Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-08T19:27:28.087Z Has data issue: false hasContentIssue false

Fibromyalgia

from Chief complaints and diagnoses

Published online by Cambridge University Press:  18 December 2009

Stephen H. Thomas
Affiliation:
Harvard Medical School
Get access

Summary

Fibromyalgia is marked by high interpatient variability in both clinical course and efficacy of particular therapies. Fibromyalgia pain does not result from peripheral nociceptor stimulation but instead arises from deficient CNS processing and modulation of pain signals. Tricyclic antidepressants (TCAs) and related drugs have some efficacy when compared with placebo in clinical trials. In addition to TCAs and antidepressants, the other commonly seen approach to treating fibromyalgia pain is the use of anticonvulsants. In fibromyalgia patients taking long-term opioids, a methodologically rigorous study shows that administration of the non-ergot dopamine agonist pramipexole significantly reduces pain and improves myriad quality-of-life indices. The benzodiazepines are also associated with mixed results in fibromyalgia trials. Given the lack of inflammatory pathophysiology in fibromyalgia, it is not surprising that no data support use of corticosteroids or NSAIDs in treating fibromyalgia pain.
Type
Chapter
Information
Emergency Department Analgesia
An Evidence-Based Guide
, pp. 204 - 212
Publisher: Cambridge University Press
Print publication year: 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×