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Chapter 18 - Psychopharmacology and Evolution

Published online by Cambridge University Press:  08 September 2022

By
Paul St John-Smith ,
Riadh Abed  and
Martin Brüne
Edited by
Riadh Abed  and
Paul St John-Smith
Riadh Abed
Affiliation:
Mental Health Tribunals, Ministry of Justice, UK
Paul St John-Smith
Affiliation:
Hertfordshire Partnership University NHS Foundation Trust, UK
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Summary

Psychopharmacology is the scientific study of the effects of drugs on thoughts, emotions and behaviour as well as the therapeutic implications of their role in treating mental disorders. Psychopharmacology focuses on understanding relevant mental processes as the key to finding new medications and improving clinical outcomes in mental disorder. Interconnected with this, neuropsychopharmacology is the complementary discipline of the study of the basic neural mechanisms that drugs act upon to influence behaviour. Progress has been slow in recent decades with no major new classes of medication being added to the psychiatric formulary. We suggest that evolutionary thinking brings novel additional scientific perspectives to psychiatry and its basic sciences that highlight the evolutionary history of cell communication, neurotransmission and substances that can alter the brain in various ways. Evolutionary perspectives of function and phylogeny also provide a deeper understanding of how natural as well as artificial chemicals (i.e. psychotropic medications) utilise evolved neuronal pathways for their actions. Evolutionary theory can thereby help us to understand the psychological effects and side effects of psychotropic medications as well as assist in the discovery and testing of new drugs.

Keywords

evolutionevolutionary psychiatrynatural selectionneuromodulatorsneurotransmitterspsychopharmacology
Type
Chapter
Information
Evolutionary Psychiatry
Current Perspectives on Evolution and Mental Health
 , pp. 276 - 294
Publisher: Cambridge University Press
Print publication year: 2022

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References

Abed, R. and St John-Smith, P. (2021). Evolutionary psychology and psychiatry. In: Shackleford, T. K. (ed.), The Sage Handbook of Evolutionary Psychology: Applications of Evolutionary Psychology. London: Sage, pp. 24–50.Google Scholar
Allman, J. M. (1999). Evolving Brains. New York: Scientific American Library: distributed by W.H. Freeman and Co.Google Scholar
Amunts, K. and Zilles, K. (2015). Architectonic mapping of the human brain beyond Brodmann. Neuron, 88, 1086–1107.Google Scholar
Attwell, D. and Laughlin, S. B. (2001). An energy budget for signalling in the grey matter of the brain. Journal of Cerebral Blood Flow & Metabolism, 21, 1133–1145.Google Scholar
Azmitia, E. C. (2010). Evolution of serotonin: sunlight to suicide. In: Müller, C. P. and Jacobs, B. L. (eds.), Handbook of the Behavioral Neurobiology of Serotonin. London: Academic Press, Elsevier, pp. 3–22.Google Scholar
Belzung, C. and Lemoine, M. (2011). Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression. Biology of Mood & Anxiety Disorders, 1, 1–14.Google Scholar
Bender, G. A. (1965). Great Moments in Pharmacy. Tucson: Arizona Medical Center Library.Google Scholar
Brüne, M. (2014). On aims and methods of psychiatry. A reminiscence of 50 years of Tinbergen’s famous questions about the biology of behavior. BMC Psychiatry, 14, 364.Google Scholar
Brüne, M. (2015). Textbook of Evolutionary Psychiatry and Psychosomatic Medicine: The Origins of Psychopathology. Oxford: Oxford University Press.Google Scholar
Changeux, J.-P. (2005). Genes, brains, and culture: from monkey to human. In: Dehaene, S., Duhamel, J.-R., Hauser, M. and Rizzolatti, G. (eds.), From Monkey Brain to Human Brain. Cambridge, MA: MIT Press, pp. 73–94.Google Scholar
Chen, G. Q., Cui, C., Mayer, M. L. and Gouaux, E. (1999). Functional characterization of a potassium-selective prokaryotic glutamate receptor. Nature, 402, 817–821.Google Scholar
