motor functions. Fatigue may be the complaint for a broad differential diagnosis, including acute coronary syndrome, anemia, chronic inflammatory diseases, dehydration, hypoglycemia or other electrolyte derangements, adrenal insufficiency, a variety of infections, pulmonary disorders, medication side effects, and depression. These disorders are characterized by a lack of true muscular weakness on examination. True muscular weakness is not painful, and pain should guide the examiner to other etiologies such as fibromyalgia or polymyalgia rheumatica.
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