Book contents
- Frontmatter
- Dedication
- Contents
- List of insights
- Preface
- Notation
- Part I Preliminaries
- Part II Fundamentals of Biological Sequence Analysis
- Part III Genome-Scale Index Structures
- Part IV Genome-Scale Algorithms
- Part V Applications
- 14 Haplotype analysis
- 15 Pangenomics
- 16 Transcriptomics
- 17 Metagenomics
- References
- Index
15 - Pangenomics
from Part V - Applications
Published online by Cambridge University Press: 28 September 2023
- Frontmatter
- Dedication
- Contents
- List of insights
- Preface
- Notation
- Part I Preliminaries
- Part II Fundamentals of Biological Sequence Analysis
- Part III Genome-Scale Index Structures
- Part IV Genome-Scale Algorithms
- Part V Applications
- 14 Haplotype analysis
- 15 Pangenomics
- 16 Transcriptomics
- 17 Metagenomics
- References
- Index
Summary
Several large-scale studies aim to build comprehensive catalogs of all the variants in a population, for example all the frequent variants in a species or all the variants in a group of individuals with a specific trait or disease. Such catalogs are the substrate for subsequent genome-wide association studies that aim to correlate variants to traits, and ultimately to personalized treatments. Such catalogs can also be leveraged for making basic analysis tasks, such as read alignment, using not just one reference genome but a pangenome data structure representing all genomes in the catalogue. The chapter gives an overview of different pangenome data structures and their applications. Selected data structures are covered in more depth, including the r-index.
- Type
- Chapter
- Information
- Genome-Scale Algorithm DesignBioinformatics in the Era of High-Throughput Sequencing, pp. 344 - 366Publisher: Cambridge University PressPrint publication year: 2023