Davies, B. (1999). The first patient to receive lithium. Australian & New Zealand Journal of Psychiatry, 33, 366–368.Google Scholar
Desai, N. C., Makwana, A. H. and Senta, R. D. (2016). Synthesis, characterization and antimicrobial activity of some novel 4-(4-(arylamino)-6-(piperidin-1-yl)-1, 3, 5-triazine-2-ylamino)-N-(pyrimidin-2-yl) benzenesulfonamides. Journal of Saudi Chemical Society, 20, 686–694.CrossRefGoogle Scholar
Dreborg, S., Sundström, G., Larsson, T. A. and Larhammar, D. (2008). Evolution of vertebrate opioid receptors. Proceedings of the National Academy of Sciences of the United States of America, 105, 15487–15492.CrossRefGoogle ScholarPubMed
Durisko, Z., Mulsant, B. H., McKenzie, K. and Andrews, P. W. (2016). Using evolutionary theory to guide mental health research. Canadian Journal of Psychiatry, 61, 159–165.Google Scholar
Edeleano, L. (1887). Ueber einige Derivate der Phenylmethacrylsäure und der Phenylisobuttersäure. Berichte der deutschen chemischen Gesellschaft, 20, 616–622.CrossRefGoogle Scholar
Edgar, N. and Sibille, E. (2012). A putative functional role for oligodendrocytes in mood regulation. Translational Psychiatry, 2, e109.Google Scholar
Ellis, L. (ed.) (2003). Archaeological Method and Theory: An Encyclopaedia. London: Routledge.Google Scholar
Emes, R. D. and Grant, S. G. N. (2012). Evolution of synapse complexity and diversity. Annual Review of Neuroscience, 35, 111–131.Google Scholar
Fabrega, H. Jr (1997). Earliest phases in the evolution of sickness and healing. Medical Anthropology Quarterly, 11, 26–55.Google Scholar
Faissner, A., Pyka, M., Geissler, M., Sobik, T., Frischknecht, R., Gundelfinger, E. D. and Seidenbecher, C. (2010). Contributions of astrocytes to synapse formation and maturation – potential functions of the perisynaptic extracellular matrix. Brain Research Reviews, 63, 26–38.Google Scholar
Fehm, H. L., Kern, W. and Peters, A. (2006). The selfish brain: competition for energy resources. Progress in Brain Research, 153, 129–140.Google Scholar
Fields, R. D., Araque, A., Johansen-Berg, H., Lim, S. S., Lynch, G., Nave, K. A., Nedergaard, M., Perez, R., Sejnowski, T. and Wake, H. (2014). Glial biology in learning and cognition. Neuroscientist, 20, 426–431.Google Scholar
Galanter, M., Kleber, H. D. and Brady, K. (eds.) (2014). The American Psychiatric Publishing Textbook of Substance Abuse Treatment. Washington, DC: American Psychiatric Publishing.Google Scholar
Gluckman, P. D., Low, F. M., Buklijas, T., Hanson, M. A. and Beedle, A. S. (2011). How evolutionary principles improve the understanding of human health and disease. Evolutionary Applications, 4, 249–263.Google Scholar
Guyton, A. C. and Hall, J. E. (2006). Textbook of Medical Physiology. Philadelphia, PA: Elsevier.Google Scholar
Halbreich, U. and Endicott, J. (1981). Possible involvement of endorphin withdrawal or imbalance in specific premenstrual syndromes and postpartum depression. Medical Hypotheses, 7, 1045–1058.Google Scholar
Hardy, K., Buckley, S., Collins, M. J., Estalrrich, A., Brothwell, D., Copeland, L., García-Tabernero, A., García-Vargas, S., De La Rasilla, M., Lalueza-Fox, C. and Huguet, R. (2012). Neanderthal medics? Evidence for food, cooking, and medicinal plants entrapped in dental calculus. Naturwissenschaften, 99, 617–626.Google Scholar
Haroon, E., Miller, A. H., and Sanacora, G. (2017). Inflammation, glutamate, and glia: a trio of trouble in mood disorders. Neuropsychopharmacology, 42, 193–215.Google Scholar
Healy, D. (1997). The Antidepressant Era. Cambridge, MA: Harvard University Press.Google Scholar
Herculano-Houzel, S., Avelino-de-Souza, K., Neves, K., Porfírio, J., Messeder, D., Mattos Feijó, L., Maldonado, J. and Manger, P. R. (2014). The elephant brain in numbers. Frontiers in Neuroanatomy, 8, 46.Google Scholar
Hofman, M. A. (2014). Evolution of the human brain: when bigger is better. Frontiers in Neuroanatomy, 8, 15.Google Scholar
Horwitz, A. V. and Wakefield, J. C. (2007). The Loss of Sadness: How Psychiatry Transformed Normal Sadness into Depressive Disorder. Oxford: Oxford University Press.Google Scholar
Huffman, M. A. (1997). Current evidence for self‐medication in primates: a multidisciplinary perspective. American Journal of Physical Anthropology, 104, 171–200.Google Scholar
Huron, D. (2018). On the functions of sadness and grief. In: Lench, H. C. (ed.), The Functions of Emotions: When and Why Emotions Help Us. Cham: Springer, pp. 59–92.Google Scholar
Jaiteh, M., Taly, A. and Hénin, J. (2016). Evolution of pentameric ligand-gated ion channels: Pro-loop receptors. PLoS ONE, 11, e0151934.CrossRefGoogle ScholarPubMed
Jakobsen, J. C., Katakam, K. K., Schou, A., Hellmuth, S. G., Stallknecht, S. E., Leth-Møller, K., Iversen, M., Banke, M. B., Petersen, I. J., Klingenberg, S. L. and Krogh, J. (2017). Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and trial sequential analysis. BMC Psychiatry, 17, 1–28.Google Scholar
Jerison, H. J. (1973). Evolution of the Brain and Intelligence. Cambridge, MA: Academic Press.Google Scholar
Jones, C. A., Watson, D. J. G. and Fone, K. C. F. (2011). Animal models of schizophrenia. British Journal of Pharmacology, 164, 1162–1194.Google Scholar
Kavan, M. G. and Borone, E. J. (2014). Grief and major depression – controversy over changes in DSM-5 diagnostic criteria. American Family Physician, 90, 693–694.Google Scholar
Kendler, K. S. (2008). Explanatory models for psychiatric illness. American Journal of Psychiatry, 165, 695–702.Google Scholar
Kirsch, I. (2019). Placebo effect in the treatment of depression and anxiety. Frontiers in Psychiatry, 10, 407.Google Scholar
Konstantinidis, K. T. and Tiedje, J. M. (2004). Trends between gene content and genome size in prokaryotic species with larger genomes. Proceedings of the National Academy of Sciences of the United States of America, 101, 3160–3165.Google Scholar
Kristiansen, J. and Amaral, L. (1997). The potential management of resistant infections with non-antibiotics. Journal of Antimicrobial Chemotherapy, 40, 319–327.Google Scholar
Kudryavtsev, D., Shelukhina, I., Vulfius, C., Makarieva, T., Stonik, V., Zhmak, M., Ivanov, I., Kasheverov, I., Utkin, Y. and Tsetlin, V. (2015). Natural compounds interacting with nicotinic acetylcholine receptors: from low-molecular weight ones to peptides and proteins. Toxins, 7, 1683–1701.Google Scholar
Le Duc, D. and Schöneberg, T. (2019). Cellular signalling systems. In: Brüne, M. and Schiefenhövel, W. (eds.), The Oxford Handbook of Evolutionary Medicine. Oxford: Oxford University Press, pp. 45–76.Google Scholar
López-Muñoz, F., Alamo, C., Cuenca, E., Shen, W. W., Clervoy, P. and Rubio, G. (2005). History of the discovery and clinical introduction of chlorpromazine. Annals of Clinical Psychiatry, 17, 113–135.CrossRefGoogle ScholarPubMed
Maeda, N. (2015). Proteoglycans and neuronal migration in the cerebral cortex during development and disease. Frontiers in Neuroscience, 9, 98.Google Scholar
Matthysse, S. (1986). Animal models in psychiatric research. Progress in Brain Research, 65, 259–270.Google Scholar
McQueen, D. and St John-Smith, P. (2008). What should clinicians do when faced with conflicting recommendations? BMJ, 337, a2530.Google Scholar
McQueen, D. and St John-Smith, P. (2012). Placebo effects: a new paradigm and relevance to psychiatry. International Psychiatry, 9, 1–3.Google Scholar
McQueen, D., Cohen, S., St John-Smith, P. and Rampes, H. (2013a). Rethinking placebo in psychiatry: how and why placebo effects occur. Advances in Psychiatric Treatment, 19, 171–180.CrossRefGoogle Scholar
McQueen, D., Cohen, S., St John-Smith, P. and Rampes, H. (2013b). Rethinking placebo in psychiatry: the range of placebo effects. Advances in Psychiatric Treatment, 19, 162–170.Google Scholar
Miller, F. G., Colloca, L. and Kaptchuk, T. J. (2009). The placebo effect: illness and interpersonal healing. Perspectives in Biology and Medicine, 52, 518–539.Google Scholar
Molendijk, M. L. and de Kloet, E. R. (2015). Immobility in the forced swim test is adaptive and does not reflect depression. Psychoneuroendocrinology, 62, 389–391.Google Scholar
Moncrieff, J. (2008). The myth of the chemical cure. In: The Myth of the Chemical Cure. London: Palgrave Macmillan, pp. 217–224.Google Scholar
Moroz, L. L. (2009). On the independent origins of complex brains and neurons. Brain, Behavior and Evolution, 74, 177–190.Google Scholar
Nedergaard, M., Ransom, B. and Goldman, S. A. (2003). New roles for astrocytes: redefining the functional architecture of the brain. Trends in Neurosciences, 26, 523–530.Google Scholar
Nesse, R. M. (2011). Why has natural selection left us so vulnerable to anxiety and mood disorders? Canadian Journal of Psychiatry, 56, 705–706.Google Scholar
Nesse, R. M. and Ellsworth, P. C. (2009). Evolution, emotions, and emotional disorders. American Psychologist, 64, 129.Google Scholar
Nesse, R. M. and Stein, D. J. (2019). How evolutionary psychiatry can advance psychopharmacology. Dialogues in Clinical Neuroscience, 21, 167.CrossRefGoogle ScholarPubMed
Owens, D. C. (1999). A Guide to the Extrapyramidal Side Effects of Antipsychotic Drugs. Cambridge: Cambridge University Press.Google Scholar
Panksepp, J. (1998). Affective Neuroscience: The Foundations of Human and Animal Emotions. New York: Oxford University Press.Google Scholar
Perry, C. J. and Baciadonna, L. (2017). Studying emotion in invertebrates: what has been done, what can be measured and what they can provide. Journal of Experimental Biology, 220, 3856–3868.Google Scholar
Petit-Demouliere, B., Chenu, F. and Bourin, M. (2005). Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology, 177, 245–255.CrossRefGoogle ScholarPubMed
Petraglia, F., Comitini, G. and Genazzani, A. R. (1993). β-Endorphin in human reproduction. In: Herz, A. (ed.), Opioids II. Berlin: Springer, pp. 763–780.Google Scholar
Ramachandraih, C. T., Subramanyam, N., Bar, K. J., Baker, G. and Yeragani, V. K. (2011). Antidepressants: from MAOIs to SSRIs and more. Indian Journal of Psychiatry, 53, 180.Google Scholar
Rantala, M. J., Luoto, S. and Krams, I. (2017). An evolutionary approach to clinical pharmacopsychology. Psychotherapy and Psychosomatics, 86, 370–371.Google Scholar
Rantala, M. J., Luoto, S., Krams, I. and Karlsson, H. (2018). Depression subtyping based on evolutionary psychiatry: proximate mechanisms and ultimate functions. Brain, Behavior, and Immunity, 69, 603–617.Google Scholar
Raven, P., Johnson, G., Mason, K., Losos, J. and Duncan, T. (2017). The nervous system. In: Biology. New York: McGrath-Hill Education.Google Scholar
Roshchina, V. V. (2010). Evolutionary considerations of neurotransmitters in microbial, plant, and animal cells. In: Lyte, M. and Freestone, P. E. (eds.), Microbial Endocrinology. Berlin: Springer, pp. 17–52.Google Scholar
Ryan, T. J. and Grant, S. G. (2009). The origin and evolution of synapses. Nature Reviews Neuroscience, 10, 701–712.Google Scholar
Salzman, C. (2005). The limited role of expert guidelines in teaching psychopharmacology. Academic Psychiatry, 29, 176–179.Google Scholar
Schiefenhövel, W. (2000). [Suffering without meaning? Illness, pain and death. Development of evolutionary medicine]. Gesundheitswesen, 62, S3–S8.Google Scholar
Sherratt, A. (1995). Alcohol and its alternatives: symbol and substance in pre-industrial cultures. In: Goodman, J. (ed.), Consuming Habits: Global and Historical Perspectives on How Cultures Define Drugs. London: Routledge, pp. 11–45.Google Scholar
Shorter, E. (2005). A Historical Dictionary of Psychiatry. Oxford: Oxford University Press.Google Scholar
Sneader, W. (2005). Drug Discovery: A History. Hoboken, NJ: John Wiley & Sons.Google Scholar
Solms, M. (2021). The Hidden Spring: A Journey to the Source of Consciousness. London: Profile Books.Google Scholar
St John‐Smith, P., McQueen, D., Edwards, L. and Schifano, F. (2013). Classical and novel psychoactive substances: rethinking drug misuse from an evolutionary psychiatric perspective. Human Psychopharmacology: Clinical and Experimental, 28, 394–401.Google Scholar
Stahl, S. M. (2000). Essential Psychopharmacology: Neuroscientific Basis and Practical Application. Cambridge: Cambridge University Press.Google Scholar
Stearns, S. C., Nesse, R. M., Govindaraju, D. R. and Ellison, P. T. (2010). Evolution in health and medicine Sackler colloquium: evolutionary perspectives on health and medicine. Proceedings of the National Academy of Science of the United States of America, 107, 1691–1695.Google Scholar
Steegborn, C. (2014). Structure, mechanism, and regulation of soluble adenylyl cyclases – similarities and differences to transmembrane adenylyl cyclases. Biochimica et Biophysica Acta, 1842, 2535–2547.Google Scholar
Stein, D. J. (2006). Evolutionary theory, psychiatry, and psychopharmacology. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30, 766–773.Google Scholar
Stein, D. J. and Bouwer, C. (1997). A neuro-evolutionary approach to the anxiety disorders. Journal of Anxiety Disorders, 11, 409–429.Google Scholar
Sullivan, R. J. and Hagen, E. H. (2002). Psychotropic substance‐seeking: evolutionary pathology or adaptation? Addiction, 97, 389–400.Google Scholar
Tamames, J., Ouzounis, C., Sander, C. and Valencia, A. (1996). Genomes with distinct function composition. FEBS Letters, 389, 96–101.Google Scholar
Tasneem, A., Iyer, L. M., Jakobsson, E. and Aravind, L. (2005). Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels. Genome Biology, 6, 1–12.Google Scholar
Tignol, J., Martin‐Guehl, C., Aouizerate, B., Grabot, D. and Auriacombe, M. (2006). Social phobia and premature ejaculation: a case–control study. Depression and Anxiety, 23, 153–157.Google Scholar
Tinbergen, N. (1963). On aims and methods of ethology. Zeitschrift für Tierpsychologie, 20, 410–433.Google Scholar
Toga, A. W., Thompson, P. M., Mori, S., Amunts, K. and Zilles, K. (2006). Towards multimodal atlases of the human brain. Nature Reviews Neuroscience, 7, 952–966.Google Scholar
Tomasetti, C., Iasevoli, F., Buonaguro, E. F., De Berardis, D., Fornaro, M., Fiengo, A. L. C., Martinotti, G., Orsolini, L., Valchera, A., Di Giannantonio, M. and de Bartolomeis, A. (2017). Treating the synapse in major psychiatric disorders: the role of postsynaptic density network in dopamine-glutamate interplay and psychopharmacologic drugs molecular actions. International Journal of Molecular Sciences, 18, 135.Google Scholar
Ulrich, A. (2005). Hitler’s drugged soldiers. Der Spiegel. Retrieved from www.spiegel.de/international/the-nazi-death-machine-hitler-s-drugged-soldiers-a-354606.htmlGoogle Scholar
Wakefield, J. and First, M. B. (2012). Validity of the bereavement exclusion to major depression: does the empirical evidence support the proposal to eliminate the exclusion in DSM-5? World Psychiatry, 11, 3–10.Google Scholar
Wakefield, J. C. and Schmitz, M. F. (2014). Uncomplicated depression, suicide attempt, and the DSM-5 bereavement exclusion debate: an empirical evaluation. Research on Social Work Practice, 24, 37–49.Google Scholar
Watson, C., Provis, J. and Herculano‐Houzel, S. (2012). What determines motor neuron number? Slow scaling of facial motor neuron numbers with body mass in marsupials and primates. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 295, 1683–1691.Google Scholar
Wybran, J. (1985). Enkephalins and endorphins as modifiers of the immune system: present and future. Federation Proceedings, 44, 92–94.Google Scholar
Young, J. W., Henry, B. L. and Geyer, M. A. (2011). Predictive animal models of mania: hits, misses and future directions. British Journal of Pharmacology, 164, 1263–1284.Google Scholar
Zilles, K. (2005). Evolution of the human brain and comparative cyto- and receptor architecture. In: Dehaene, S., Duhamel, J.-R., Hauser, M. and Rizzolatti, G. (eds.), From Monkey Brain to Human Brain. Cambridge, MA: MIT Press, pp. 41–56.Google Scholar

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